The mushonga "Atokor": mirayiridzo manual, analogue uye wongororo

High remafuta akawandisa mumatunhu ari plasma kunoita kuti pave atherosclerosis uye mwoyo chirwere rikurumidze.

Nokuti akatakura lipid richikwidibira kurapwa kushandisa chaiwo nzira, rimwe riri chinodhaka "Atokor". Mirayiridzo mushonga uyu anorondedzera ayo hypocholesterolemic uye gipotriglitseridemicheskuyu basa mukuderedza wevasungwa anokuvadza remafuta akawandisa uye mamwe mafuta ari mumuviri womunhu.

General unhu

The mushonga anoreva FIs 3-methylglutaryl-3-hydroxy-CoA reductase. "Laboratories Dr. Reddy kuti" rinobudiswa nevanhu Indian kambani.

Mukugadzirira "Atokor" chipimo chemushonga angava 0,020 uye 0,010 d

kusunungurwa Form

Yakabudiswa muiti mu piritsi muchimiro zvemapuranga ane chena firimu. Mahwendefa extruded mune netriangle chimiro ne biconvex hukawanika parimwe iyo tsamba "A" parinoshandiswa, uye umwe akasarudzwa kuva dose kuti "10" kana "20".

mamiriro

The kushingaira wemafuta zvinodhaka ndiko atorvastatin, uko kunomiririrwa micronized karusiyamu trihydrate. In mushonga "Atokor" chipimo chemushonga uye Zvinoumba quantitative vanoshingaira chirungiso siyanei. Ose 0,01084 kana 0,02168 g atorvastatin karusiyamu trihydrate yakaenzana 0.01 kana 0.02 g yakaisvonaka atorvastatin.

Mukaka shuga, karusiyamu carbonate, croscarmellose yavaibvisa, polysorbate 80, hydroxypropyl cellulose, lactose DT, magnesium stearate hwendefa aumba mamiriro.

The casing firimu aumba kubva hypromellose 15 cps, propylene glycol, Yakanatswa talc, titanium dioxide.

Zvakafanana vose dose zvinoreva "Atokor" sezvamunoita, uye kutungamirira kwavo nhamba.

Mahwendefa 0.01 kana 0.02 g zvidimbu 10 anogadzirwa mune mhoni mumapepa ari makadhibhokisi bhokisi.

mashandiro chiito

Mishonga mirayiridzo application inobatana yakasarudzwa yemakwikwi retarders 3-methylglutaryl-3-hydroxy-kofermentaA reductase. Chinhu chinokosha enzayemu kutendeuka remubatanidzwa 3-hydroxy-3-metilglyutarilkoenzima A kuti mevalonic asidhi izvo kunotangira styrenes uye remafuta akawandisa.

Kana varwere kuti hypercholesterolemia, homozygous heterozygous rwapedyo neasiri rwapedyo mhando, uye zvakavhenganiswa dyslipidemia, zvinodhaka yaunodya "Atokor" kunobatsira kuderedza zvachose remafuta akawandisa, remafuta akawandisa inoramba iri lipoproteins yakaderera uye vakaderera chaizvo arambe achirema, triglycerides uye apolipoprotein B.

Medicament "Atokor" tsanangudzo zvinodhaka kunoratidza angaguma kusagadzikana mahwendefa anobatsira kuwedzera padanho sterol mu lipoproteins dzakakwirira arambe achirema.

In chiropa masero, uye triglycerides holesterolovye mamorekuru kuva chinokosha pamusoro lipoprotein zvinhu ane simba pasi arambe achirema. Ivo inotumirwa plasma, izvo kupinda munzvimbo peripheral tishu. Of yeimwe izvi kuumbwa lipoprotein pamwe yakaderera saturation vaigona catalyzed maitiro dzakakwirira sungano Kanotokonya mhando idzodzo. Zvose izvi zvinhu zvinogona kuwedzera kukura atherosclerotic chirwere.

Action Atorvastatin kunoratidzwa anyatsoona uye kuwedzera kwakuri iri kunyatsoshanda iri LDL-Kanotokonya zvivako, achidzikisa kunokuvadza remafuta akawandisa kuwanda panguva yakakwirira hypercholesterolemia pakati homozygous enhaka mhando.

Rinoreva "Atokor" mirayiridzo rinoratidza kukwanisa rayo tikarega yeplasma remafuta akawandisa mumatunhu uye lipoprotein kuburikidza zvichivhiringidza HMG-CoA reductase enzayemu. It DZEMUNHU DZINODZORA paumbwe remafuta akawandisa ari chiropa mumasero, anowedzera uwandu Kanotokonya idzodzo kuti lipoproteins pamwe pasi saturation muchitokisi membranes. Izvi runogonesa kuti kubatwa uye catabolism ose remafuta akawandisa kubva lipoprotein mamorekuru yakaderera yevasungwa.

Chii rinoshandiswa

Medicament "Atokor" User Application rinokurudzira kutora mapiritsi panguva chikuru zviratidzo yakawedzera cholesterolemia heterozygous mhando, omunharaunda uye asiri yemunyika kuwedzera remafuta akawandisa wevasungwa, zvakavhenganiswa geterlipidemii, yakawanda yeplasma triglyceride mamorekuru.

Vari kutarisirwa akabatana Mishonga mirayiridzo richikwidibira yakakwirira remafuta akawandisa pamwero ari lipoproteins pamwe yakaderera saturation, apolipoprotein B uye triglyceride yeimwe.

Mahwendefa dzinoderedza plasma wevasungwa kuti remafuta akawandisa mu LDL cholesterolemia panguva akakwidziridzwa homozygous rwapedyo mhando, apo Mishonga zvokudya uye nevamwe vasiri pharmacological nzira isashande.

How kutora

Medicament "Atokor" mirayiridzo kushandiswa rinokurudzira kunwa chete pashure kugadzwa mureza hypocholesterolemic kudya munhu anorwara, izvo zvinofanira kushandiswa munguva mushonga. Dosing wakaiswa yoga nerimwe murwere, iro rinowanikwa pamusoro kwokutanga nenhanho remafuta akawandisa mu lipoproteins pamwe yakaderera saturation. Zvakakosha kufunga inozoshandisirwa kushandiswa, kubudirira yokurapa ne "Atokor 'uchapupu.

Kazhinji, kwokutanga chipimo chemushonga kwakafanana 0.010 d pane imwe nguva pazuva. Kushandiswa Mahwendefa hakutsamiri nguva zuva uye zvokudya zvinodyiwa.

The chipimo chemushonga nzira zuva nezuva 0,010 kusvika 0,080 d anosarudzwa kubva kutanga chizvidavirire zviratidzi anokuvadza remafuta akawandisa, kubaya kwakavakirwa uye munhu kushanda. In Paunotanga kushanda uye nokuwedzera wevasungwa zvinodhaka inofanira kuva hafu mwedzi tarisa padanho yeplasma mafuta, uye kuchinja dose sezvo zvakafanira.

Primary hypercholesterolemia uye kubatanidzwa hyperlipidemia hunhu kubatwa chipimo chemushonga zuva muna 0,010 d

Kuchirapa basa kunoitika mukati memazuva 14, uye kufadza kunyatsoshanda zvinogoneka pashure mwedzi mumwe. Refu kushandiswa zvinoita kuti tirambe kuchirapa kushanda.

Mishonga "Atokor" mumutauro wokuRussia Chinyorwa rine mashoko terapiigiperholesterinemii pamusoro homozygous rwapedyo mhando. Kazhinji, ushandiswe zuva chipimo chemushonga muna 0.080 d In ichi kushandiswa iri kuderera LDL remafuta akawandisa tsika kusvika 40%.

Features kurapwa

Mahwendefa "mirayiridzo Atokor 'kushandiswa inokurudzirwa asati atanga kushandisa zvinodhaka vanofanira kuwana mhosva kuwedzera wechipiri remafuta akawandisa tsika zvakasimba. Zvinhu izvi zvinosanganisira chirwere cheshuga, murombo pakurapwa kwechirwere cheshuga, hypothyroidism, nephrotic muitiro disproteinemicheskih kuchinja, obstructive chiropa chirwere. Izvi zvinogona kusanganisira mimwe kurapwa nedzimwe zvinodhaka uye kupindwa muropa nedoro. Chete pashure ndichipfeka kuparadza pamusoro zvikonzero, iwe wagadzirira kushandisa piritsi "Atokor".

Kunyange asati kurapa rinoitwa Kutsunga lipid mwero pakati yose remafuta akawandisa, LDL remafuta akawandisa ari HDL remafuta akawandisa uye triglycerides.

Hapana mashoko ari kushandisa mishonga iri chiremba vakawanda, saka mahwendefa aya haana yakaratidza kuti vana.

In pakurapa varwere vakwegura, ane zera riri makore anopfuura 60, iri kuwedzera yeplasma kwevari yezviri zvinoriumba mumiririri kuti 40%.

Kana zvaipesana renal kushanda hakusi zvakakodzera kuchinja dose, sezvo ichi haasi kukanganisa atorvastatinovoe tigutsikane iri muropa uye kubudirira richikwidibira remafuta akawandisa zvakaipa.

Pane uchapupu hwokuti kushandisa mukirasi iyi zvinodhaka kuti kukura rabdomioliznoy myopathy uye kushomeka itsvo basa iri rikwanise muchimiro. In zvirwere izvi nemishonga anofanira kuraswa panguva.

Kugadzirira pahwaro atorvastatin zvinofanira kutorwa nokungwarira kuvanhu vanoshungurudza doro kana vakava chiropa chirwere kare.

Kuitwa FIs ose HMG-CoA reductase enzayemu kungava kuchinja nokukanganisika zviratidzi kuti chiropa chaitika. Nokuti nenguva kuisa kutyorwa vakadaro vanofanira kuita kunyatsoongorora hepatic basa, uye ipapo 3 months pashure kutora mapiritsi aite cheki asati kurapwa.

Drug "Atokor" riri murayiridzo Russian inosanganisira mashoko pamusoro anyatsoona kuwedzera yeplasma tsika yezviri pazvokudya varwere chiropa chirwere, vanotambura udhakwa. Temporary kana zvakakwana kukundikana yokurapa anodzoka chiropa transaminase basa chepakutanga puranga. Varwere vakawanda havana ubvise kushandiswa kwezvinodhaka iri mishonga diki, uye hapana nenjodzi yakamuka.

In marapirwo vanganzwa nzwa dzungu, kuva hope, saka panguva kushanda mahwendefa varwere hazvibvumidzwe kudzora chokufambisa, namajoko yakaoma.

Ndiani havafaniri kushandisa

On medicament "Atokor" contraindications ichisanganisira rakawedzera aikanganiswa mumwe wemafuta ari medicament.

Haana kutora nyaya rikwanise chiropa chirwere uye yakakwirira activation kuti transaminase serum makemikari apo basa ravo ka3 kupfuura rokumusoro panogumira kwomuzvarirwo tsika.

The mushonga haungopiwi vakadzi dzokubereka zera vasiri kushandisa pamuviri zvakakwana. Contraindication ndicho chimiro vana uye achiyamwa.

Medicine haadi kubata vana uye kuyaruka pasi pemakore 18.

Nokuda pamberi mukaka ari Zvinoumba mahwendefa 'Atokor "shuga mirayiridzo application unorambidza kushandiswa navo nhaka kusashivirirana kuti galactose mamorekuru, nokusava lactase uye shuga-galactose malabsortsii.

analogs

Kune vakawanda zvinodhaka nokuda atorvastatin. Remafuta akawandisa-richikwidibira zvinodhaka basa kuti "Atokor" mirayiridzo Chinyorwa. Analogs dzava kukwanisawo kudzikisa padanho remafuta akawandisa zvakaipa muropa.

Imwe mishonga yakadaro mushonga nokuda Slovenian "Atoris", inova kambani rwakashodoka kambani ndiri "Krka, Novo zeme." It anogadzirwa muchimiro mapiritsi pamwe chinoshingaira kuchatibatsira zviri 0.010 g, 0.020 g, 0.040 d

The mushonga rinotarisirwa yokubvisa hyperlipidemic ezvinhu, apo parameters zvakafanira kuderedza zvachose remafuta akawandisa, lipoprotein remafuta akawandisa mu yeimwe ane pasi saturation, uwandu apolipoprotein uye mamorekuru ose triglyceride muropa murukova.

Drug vaitire vanhu vane hypercholesterolemia polygenic heterozygous homozygous rwapedyo mhando.

Achibatsirwa "Atoris" chinodhaka kunowedzera wevasungwa kuti remafuta akawandisa mu lipoproteins dzakakwirira saturation.

Imwe Slovene analogue vaiona zvinodhaka "Tulip," yakaitwa zvino "naAmareki Pharmaceutical Company". Kune dosages matatu Mahwendefa film-zvemapuranga: 0.01 g, 0.02 d uye 0,04 d

The mushonga inoratidzwa kuti zvibviswe zvikuru siyana hypercholesterolemic uye zvabatanidzwa hyperlipidemic ezvinhu, nokuti pakurapa mafuta omumuviri akawandisa anokoshesa heterozygous uye homozygous mhuri mhando.

Saizvozvowo, nzira vaiona Indian mushonga "Astin", izvo zvinoberekwa zvebhizimisi "Micro Labs Limited". Inowanika dosages zviviri: pa 0,010 d uye 0,020 g atorvastatin.

The mushonga ari inenge yakawedzerwa lipid kugutsikana, kana haina kuchengetwa Mugumisiro Mishonga uye zvimwe zviitiko.

Indian mukugadzira munhu medicament "Storvas" inobva karusiyamu munyu atorvastatin. Kugadzirwa ne "Ranbaxy Laboratories Limited" muchimiro pahwendefa zvemapuranga aine mumuhara mu dosages zviviri: pa 0,010 d uye 0,020 d

Drug "Storvas" kuderedza mukuru zviri zvachose remafuta akawandisa, LDL remafuta akawandisa mamorekuru mukati, uye wevasungwa zviri apolipoprotein triglyceride yeimwe iri huru, uye nonmarried heterozygous rwapedyo hypercholesterolemic ezvinhu, uyewo yakavhenganiswa hyperlipidemic chirwere.

Mishonga akazoita mukana myocardial infarction myocardial hunoshamisa ezvinhu tsandanyama, sitiroko uye kuchinja ropa riyerere chepfungwa. Mahwendefa zvishoma kuchiita coronary atherosclerotic ezvinhu.

American ishamwari ndiye chinodhaka "Lipitor" iri zvinoberekwa "Pfizer". It anogadzirwa muchimiro mahwendefa zvemapuranga aine goko mu dosages matatu: pa 0.010 g, 0.020 g, 0.040 d The mushonga chinoshandiswawo kubvisa hypercholesterolemic inoti pakubhadhara akasiyana mavambo.

Reviews

Medicine "Atokor" User Application anotsanangurwa zvinoreva dzakakwirira nekusimba efficacy. Varwere vakawanda yakakwirira yeplasma kuwanda kunokuvadza remafuta akawandisa, pashure munzira unoshandiswa nani. Tsika zvachose remafuta akawandisa uye LDL remafuta akawandisa vari airarama zvisingatomboiti pamwero, izvo zvinoderedza mukana kusimukira atherosclerosis, uye ischemic ezvinhu.

The mushonga ndohwaJehovha vezvenhau pamwe tolerability zvakanaka, asi mune dzimwe varwere zvinogona kukonzera kunonoka chitsiko, bloating, marwadzo mudumbu, kuda kurutsa, fufune. Kune nomusoro, vakanetseka hope. Zvingamuka jerky, asthenic uye myalgic ezvinhu.

Mune zvisingawanzoitiki Muzviitiko, divi Marwadzo vakaratidzawo myositis, myopathy, paresthesia, peripheral neuropathy, pfungwa nomuviri zvemwana asati, hepatitis, cholestatic jaundice.

Mahwendefa zvinogona kukonzera zvinetso zvokudya, kurutsa, hepatotoxicity anokuzviratidza, alopecia, pruritic kuratidzwa rashes, kusabetsera, tsanga, hyper- kana yomuropa.