The mushonga "valparin": mirayiridzo kushandiswa, akafanana, anoreva zvakafanana, neShanduro. Reviews kugadzirira

Sei ndichida mishonga "valparin"? Mirayiridzo kushandiswa, anoreva zvakafanana uye zvairatidza zvinodhaka izvi zvinotsanangurwa munyaya ino.

The chimiro uye Kuronga

Wakadiniko tinoberekwa mushonga "valparin"? Piritsi - zvinonzi chimiro iyi mushonga uri mubvunzo inogona kutengwa chemishonga. Ivo vanoratidza chiito nguva refu, rakatenderera biconvex chimiro, uye chena ruvara unhani.

Kuti chikamu zvinodhaka "valparin"? Guide anogovera kuti chishandiso chine valproic asidhi uye yavaibvisa valproate. Kunosanganisirawo zvinotevera Excipients: glycerol, colloidal nesilicon dioxide, evdragit E-100, hydroxypropylmethylcellulose, polyethylene glycol 1500, ethylcellulose, yavaibvisa saccharin, nesilicon yakasviba hydrate, evdragit KWETE-30d, titanium yakasviba uye talc.

Buy Mahwendefa zvinogona kuonekwa micheka yakatsemurwa zvidimbu 10 ari makadhibhokisi svinga azvaitwa.

The zvinodhaka

Sei mushonga "valparin"? Mirayiridzo dzokushandisa (sezvamunoita zvinoreva rave richirondedzerwa apa) rinoti chiri anticonvulsant zvinodhaka. Rine yavaibvisa valproate zviri dzekugonesa neGhebha muuropi, izvo zvinoita kuti kuwedzera kwayo postsynaptic Tutsinga tunofambisa mashoko utwu.

Tinofanira kuonawo kuti chimwe chezvinhu mubvunzo paupenyu chokufambisa kuti potassium ions mhiri neuronal membranes. Izvi anovanza kukura uye kupararira zvipusha excitation mune tsinga fibers.

Zvinofanira akati kuti yavaibvisa valproate ane anticonvulsant kushanda muna-siyana netsviyo.

Drug "valparin" hakuiti nhaka kunyaradza uye hypnotic zvinokonzerwa, uye hatisi mwoyo pakati yokufema. Uyezve, ayo vanoshingaira chirungiso hakuna nemigumisiro pamwoyo zvazvingava, muviri tembiricha murwere, ropa rake kumanikidza uye itsvo chaitika.

The kinetic ehupfumi zvinodhaka

Ndezvipi pharmacokinetic zvechadenga zvinodhaka ane "valparin"? Guide anoti mushure kutora mapiritsi mukati inodzorwa kusunungurwa vanoshingaira fuma kunotanga pakarepo, uye pashure pemaawa 2-8, anosvika vaifanira yeplasma pamwero.

Bioavailability zvinoreva vaiona 100%.

The kuchirapa mugumisiro zvinodhaka rinooneka chete pashure kusvika valproic iine acid wevasungwa muropa, akaenzana 45-100 MG / l. It achaongwa kuti mishonga uye pharmacological nezviito achishandisa kudzorwa kusunungurwa makirisito chinoumba hapasi pakuti plasma kuwanda.

Communication vaiona zvinodhaka mapuroteni eplasma iri vanenge 85-90%. It rinoita muna chiropa uye goho pamwe chete weti. In ichi vomuzana vanopfuura muviri ari kuchengetwa.

Hafu-upenyu pomutumwa iri maawa anenge 9-20. In vana, ichi nguva ipfupi.

Zvairatidza kuti rubvumo

Under chii ezvinhu inonyatsobudirira zvinodhaka achiita "valparin"? Mirayiridzo yokushandisa, chaiko ruzivo nenyanzvi mushumo kuti akati medicament anogadzirwa zvakananga pakurapa generalized pfari, kusanganisira marudzi anotevera kurwiswa:

• myoclonic;
• tisipo;
• atonic;
• tonic-clonic.

Uyewo, mushonga uyu nachiremba zvishomanana pfari, uye zvakawanda zvakananga, pa:

• yechipiri generalized pfari;
• kubatanidzwa kana nyore pfari.

Uyezve, mapiritsi kazhinji vaiona kushandiswa apo chaiyo syndromes (Lennox-Gastaut urwere, West).

Kurambidzwa kushandiswa mahwendefa

It ane contraindications zvinodhaka "valparin"? Maererano mirayiridzo kubva chokushandisa, pane mitemo yakawanda kuti kushandiswa:

• panguva pamuviri;
• chakakomba zvirwere zviri rwatata;
• thrombocytopenia;
• chiropa chenjera kana refu;
• porphyria;
• rinoita chiropa nyaya (zvinodhaka Genesis);
• achiyamwa;
• zera vana kusvikira makore matatu;
• hypersensitivity kuti mushonga, kusanganisira kuti valproic acid.

Anticonvulsant "valparin": mirayiridzo kushandiswa

The chipimo chemushonga zvinodhaka anosarudzwa nomumwe, zvichienderana uremu muviri uye zera murwere.

Kazhinji, nokuti mukuru pokutangira dose ndiyo MG 600 zvinodhaka pazuva. Munyaya inotevera nhamba iyi yakawedzera 200 MG (ose matatu mazuva kuzadzisa zvinodiwa mugumisiro).

Multiplicity anogamuchira zvinoreva pasi kufunga 1-2 nguva pazuva. Kufadza rakarumbidza chipimo chemushonga ndiyo 1-2 g zvinodhaka pazuva.

Mahwendefa "valparin", mirayiridzo kushandiswa zviri munyaya bepa iri rinofanira kumedzwa seboka, kunwa shoma mvura inodziya.

In vanhu vakwegura vari dosing zvaiitwa kuti chokushandisa ichi rakafanana dosing zvaiitwa pavarwere akura, asi vakasarudzwa nomunhu.

For vacheche yairema makirogiramu 20 kutanga dose kuti medicament ndiro 400mg pazuva. Zvakakodzera kuwedzera mari zvishoma nezvishoma kuti vabudirire kutsvakwa mugumisiro (anenge 20-30 MG / makirogiramu pazuva, muna 1-2 mishonga).

Child yairema kusvika 20 makirogiramu ndipe mishonga anticonvulsant hakubvumidzwi.

Zviito ne-hunhu

Ndezvipi nemishonga chikonzero "valparin" piritsi? Mirayiridzo yokushandisa notifies kuti yaunodya zvinodhaka izvi varwere dzevanhu vanogona sadikanwa Migumisiro:

• Neutachiona: Stevens-Johnson urwere, ganda mapundu, erythema multiforme, pruritus, ganda, photosensitivity.
• Zvomudumbu hurongwa: svoto, hepatitis, kurutsa, kupatira, manyoka, pfungwa nomuviri zvemwana asati.
• Dzokubereka nadzo: amenorrhea chesekondari, mugari kumwedzi.
• CNS: pakoma, chakamira pakunodengenyeka zvine, ataxia, havachanyatsogoni kuziva.
• hemopoietic hurongwa: kupererwa, platelet aggregation chinovhiringidza, thrombocytopenia, leukopenia, neutropenia, ungaderedza fibrinogen.
• Other: kufuta, kurasikirwa bvudzi, serum creatinine, hyperammonemia.

ovhadhozi anticonvulsant

Ndezvipi zviratidzo zvinogona kuitika kana achitora dzakakwirira mishonga yacho zvinodhaka "valparin"? Mirayiridzo dzokushandisa (mahwendefa inogona kutengwa chero chemishonga pamusoro mushonga) anoti kuna musi nemaune kana netsaona ovhadhozi zvinodhaka pasi kukurukurwa vakaudza kashoma. Sezvo kutonga, kutyora dosing zvinodhaka kunoita kuti chimiro kuda kurutsa, dzungu, kurutsa, manyoka, kufema mwoyo, pakoma, uye hyporeflexia.

Kubvisa zvinhu zvakadai murwere ushandiswe gastric lavage neactivated charcoal. Kana zvakakodzera, murwere kurapwa rinoitwa muchimiro symptomatic kurapa uye hemodialysis.

Kudyidzana nevamwe zvinodhaka

Kana achipinda kudyidzana nevamwe zvinodhaka mushonga "valparin"? Mirayiridzo yokushandisa inozivisa murwere kuti yavaibvisa valproate kuatsanangura migumisiro antipsychotics, antidepressants uye zvinodhaka antiepileptic.

Kusiyana nevamwe anticonvulsants , vasina mushonga kunoita hepatic enzayemu induction, uye naizvozvo hazvideredzi kubudirira nomumukanwa pamuviri.

In zvakafanana negashiro "warfarin" uye yavaibvisa valproate kunoderedza kuti chikamu ndichisunga pakutanga mapuroteni eplasma.

The rinoita mushonga fuma anoonekwa kukwanisa kushandura yeplasma kuwanda lamotrigine, uye phenytoin. Kana zvasangana nomukaka zviri acetylsalicylic iine acid anticoagulant uye antiplatelet kushanda kunosimudzirwa.

With mawa kushandiswa "valparin" kubva panyaya iyi uye nezvimwe zvinodhaka kuti inoodza mwoyo CNS akavhara (semuenzaniso, Mao FIs ndiyo tricyclic antidepressants, antipsychotic zvinodhaka) anogona kunowedzera CNS depression.

Doro nezvimwe zvinodhaka hepatotoxic kuwedzera pangozi kukuvara chiropa.

Viewed Pfungwa kunowedzera hafu youpenyu "lamotrigine" uye DZEMUNHU DZINODZORA muviri wayo uye anovanza hepatic makemikari. Maererano neizvi hafu-upenyu zvinodhaka anogona ngazviwedzerwe maawa 70 varwere akura uye maawa 45 - Vana.

"Valparin" anogona kuderedza Clearance "zidovudine" munenge 40%. Uyezve, ayo hafu-upenyu haachinji.

Mao FIs antidepressants, tricyclic uye zvinodhaka antipsychotic (neuroleptics), uyewo zvimwe zvinodhaka kuti yakaderera nezvokubvuta chikumbaridzo, zvikuru kuderedza kubudirira vaiona medicament.

Achiyamwa uye pamuviri

Maererano nenyanzvi, kushandiswa kwezvinodhaka "valparin" panguva gestation ndiyo chete zvinogoneka kana inozoshandisirwa kubatsirwawo vanaamai yemberi yekudyidzana akapfuudza zvingakanganisa mwana.

Kana muchigamuchira mushonga panguva pamuviri, iva nechokwadi kuti kuitisa kushandiswa pamuviri richiona ari mudumbu.

Kushandisa zvinodhaka panguva lactation haisi inokurudzirwa.

chaicho mashoko

Usati watanga pakurapa mari, iva nechokwadi kuti bvunza chiremba wako.

Mukuita kupiwa anticonvulsant mishonga kunoda nguva richiona nezvezvabuda bilirubin muropa, amylases uye maplatelet, uyewo chiropa transaminases (ose 3 months).

Maererano nenyanzvi, valproic asidhi anokwanisa zvichivhiringidza platelet aggregation. Izvi rinowedzerawo zvikuru njodzi yakawedzera ropa coagulation nguva yokuti ropa. Zvakakodzera kufunga mukana wokuti yematambudziko dzinoitwa ropa ari postoperative nguva, muna vanhu pakugamuchira yavaibvisa valproate.

Kana mabatiro-refu zvinodhaka izvi varwere zvingamuka vaingoerekana ropa uye hematoma aumba. Panyaya iyi, mapiritsi dzinofanira kumiswa pakarepo.

Sezvataurwa pamusoro apa, yavaibvisa valproate, mumwe mushonga kunowanzokonzera pfungwa nomuviri zvemwana asati, uye kunosimudzirawo nokuvhiringidzirwa chiropa basa (kakawanda muna 6 Mwedzi yokutanga kurapwa). Panyaya iyi, pakutanga yokurapa zvakafanira kuongorora mamiriro pancreatic kenza murwere, uyewo kugara akuteerere chiropa basa nemiedzo, uye padanho prothrombin.

Zvirwere chiropa uye hepatic kukundikana pavarwere kugamuchira yavaibvisa valproate anogona kuonekwa nevana nepfari mune metabolic uye chinopedza zvirwere, retardation mupfungwa uye makemikari uropi zvokurwara.

Mune Maonero zviratidzo zvakadai lethargy, kwakaratidzwa utera, kuzvimba, uye kurutsa, jaundice, vanofanira regedza pakarepo kushandiswa medicament.

In pakurapa "valparin" murwere vanofanira kungwarira chaizvo kana kushanda michina ngozi. Izvi imhaka yokuti yezviri medicament anokwanisa kuderedza yevasungwa.

Terms uye mamiriro ezvinhu okuchengetera

Anticonvulsant mapiritsi "valparin" kupiwa mu Pharmacies chete chiremba mushonga. Vanofanira inochengetwa pasingasvikire vana uye kuchengetedzwa kubva unyoro uye ari kudziya kwete kupfuura 30 inegumi.

The pasherefu upenyu mushonga pasi kufunga makore matatu (kubvira musi gadzira).

Medicament "valparin": analogues, anoreva zvakafanana

The mushonga mu mubvunzo zvinogona kutsiviwa? Anoreva zvakafanana uye analogues ari chokushandisa ichi, pane zvakawanda. Izvi zvinosanganisira zvinotevera mishonga: "Apilepsin" "Depakine," "Atsediprol" "Depakine Enterik" "Depakine Chronosphere" "Depakine Chrono", "Dipromal", "Konvulsofin", "Konvuleks", "Orphir" "Enkorat", "Everiden", "Enkorat Chrono".

Sezvakaita ne "valparin", mari izvi zvinofanira kutorwa chete yachiremba akarayira, muna kunokurudzirwa dosages kunyatsoteerera.

Zvinofungwa vatengi uye nyanzvi

Chii vanachiremba vanoti pamusoro mishonga iyi, akadai sokuti "valparin"? Nyanzvi Guest zvinoratidza kuti mushonga unoshanda chaizvo uye basa, kunyanya generalized uye kukwana netsviyo.

Kana vatengi, vazhinji vavo vanobvuma pfungwa chiremba. Varwere vanoti kugamuchirwa ichi zvinoreva hwezvekukurukurirana kufambira kukura uye vakapararira kudzvanyirira excitation (tsviyo) ne Tutsinga tunofambisa mashoko utwu. Zvisinei, zvinofanira kucherechedzwa kuti kushandiswa kwezvinodhaka izvi kunowanzokonzera marwadzo. Maererano mutengi inofambiswa, nevazhinji yokuvamba nenjodzi dziri: ganda chisimbwa, kuda kurutsa, kupererwa neropa, uye uremu. Kana mukawana Zviratidzo izvi hwobva kutaura chiremba.