Mirayiridzo yekushandiswa "Tiapridal." Analogues uye nekuongorora

"Tiapridal" chirwere chinorwisa antipychotic chakaitwa pachikonzero chetiaprid. Mishonga inoshandiswa seinozorodza, analgesic uye inofungidzira. Nheyo yehutachiona hwechirwere ndeyekuvhara dopamine receptors, iyo inonyanya kukanganisa kushanda kwepakati penheyo system. Muchikamu chino ticharondedzera zvakadzama nezvekugadzirira.

Kubudiswa kusununguka, zvikamu zvechirwere

Mushonga uyu unowanikwa mumhando mbiri, unogona kutenga mahwendefa uye sarudzo:

• Rimwe piritsi, rakafanana ne-ampoule, rinobatanidza mamamiriyoni zana ezvakakosha uye zvigadzirwa. Sezvo zvipindiro zvekubatsira muzvakashandiswa zvinoshandiswa povidone, magnesium stearate, mannitol. Izvo zvakagadzirwa zvinowedzerawo ne microcrystalline dioxide ye aqueous colloidal, silicon uye cellulose.
• Mukuwedzera kune chikamu chikuru, sarudzo ine sodium chloride uye mvura yejojo.

Mune rimwe bhokisi rine mahwendefa makumi maviri (2 blisters pamapiritsi gumi) kana 12 maboule (2 blisters ye 6 ampoules). Mirayiridzo yekushandiswa kwe "Tiapridal" muchimiro chemugadziro wejojo inogona kugadziridzwa mukati uye muchidimbu. Ichi chimiro chemishonga chinokodzera chete kurapwa kwevarwere vakuru.

Pharmacodynamics of Tiapridal

Mishonga ine neuroleptic, analgesic uye anxiolytic migumisiro. Sezvo mirayiridzo yekushandiswa inoratidza, Tiapridal inonyanya kudzivirira kushanda kweD2 receptors yepakati yedopamine. Panguva imwe chete, hapana chakaipa paD ₁ -receptors. Mishonga inokubvumira kubvisa dyskinesia, kana yakashandiswa kune vakwegura inovandudza mafungiro ako.

Pharmacokinetics of Tiapridal

Kana chirwere chepiruscular chirwere (200 mg), chikwata chayo chikuru mumuviri chinowanikwa mushure memaminitsi makumi matatu, kana uchishandisa mahwendefa pachiyero chimwechete - mushure memaminitsi 60. Bioavailability pakushandiswa kwekugadzirira panguva imwe chete musati wagamuchira kudya kunobva kune 75% inowedzera kusvika 95%. Somugumisiro wekushandiswa uku kwechirwere, huwandu hwahwo huri mumuviri hunowedzerawo (ne40%).

Kubvisa muviri mumuviri wevarwere vakwegura kunonoka. "Tiapridal" mirayiridzo yekushandiswa inoreva madhiragi anopinda nepakadzika uye neropa-brain. Zvinonyatsozivikanwa kuti panguva yekurapa mushonga wacho uripo mukuumbwa kwemukaka wemvere. Madzimai, zvinokonzerwa nehuwandu hwechirwere zvinowanzokurumidza kupfuura varume (2.9 maawa), musiyano uri 0.7 maawa. Metabolism inoratidzika seyakakwana. Chizhinji chechirwere (70%) chakabviswa mumuviri neitsvo muhupenyu husina kuchinjwa.

Zviratidzo zvekushandisa kwechirwere "Tiapridal"

Kushandisa kurapa nekushandisa kwechirwere "Tiapridal" kuverenga kunoita seizvi:

• Dyskinesia (nguva, nguva dzose);
• Gilles de la Tourette's syndrome;
• Chorea;
• Zvinetso zvekuita (utsinye hunotaura, kushushikana, nezvimwewo), izvo zvinowanzokonzerwa nekudhakwa kwekusingaperi uye kune vakwegura vakwegura;
• Maitiro asina kunaka ekuratidzira, zvakadai sechisimba uye kushungurudzika;
• Zvinorwadza zvinotyisa zvehupenyu hwakawanda (asingagumi mafomu).

Kusiyana-zviratidzo, zvigadziro zvekugamuchira kugadzirira "Tiapridal"

Inorambidza kusarudzwa kwe "Tiapridal" mirayiridzo yevana vane makore masere kudarika matanhatu. Mukurapa vana, kurapwa kunoitwa chete nemapiritsi. Mishonga haigone kurapwa vakadzi vane pamuviri nevarwere vari kuyamwa. Mushonga hausi kushandiswa kune hypersensitivity kune zvikamu zvaro uye mamwe maitiro akafanana. Contraindications inosanganisira mamiriro akadaro:

• Kukundikana kwepachivi uye kushaya simba, izvo zvinokosha;
• Kuongororwa kweprolactini-inotenderera neoplasm, inopomerwa nekuvapo kwayo;
• Dambudziko reHypertensive;
• Kuongororwa kwepopochromocytoma, kunyunyuta kwekuvapo kwayo.

Matafura uye sarudzo hazvishandiswi pamwe chete ne "Sultopride" uye dopamine receptor agonists (kunze kwekurapa kwevarwere vane chirwere chePasinson), usabatanidza nemamwe marudzi eurouroptics, antiarrhymics yezvikoro III uye I A.

Kurapa neTiAdridal mishonga haibvumi kuti mirayiridzo inofanira kuitwa panguva imwe chete nekushandiswa kweMoxifloxacin, Sparfloxacin, Difemannila, Erythromycin, Bepridil, Mizolastina, Levadopy, Cisapride uye kuvharwa kwemavara kweVinkamina .

Kana murwere (kunyanya avo vakwegura) achibatwa nemishonga inogona kutungamirira ku hypokalemia, kuwedzera kwekutengesa mwoyo, kuwedzerwa kwemukati weKT, kubuda kwe bradycardia yezvakataurwa, kushandisa "Tiapridal" nekuchenjerera. Kuchenjerera kunodiwawo mumamiriro ezvinhu akadaro:

• Chirwere chePasinson;
• Kuwedzerwa kwemukati weKT yehutano hwekuzvarwa;
• Hypokalemia;
• Chikoro chisingaperi chekukundikana kwetsitsi;
• Bradycardia;
• Zvirwere umo basa remwoyo yematambudziko rinokanganiswa (kuburitsa chikwata);
• Kuora mwoyo.

Kurapa neTiAdpril

Mirayiridzo yekushandisa "Tiapridal" kutanga inokurudzira kushandiswa mumadhani maduku, zvishoma nezvishoma kuwedzera kwavari, kuitira kuti vawane simba guru.

Zvinetso zvekuita

Nokuda kwavo, 200 mg yemishonga (kusvika ku300) inofanira kushandiswa zuva rega rega. Izvozvo zvinobudirira zvinowanikwa muvhareji yemwedzi nehafu. Varwere vakwegura vanorayirwa kaduku kadiki yemushonga - 50 mg. Chirwere chimwe chete chinofanira kupedzwa kaviri pazuva, kana kuwedzera kwayo kuchibvumirwa neimwe nguva, chiito ichi chinoitwa zvishoma nezvishoma, tichifunga nezvekurudzirwa kweumwe nyanzvi. Nhamba yezuva nezuva haigone kudarika 300 mg.

Inogara Isinganyanyi kurwadziwa

Nhamba yezuva nezuva yemishonga yekurapa mamiriro akadaro inobva 200 mg kusvika 400.

Chorea, Gilles de la Tourette's syndrome

Kana mwana wacho achibatwa, chirwere chezuva nezuva chemishonga chinosarudzwa chichifunga nezvehutatu hwemuviri uye 3-6 mg / kg. Kana kurapwa kuchidiwa kune munhu mukuru, kutanga 25 mg yemishonga zuva nezuva inoshandiswa, gare gare (mushure mokuwedzera kuwedzera muzana), 300-800 mg.

Kushungurudzika, utsinye

Nhamba yakakurudzirwa yezuva nezuva yemishonga inobva ku 100 mg kusvika ku 150.

Zvinetso zvekuita

Nhamba yakakurudzirwa yekushandiswa kwezuva nezuva (kubva pa200 kusvika ku300 mg) munyaya yekuvandudzwa kwekudya kwakasununguka kana yekutanga kunowedzera kusvika 400-1200 mg. Nhamba yepamusoro inogona kuitika, iyo isingagoni kudarika, ndeye 1800 mg. Kugadzirirwa kunowanikwa pavhareji neyenguva yemaawa mashanu. Kana kurapwa kwakakosha kune munhu akwegura, majekiseni 2-3 anoitwa zuva roga roga, pakati peiyo nguva yeawa maawa matanhatu inoonekwa. Kurapa kwevarwere vakadai, kudya kwemazuva ose emamiriyoni 200 emishonga kunokurudzirwa kusvika 300. Pane imwe nguva, kwete kupfuura 100 mg yeTiapridal inobvumirwa kupiwa.

Kunyatsorondedzerwa kunonzi kurwadziwa kusingaperi

Therapy inobva pakugadzirisa kwemazuva ose kuenzanirana ne 200-400 mg yemishonga.

Zvimwe zvikanganiso pakutora mishonga "Tiapridal"

Kana kurapwa nemishonga "Tiapridal" mirayiridzo yekushandiswa, kuongorora kunosimbisa humwe humwe hutano hwehumwe hunovhiringidza. Panogona kuva nekusava nehutano mubasa re genitourinary, nervous, endocrine nemoyo maitiro. Mukuwedzera, kune ngozi yezvinetso nemanzwi. Zvimwe zviitiko zvinotambudza zvinosanganisira kushaya mishonga, pamwe chete nehumbwa kuratidzwa, kuwedzera kuwanda, orthostatic hypotension.

Overdose of Tiapridal

Kana uchinge uchishandisa chirwere chechirwere chechirwere chechirwere, kuwedzereka kunokwanisika, zviratidzo zvaro zvinetso zvekuziva, iyo yakanyanya kukura iyo iyo coma, neuroleptic syndrome (yakaipa, maitiro akaoma). Nechinangwa chokubvisa hurumende iyi, kurapa kunobva kune cholinolytic agents kunoitwa. Mushure mokubviswa kwechirwere, chirwere chechiratidzo uye plasmapheresis chinodiwa.

Special instructions

Usati washandisa mishonga iyi "Tiapridal", mirayiridzo yekushandisa inokurudzira kugadzirisa hypokalemia. Munguva yekurapa zvinokosha kuti nguva dzose iongorore kushandiswa kwe electrolyte, kutungamira electrocardiogram, kutarisa kuchinja mumufananidzo wekliniki.

Kana, semugumisiro wekutora neuroleptics, extrapyramidal syndrome inokura, zvinodhaka zve anticholinergic zvinofanira kushandiswa pane dopamine receptor agonist.

Nokuda kwehutano hwehutano, zvakakosha kuziva zvinhu zvinoratidza ngozi inogona kuitika, hazvibvumirwi kuita mabasa anoda kutarisirwa kwakakwana uye kupindura nokukurumidza.

Kuwirirana nezvimwe zvinhu

Kubatanidzwa kweimwe mishonga nekutora mishonga "Tiapridal" mirayiridzo, kuongororwa kunobatanidza nehutano hwekusafarirwa kwemuviri. Hazvikurudzirwi kushandisa Clonidine, antihistamines, anxiolytics, barbiturates uye analgesics ye opioid panguva yekurapa, sezvo chiito cheTiapridal chichawedzerwa. Nemhaka yekusawirirana, usatora "Levodopa" uye doro. Mishonga inogona kusanganiswa nekushandiswa kweeurotropic madawa, analgesics, antidepressants, neuroleptics. Kungozi yakakura yehutano hwehutano huripo panguva imwechete yekushandisa zvinodhaka zvinodhaka ne "Tiapridal".

Mari inoshandiswa nemishonga, zvakafanana, maitiro pamusoro pezvinodhaka "Tiapridal"

Kana zvichidikanwa, tora "Tiapridal" nemirayiridzo, tsanangudzo inokubvumira kuti uone kuti chirwere ichi chii. Mutengo wemishonga hauna kukosha pakusarudza mushonga werapi. Mhinduro mu-ampoules inogona kutengwa ne-995 rubles, uye mahwendefa - makumi maviri nemasere.

Pakati pemakwenzi emishonga ndeye "Eglonil", "Betamax". Kubva kune vatsigiri vanogona kusarudzwa "Sulpirid" kana "Prosulpin". Ikoko kune imwe mifananidzo yechirwere - Tiaprid, inonzi inonyanya kukosha, iyo inoshandiswa zvakakurumbira, mishonga yemishonga yemunharaunda, iyo inoshandiswa iyo inoshandiswa nekambani "Organica". Muhutano hweTiaprid, chinhu chakafanana chinoshanda chiripo, icho chikamu chechirwere TiAdpril. Mirayiridzo yekushandiswa kwezvifananidzi zvinopa mazano ekusarudza kana zvisikwa zvisingagone kushandiswa panguva imwe chete nemimwe mishonga, zvinokonzera migumisiro yega kana kuti hazvipi izvo zvinodiwa. Kuita kuti chirwere ichi chibudirire, zvisarudzo zvakawanda zvinotorwa mukutarisa pazvisarudzo.

Penguva yekurapwa kunokosha kutevera mazano ose echiremba uye mazano, ane mirayiridzo yekushandiswa. "Tiapridal", sezvinoratidzwa maongororwo, mumatambudziko akawanda anoshandiswa kubvisa mamiriro akafambidzana nekunetseka kwemanzwi uye unhu hutsinye, hutano husina kunaka . Kazhinji varwere uye vanachiremba vanogutsikana nemugumisiro werapi. Chaizvoizvo, chikamu chechipiri hachidikanwi nokuti zvinodiwa zvinokura mushure mokushandiswa kwekambani yekutanga. Mhinduro dzinoratidza kuti kune varwere mishonga "Tiapridal" inoshandiswa kushandisa.