"Azathioprine": mirayiridzo manual, ongororo, rondedzero, analogs

Izvo zvinoda zvinodhaka "Azathioprine"? Instructions pamusoro pokushandisa vakabvuma nevamiririri chichange zvinotsanangurwa munyaya ino. Nesuwo kukuudzai kana varipo contraindications uye analogues vane mushonga uyu, chii tinorasikirwa, chii chichaitika kana ane ovhadhozi, uye zvichingodaro. D.

Zvinoumba, kavha, chimiro, tsananguro medicament

In chii chimiro aripo zvinodhaka "Azathioprine"? Mirayiridzo dzokushandisa kunoratidza kuti mushonga uyu rinowanika piritsi fomu. Dzavo vanoshingaira chirungiso anoita se azathioprine. Uyewo ari zvinodhaka uye zvinosanganisira zvimwe zvokubikisa muchimiro mbatatisi starch, gelatin, lactose, uye calcium yakawanda stearate.

In pasuru vaitengesa zvinodhaka "Azathioprine"? Mirayiridzo kushandiswa kwezvinodhaka iri akanyudzwa imwe makadhibhokisi bhokisi, aiswamo akacheneruka yero Valium mapiritsi ari mhoni packs it zvezvimedu 50.

Pharmacological zvechadenga medicament

Chii mushonga ichi se "Azathioprine"? Mirayiridzo yokushandisa, chaiko ruzivo nenyanzvi vanoti mushonga mu mubvunzo chinhu analoginen "hypoxanthine", "Adenine" uye "guanine", vanobatanidzwa maumbirwo nucleic acids uye vanoratidza ichivharira maturo chokuita zvinyama kuwanda uye masero kupesana.

"Azathioprine" - immunosuppressive mumiririri. chiito Its nechinangwa cellular cytotoxicity.

Vaitirei mushonga kukwanisa tunodzivisa zvakaitwa zvinyama kusapindirana uye zvazvinoita kuberekana kubva antibodies, asi chete chiduku pamwero. Tichienzanisa "mercaptopurine" kushingaira mushonga akava kupfuura raidudzwa.

Pharmacokinetic mushonga

Pashure zvokuudzwa mushonga zvakanaka woga kubva nemudumbu. It ane pasi ukama mapuroteni eplasma (vanenge 30%).

The biotransformation zvinodhaka kusunungurwa kunoitika ne tioinozinovoy asidhi uye mercaptopurine (i.e., kushingaira metabolite). The shoma kurapwa kupinda tishu. Muchiitiko chino, duku wevasungwa zvinodhaka inowanikwa muuropi.

The hafu-upenyu azathioprine, uye chacho vanoshingaira metabolites iri maawa anenge 6. The soro wevasungwa zvinodhaka muropa vakachengeta pashure maminitsi 70-110.

The mushonga ari pauri zvinenge chose pamwe bile, uye 1-2 chete% - ne neitsvo.

zvairatidza mahwendefa

Chii prescribers "Azathioprine" (mirayiridzo kushandiswa kwezvinodhaka, analogs, wongororo zvichakurukurwa gare gare)? gadziriro iyi zvinoratidza pacharo zvinobudirira kana zvinotevera abnormalities:

• psoriasis;
• dzinonzi rheumatoid arthritis;
• tsvuku chinonzi systemic lupus erythematosus ;
• maronda colitis;
• dermatomyositis;
• myasthenia gravis;
• Pemphigus nyadzisa;
• periarteritis nodosa;
• Crohn nehosha ;
• glomerulonephritis, autoimmune;
• chisingaperi achishingaira chiropa;
• Reiter kuti urwere ;
• purpura idiopathic thrombocytopenic.

Zvinofanira kucherechedzwa kuti chingamubatsira ichi rinowanzoshandiswa nachiremba kudzivisa nokuisazve kurambwa. Asi muchiitiko chino rakundwa akabatana nevamwe mishonga.

Contraindications pakushandisa zvinodhaka

Mirayiridzo kushandiswa zvinodhaka "Azathioprine" anoudza varwere pamusoro zvinotevera contraindications:

• hepatic kukundikana ;
• hypersensitivity kuti basa kana ebetsero zvinoriumba mishonga;
• panguva pamuviri;
• mamiriro vanomanikidzwa hematopoiesis;
• chevana zera;
• achiyamwa.

Medicament "Azathioprine": chipimo chemushonga uye adhimini

Tora "azathioprine" Mahwendefa vanofanira chete kupiwa nomuromo. Muchiitiko chimwe nechimwe, kuti dose zvinodhaka akatsunga nomumwe, zvichienderana huripo, uyewo kwokuomerwa chirwere uye concomitant mishonga.

Nokuti kudzivirira mishonga batanidza kuramba ushandiswe akabatana "cyclosporin" uye corticosteroids. Pakutanga kunwa mishonga yokurapa nenzira vachizvitakudza dose kuti 5 MG pa makirogiramu (pamusoro miviri). Naizvozvo mushonga pakuita dose (1-4 MG pa makirogiramu muna 3 mishonga). Kazhinji, kurapwa kwakadaro mberi kwenguva yakareba. Kana kubvisa kurapa dose mishonga iri ashaye zvishoma nezvishoma.

Panguva panowanikwa zviratidzo kuramba wakasimwa nhengo rokutanga kunodiwa kuwedzera zuva nezuva chipimo chemushonga pakati medicament zvakare kuna 4 MG muzana makirogiramu.

Nokuti kurapa zvimwe zvirwere medicament anowanzoitwa raitongwa mune zuva dose pamusoro 1.5-2 MG pa makirogiramu kusvika 4 yakakamurwa mishonga. Kana zvakakodzera, yakati uwandu zvinodhaka anogona ngazviwedzerwe 200-250 MG (akakamurwa 4 mishonga). Ya kurapwa pamwe chokushandisa uyu wakaisirwa nomumwe, ane ruzivo nyanzvi.

How kushandisa "Azathioprine" (Mahwendefa) mu dzinonzi rheumatoid arthritis? Mirayiridzo yokushandisa, ratings (akatsanangura gadziriro chaipiwa pamusoro) rinoti nokuda kurapwa kwezvirwere zvakadai ushandiswe 1-2.5 MG paminiti makirogiramu pazuva (akakamurwa 2 mishonga). Duration yokurapa kunofanira zvinenge 3 months. Kuti abate murwere anopiwa dose pamusoro 0.5 MG paminiti makirogiramu (kuroora dose).

Nokuti kurapa echirwere nehepatitis B (active) varayire zuva nezuva dose pamusoro 1-1.5 MG pa makirogiramu.

Nyaya zvinodhaka ovhadhozi

Ndezvipi zviratidzo ovhadhozi kuitika panguva isiri kugamuchira "Azathioprine" chinodhaka? Mirayiridzo yokushandisa, vanachiremba chaivo ruzivo vanoti rokumusoro dose zvinodhaka kungaita siyana dyspeptic mamiriro, pancytopenia, kusagadzikana chiropa mashandiro uye dzekugonesa mhiri zvinokonzerwa zvinodhaka.

Pakurapa akadai mananara vachishandisa symptomatic kurapa. Kana zvakakodzera, hemodialysis. Zvisinei, ziva kuti nzira iyi hakurevi wakakwana kubviswa yezviri fuma kubva mumuviri.

zvinodhaka kwavatori

Kufanana nevamwe zvinodhaka zvinokanganisa zvinodhaka "Azathioprine"? Mirayiridzo dzokushandisa rinoti mushandirapamwe kwokubatsira pomutumwa ne "Allopurinol" anogona kuwedzera chepfu migumisiro wokutanga, uye pavanoparidza "co-trimoxazole" kazhinji kunotungamirira vawedzere myelotoxic migumisiro.

Mawa kurapwa pamwe ACE FIs kunowedzera mukana chakakomba leukopenia.

Akabatana nevamwe immunosuppressants (semuenzaniso, "Cyclosporins", glucocorticoids, Anti-CD3 antibodies) kazhinji vane siyana neoplasms uye zvirwere.

Viewed kugadzirira rinoratidza anopikisana zvazviri kuti nedepolyarizuyushim tsandanyama relaxants.

Zvinofanira kucherechedzwa kuti kubaya panguva kurapwa "azathioprine" kungaita kuti kudzvinyirira ari kugadzirwa antibodies zvikuru nyore (pakuparwa inactivated yokudzivirira), uyewo kuwedzera nemavhairasi kuberekana (pakatanga yokudzivirira live).

chaizvo kurumbidza

Things kuziva usati mishonga "Azathioprine"? Mirayiridzo yokushandisa, zvechokwadi (analogues mishonga pasi apa) mamiriro kuti mumwedzi miviri kurapa rokutanga kunodiwa vhiki imwe neimwe kuti vachengete muenzaniso peripheral ropa. Shure kwenguva ino, kuongorora kunoratidza zvakamisa hurongwa ane kakawanda 1 ose mazuva 30.

Zvinokoshawo kuti kuongorora padanho bilirubin, alkaline phosphatase uye chiropa makemikari.

In pamberi abnormalities ose itsvo kana chiropa uyewo Joint womuchato "Allopurinol" medicament chipimo chemushonga pasi kukurukurwa anofanira airarama 1/4 chikamu.

"Azathioprine" nokungwarira hwakanyanya ndinoshandira avo varwere ane herpes zoster, chibhokisi, xanthine oxidase kushaikwa, uye panguva nemwaranzi kana cytotoxic mishonga.

Analogues zvinodhaka mutengo

Chii chinogona kutsiva "Azathioprine"? Mirayiridzo yokushandisa (mutengo mishonga dziri pazasi) rinoti kuti vaiona mushonga une vezera shoma. Zvikuru zvakafanana kukanganisa zvinosanganisira zvinotevera mishonga:

• "Alpha-fetoprotein."
• "Alfetin".
• "Stemokin".
• "Profetal".
• "Revlimid".

Kana mutengo, ipapo chigadzirwa ichi hachisi yakakwirira chaizvo. Mahwendefa 50 "azathioprine" paavhareji anenge 230 rubles Russian.

Reviews kuti medicament

A Wongororo mashomanana zvinodhaka "Azathioprine" rinoreva zvakasiyana. Vamwe vanhu kutora mishonga pamusana autoimmune chirwere, vanogutsikana ayo inobudirira nokufumurwa uye kushaya zvikuru nemishonga. Vamwe Zvisinei, varwere vasiri vainzwa upi mugumisiro, uye saka vakasarudza kupa zvatinofarira zvavo nedzimwe nzira.

Zvinofanira kucherechedzwa kuti ose zvinoratidza kuti kushandisa zvinodhaka "Azathioprine" kureva zvirwere asi dzakakura zvakakwana kurapa kunogona chete kuva ruzivo nyanzvi. Panyaya iyi, panyaya nokufungirana kuvapo chero chirwere kubva pamusoro apa, iwe unofanira kumbotambudzika yokurapa kuongororwa izere, kwete kuti kuzvidzora medicate.