Alkaline phosphatase - imwe enzayemu inokosha muviri womunhu

Kusvika panguva kunzwisisa zvokuongorora kwezvirwere zvakawanda vaishandisa rabhoritari nzira bvunzo. Izvi zvinosanganisira nokukanganisika kuongorora ropa.

Alkaline phosphatase: mukuru zvechadenga enzayemu

Alkaline phosphatase - chimwe chezvinhu zvinokosha zviratidzo. remubatanidzwa uyu enzayemu iyo akava phosphatase basa. Hazvina aripo anenge masero ose evanhu. kunonyanyisa basa rayo anoratidzwa ari alkaline svikiro uye hwakabatana muchitokisi membranes. The soro Kuwanda remubatanidzwa ichi chakanyorwa osteoblasts (masero ari pfupa rinenge), chiropa masero uye renal tubules ari intestinal mucosa, uyewo placenta. Alkaline phosphatase, riri huri serum, sezvo mutemo, zvinobva pfupa kana hepatocytes. Basa raro pakakwirira kuchengetwa kunyanya chiropa zvirwere kuti nokuitika mhingaidzo pamusoro bile mutsinga dzinofamba nemukaka, uyewo maronda pfupa vari pamwe pfupa yagadziriswa.

Alkaline phosphatase pamwero zvakakwirira. Sei?

Kune vazhinji chirwere inoti umo yakawedzera alkaline phosphatase. Ndozvakajairwa kuti chakarurama ichi zvinoenderana nezera uye pabonde, saka ngaafunge izvi apo nokududzira ropa nemakemikari omuviri.

Pakati etiological zvinhu zvingavhiringidza pachiyero makemikari, kusanganisira alkaline phosphatase, zvinofanira kusanganisira zvinotevera:

• pamuviri;

• Postmenopausal;

• kukwana yaunodya pamusoro Mishonga calcium, uye phosphates;

• nekumwisa ascorbic asidhi mumuviri;

• kushandisa chete pharmacological vamiririri (semuenzaniso, nhumbu ane inonzi estrogen uye progesterone, uyewo nemishonga).

Uyezve, alkaline phosphatase anogona zviwedzerwe zvinotevera zvirwere:

• hyperparathyroidism;

• mwoyo Kurwisa itsvo kana bapu tishu;

• vakawanda myeloma;

• rwarisa mononucleosis;

• pfupa chirwere, kusanganisira kenza zvakasikwa;

• chirwere Hodgkin vake, kunoitika nokuparadzwa pfupa;

• kusimba;

• akaipa lesion pamusoro biliary turakiti;

• kuzvimba zvinotapukira hunhu kana cirrhosis chiropa, ayo kukundwa tibhii.

Etiology kuderedza alkaline phosphatase

Kune vakawanda pathologies iyo, nekusiyana, alkaline phosphatase ipfupi. Saka, padanho enzayemu pazasi zvakajairika mu hypothyroidism. Kutyora pfupa kukura, kushayikwa zingi uye magnesium, uyewo kupererwa neropa - etiological zvinhu zvingavhiringidza huwandu alkaline phosphatase muropa serum. Kutora mamwe mishonga uyewo kuchinja pakuongororwa. Uyezve, kuvapo chakakuvara, iyo anova nokuda insufficiency pakati ascorbic asidhi kunotungamirira kuti kuderera yacho enzayemu.

Zvinofanira kucherechedzwa kuti pamuviri alkaline phosphatase anogona kukura nokuwedzera kuwanda placental isoenzyme. Izvi ndizvo okupedzisira zvokukura pamuviri uye ari chokuita kunonyanyisa kuvandudzika placenta. muenzaniso kwakadaro asina chirwere ukoshi, saka hazvisi kushanda zvekuongorora mamiriro amai kana mudumbu. Muzviitiko kana mukadzi ari chirwere placental insufficiency, wevasungwa pamusoro mukomboni ino ipfupi enzayemu.

Features kwokuchinja pachiyero alkaline phosphatase

Alkaline phosphatase ari muchimiro isoenzymes anoverengeka. The mwero yakawedzera wevasungwa pakati mukomboni iri correlated nokuva osteoblastic (mapfupa inotungamirwa muitiro), saka kuti soro nenhanho mapfupa isoenzyme kuchengetwa Paget chirwere. Kana murwere anovandudza zvokurwara pamwe osteolytic basa (semuenzaniso, vakawanda myeloma), kuti alkaline phosphatase kuwedzera, asi chete zvishoma.

Apo maronda ari hepatobiliary hurongwa anowedzera hepatic isoenzyme. In kurapwa tsika, rinoshandiswa sechiratidzo zvechinguvana kuti cholestasis. Panyaya iyi, rakananga kurasikirwa chiropa masero anogona kutora nzvimbo tikafunga kuipa kana kunyange yakaderera kwevari alkaline phosphatase. muenzaniso uyu kwese, ave mutemo, nokuti vakawanda kurapwa kacho, kunyange urege kuonekwa munguva murwere nomumwe, kunyange kuchikuvadza chiropa kana biliary turakiti.

Zvinokosha kucherechedza kuti yakawedzera alkaline phosphatase ari mwana - munhu vasiri chakajairika, iyo chokuita simba kukura. Saka, padanho enzayemu ichi muvana isvike pamwero rinopfuura ndozvakajairwa kuti akura munhu 1.5-2 nguva (kubvira 82 kusvika 341 U / L).

Specificity Pakusarudza pachiyero alkaline phosphatase

Kusvika panguva Zvakanyanya Kunaka Panguva Yepamuviri ezvinhu kuti kuongorora pamusoro kutsunga wevasungwa ose alkaline phosphatase yakasiyana, nekuti Murabhoritari neimwe ine mitemo yayo. Kune akawanda munhu akaidza nzira iyo kuvimba enzayemu substrate uye buffer gadziriro uyewo tembiricha panguva iyo ivhu inoitwa. Dzakafanana miganhu chakarurama "alkaline phosphatase" harisi, saka hazvisi zvakakodzera kuenzanisa tsika yacho enzayemu, dzakanga vakawana mumarabhoritari siyana. Izvi ndezvechokwadi kunyanya kana asingazivi chii anotonga mumarabhoritari izvi kuisa.

Nokuti Kuongororwa ropa serum rinoshandiswa. Kazhinji, vachitora pamusoro layer riri kuumbwa mune separator chubhu. Zvinokosha kucherechedza kuti ufanane alkaline phosphatase anogona zvisizvo kwakawedzera, kana ropa zvakabudiswa tourniquet pamusoro yokumusoro muzvidimbu yave zvavakatemerwa masekondi anopfuura 30. Uyezve, basa enzayemu ichi dzingasiyana zvishoma kana ropa yokuenzanisira yaichengetwa mumupanda tembiricha. In ichi ezvokunambira kunze kwomuviri waamai hemolysis hakurevi kukanganisa pakuongororwa.

Zvokuita apo mumwe pathological azvipire alkaline phosphatase?

Kana alkaline phosphatase yakawedzera, marapirwo anofanira kuva etiological mirayiridzo. Saka, kuvapo chiropa kana biliary zvirwere vanofanira kutanga gastroenterologist. Cholestasis, kuvapo pfungwa nomuviri zvemwana asati, zvinwiwa kuzvimba chiropa kana cirrhosis kunoda runoenzanirana kururamiswa zvinodhaka ane inzwi chete pakutsvaga chiremba. Self muchiitiko ichi kungaita kuti kusembura chezvinhu chirwere.

Changing wevasungwa kuti makemikari, kusanganisira alkaline phosphatase, anogona kuonekwa mumwoyo kukundikana, kenza zvokurwara uye yakanyanya kukuvara itsvo, uyewo cheshuga, saka unofanira kutanga cardiologist, nephrologist kana endocrinologist. Chiremba achasarudza kuti mishonga nzira zvichienderana kunotoda mufananidzo.

Nokubvisa etiological zvinhu, alkaline phosphatase basa anodzokera dzose. In kugadzwa mushonga zvinofanira kufungwa kuti Somuenzaniso, imwe vasiri nokuwedzera chakarurama izvi zvinogoneka mitswe, kushingaira ikure skeletal ezvinhu, pamwe gestation. It haatarisiri zvokurapa kupindira. Dudziro migumisiro sokuongorora kwomurabhoritari yaifanira comprehensively, kufungisisa zvimwe nokukanganisika parameters uye anoshivirira zvichemo.