"Relpaks": murairo wekushanda, mhinduro. Drug analogues

Kutemwa nemusoro, kunyange asina upenyu kutyisidzira kutambura kwevanhu, asi panguva imwe chete yekudyidzana akazoita mararamiro. Kwemakore, neindasitiri inogadzira mishonga iri kushanda kusika zvinhu kuti aizorega chete kubvisa inorwadza zviratidzo chirwere ichi, asiwo kufurira kwemasayendisiti kuti inouyisa migraine. Pashure pezvose, kumisa marwadzo anogona kuva inonyaradza marwadzo omusoro simba. Asi zvimwe zviratidzo migraine akadai kuda kurutsa, chiedza nehanya uye kusashivirira kune ruzha, hazvisi nyore kubvisa. The mushonga nokuda migraine "Relpaks" panyaya iyi, nyanzvi dzinoti chimwe chezvinhu inonyatsobudirira. Chii chinodhaka ichi? Sei kutora uye chii dzomuzana ake ikoko? izvi zvose unogona kuverenga pamusoro.

Pfungwa tsananguro

Huru vanoshingaira fuma "Relpaks" gadziriro - muchimiro eletriptan hydrobromide zvirimowo pamahwandefa 20 MG. Panewo chipimo chemushonga 40 MG. Upiyona hwebetsero vari yaiwanzoshandiswa neindasitiri inogadzira mishonga lactose monohydrate, magnesium stearate, croscarmellose yavaibvisa uye MCC. yeimwe izvi regai kukanganisa nekugona zvinodhaka kuti kugaya, uye hazvina chokuita seboka. Mahwendefa migraine "Relpaks" zvemapuranga Kamudzira goko orenji, rine titanium dioxide, colorants, lactose monohydrate, hypromellose uye triacetin.

Hwendefa Mumwe achiumbwa rakatenderera biconvex chimiro. Rimwe divi riri kurovererwa «REP 20» kana «REP 40 '(zvichienderana huwandu huri pahwendefa basa chirungiso) uye« Pfizer »- kune mumwe. Mune imwe mhoni zvinonyatsoenderana 2, 3, 4, 6 kana 10 pamahwendefa, izvo, akavapindurawo, dzaizara mumabhokisi makadhibhokisi 1, 2, 3, 4, 5, 6 kana 10 zvidimbu.

Pharmacokinetics uye pharmacodynamics

Medicine "Relpaks" nokukurumidza uye zvakanaka kunyura pashure nemumuromo Kutarisirwa, kunyanya akabatana mafuta zvokudya. Absorção de Água eletriptan Avharenji vanenge 81%, uye vanonzi bioavailability - 50%. The kunonyanyisa kugutsikana yezviri fuma iri plasma iri kare maawa rimwe nehafu pashure achitora zvinodhaka.

Huru vanoshingaira fuma "Relpaks" gadziriro ane waivako yakanaka maererano mapuroteni eplasma (anenge 85%). Primary eletriptan muviri kunoitika muna chiropa mumasero. Saka akaumba vaviri achiparadzira metabolite, mumwe (inoumbwa N-oxidation) haana basa. Wechipiri (akaumba muna N-demethylation) ane substantially zvakafanana ehupfumi sezvo mashoko yepakutanga, asi pfungwa yawo yeplasma ndiyo 10-20 chete% of wevasungwa pakati eletriptan. Nokuda vanoshingaira metabolite haana kuti munhu kuchirapa maturo.

Mahwendefa Migraine "Relpaks" mhinduro nyanzvi dziri zvikurukuru akanaka, inoshanda zvisinei zvepabonde murwere. Excretion zvinodhaka metabolites kuitirwa mukuru zvakadini kuburikidza itsvo (vanenge 90%), uye kubudikidza ura.

Studies ndikazvisimbisa kushaya mugumisiro habituation kune huru vanoshingaira wemafuta zvinodhaka, saka nhasi hapana kurambidzwa nokushandisa zvinodhaka "Relpaks" pamusoro nguva yokurapa kurwadziwa migraine.

Tichishandisa zvinodhaka pharmacodynamic "Relpaks" User chikumbiro rinotaura chokwadi kuti ayo huru vanoshingaira fuma kungova boka kusarudza kweserotonin vascular uye neuronal receptors, rine migumisiro dzimwe mhando pavo. Nokudaro selectivity kunoratidzwa kune mukuru zvakadini hama kuti receptors iri riri carotid arteries. Protivomengrinoznuyu basa eletriptan anosarudza kwete chete ayo anokwanisa aienda midziyo ropa riri mukati cranium, asi kunobatsirawo pamusoro pemhando neurogenic kuzvimba. Panyaya iyi, zvinoshingaira fuma ine kushanda hapana zvainoita receptors ari femoral uye coronary arteries.

umboo

Drug "Relpaks" mirayiridzo kushandiswa zviri anokurudzirwa marudzi maviri migraine:

1. Tiine Aura kana kuwedzera kurwadziwa zviratidzo zvakadai kutarisana, tactile, injini, olfactory uye auditory zvirwere.
2. Pasina Aura, kana kuwedzera nomusoro murwere hanya kuda kurutsa, kurutsa, aikanganiswa chiedza uye ruzha.

Kana pane kumwe hosha kushandisa zvinodhaka kwete chete kunobatsirawo, asi kunogona kukonzera matambudziko akawanda. Saka, usati kushandisa mushonga uyu kubvisa nemusoro, migraine, unofanira kubvunza nyanzvi uye chaidzo hwakadzama kuzviongorora. Izvi zvichabatsira kwete chete kuti taurira zvakakwana kurapwa, asi kubvisa pakarepo njodzi kune utano murwere.

Contraindications

Funga pamazita contraindications dzokushandisa "Relpaks" chinodhaka. Mahwendefa, sezvataurwa pamusoro apa, ane eletriptan inokwanisa systemic migumisiro pamusoro Muviri zvinochinja pezvakaitwa zhinji. Mune zvimwe zviitiko, uchishandisa chigadzirwa zvisingagamuchirwi kana kuti pamamiriro:

• pamberi yakakwirira nehanya murwere kuti zvose zvinhu achiumba chikamu zvinodhaka;
• mune zvinetso chiropa uye itsvo, sezvo muviri uye excretion huru vanoshingaira chinoita kunoitika mavari;
• pamwe kusingadzorwi neBP;
• pamwe Isimba rakadini rinogona kubudiswa kana achangobva ported zvirwere zvomwoyo, kusanganisira mwoyo kurwisa, angina, coronary tsinga chirwere;
• pamberi inklyuzionnyh peripheral vascular chirwere;
• paanoendeswa kana huripo panguva yose zvinopfuura ischemic kurwisa, uyewo chero kutyora chepfungwa kutenderera.

Drug "Relpaks" categorically asina pachii vanhu vane zera idukusa makore 18. Uyezve, mushonga haagoni kushandiswa rusununguko kurwadziwa chokuita musoro zvakadai migraine siyana sezvo basilar, ophthalmic uye hemiplegic.

Shandisa panguva pamuviri uye lactation

Kushandisa zvinodhaka "Relpaks" panguva pamuviri kwave insufficiently kudzidza. Zvisinei, rabhoritari zvidzidzo kwemhuka anoratidza kushanda eletriptan pamusoro kukura azvarwa. Chekutanga, vashomanana mutated majini (maererano nheyo polyploidy) akanga dzakaonekwa mu embryo. Chechipiri, munhu wenguva refu kubereka uremu kwakanga yekudyidzana kudzika kupfuura mhuka dzisina kugamuchira panguva gestation eletriptan. Ndokusaka nyanzvi ake kugadzwa anotungamirirwa kutonga, riri kuti zvinotarisirwa kubatsira kuti mai kudarika yavanababa ramangwana ngozi kune azvarwa. Zvinofanira kucherechedzwa kuti eletriptan, chikamu zvinodhaka inowanikwa mukaka dzevanhu, kunyange pashure pashure mutambo mazuva. Naizvozvo, kushandisa mishonga nokuda ekukurerai zvinogoneka chete kana kukundikana breastfeed kweinenge rimwe zuva.

Nemishonga chokuita zvinodhaka "Relpaks"

Portability "Relpaks" chinodhaka wongororo vanachiremba mashoko pamusoro simba kwokuomerwa nemishonga, izvo chete vari pfupi nguva. Hazvina basa dose chii (20 MG kana 40) yakagamuchirwa murwere. Rakajairika zviratidzo ruzivo apo kutora mushonga ndiwo:

• kuzvimba nasal mhango uye pharynx (pharyngitis, uye rhinitis);
• kutsinga dzinouya vachivavhiringidza akadai tingling, "hanzi anorovera";
• hope;
• dzungu kana kutemwa;
• myasthenia gravis kana hypoesthesia;
• hypertonicity of mhasuro fibers;
• kurwadziwa kana kunzwa zvakasimba kumashure uye chipfuva;
• cardiac arrhythmias, kunyanya tachycardia;
• dyspeptic zvinetso zvakadai kurwadziwa kana kusagadzikana mudumbu, muromo yakaoma , uye svoto;
• kuwedzera vangadikitira;
• Hot flushes kana chills zvakatarisana.

Kufungisisa makemikari anoumba "Relpaks", nyanzvi regai haabatanidzi kukura neutachiona kuti zvinoumba mushonga, izvo zvinogona kuratidzwa pakuonekwa mapundu, kuvaviwa kana akatsvuka. Mukuwedzera, muna zvisingawanzoitiki zviitiko, varwere vanogona kuva nehanya mananara akadai:

• neanorexia;
• lymphadenopathy;
• kuvhiringidzika, euphoria kana kuora mwoyo, kushaya hope uye mupfungwa lability;
• photophobia, kurwadziwa yeziso, conjunctivitis, akaderedza kana yakawedzera lacrimation;
• ngazvirege kutongoravira dysfunction;
• achirira munzeve, kana soreness;
• cheBP;
• asima kurwiswa;
• kushandura inzwi inzwi;
• kuzvimba ari nemumuromo mhango;
• kupatirwa kana manyoka;
• yemajoini kana arthrosis;
• myalgia kana myopathy;
• polyuria kana kuita weti kakawanda;
• kumwedzi zvirwere;
• ischemic colitis.

Kufungisisa-vataurwa pamusoro nemishonga, kushandisa nzira migraine "Relpaks" inokurudzirwa kuita pasi pokudzora nyanzvi, uye chete pashure anodiwa ongororo kuti huripo zvirwere chichaitwa, izvo zvinogona kuomesa kurapwa.

kudyidzana

Funga kukurukurirana nevamwe zvinodhaka antimigraine nevasori "Relpaks". Mishonga gwaro rine mashoko zvikuru pamusoro kugarisana wayo nevamwe zvinodhaka havafaniri kutorwa pamwe anodiwa mishonga anotevera mapoka:

• isozyme FIs, izvo zvinosanganisira "erythromycin", "ketoconazole" "Clarithromycin" uye "Itraconazole";
• runovharidzira mamwe FIs, kusanganisira "nelfinavir" uye "Indinavir".

Nyanzvi ona yokuti mawa kugamuchira "Relpaks" zvinodhaka mushonga "Propanolol" uye "Verapamil" anogona chete kutsamwisa kuwedzera BP, asi kunowedzera ngozi mhiri migumisiro. Inosimudzira BP angatarisirwa panyaya kwemajoini kushandiswa kwezvinodhaka pamwe zvine caffeine zvinodhaka. Ndokusaka nyanzvi dzinokurudzira kuti zuva penguva pakati yemichato zvinodhaka akadai "Relpaks" (analogues vachawa pasi tsanangudzo iyi) uye zvinodhaka ergotaminopodobnyh.

Akaora, ichiidzwa kuti nzira migraine mune mubvunzo munyaya ino hazvirevi sei nezvinhu zvine chokuita Beta-blockers, estrogensoderjath kemikari yokutsiva kana nemumuromo pamuviri, asi vo tricyclic antidepressants.

ovhadhozi

Kana iwe kusapfuudza rakarumbidza chiremba huwandu zvinodhaka "Relpaks" mirayiridzo Chinyorwa anonyevera ovhadhozi, izvo zvingakonzera kuwedzera vanoramba BP uye zvimwe zvirwere zviri kumwoyo. Vakati kuoneka uye symptomatic kurapwa inokurudzirwa kana zvakakodzera gastric lavage.

Dosing

Drug "Relpaks" nyanzvi dzinorumbidza kutora pakutanga migraine kurwiswa. Kana nomusoro uye zvimwe zvirwere Conjugate zvinokunetsa murwere kwemaawa anoverengeka, sezvo mushonga anoramba kushanda kwayo. Zvinofanira kuzivikanwa kuti womuchato zvinodhaka sechinhu chokudzivirira mumiririri kuti migraine riri inexpedient, sezvo akaratidza kuti pane iyi haina zvinozoita. Panguva iyoyowo apo pedyo Aura (varwere, refu migraine vanorwara vanogona kuziva ichi) achitora mushonga kwete chete kunoderedza marwadzo kuti kunotevera Aura, asi anobatsira zviratidzo zvakadai kuda kurutsa, hope uye photosensitivity. Izvi kunoitika kwete kamwe, asi chete pashure kutanga nomusoro. Naizvozvo, migraine vanorwara havafaniri kumhanyira kunwa piritsi neimwe nguva imwe zvirwere.

The kwokutanga dose zvinodhaka varwere makore 18-65 pazera iri 40 MG. Pashure zvakazorodza migraine marwadzo zvinogona ndokutangazve. Panyaya iyi, mutungamiriri rinokurudzira achitora chinodhaka zvakare panguva iyoyo chipimo chemushonga, asi kwete nokukurumidza kupfuura 2 maawa pashure wokutanga kugamuchira. Kana kukundikana zvinodhaka kana kutemwa vachimuvenga zvokutoda kumuponda panguva 2 maawa pashure zvinodhaka kutarisira, kuzodzosera kupinza haina inokurudzirwa dose. The vanachiremba vanoti inotevera kurwisa migraine zvakafanana murwere anogona yacho pakutanga dose "Relpaks" chinodhaka. Consumer wongororo pachiitiko ichi dzinewo mashoko akafanana.

The kunonyanyisa dose pamusoro medicament akagamuchira mukati zuva rimwe haafaniri kupfuudza 160 MG. Kunwa piritsi inofanira yose, pasina kutsenga, kunwa zvinwiwa zvakawanda.

Zvokungwarira

Kushandiswa "gadziriro Relpaks 'zvinogoneka chete pashure nokusimbisa nechirwere kuti" migraine ". Izvi imhaka yokuti kana atypical nomusoro, iro rinogona kukonzerwa sitiroko, aneurysm atsamwira nezvimwe zvirwere zvakakomba, kugadzwa kwake aigona rinokonzera matambudziko akasiyana-siyana. Uyezve, zviri zvisingadiwi kushandisa zvinodhaka ichi kubvisa kurwadziwa zvikuru migraine pakati zvemwoyo uye zvinetso zviri itsvo uye chiropa, sezvo izvi zvinogona kukonzera cheBP kuti yakaoma pamwero. Izvi zvinoshandawo varwere uyo pangozi yokuita zvemwoyo chirwere zvakakwirira. Ndokusaka pamberi varwere mushonga "Relpaks" murwere vanofanira rakagara kuongorora zvizere. Varwere panguva kushandiswa makore 65 ari zvinodhaka inofanira kuva pasi pokudzora nyanzvi, sezvo ivo inonyanyoshandiswa vakachengeta kuwedzera BP.

Yambiro! Achitaura negashiro zvinodhaka "Relpaks" mirayiridzo Chinyorwa rinotaura kuti zvakadai nemishonga sezvo dzungu Hope, saka unofanira kungwarira kunyanya kana kutyaira motokari uye pakushandisa kunzwisisa rwokugadzira.

Analogs "Relpaks" chinodhaka mutengo

Vazhinji zvinodhaka zvinoberekwa nemakambani anogadzira mishonga kuMadokero, pane mudzimba dzomuzana. Tinogona kutaura uye pamusoro Pfizer - mugadziri "Relpaks" chinodhaka. Zvisinei, sezvo rakanyoreswa chete yapfuura, kufambidzana hapana mishonga kuti vaizova zvakafanana ehupfumi sezvo mushonga "Relpaks". Analogs chikuru achishingaira chirungiso eletriptan aizivikanwa, izvo zvinogona vakagumisa kuti kugadzirira akasiyana nemamwe. mutengo wayo mu Russia inobva 380 kusvika 1200 rubles. The wakananga mutengo kunoenderana nenhamba mahwendefa pasuru uye chii chipimo chemushonga kwavo.

Pakazosvika nzira nezvainoita uropi midziyo pamahwandefa "Relpaks" pane dzomuzana dzakawanda, izvo kwete chete regai kusiyana zvikuru kwaari panguva cost, asi kazhinji kacho zvikuru anodhura. Somuenzaniso, mushonga migraine "Zomig" inogona kutengwa panguva mutengo kumativi 400 rubles kuti mapiritsi matatu. Zvinodhaka "Imigran" uye "Sumatriptan" Uyewo zvakafanana "Relpaksom" ane migumisiro uye mutengo. The chete chinodhaka, mutengo shoma zvikuru pane "Relpaks" Hwendefa - a "Kofetamin". mutengo wavo haadi kupfuudza rubles 75 paminiti rongedza.

Reviews kugadzirira

Saka, pane kuti inokosha mubvunzo. Ko vanofunga pamusoro somushonga chigadzirwa "Relpaks" vatengi vavo vanachiremba? Ndezvipi zvayakanakira nezvayakaipira kunge mushonga uyu? Chinhu chokutanga vanoti vanenge 80% of vakabvunzwa - ndiye mukuru kunyatsoshanda kuti mapiritsi "Relpaks" kunyange severe Migraine kurwisa. Feedback kubva varwere, pashure kutora chete piritsi rimwe marwadzo anoenda kure pashure maminitsi 30-40. About 8% yevatengi vakabvunzurudzwa akaratidza kuti pashure kushandiswa kwokutanga dose 40 MG vakaona zviratidzo zvakadai tremor maoko nemakumbo uye tingling kumeso uye maoko. Zvisinei, zvisingafadzi zviitiko izvi zvakaitika kwemaawa maviri pasina zvimwe chiito.

Asingasviki 1% wevarwere avo akapiwa mushonga "Relpaks", mabiko wokutanga haina vainzwa ose zvainoita. Imwe-chetatu chazvo kana kuzodzosera vadzidza zvinodhaka rave zvazviri, uye vamwe vakanga vakamanikidzwa kuwana yokutsiva.

Nyanzvi dzinoti pakati zvakanakira kwegadziriro zvayo nyoro zvazvinoita ropa nhumbi musoro. Zvisinei, ivo cherechedza kuti chitarisiko kunyange zviduku divi migumisiro murwere inofanira chete kurara. Izvi zvichava zvakakwana vose zvisingafadzi mananara kare. Nyanzvi onawozve zvinotevera: kusiya- kune mishonga yakafanana, izvo vasiri chikamu eletriptan zvinodhaka "Relpaks" nyore zvikuru akashivirira migraine vanhu.