"Montelukast": wongororo, mirayiridzo analogues zvinodhaka

"Montelukast" - pamusoro zvinodhaka wongororo anogona nyore kuwanikwa paIndaneti forum uye nzvimbo vakazvitsaurira kuna dambudziko asima - munhu chaiwo antagonist kuti leukotriene D4-Kanotokonya. The mushonga unoshandiswa nevakawanda senzira chawo panguva kurapa uye kudzivirira maitiro kurwisa chirwere chacho. Pakati Nepakati sezvamunoita kunoita kushandisa zvinodhaka nokuda pakurapa varwere kuti chero zera boka.

kusunungurwa Form

Zvikonzero nei "montelukast" vakagamuchira zvikurukuru wongororo akanaka, mumwe mujenya. Zvisinei, chinhu chokutanga kuti anobata ziso rako - ndicho Chokwadi, zvakasiyana-siyana pamahwendefa, ndakatengeswa pasi kutengeswa zita mashoko.

Panguva iyoyo kwacho iri hunodzorwa matatu chizvaro. Zviri pamusoro mureza mapiritsi ane foil hamvuropu (1 chikwata rine 10 MG pakati vanoshingaira fuma) uye analogues dzavo kutsenga (4 MG uye 5 MG azvaitwa pamusoro reagent). Base hwaro mbiri idzodzo, anoita montelukast yavaibvisa, asi murwiyo anoverengeka ebetsero siyana zvinoriumba - Mannitol uye aspartame varipo mune ivhu aiendeswa pakarepo ingestion panguva kushandiswa.

Mumashoko kakawanda zvabuda mubvunzo ndevokunyepedzera, iyo zvino uye ipapo akazviratidzazve chemishonga nengetani. Dzivirirai pamusoro counterfeiting anogona kuva, kana asina nenguva Chenjerera pakuonekwa pharmacological chigadzirwa.

Zvikurukuru, kutsenga piritsi pamwe 4 milligrams pamusoro vanoshingaira chirungiso, ane denderedzwa chimiro uye vaaleanpunainen tinge (tsananguro anoenderana mapiritsi pamwe Cherry yeshoko, nokushandiswa dzimwe flavorings bvumidzwa kusiyana), uye anozivikanwa ne nhamba "4" rimwe divi. Analogs umo huru vanoshingaira chirungiso 1 MG zvakawanda - kumativi uye akanzi "shanu". Mapiritsi somunhu goko geometrically akafanana rectangle; Ivo Beige uye kuverengwa "10" nhamba.

pharmacological chavanopinda

"Montelukast" (nezvemadzinza achirondedzera mamiriro ezvinhu apo kunzwisisa reagent wakatsamwisa Kurwara vari apo neapo) - iri hwezuva mumiririri boka antibronhokonstriktornyh zvinodhaka. The algorithm unobvumidza maitiro ake kutaura pamusoro "pedyo ukama" pamwe intermedianty / prostaglandins uye thromboxanes.

The chikuru kushanda zvinodhaka - ichivharira cysteinyl leukotriene "sensors" ari kufema hurongwa. receptors izvi kuchengetedza basa Árbol asima kukura uye kukurudzira kubatana kwetunhu secretions iyo zvino rinoungana uye zvinoomesa ari mucosa.

Kugara yaunodya zvinotisvitsa chinokosha zvinoderedza kwokuomerwa zviratidzo zviri pakanyorwa mukuru kuderera kwenhamba asima kurwiswa (sezvataurwa nevarwere vazhinji, yakanaka kuchinjai kare kuchengetwa mumazuva yokurapa okutanga).

metabolic zvinhu

"Montelukast" (wongororo vemishonga zvinoratidza kuti zvechokwadi kusarudza kumira-dzi ndeyevanyori mutengo wokuti vagadziri, kureva munhu mishonga-anoreva zvakafanana, kureva ayo sezvamunoita akafanana-muronga mamorekuru chikuru zvinoriumba, pane kanoverengeka anodhura kupfuura zvinorondedzerwa gadziriro), akapinda plasma ropa, runokusunganidzai zvakakwana pamwe mapurotini ayo. In kurapwa ongororo, mugumisiro hwakanyorwa pana 99, 37%. Panguva iyoyowo, ayo bioavailability iri maererano nedanho issuance. Somuenzaniso, zvokubikisa 5-milligram Mahwendefa amenable kuti Absorção de Água kubudikidza 73%, asi analogues pamwe Kamudzira liner umo 2 nguva yakawanda vanoshingaira zvinhu, - bedzi 64%.

Mamiriro ezvinhu akafanana ne nehafu-upenyu reagent: hurongwa kutsenga mapiritsi, nokutongwa kwawo muviri, vachisiya muviri mushure 2 maawa pashure mabiko, asi constituent zvinhu kwakajairika mahwendefa - pashure maminitsi 180-200. In ichi yeplasma Clearance kunosiyana-siyana pakati 43-45 Rine mamiririta / miniti. Uye, Sezvineiwo, 0.2 chete% of dose zvinoratidzwa Urinary makwara. Ura, nokuenzanisa, - vanopfuura 85%.

Kubva zvakataurwa vanoremekedzwa zviremera, zvinoreva kuti pharmacokinetic muitiro uri zvakafanana zvakanaka Varwere vose varume navakadzi, uye kuti tigadzirise chakakomba zera uye renal zvokurwara dzemaitirwe rugwaro huwandu kurapwa runodiwa. Asi kukundikana chiropa, kunyanya kana totaura chirwere chakakomba, akakodzerwa ngwariro chaiyo iri kugadzirira muviri purogiramu.

zvairatidza kuti

Kana wakarurama nokushandisa "montelukast" chinodhaka wongororo (vana kurapwa yakarumbidza muchimiro chingamu, mapiritsi, zvemapuranga Kamudzira goko, zvinokurudzirwa kugadza chete vakuru kuyaruka), akasiya pamusoro forum Chokwadi, anotibatsira kunzwisisa. Zvisinei, chete anotungamirirwa nevamwe vanhu mafungiro - chiri chikanganiso chikuru, nekuti pasina zano chiremba, "kuziva" mhando asima, uye Chikurukuru - kuziva zvikonzero parinowanika kwakaoma zvisingaiti.

Panyaya pamutemo mashoko, denderedzwa ikoko zviratidzo, zvirwere uye zvimwe zvirwere ataurwa sezvinotevera:

• Árbol kurwadza kwacho akaparirwa nokutaurisa chaiko mutoro;
• Pamwaka / chisingaperi rhinitis, sema hunhu mavambo;
• asima;
• kudiwa matanho.

The optimum chipimo chemushonga

"Montelukast" (kunaka inofambiswa zvakaoma zvikuru kuwana, nokuti basa chirungiso yagara vakabudirira kushandiswa senzira chezvinonhuwira vazhinji zvinodhaka chinoumba) chinotarisirwa zvokunwiwa, kamwe pazuva, pasina kuita kuti purogiramu "zvemangwanani - zvemasikati -. Chisvusvuro"

For chewable mapiritsi, 4 MG uye 5 MG vakadaro dosages mitemo:

• vana makore pakati 2 uye 5 makore: 1 chairema chigadzirwa (4 MG) pazuva, panguva yokurara, kusvikira kuwana kudzora zviratidzo uye prolongation pakati rokumanikidzirwa kosi kwevhiki 2-4 kugadzirisa Pamusana chaizvoizvo;
• Varwere 6 kusvika 14 makore: zvakafanana rudzi, asi mumwe-nguva yevanhu - 5 MG.

Nokuti mapiritsi ane foil wrapper akakodzera anotevera audzwa:

• vakuru nevana anopfuura 15 okuberekwa, nechirwere Árbol asima kana chirwere rhinitis: 1 Unit (10 MG zvinhu) / zuva manheru;
• kudzivisa chinyamunhari chinorwadza: zvakafanana dose iri nguva penguva kureba mazuva 14-28.

divi kushanda

"Montelukast" mirayiridzo (wongororo zvinoratidza kuti kunyange zvizere zvaidiwa pamutemo utungamiriri atypical siyana pakuvapo zvinhu kusvika kumagumo haigoni kunze) iri papi somunhu vanokwanisa yakachengeteka mushonga, asi pamwe proviso kuti asiri chaiyo "Achipindura" kudivi muviri wacho zviitiko achiri zvinogoneka.

Achirega muenzaniso:

• GI: manyoka, muromo yakaoma, marwadzo mudumbu urwere, kuda kurutsa,
• mwoyo uye ropa mitsetse: inokosha zvikuru kuwedzera kufamba kweropa zvazvingava;
• ganda mapundu, urticaria, zvomunharaunda hematoma;
• kufema maitiro: runny mhino uye vangakosora;
• CNS: dzungu, kurukutika, manzwiro mwoyo rakatumbuka pamwe kunyanya psychomotor nokusagadzikana;
• zvetsandanyama nemapfupa: myalgia uye arthralgia (kusanganisira nokugwinha.).
• Other: Zviratidzo yo chakasimba zvirwere kufema uye yokuSpain.

Zvausingakwanisi uye contraindications

"Montelukast" (mirayiridzo kushandiswa ndiyo Wongororo, uye ruzivo ririmo, maererano zvinhu sezvazviri, mibvunzo kubva nhengo Forum riri anenge asipo) haafaniri kushandisa kana:

• It akawana yakawedzerwa aikanganiswa murwiyo mishonga (kazhinji wechokwadi marudzi ose mahwendefa);
• chirwere zvisingawanzoitiki nhaka chirwere, kusanganisira avo umo nhengo hakuiti nezvairehwa galactose kana kusangana yakaoma lactase kushaikwa (akavarambidza izvi hairevi kutsenga mapiritsi);
• murwere vakaremerwa phenylketonuria;
• murwere haisati dzikava makore maviri (nokuti Coated mahwendefa "zera muganhu" - makore 15).

Ovhadhozi: Zviratidzo neMarapirwo

Netsvakurudzo, "Montelukast" 4 MG (nezvakanyorwa pamusoro ichi zvebhizimisi chimiro reagent, chokwadi, akafanana kuti mashoko ari kutaurwa kutsenga analogs ane 5 MG pakati vanoshingaira fuma) kupfuura zuva kuparadzwa mwero ane pamusoro zvimwechetezvo sezvo 10 Mahwendefa MG . The kupfuura akazivisa zviratidzo ovhadhozi kunogona kuonekwa varwere boka duku. Vakuru, kunyange kana achitora 200 MG / zuva 5 months, vamwe kanganisika siyana dzakanga kuchengetwa.

The chete chiratidzo Zvikamu vawedzere kuwanda mushonga ndiwo:

• risingadzime nyota;
• hope;
• nomudumbu. marwadzo nzvimbo;
• kurutsa;

Treatment rinoitwa, inobva kunotoda mufananidzo kuchengetwa. Information pamusoro kubudirira hemodialysis vasipo.

Drug kwavatori, uye zvikuru dzakakurumbira analogues

"Montelukast" 5 MG (wongororo kuti kutsenga ivhu kusiiwa pediatricians, bikai pasi pfungwa yokuti chinodhaka, hapana mubvunzo akakodzera pfungwa vabereki vaduku), uyewo kumwe leukotriene Kanotokonya antagonist, kana anoshandiswa kufanana kuMudzidzisi yomuchipatara kuwedzera zvakanaka rinomutsa : zviratidzo asima kwava zvishoma kwazvo, nhamba kurwiswa ungaderedza. Zvisinei, mashoko chimbichimbi kushaya yokurapa kuitwa pahwaro inhaled corticosteroids haina inokurudzirwa.

Rinokosha kusiyana ari pharmacokinetic pezvakaitwa chokuita theophylline uye prednizola dzakaonekwa. Asi Absorção de Água pa "pamwe 'phenobarbital zvinoderedza nokuda sezvinongoitawo 40%.

Reagents kuti tunodzivisa kwetunhu CYP3A4 isoenzyme, inofanira kushandiswa chete pasi zvokurapa achitarisirwa.

Structural analogs kuti kunowanzoitwa kuwanikwa pasero:

• "Monkasta".
• "Singlon".
• "Singulair".
• "Ektalust".
• "Singuleks".

"Singulair" kana "montelukast": wongororo vanachiremba uye vemishonga

Maererano nyanzvi pharmacologists, Chavanoitirana nharo pamusoro zvinodhaka nani uye hubudirire, maturo, sezvo "Singulair" uye "montelukast" tiri mumwe chete mishonga chawo. Just vakapfuura wokutanga muchiso zita bvumidzwa kunyoresa, uye wechipiri dzakawanda. Zvisinei, vanachiremba pachake uye varwere, anotora akasiyana maonero uye funga kurapwa kuparadzirwa pasi INN, chete zvakarurama chisarudzo.