The mushonga "Sulpiride": wongororo, zviratidzo, analogs

Psychosis kunosiyana nekuomarara akaperekedza vanhu nokusingaperi. Over emakore Zvaidavirwa kuti vakagarwa nadhiabhorosi mune munhu anorwara, saka "mushonga" dambudziko iri rave zvakakodzera. Asati paakasika neuroleptic mishonga Mufananidzo vairwara nepfungwa anobudiswa mishonga kurapwa yakatanga pahwaro belladonna, henbane, opiates. Kunoitwa pakurapa pamwe karusiyamu (intravenous) uye kunyudza murwere ari akarara zvinodhaka.

The antipsychotic chlorpromazine yokutanga kwazvo anogona kunzi, iyo achishingaira kushandiswa pakurapa varwere nezvinetso chepfungwa kubva 1953. Pari ndandanda antipsychotic mishonga, antipsychotics yekudyidzana kuwedzerwa. Mumwe zvinowanzoshandiswa zvinodhaka kuti boka iri "Sulpiride". Testimonials anorondedzera iye ave zvikuru atypical antipsychotic.

pharmacodynamics zvinodhaka

Neuroleptic chaizvoizvo "sulpiride" antidofaminergicheskim chokuita nechiito, m. E. In musimboti tsinga zvinodhaka kutigumbura kunyanya dopaminergic receptors. Dopamine kunokosha chezvinonhuwira kuti "mubayiro mamiriro" uropi - kunomutsa mufaro manyawi, kugutsa kupfuura, uyewo, kunokanganisa pezvakaitwa inodzidzisa uye motivational. In dzakakwirira mishonga zvakakwana, anogadzirwa muitiro upi zvakanaka ruzivo (pamusoro kuzviitira mafungiro munhu) - negashiro zvinonaka chikafu, pabonde, hapana unofadza pamuviri nezvekufadza. Pamwe raiwedzera dopamine nechepakati tsinga inowedzerwa mupfungwa kunyaradzwa, aine kuderera - kutanga zviratidzo zvokuora mwoyo.

Action "sulpiride" pane imwe dose kwazvo MG 600 (daily yakawanda mishonga) chiri antipsychotic hunhu. Kana dosages asingasviki 600 MG - zvapararira rinodhaka uye antidepressant nemigumisiro. Zvisinei serotonicheskie, histamine, adrenergic receptors zvinodhaka ane kuvabatsira.

Mishonga - analogues

The medicament "Sulpiride" - atypical neuroleptic, kuva boka kuchiiswa benzamides - ane zvakakwana yokuwanda mishonga yakafanana iri sezvamunoita uye ane kushanda. Kune mishonga kuenzaniswa bumbiro ATC 4th pamwero. Ndivo "Betamax", "tiaprid", "Eglonil". Kunze izvi, yakakura nevatengi kudiwa "Prosulpin", "Eglek" "Restful" "Vero Sulpiride", "Sulpiride Belupo." Reviews vose mishonga kubudikidza vatengi vanogona kuva vari kutungamirira zvakanaka uye kunaka. Zvose zvinoenderana kwokuomerwa murwere ezvinhu utano, nehanya kwake huru vanoshingaira chirungiso - sulpiride, uye uwandu husingakuvadzi zvinodhaka basa kugamuchira chiremba.

Zvairatidza kuti kurapwa

Sam neuroleptic "Sulpiride", analogs ayo vane kumbonyanya wakafara zvoupenyu simba uye anogona kupiwa kugamuchira zvirwere zvakakwana chakakomba. Kuutora pamberi schizophrenia iri rikwanise matanho, uye kana zviri chisingaperi. Sulpiridsoderzhaschih wakarurama kushandiswa antipsychotics panguva rikwanise pavaipfuura kukura delirium (kukanganisika mupfungwa rezvakasikwa, achiperekedzwa nyonganyonga kuti pfungwa kubvira dzungu uye kunyange pakoma). Kazhinji mushonga wacho nachiremba siyana neurotic zvinetso uye kuora mwoyo, zvisinei dzakavapo.

Kana vertigo dzakasiyana mavambo rinokurudzira achitora "Sulpiride" mirayiridzo Chinyorwa. Reviews wevarwere uye navanachiremba vari zvakanaka yoku medicament mukurapa vestibular neuritis, kana kukundikana vertebrobasilar-basilar mhando ne otitis venhau uye cranial traumas, pamwe Meniere nehosha (rakawedzerwa kuti mvura munzeve mhango, izvo anoisa kumanikidza masero mutoro kuramba zvakanyatsoenzana muviri wayo dzidziso iri muchadenga).

Sezvo "Sulpiride" chikamu misoro mushonga inogona kushandiswa kuchirapa mabasa peptic urikanwi chirwere uye kusagadzikana bowel syndrome.

Ndiani anofanira kurega kushandisa zvinodhaka antipsychotic pahwaro sulpiride?

Neuroleptics "Sulpiride" chinodhaka analogues huru vanoshingaira chirungiso ane dzakananga mazita contraindications. Musatora kuti vanhu vane hypersensitivity kuti sulpiridu uye kutambura kubva hyperprolactinemia (yekudyidzana akakwidziridzwa kwevari kemikari prolactin muropa). Saka, mushonga uyu haasi basa namamota prolactin-zvaanoda (kenza yemazamu, prolactinoma pituitary shwanu , etc.).

Uyezve, "Sulpiride" (zvairatidza pamusoro apa) unorambidza murayiridzo pheochromocytoma (hormonally kushingaira chromaffin muchitokisi mapundu), nemanic psychosis uye siyana kuvhiringidzika nepfungwa pamwe maitiro kurwisa netsviyo. Usashandisa ichi kurapwa sulpiridsoderzhaschih pamusoro colour kuti rikwanise doro kudhaka, Kusvibisa zvinodhaka hypnotic somushonga uye marwadzo analgesics.

Not kuratidzwa kuri kushandiswa neuroleptic "Sulpiride" varwere makore pasi pemakore 18 uye vakadzi panguva lactation.

Possible divi migumisiro

Nenjodzi kuti neuroleptic pachake uye analogues "sulpiride" murwere uchapupu uye nyanzvi utano zvaizobatsira sezvo zvakakwana chakakomba, yekudyidzana kuwedzera ezvinhu varwere. Pane mukana hyperprolactinemia mune zvakasiyana-siyana (gynecomastia, dysmenorrhea, frigidity, akaderedza potency, galactorrhea, kuwedzera uremu muviri).

Humwe zvichibvira nokuratidzwa extrapyramidal urwere, izvo kunoratidzwa pathological nepfungwa yacho uwandu uye unhu espontáneo zvinoberekwa skeletal tsandanyama, kushandura mune tsandanyama inzwi. Zvisinei, rutivi rwomuviri hakusi chiratidzo inobvumirana chokwadi extrapyramidal syndrome.

Sezvo divi anwa "Sulpiride" analogs neuroleptic, kunogona kuitika tremor, akathisia (nekusagona gadzikana), dyskinesia, kushaya hope, hope, kuzvidya mwoyo mukuru excitability, kugumbuka. Anogona kuratidza zviratidzo neuroleptic akaipa urwere, dzinoratidzwa autonomic abnormalities, hapana ganda, hyperthermia.

Side migumisiro kubva nemudumbu angava kutekenyedzwa kuti kuoma iri mumuromo, kukura chirungurira, kuda kurutsa chitarisiko, retching, kupatira. Possible activation pamusoro hepatic transaminases uye alkaline phosphatase.

Kumwoyo Chikumbiro "sulpiride" anogona kuita kuwedzera BP (kazhinji - vasanyanye BP, dzungu), wakawedzera kwemwoyo, vakawedzera QT-penguva. Very kashoma, asi unogona kunzwa kuti pane "Sulpiride" chinodhaka apindure vanachiremba anoratidza kukura torsadedepointes mhando arrhythmia.

Sema kuratidzwa akadai ganda mapundu, pruritus, eczematous maronda. Dzimwe nguva unogona kunzwa pamusoro kutyora kutarisana acuity.

dosing uye kushandisa redunhu muoti

Maererano mirayiridzo kushandiswa medicament, varwere yemanyorero vakura zvichienderana chirwere waakaudzwa dose pakati 100-300 MG pazuva (akakamurwa 2-3 mishonga). Oral mhinduro raitongwa dzakasiyana chipimo chemushonga: 100-800 MG pazuva nokuda intramuscular Kutarisirwa (asati kushandisa hazvo guda). Kufadza akashivirira dose nokuti mukuru ari 1.6 d

Kana zvinovawo zvakakodzera kuti kupa "sulpiride" vana pasi nemakore 18, ari chipimo chemushonga anofanira dzaona kufungisisa uremu pachishandiswa 5 MG chete kilogram kurema muviri.

Kana murwere ane chimiro psychosis iri rikwanise kana chirwere Danho, kurapa yemanyorero kunotanga intramuscular Kutarisirwa (400-800 MG daily). Kazhinji, nguva kurapwa iri zvinenge 2 weeks. Pangosvika utano murwere, kubudikidza intramuscular jekiseni kune mabiko "sulpiride" mukati piritsi. Neuroleptic "Sulpiride" kushivirira wongororo anorondedzera sezvo mishonga inobudirira. Duration weboka mushonga zvinogona vakatsunga uye kushandurwa chete kupinda chiremba.

Kunwisa mishonga

Chero chaizvo zviratidzo inotaridza chokwadi kuti kwazvo kufadza bvumidzwa mishonga kumusoro, kwete. Kazhinji pazvinenge izvi, pane rakawedzera BP, madzerere. Zvichida kukura nyaradzo (kudzvinyirira kuti pfungwa kushatiriswa zvinodhaka rakanyorovera Chaizvoizvo, apo dzakakwirira mishonga - hypnotic). Kazhinji, migumisiro zvinodhaka "Sulpiride" uchapupu murefu anoratidza nechitarisiko kuda kurutsa, muromo yakaoma, wakawedzera vangadikitira, kurutsa. Mune zvisingawanzoitiki zviitiko kuva extrapyramidal zviratidzo, gynecomastia anogona kuitika varwere munhurume (zamu akawedzera). Very kashoma vanotaura raidudzwa parkinsonism, pakoma.

Sezvo mushonga vanosarudza kuti "sulpiride" is, symptomatic kurapwa inokurudzirwa, zvichienderana ezvinhu omurwere. Mune zvimwe zviitiko, shandisa holinoblokatory nechepakati chiito.

On chii unyatsoteerera?

Absolutely zvigadzirwa zvose antipsychotic boka (kusanganisira sulpiridsoderzhatsie "Betamax", "Vero Sulpiride", "Prosulpin", "Sulperid Belupo", "Eglonil", "Sulpiride") akaongororazve vanachiremba uye anodawo mirayiridzo unorambidza yaitwa doro hwahwa. Nokuti varwere nepfari inokurudzirwa kuti kuitisa kurapwa uye electrophysiological zvidzidzo zvave sulpiride izvozvo lowers pachikumbaridzo kuti kufenda basa. Kana mushonga unoshandiswa concomitantly zvinodhaka zvinowedzera mukana ventricular arrhythmias, varwere kwakadaro kunoda nguva richiona yacho kwemwoyo unonzi, electrocardiograph. Inosimudzira QT-penguva kunobva dose.

Kana panguva kurapwa, "sulpiride" vaiva zviratidzo hyperthermia (a chokwadi anotaura chitange neuroleptic akaipa chirwere), nokushandisa zvinodhaka anofanira vakarega.

Sudden kumira yokurapa "sulpiride" kungakonzera ucharwadziwa. Maltitol aripo ari zvinodhaka haikwani kushandisa nevanhu kutambura kubva fructose kusashivirirana.

Munguva yose kurapwa nguva inofanira vasingafariri nemotokari uye Implementation management remapazi yaida nokukurumidza Mhinduro psychomotor uye yakakwirira yevasungwa.

Sulpiridsoderzhaschie mishonga uye pamuviri

Women panguva pamuviri "Sulpiride 'wongororo vasara kupfuura zvakanaka negwara. Maximum zvinobvumidzwa dose kuvakadzi vane mimba ndiyo 200 MG pazuva haana vanotsamwisa teratogenic Migumisiro (Kutsauka embryo pakukura). The pfupi guru mishonga zvinodhaka kuvakadzi vane mimba No ruzivo kuwanikwa. Uyewo, hapana mashoko pamusoro zvinogona kukanganisa zvinodhaka-antipsychotics pamusoro uropi kukura kwemwana.

Kazhinji, vashandi vezvoutano havadi kushandisa "Sulpiride" nokuti mishonga vakadzi nepamuviri, kunze zviitiko apo kunobatsirawo vakadzi akavamba pamusoro zvingakanganisa azvarwa. Muzviitiko zvakadaro, "Sulpiride" mirayiridzo (wongororo vakashinga akasimbisa) rinokurudzira chinotarisirwa chepasi inobvira mishonga uye kana zvichiita kurerutsa nguva kurapwa.

In vana vakaberekwa nevakadzi kutora panguva pamuviri sulpiridsoderzhaschie mishonga neapo vakachengeta gastrointestinal zviratidzo (bloating, uye zvichingodaro. N.) Manzwi atropinopodobnye kufurirwa neuroleptics. Dzimwe nguva unogona kunzwa extrapyramidal syndrome. Panguva pamukaka ndakasununguka "sulpiride" contraindicated.

Opinion wevarwere "sulpiride"

Unorema varwere pamusoro zvinodhaka "Sulpiride" wongororo kunosiya yakanaka negwara. Neuroleptic zvakakwana inobudirira uye kupembedza rakaziviswa unhu. Vanhu achitora "Sulpiride" kana ayo analogues kuti mupfungwa zviratidzo panguva gastric urikanwi kana duodenal urikanwi, vakashuma vasanyanye kusimba abdominal marwadzo uye kuvandudzika zvavo ezvinhu.

Mavhoriyamu duku medicament (50 kusvika 300 MG pazuva) kazhinji ushandiswe varwere kugamuchira zvichemo kungogaroita dzungu yomuka nezvikonzero zvakasiyana-siyana. Unorema varwere izvi akagutsikana nemigumisiro kurapwa.

mishonga Large "sulpiride" (anopfuura 600 MG pazuva), mu pfungwa vashandi vezvokurapa kupa kunobudirira antipsychotic chaizvo varwere. Mishonga asingasviki 600 MG, uye mafungiro kuvarapi uye varwere, akatakurwa anotokonya uye antidepressant kushanda.

Pane boka uyo akasiya "sulpiride" mune zvakaipa nenzira varwere. Ko vanhu kuva kuda kurutsa, mafaro, giddiness. Negative zviratidzo akanyangarika pashure discontinuation of "sulpiride".