"Dopamine" - chii ichocho? "Dopamine": kurairirwa, chikumbiro, mutengo

The mushonga "Dopamine" sokunge munhu crystalline guruva rinopfumburwa chena ruvara ane haawanzotauri oneka zvakanaka pamusoro hydrochloric acid. chimiro ichi ine muchimiro hydrochloride. "Dopamine" - imwe pfuma soluble mumvura uye doro. Zvinonzi sei alkalis, siyana oxidizing vamiririri uye munyu simbi. Zvairatidza uye contraindications pakushandisa zvinodhaka "Dopamine", mirayiridzo iri kushandiswa kwayo anoiswa mumabhuku edu.

Zvinoreva rakapa sezvo aizomupa mhinduro Kuisa pfungwa pachinhu chimwe.

pharmacological unhu

"Dopamine" - imwe pfuma, mumwe neurotransmitter. Pazuva metabolic ehupfumi ose dopamine ari aizotangira kuti adrenaline uye noradrenaline. The mushonga kunokanganisa unoenderana receptors, uye pamatunhu kuwanda kunonatsiridza basa α- uye β-adrenoceptors. "Dopamine" basa nechinangwa:

• enhancement pamusoro peripheral vascular nemishonga;
• mukuvandudza systolic BP;
• Kukuchidzira kwemwoyo;
• kuwedzera cardiac goho;
• kuduku Kuchinja kwemwoyo;
• chinokosha okisijeni zvitengeswa.

"Dopamine" hunowedzerawo ropa riyerere nemidziyo uropi, mwoyo, neitsvo uye ura. Inosimudzira glomerular filtration mwero uye yavaibvisa excretion pedyo itsvo.

"Dopamine" - kutsanya-kuita zvinodhaka. Mushure 5-10 maminitsi pashure ini / V aizomupa oparesheni rinoguma. The hafu-upenyu - anenge maviri maminitsi. Hafu pfuma interacts ane puroteni muropa plasma. The mushonga rinopfuura nokukurumidza muviri kwacho netsvo, chiropa uye plasma nokuda pokudzora Mao uye catechol-O-methyltransferase kumamiriro ezvinhu vakaneta metabolites uye ari kushingaira zvinoberekwa itsvo. A kota kushandiswa dose iri kutendeukira norepinephrine ari adrenergic etsinga zvinomera. Nokuda vanoshingaira kuchaitwa hakusi kuunganidza zvinodhaka mumuviri womunhu, kunyange pashure refu kugamuchirwa.

"Dopamine": kushanda

Zvairatidza kuti vagamuchire:

• Mhando Various nehana, zvakadai somunhu wakapona, cardiogenic, postoperative, hypovolemic, endotoxin.
• Chenjera vascular uye mwoyo nokukundikana.
• Low cardiac goho.

"Dopamine" pamwe cardiogenic kuvhunduka zvidikanwi, izvozvo anowedzera myocardial contractile chaitika.

The mushonga chinotarisirwa nomutsinga. 125 kana 400 ml shanu muzana mhinduro kubva yavaibvisa chloride kana shuga mhinduro zvinodiwa pa 25 kana 200 MG azvaitwa. Saka, 1 ml agadzirise vakawana 200 kana 500 .mu.g fuma. Kana murwere asingagoni kupiwa Mavhoriyamu makuru Urume zvinogona kuitwa zvikuru kuramba mhinduro kuitira kuti 1 ml 800 micrograms aiva "dopamine". Kuti aite izvi, tora 200 MG pa 250 ml mhinduro. Mwero Sumo rinosvika 1-4 ug / makirogiramu paminiti kuti muviri uremu kg 70 (2 kusvika 11 samadonhwe 0,05% mhinduro kana kubva 1.5 kusvika 6 samadonhwe 0.08% mhinduro) avhareji. The kuchirapa chipimo chemushonga - kubva MG / makirogiramu 5 kusvika 9 muna 1 min. Chipimo chemushonga "Dopamine" 10-15 .mu.g / makirogiramu paminiti zvinobatsira mune vasodilation uye hypotension. The Kutarisirwa zvazvingava anogona ngazviwedzerwe 18 .mu.g / makirogiramu paminiti. The aizomupa kunoitika pasina dzongonyedzo uye zvinovhara nguva kubva pamazuva 2-3 maawa kuti 1-4 kana refu. The dose pazuva isingadariki 800 MG. Pakatanga "Dopamine" ndakaiswa ECG zvichiongororwa. Kutsunga of dose uye mwero chourongwa maererano arterial kumanikidzwa, kwemwoyo, cardiac goho, mwoyo mwero uye diuresis. Kana hypotension harimuki, uye ungaderedza weti goho, kuti dose anofanira kuderedzwa.

Contraindications

The mushonga iri contraindicated mune chiitiko matambudziko akadai:

• arrhythmia;
• pheochromocytoma;
• prostatic hypertrophy;
• kuvhara yemaziso.

nemishonga

Kutanga nefuma huru mishonga, yakakwirira azvipire "Dopamine" anogona kukonzera marwadzo, kusanganisira:

• tremor;
• tachycardia;
• vasospasm;
• arrhythmia;
• kutyora kufema mutinhimira;
• anginal uye kurwadziwa nemusoro;
• psychomotor nokusagadzikana ;
• dzimwe kuratidzwa Adrenomimeticalkie chiito.

Sezvo kubviswa "Dopamine" rinoshanda, pamusoro apa zviratidzo inonyangarika kana kudzikisa dose kana regedza kwokubatsira chezvinodhaka. Kana mutinhimira yaputswa, zvakakodzera kushandisa zvinodhaka antiarrhythmic, kusanganisira "Verapamil", "lidocaine" uye vamwe. Extravasation mhinduro "Dopamine" kungaita kuti necrosis ari subcutaneous adipose zvinyama uye ganda.

Zvokungwarira

"Dopamine" panguva yepamuviri zvaangatarirwa chete kana mukanyatsochengeta zvakakodzera kurapwa kuti mai, uye mishonga nezvinozoitika kupfuura pakaoma kuti azvarwa.

Fresh mhinduro inofanira kuva kusachinja-chinja uye kushaya segirazi extraneous Hue.

Mawa kurapwa nedzimwe zvinodhaka

The mushonga anogona kubatwa zvakafanana pamwe cardiac glycosides uye diuretics (semuenzaniso, furosemide nezvimwe). Hypovolemic kuvhunduka zvinoda kutanga "Dopamine" pamwe neropa, yeplasma kana kuti plasma yose Sevamiririri.

Musatora "Dopamine" panguva imwe chete ne "cyclopropane", Mao FIs nevanhu kuti yokutindivadza ne denderedzwa rechiedza ( "Halothane" uye vamwe).

Dhaka kunovhengana Pfungwa zvisingagamuchiriki pamwe alkaline mhinduro vemamwe zvinodhaka.

"Dopamine" - imwe mishonga iri kushandiswa chete mushonga. mutengo wayo kunobva chipimo chemushonga uye uwandu ampoules ari pasuru, kubvira 80 kusvika 300 rubles muzana rongedza (5-10 ampoules).