Beta-blockers: zvinodhaka list, zvairatidza kuti kushandiswa

Zvinodhaka chinokosha kuchirapa Migumisiro zvinonzi nevakawanda kushandiswa unyanzvi. Ivo inoshandiswa pakurapa cardiac zvirwere, zvinova zvikuru kakawanda pakati dzimwe pathologies. Zvirwere izvi kazhinji kutungamirira kurufu varwere. Mishonga inodiwa kubata zvirwere izvi, tiri Beta-blockers. Kirasi List zvinodhaka, zvinosanganisira 4 zvikamu, uye avo kupatsanura dzinoturwa pazasi.

Kupatsanura pakati Beta-blockers

The kwemakemikari nemamiriro zvinodhaka kirasi asiri yunifomu kubva zvekuchipatara Marwadzo akazvimirira. Zvikuru kukosha govera zvakananga kuti imwe Kanotokonya uye sungano naye. The kumusoro ari specificity nokuda Beta-1 receptors, vashoma divi anokonzerwa nemishonga. Panyaya iyi, ndandanda Beta-blocker zvinodhaka anounzwa rationally.

chizvarwa chokutanga zvigadzirwa:

• non-vanosarudza Beta-Kanotokonya 1 uye mhando 2, "Propranolol" uye "Sotalol", "timolol" uye "oxprenolol", "nadolol," "Penbutamol".

chizvarwa chechipiri:

• vanosarudza Beta Kanotokonya mhando 1, "bisoprolol" uye "Metoprolol", "acebutolol" uye "Atenolol", "Esmolol."

Zera Third:

• Kusarudza Beta 1 blockers zvimwe pharmacological ehupfumi: "Nebivolol" uye "Betaksalol", "talinolol" uye "celiprolol".
• Nelektivnye Beta-1 uye Beta-2 blockers zvimwe pharmacological ehupfumi: "Carvedilol" uye "carteolol," "Labetalol" uye "bucindolol".

Izvi Beta-blockers (ona mazita zvinodhaka. Above) panguva dzakasiyana vaiva boka guru zvinodhaka kuti zvave uye zvino kushandiswa nezvirwere midziyo ropa uye mwoyo. Vakawanda vavo, kunyanya vamiririri zvizvarwa wechipiri nowechitatu, anoshandiswa nhasi. Nokuda kwavo pharmacological zvinokonzerwa vanokwanisa kudzora kwemwoyo uye kuomerera ectopic mutinhimira kuti ventricles, kuderedza kakawanda angina yokurwiswa angina.

Kiyi kupatsanura

The tanga zvinodhaka inhengo rudzi wokutanga, kureva, vasiri haangotongi Beta-blockers. A ndandanda zvinodhaka uye kugadzirira anopiwa kumusoro. zvinodhaka izvi inokwanisa rakavhara receptors yacho 1st uye 2nd mhando, ichipa zvose kuchirapa zvinokonzerwa uye divi, izvo runoratidzwa bronchospasm. Nokuti contraindicated vari varwere COPD, Árbol asima. Anokosha vomuzana chizvarwa mishonga ndivo "Propranolol", "Sotalol", "timolol".

Pakati vamiririri chizvarwa yechipiri mazita zvinodhaka Beta-blockers, kuti mashandiro chiito uko chokuita chikuru ichivharira rokutanga mhando receptors. Vari dzinoratidzwa simba sungano nokuda Kanotokonya mhando 2, nekuti kashoma kukonzera bronchospasm pavarwere vane asima uye COPD. Chinonyanya kukosha kugadzirirwa 2nd chizvarwa vari "bisoprolol" uye "Metoprolol", "Atenolol".

The parudzi rwechitatu Beta-blockers

Vamiririri vorudzi rwechitatu - ndiyo azvino Beta blockers. The pamazita zvinodhaka rinosanganisira "Nebivolol", "carvedilol", "Labetalol", "bucindolol", "celiprolol" uye vamwe (ona. Above). Anokosha kubva chiremba nemaonero ndedzinotevera: "Nebivolol" uye "Carvedilol". Origin advantageously chakavhara Beta-1 receptors uye kunomutsa kusunungurwa NO. Izvi zviri kukonzerwa pakuwedzera tsinga uye yekuzvidzivirira atherosclerotic plaques.

Zvinofungidzirwa kuti Beta-blockers - zvinodhaka kuti BP uye mwoyo chirwere, nepo "Nebivolol" - a Generic mushonga kuti unonyatsokodzera vose zvinangwa. Zvisinei, rinodhura iri zvishoma kupfuura mutengo vamwe. Similar ehupfumi asi zvikuru zvishoma zvinodhura, ndiyo "Carvedilol". Chine mashoko ehupfumi of Beta-1 Alpha-blocker kuti zvinobatsira kuderedza kakawanda uye simba mumwoyo sunga, uyewo kuwedzera arikunze midziyo.

Migumisiro izvi kukubvumira kudzora chirwere chemwoyo uye BP. Zvino nyaya mwoyo kukundikana, "Carvedilol" - mushonga rwokusarudza, nokuti uchiri chiri antioxidant. Nekuti turusi kunodzivisa kusembura pamusoro atherosclerotic plaques.

Zvairatidza zvinodhaka boka

zvairatidza All nokuti kushandisa Beta-blockers kuvimba dzakananga ehupfumi veboka zvinodhaka zvikuru. In blockers asiri zvokusarudza zvinoratidza maduku, asi vanosarudza nani uye anogona kuiswa munzvimbo dzakawanda. Kazhinji, asi zvinoratidza nevakawanda, kunyange vari zvakawanda maererano hazvibviri kushandiswa kwezvinodhaka mune vamwe varwere. For zvinodhaka asiri zvokusarudza anotevera zvairatidza:

• myocardial infarction ose nguva, angina, zororo, kusagadzikana angina ;
• Atrial fibrillation normoforma uye tahiforma;
• sinus tachyarrhythmia vane akatakura mberi kana pasina iye ventricles;
• mwoyo kutadza (refu);
• neBP ;
• hyperthyroidism, hyperthyroidism, kana pasina dambudziko payo;
• pheochromocytoma kubva dambudziko chikuru kurapa kana chirwere preoperatively;
• migraine;
• Nokupatsanura kutsemuka aneurysm;
• mushonga kana doro kurega syndrome.

Nokuda kuchengetedzwa mapoka zvinodhaka, kunyanya zera wechipiri nowechitatu, mazita mishonga Beta-blockers zhinji, kazhinji rinowanikwa zvinyorwa kurapa mwoyo uye vascular zvirwere. Maererano kakawanda chikumbiro, vari anenge akafanana ne ACE FIs, izvo anoshandiswa kurapa mwoyo nokukundikana uye BP ne metabolic chirwere uye pasina izvozvo. Pamwe chete diuretics, mapoka maviri aya zvinodhaka vanokwanisa kuwedzera upenyu hunotarisirwa mune chirwere cardiac kukundikana.

Contraindications

Beta-blockers, uyewo zvimwe zvinodhaka, vamwe contraindications. Uye nekuti zvinodhaka vanoita pamusoro receptors, vane ngozi pane ACE FIs. General contraindications:

• asima, COPD;
• bradyarrhythmia, sinus achirwara urwere;
• atrioventricular nechigumbuso II dhigirii;
• symptomatic hypotension;
• pamuviri, mwana;
• decompensated mwoyo kutadza - mwoyo nokukundikana II B-III.

Uyewo anoita somunhu contra sema maitiro semhinduro kugamuchirwa blocker. Kana mushonga chisimbwa zvikamuka, kuti yokutsiva mushonga mumwe anopedza dambudziko.

Migumisiro yacho kunotoda zvinodhaka

Kana zvinodhaka angina kuderedza kakawanda kuti angina kurwiswa uye simba ravo, kuderedza mukana wokuti chakasimba coronary zviitiko. In CHF kurapwa pamwe Beta-blockers pamwe ACE FIs uye diuretics maviri inowedzerawo upenyu anotarisirwa. Mishonga dzinobudirira zvaanoda tachyarrhythmias uye vanodzvinyirira kakawanda ectopic anorova ari ventricle. In zvachose, yokubatsira kudzora chero zviratidzo mwoyo chirwere.

Mhedziso pamusoro Beta-blockers

"Carvedilol" uye "Nebivolol" - ndiyo yakanakisisa Beta-blockers. The pamazita zvinodhaka kuti aratidze zvaunoda basa Beta-receptors, anotsigira mazita chikuru mishonga therapeutically kukosha. Nokuti kurapwa tsika dzinofanira kushandiswa kana norudzi wechitatu, kureva "Carvedilol" kana "Nebivolol" kana vakawanda vanosarudza kuti Beta-1 Kanotokonya zvinodhaka, "bisoprolol", "metoprolol". Kunyange nhasi, chikumbiro chavo unokubvumira kudzora neBP uye kurapa mwoyo chirwere.