"Nebivolol": analogues, mirayiridzo kushandiswa, wongororo. "Nebivolol Sandoz"

Kugadzirira kubva boka blockers zvinonzi nevakawanda kushandiswa pakurapa zvemwoyo zhinji. Pakati boka iri mishonga zvinoshamisa dzinounzwa "Nebivolol". Analogs zvinodhaka uyu akagamuchira mukurumbira zvikuru nokuda kubudirira kwayo. Imhandoi mushonga, sei akunoita uye kana iwe unogona kurishandisa?

Chii chinodhaka ichi?

"Nebivolol" rinoreva boka Beta-blockers. The chikuru mugumisiro ichi ndicho antihypertensive chinodhaka (mushonga kunoderedza kumanikidzwa). Kuvhiringidzwa iri chaichengetwa zvokusarudza rakavhara Beta-receptors iri midziyo (kubatsira Beta-1-adrenergic receptors).

Parizvino kushandiswa "Nebivolol Sandoz."

mushonga Uyu mubatanidzwa zvinosanganisira zvakawanda isomers (D- uye L-Rotating). Kubatana uku zvinhu zvinobatsira kuti pave yokuora maturo. Imwe isomer ndiye anokonzera kukura antihypertensive chiito, ukuwo yechipiri ine mukuru kukanganisa kwemwoyo.

The mushonga akazviratidza tichishandisa yapfuura, pakati rokupedzisira remakore. Kubvira ipapo, kwakapararira munzvimbo cardiac zvakatipoteredza. "Nebivolol Sandoz" ndiwo mushonga rwokusarudza pakurapa neBP uye vamwe mwoyo mutinhimira zvirwere.

Saka, inoshanda zvinodhaka uye chii zviremera vane basa rayo digestibility?

Pharmacokinetics

Best takabatikana "Nebivolol Sandoz." The mushonga zvakanaka kunakidzwa nemudumbu. Inogona kutorwa pamwe nezvokudya (Absorção de Água haina kunetse). Bioavailability achiri yakaderera - vanenge 12 muzana. Kana zvichiita, dzivisa kuudzawo mishonga pamwe doro, sezvo mukana nemishonga.

Kamwe muropa plasma, mushonga runokusunganidzai kuti sealbumin nokuumba insoluble zvivako. Izvi akasungwa chimiro Kuwanikwa kwezvinodhaka anenge 98 muzana, kureva. E. Substantially zvose takabatikana "Nebivolol Sandoz". analogues ayo saizvozvo vasati kupinda plasma uye asingauyi kuonana navo puroteni.

Regai internalize mushonga zvinobva nemudumbu uye neitsvo. It chinogadzirwa ari chiropa, apo runokusunganidzai kuti glucuronic acid.

The hafu-upenyu mushonga pavarwere vane wakakurumidza metabolite riri pamusoro zuva. Kana kunonoka muviri "Nebivolol" rinogona kuunganidza uye kuramba vari plasma kwemaawa anenge 48.

In munyama mushonga hazvirevi -wedzera kuti haambotauri ovhadhozi (zvinokwanisika chete panyaya kushandiswa kwayo varwere itsvo kana chiropa zvirwere).

zvairatidza

Mune zvimwe zviitiko, zvisinei vakagadza "Nebivolol" analogues zvinodhaka kana zvinodhaka pharmacological chiito zvakafanana?

The chiratidzo nokuti mushonga wekutanga neBP. Nokushandisa Beta-blockers vakaungana kuti ineffectiveness kushandisa ACE FIs ( "Enalapril", "captopril"). Uyezve, "Nebivolol" kushandiswa uye kwemakemikari anobudiswa neBP.

Mumwe, hapana zvisinganyanyi kukosha chinoratidza kuti kushandisa "Nebivolol" ndiyo chirwere mwoyo coronary. With kakawanda exacerbations angina uye kuti kudzivirira kurwiswa kwakadaro, uye anoratidza "Nebivolol". analogues ayo iyi inogona kuva vanobudirira pane yakachena chinodhaka pachayo.

Anosanganisira "Nebivolol" uye chikamu mubatanidzwa mishonga nekuda pakurapa chirwere chemwoyo. Panyaya iyi gadziriro kunoita kuti kuvandudzika kwemoyo, kudukupiswa chi- uye afterload kamuri muviri, uyewo vasanyanye kuitiswa.

Unogona kushandisa mushonga uye nokuda kudzivirira chirwere cheBP nematambudziko, uyewo vaya havatani atherosclerotic maronda ose chepfungwa midziyo.

Contraindications

Kana zviri haumanikidzwi kushandisa "Nebivolol"? Mirayiridzo dzokushandisa yemanyorero rinosanganisira Muzviitiko zvose izvo rakazivikanwa akaora, kana yaitwa kushandiswa mari akaona kukura yematambudziko siyana. Nokuda simba mugumisiro antihypertensive mumiririri hakufaniri nezvaro zvikuru hypotension.

Chokutanga, hazvina hakubvumidzwi kushandisa mushonga mu rikwanise mwoyo kukundikana. Izvi imhaka yokuti ane inotropic mugumisiro, izvo zvinogona kukanganisa muviri nokuda kukundikana mwoyo ushande.

With kukura pheochromocytoma zviri wairambidza kushandisa "Nebivolol." Mirayiridzo dzokushandisa kunoratidza kuti pane imwe kwemakemikari anobudiswa nebundu gadziriro zvingashandiswa chete pachiimbwa Arufa Kanotokonya blocker.

Hazvina zvakafanira kugadza mushonga vana uye vanhu vane yaivapo matambudziko chepfungwa.

"Nebivolol" iri contraindicated muvanhu pamwe nomumwe kusashivirirana kuti zvinodhaka. At zviratidzo zvokutanga (kubvambura, kupfupika mweya) vanofanira kurega pakarepo kushandisa zvinodhaka uye kutamira ngozi chisarudzo.

nemishonga

Kungofanana zvinodhaka, "Nebivolol" rine yayo nemishonga. Huru pakati pavo vari:

Tsinga - nemusoro, kuora mwoyo, hope, kushaya hope, aone zvinhu zvisipo, kufenda, dzungu.

A divi zvinokonzerwa zvomudumbu kwava kuda kurutsa, kupatira, muromo yakaoma uye kurutsa. Zvichida kuonekwa dyspeptic zvirwere, uye panguva coadministration mishonga inodzivirira - dysbiosis.

Kumwoyo ikasakendenga kutanga "Nebivolol" bradycardia, dyspnea, edema, kuvandudzwa rikwanise mwoyo kukundikana, atrioventricular chidhina, Raynaud kuti syndrome. Ovhadhozi kungaita kuti kusingadzorwi hypotension, izvo zvinogona kuoma ne kuparara uye syncope. In Muzviitiko zvakaipisisa, kuvhunduka hwapedyo.

Side chaizvoizvo "Nebivolol" anogona kuonekwa sezvo erythematous mapundu, psoriasis.

In Muzviitiko zvakaipisisa angioneurotic edema (angioedema). In munyoro kacho pane kuvandudzwa indomitable sneezing kana vangakosora.

Zvakakurukurwa kushandiswa kwezvinodhaka

The mushonga rinoshandiswa kungwarira varwere renal insufficiency, chirwere cheshuga mellitus, kana overproduction kuti thyroid mahormone. Nokubviswa zvinodhaka inoitwa zvishoma nezvishoma pamusoro mazuva 10-14. Pakutanga kurapwa hazvo zvinofanira kudzorwa BP uye HR. Kana zvichibvira panguva kushandiswa kwezvinodhaka vanofanira kusvuta. Pamberi kuuya kuvhiyiwa kuva nechokwadi kuti pasvika vanhu nemukoti anokotsirisa kuti murwere ari kushandisa Beta-blockers.

Munguva yose nguva kushandiswa kwezvinodhaka kunofanira zvakafanira kudzora ropa shuga yomuropa, kunyanya mune chirwere cheshuga. Uyezve, inofanira dzinoongororwa filtration mano itsvo (kunyanya kwevari creatine uye urea), kana imwe nguva refu iri basa "Nebivolol". Mirayiridzo dzokushandisa (analogs vane ndozvinoitawo) anonyevera kuti anogona kutanga renal kukundikana kana kupiwa nokugadzwa safunga zvinodhaka.

Zvinonzi rambidzwa kushandisa mushonga kuvana pasi pemakore 18 uye varwere vakuru decompensated mwoyo nokukundikana. Kurambidza Izvi anonyanya nokuda zvichiita pave metabolic zvirwere uye chitarisiko dambudziko nevezera.

Sezvo kana uchishandisa mushonga zvingamuka dzungu, hazvina zvakakodzera kuti ndipe vatyairi uye n'anga.

Kushandisa zvinodhaka vane pamuviri

Chinangwa mishonga iyi kuti pamuviri mukadzi chete zvinogoneka pashure zano rimwe gayinakorojisiti uye chiremba. The mushonga haawanzopiwi kushandiswa nokuda inokanganisa amai mwana.

The mushonga anopiwa chete kana zvokuora nokurovererwa, sezvo zvichiita kukura bradycardia, hypotension, yomuropa, kufema muviri, pfari.

Mazuva matatu asati kutarisirwa kubereka zvakafanira kusiya kushandisa mishonga iyi. Kana zvisingaiti, mukuvamba postpartum nguva zvinoda kungwarira kuongorora rwaamai uye mwana utano. Iva nechokwadi paaishandisa musana yokutindivadza, kuti anesthesiologist kuyambira ziendamberi kurapwa blockers.

Zvinofanira kurangarirwa kuti pakanyorwa kushandiswa kwezvinodhaka kunogona kuva fetus hypoxia. Teratogenic mugumisiro zvinodhaka haina akaratidza, asi pane zviitiko migumisiro akadaro azvarwa.

Kana uchiri nepamuviri basa "Nebivolol" mirayiridzo application inonyevera kuti zvinobvira kukanganisa pamusoro kuchirapa zviito mushonga yake kusanganawo intravenous magnesium.

Kudyidzana nevamwe somushonga kugadzirira mapoka

Dzichidya "Nebivolol" uye antiarrhythmics kirasi 1 kungaita kuti vawedzere kunaka inotropic kushanda. Zvichida kukura AV nechigumbuso. A ndozvinoitawo ari kuchengetwa kana mawa kushandiswa calcium inoshandiswa blockers uye "Nebivolol Sandoz."

Instructions varwere rinoyambira kuti kana achiita nomutsinga zvichibvira cardiac kusungwa (chero kuti mushonga chinotarisirwa pachiimbwa "Verapamil"). Muchiitiko chino, vanoda zvashata cardioversion uchishandisa cardioversion.

Pane mukana zvikuru hypotension apo vachiita zvinodhaka "nitroglycerin".

The mawa kugadzwa sympathomimetic uye "Nebivolol" hunoita kuti kokumanikidza wokupedzisira.

Kushandiswa kwose zvinodhaka nokuda yokutindivadza kungaita kuti unopinza ichidonhedzera BP, iro richava chiratidzo nokuda zvokuimba kufefetedza uye kushandisa vane chirwere cheBP zvinodhaka.

Pamunenge mushonga anogona kuva jekiseni kemikari ovhadhozi uye yokuvanda kurapwa zviratidzo yomuropa.

chipimo chemushonga

Saka zvaunoda kushandisa chete mishonga zvinodhaka, kukudziridza zvakafanira zvekuchipatara nomugumisiro? Kana ukashandisa "Nebivolol Sandoz", murayiridzo Chinyorwa inopa zvinotevera mhando dosing.

Chinonyanya Zvakanyanya Kunaka Panguva Yepamuviri dose nokuti mukuru ari MG 20 pazuva. The mushonga rinoshandiswa mukati mangwanani usina chawadya. The kunonyanyisa mugumisiro wacho chipimo chemushonga vakashandisa hunovapo kuburikidza imwe kana mbiri vhiki yokutanga kurapwa. Kana zvakakodzera, nezuva huwandu mishonga anogona ngazviwedzerwe 10 MG. Varwere vakwegura, kufadza zuva dose 5 milligrams, uye Zvakanyanya Kunaka Panguva Yepamuviri nokuda kurapwa - 2,5 milligrams pazuva. For pamuviri uwandu rokugadzirira anosarudzwa maererano zvekuchipatara zviratidzo uye muviri uremu. Zvakanakisisa kushandisa "Nebivolol Sandoz" (5 MG) Mahwendefa.

Kana kutyora chiropa kana itsvo zviri nani kusiya kushandiswa "Nebivolol" kana basa kuti shoma chipimo chemushonga.

Kana concomitant kwokubatsira sympathomimetics uye "Nebivolol" zvichibvira potentiation zvazviri, zvichiita kuti kuderedza uwandu assignable dose zvinodhaka.

Kushandisa zvinodhaka zviri mishonga maduku asina zvainoita muviri. Zvingamuka achishivirira kuti zvinodhaka receptors pamwe kwenguva refu kwokubatsira yakaderera mishonga yacho zvinodhaka.

zvinodhaka analogues

Hazvina nguva dzose zvinogoneka kuwana Pharmacies ari zvakafanira gadziriro, saka unofanira kuita kushandisa analogs. Nokuda pakuwedzera kumusika mishonga, kuwana zvigadzirwa zvakafanana hakuna kuoma. Chii mishonga anogona kutsiva "Nebivolol"?

Analogs (anoreva zvakafanana) kwegadziriro ndeinotevera:

• "Binelol";
• "Nebivator";
• "Nebivolol seakafuridzirwa";
• "Nebivolol STADA";
• "Nebivolol din email;
• "Nebikar";
• "Nebilet";
• "Nebilong";
• "Hodhi palates."

Mumwe nemumwe zvinodhaka izvi ine zvakwakanakira uye kunaka zvinhu. Vamwe vavo vari akanatsiridzwa panzvimbo chaiwo "Nebivolol." Zvisinei, mirayiridzo kushandisa nerimwe izvi, anonyevera pamusoro zvakawanda zvinogara. Saka, kuona mubvunzo, chii zvinodhaka mhando iri nani, anogona chete kubatsira chiremba vakakodzera uye anokwanisa.

Hazvina zvakafanira kushandisa mari iyi pachavo, pasina kubvunza chiremba, nekuti chete nenzira iyi vanogona yekudyidzana achiipa avo ezvinhu uye kukuvadza zvose utano hwavo uye utano shamwari dzako uye mhuri.

Reviews kugadzirira

Varwere vazhinji kushingaira kumurumbidza zvakadaro zvinodhaka forum se "Nebivolol Sandoz." Reviews nawo anowanikwa vakawanda akanaka, sezvo mushonga akabatsira kurapa kana kusunga zviratidzo chirwere, varwere vakawanda.

Kunyange zvazvo divi migumisiro vapiwe nokuda chinodhaka, riri kuonekwa rimwe kiyi pakurapa yakakwirira dzvinyiriro uye cardiac insufficiency.

Lots rekuva inofambiswa uye ane "Nebivolol." Vakachena Analogues zvinodhaka kuti munhu yakakodzera, mumwe - shoma, saka kuti maonero varwere zvinosiyana. Unofanirawo kufunga comorbidities, izvo zvinogona yekudyidzana kanganisa kubata zvinodhaka.

Unofanira zvachose kufungawo makore varwere kurapwa ichi.

Of zvose betaadrenoblokatorov inoshandiswa varwere cardiac, pakutanga munhu "Nebivolol" (analogues). Reviews Mushonga uyu kuti tikwanise vanouti inonyatsobudirira mushonga yeboka iri zvinodhaka.