"Finoptinum": mirayiridzo kushandiswa, akafanana, dzomuzana chaiwo

From mwoyo uye vascular chirwere chinobata vanhu vakawanda. Uyezve, pamwe zera, pangozi kwakadaro chirwere inoti iri zvikurusa. Kuderedza ngozi zvakakomba pezvakaitwa pamuviri, vanachiremba vanoti kushandisa dzinokosha midziyo. Pakati pavo vane zvikuru dzakakurumbira vari karusiyamu mugero blockers. Ivo heterogeneous boka zvinodhaka. mashandiro avo zvinoitwa chokuita kukwanisa tunodzivisa kupinda calcium ions kubva extracellular nzvimbo iri mumasero uye nhumbi mwoyo ropa. Kuderedza wevasungwa pamusoro zvinhu izvi, kuti medicament rine vasodilating chiito.

Inobudirira zvikuru mushonga chete ehupfumi zvakadaro "finoptinum". Mirayiridzo kushandiswa murwiyo, analogs, zviratidzo nokuda kushandiswa kwezvinodhaka uye ayo nemishonga zvinotsanangurwa hereinafter.

Form, akafanana

Chii chimiro huri unhu zvinodhaka "finoptinum"? Instructions ari kushanda anoti rinogona kutengwa ive jekiseni uye mapiritsi.

Sezvo basa wemafuta mumiririri uyu anoita verapamil hydrochloride. Uyewo kugadzirira zvinosanganisira siyana ebetsero yeimwe (zvichienderana kusunungurwa siyana).

Pharmacological migumisiro

Zvii zviri kuri muna zvinodhaka "finoptinum"? Mirayiridzo yokushandisa, wongororo vanoti chiri karusiyamu mugero blocker (zvokusarudza) kirasi yokutanga. It rinobva difenilalkilamina uye rinoratidza antianginal, antihypertensive uye antiarrhythmic chiito.

Antianginal mugumisiro zvinodhaka uyu yakabatana kukwanisa rayo sei myocardium uye peripheral hemodynamics. Nemamwe mashoko, zvinodhaka kunoderedza mataurire arteries. Uyezve, kunoderedza transformatsiiyu ATP simba kuti zviri padunhu-simba ukama kupinda zvokuimba basa uye anoderedza myocardial contractility.

Tinofanira kuonawo kuti kushandisa zvinodhaka ichi yekudyidzana kunoderedza myocardial O2 uye ane kunaka chronotropic, inotropic uye vasodilatory nemigumisiro.

ehupfumi zvinodhaka

Nokuda sezvamunoita zvayo, medicament "finoptinum", analogues iyo dziri pasi apa, anovanza automaticity kuti sinus raiva pedyo nebundu kunoderedza AV-conduction uye anowedzera refractory nguva.

Kuwedzera kutandara nguva diastolic ventricle (kuruboshwe), mushonga uyu kunoderedza tonus myocardial rusvingo, i.e. ndiyo webetsero nzira chokubata obstructive hypertrophic cardiomyopathy.

Zvinofanira kucherechedzwa kuti vaiona mushonga inoratidza Anti-arrhythmic ehupfumi pamwe supraventricular arrhythmias.

The kinetics zvinodhaka

Kugadzirira "finoptinum" nekuraira inorondedzerwa pazasi, wefodya kubva zvomudumbu turakiti (anenge 90% of dose). kwawaiitwa ane puroteni 90%.

The mushonga rinoita mundima (pakutanga) kuburikidza chiropa. Izvi unoumba rinobva dzakadai norverapamil riri shoma hypotensive basa pane unmodified verapamil.

Nguva mushonga pamusoro okutambirwa rimwe chipimo chemushonga hafu-upenyu maawa 3-8. At kushandiswa akadzokorora mishonga ose medicament, nhamba iyi dzinosiyana (maawa 5-12).

Rinobva mushonga kuburikidza ura neitsvo.

umboo

Mune zvimwe zviitiko, mishonga "finoptinum"? Mirayiridzo kushandiswa (mahwendefa uye injectable mhinduro zvakafanana yokushamisira) inotaura kuti chokushandisa ichi inogona kushandiswa supraventricular tachycardia (kusanganisira paroxysmal, chirwere Lown-Ganong-Levine uye WPW-chirwere), sitiroko (voltage, yakatsiga pasina vasoconstriction, yakadzikama vasospastic), sinus tachycardia, atrial flutter, atrial tachyarrhythmia, atrial arrhythmia, vane chirwere cheBP dambudziko (nokuti intravenous Kutarisirwa), BP, zvinokosha neBP mu hvs diki dzaivapo, hypertrophic obstructive cardiomyopathy.

Contraindications

Kana kwete kuti vachipe "finoptinum"? Mirayiridzo kushandiswa (majekiseni uye mahwendefa vane contraindications) rinoratidza kuti chokushandisa ichi hakubvumidzwi kushandiswa kwazvo hypotension, sinoatrial akarikomba uye kurwara sinus syndrome (kunze varwere chinodzora kurova), AV-blockade wechitatu uye wechipiri-dhigirii chirwere Launa -Ganonga-Levin uye WPW-chirwere akabatana atrial fibrillation kana atrial flutter (kunze vanhu vachirwara chinodzora kurova), pamuviri, hypersensitivity kuti verapamil, achiyamwa.

Drug "finoptinum": mirayiridzo kushandiswa

The chipimo chemushonga zvinodhaka rinowanikwa chiremba nomumwe.

Adult varwere piritsi chinotarisirwa nomuromo mu kwokutanga dose pamusoro 40-80 MG katatu pazuva. Nokuti chipimo chemushonga siyana pamwe chete kuramba kusunungurwa chipimo chemushonga zvinofanira wakawedzera, uye kakawanda chourongwa - ezasi.

Kids makore makore 6-14, mishonga iyi inokurudzirwa kupinza chitsama 80-360 MG pazuva, uye kusvika 6 makore - panguva dose pamusoro 40-60 MG pazuva. Kakawanda chourongwa zvinodhaka kakapetwa mana pazuva.

Kana zvakakodzera, kuti mushonga mu mubvunzo unogona kupiwa nomutsinga (zvishoma). Saka zvinokosha kuti kuongorora ECG, BP uye mwoyo mwero murwere.

Disposable mhinduro chipimo chemushonga vanhu vakuru ndiko 5.10 MG. Kana mishonga zvazviri vasipo, maminitsi ipapo pashure 20 kugadzirira zvinogona kuzodzosera akapinda (nenguva dose).

A chete chipimo chemushonga injectable chimiro mushonga vana makore 6-14 pazera iri 2.5-3.5 MG vana 1-5 makore - 2-3 MG, uye kuti mwana kusvikira gore rimwe - 0.75-2 MG.

Varwere zvakakomba chiropa nezuva dose haafaniri kupfuudza 120 MG.

The kunonyanyisa chipimo chemushonga nomumukanwa kugadzirira pazuva iri 480 MG.

nemishonga

Kugadzirira "finoptinum" kungakonzera zvinotevera divi siyana:

• kufuta, bradycardia, agranulocytosis, kana kuwedzera mwoyo kukundikana, hyperprolactinemia, tachycardia, zvinopfuura kurasikirwa chiratidzo, peripheral edema;
• nemuumbi rutapudzo ropa kumanikidzwa, gynecomastia, galactorrhea, arthritis, angina, arrhythmia, pulmonary edema, AV-block dhigirii wechitatu asystole, thrombocytopenia asymptomatic, kuwa;
• kuda kurutsa, kuomarara ari maoko kana makumbo, gingival hyperplasia isiri yekenza, kufenda, kurukutika, kuwedzera kudya, mwoyo, kuwedzera chiropa transaminases;
• ganda mapundu, dzungu, kupatirwa kana manyoka, kutemwa nomusoro, kuora mwoyo, nyaradzo, extrapyramidal zvirwere, kurukutika, Flushing ganda, nehope, exudative erythema multiforme, pruritus.

zvinodhaka kwavatori

Zvinoita chokubatanidza nevamwe mishonga mushonga "finoptinum" Mirayiridzo application rinoti wemishonga vamiririri ava antihypertensive zvinodhaka wezvikamu unotsigira zvavo antihypertensive kushanda.

By intravenous kwokubatsira verapamil vanhu vachangobva agamuchira dose kuti Beta-blockers, pane mukuru njodzi hypotension (arterial) uye asystole.

Apo co-raitongwa "finoptinum" mushonga chete Beta-blockers, mishonga inhalation rufimbi uye zvinodhaka antiarrhythmic kunowedzera ngozi yokuva mwoyo kukundikana, bradycardia, zvikuru hypotension uye AV-blockade.

Pamwechete kubvuma "Amiodarone" yakakura bradycardia, kunaka inotropic Chaizvoizvo, AV-nechigumbuso uye conduction nenyonganiso.

Nekuti verapamil kuchititadzisa isozyme CYP3A4, munyaya muviri pamusoro simvastatin, lovastatin uye atorvastatin zvingatora kukurukurirana kuratidzwa kuti zvinokonzerwa kuwedzera kuwanda statins muropa. zviitiko rhabdomyolysis vane zvakare.

antianginal ehupfumi "finoptinum" yakakura kana pamwe nitrates.

Pamwechete kubvuma acetylsalicylic asidhi ichiwedzerwa ropa nguva nokuda chirungiso antiplatelet chiito.

Ndinogona kutora "Dizopiramid" pamwe zvinodhaka "finoptinum"? Mirayiridzo dzokushandisa inoshuma kuti mubatanidzwa uyu kungaita kuti zvikuru hypotension uye kuparara, kunyanya vanhu vane decompensated mwoyo nokukundikana kana cardiomyopathy.

Kana kuposha mahwendefa uye mhinduro kunowedzera ayo wevasungwa muropa ne "imipramine", apo ngozi kuchinja zvisingadiwi pamusoro ECG. Zvinofanira kucherechedzwa kuti verapamil kunowedzera bioavailability kuti "Imipramine", nokuderedza Clearance kwayo.

With wemishonga zvinodhaka "carbamazepine" akanatsiridzwa chiito neyokupedzisira, uyewo kunowedzera ngozi nemishonga kubva CNS.

Panguva iyoyowo achitora mushonga ne "clonidine" pane nyaya nomwoyo kukundikana mune vanhu vane BP.

Kana kubatanidza medicament pamwe lithium carbonate kuratidzirwa zvinodhaka mukukurukurirana vari nezvimwewo uye zvakasiyana. Pane zviitiko neurotoxicity, zvikuru bradycardia, kuwedzera zvinokonzerwa lithium uye rutapudzo kwayo wevasungwa muropa.

Se "Rifampicin" mabasa pamusoro zvinodhaka "finoptinum"? Manual rinoti mubatanidzwa uyu induces chiropa makemikari, kukurumidzisa akasimudza muviri kuti verapamil. Izvi pakupedzisira zvinotisvitsa zvinoderedza kurapwa efficacy zvinodhaka pasi kukurukurwa.

chaizvo kurumbidza

Zvaunofanira kuziva usati kushandisa zvinodhaka "finoptinum" (40 MG)? Guide anoshuma kuti chokushandisa ichi rinoshandiswa nokungwaririra apo AV-blockade wokutanga dhigirii, zvakakomba kutsemuka stenosis, bradycardia, myocardial infarction pamwe pamberi rworuboshwe ventricular kukundikana, congestive mwoyo kutadza chirwere hunhu, mwero kana munyoro hypotension, hepatic kana renal insufficiency. Uyewo mishonga iyi nokungwarira inokurudzirwa vakwegura uye yevana.

In chenjera zvichifanira kuitwa nenzira mubatanidzwa kurapa kuti BP uye angina kuburikidza verapamil uye Beta-blockers. Asi zvinokosha kuti vadzivise intravenous yaitonga yokupedzisira.

Pamusoro negashiro ichi chinoreva murwere anogona kuva nomumwe siyana zvakadai akadai hope kana dzungu, izvo zvingaita kuti munhu anokwanisa kuita basa ngozi.

Pregnancy uye lactation

Ingava ramangwana vanaamai vatsva zvichibvira ushandiswe mushonga "finoptinum"? Mirayiridzo kushandisa panguva pamuviri ane kuti ichi chinoreva chinhu rwakashata zvainoita fetus. Zvinoitawo zvinoenda zamu mukaka. Saka, pasi izvi mamiriro mushonga iri zvachose contraindicated.

Medicament "finoptinum": dzomuzana uye mutengo

Mutengo chokushandisa ichi angava akasiyana. Kazhinji, zvinoenderana muchimiro kusunungurwa chinodhaka, ayo uwandu kana kuvandudzwa. Paavhareji mutengo "finoptinum" ndiyo 100-170 rubles.

Kana vaitirei mushonga iwe contraindicated, izvozvo zvinogona kutsiviwa nomumwe anotevera zvinoreva: "Verapamil" "Verogalid" "verapamil-OBL" "Kaveri" "verapamil Sopharma" "Verapamil-kubatana yakatarwa," "Verapamil-Verein" "verapamil-ratiopharm" "Isoptin", "verapamil-Escom," "Vero verapamil," "verapamil hydrochloride" "Lekoptin".

Reviews vanachiremba uye vatengi

Nyanzvi dzinoti mahwendefa uye mhinduro "finoptinum" ane runziro uye isingadhuri nzira, yakaitirwa kudzorera BP, uye kuvandudza zvakanaka kunyange vamwe zvirwere zvomwoyo uye ropa midziyo.

Kana varwere, vakawanda vavo vari kugutsikana chaizvo nemigumisiro kurapwa pamwe mumiririri uyu. Mapiritsi kana intravenous aizomupa mhinduro hwezvekukurukurirana nokukurumidza kubviswa zviratidzo neBP uye zvimwe zviratidzo chirwere kumwoyo.

Tinofanirawo kuziva kuti pamusoro zvinodhaka uye akawana kunaka mishumo. Ivo vanotaura vakawanda divi siyana zvinoitika pakarepo pashure kushandisa zvinodhaka. Uyewo, vanozvishandisa zhinji vanotsutsumwa pamusoro vakawanda contraindications.