Makroprolaktin - chii here? Analysis makroprolaktin: wokuyera uye kutsauka

Prolactin (lyuteotropnym) anonzi hormone neve Anterior pituitary masero. The fuma ine nhamba siyana, chimiro pazviri muvanhu. Mumwe chimiro kwakadaro makroprolaktin luteotrophic kemikari. Chii, chii vari mabasa ayo uye zvivako, inorondedzerwa pazasi.

pfungwa prolactin

The kemikari ine mapuroteni uye vaiona prolaktinpodobnyh peptide fuma. pfuma yake kwakavakirwa kusangana dzinotsanagura kubereka, uye nhengo dziri nangananga zviito - iri mammary mumasero.

The receptors kuti sei prolactin akawanikwa mune dzimwe nhengo dzomuviri, asi zvichiri kujeka sei sei matambudziko hormone zvinhu. Kutsinga dzinouya receptors vanowanikwa zvinotevera nhengo:

• chirwatata;
• chiedza;
• ari thymus;
• mwoyo;
• rwatata;
• itsvo;
• dumbu uye ovaries;
• ganda.

The kemikari chiripo muropa romunhu matatu siyana: 85% mashoko ane chimiro monomer, 10% - dimer chimiro uye 5 chete% iri muchimiro makroprolaktina.

Mashandiro anoita prolactin

Mukuru "basa" kemikari inonzi iri kuwedzera uye kuramba zvakakwana azvipire paumbwe mukaka panguva kuyamwisa. In pamuviri, mumwe yakakwana azvipire prolactin kuramba bonde kemikari inonzi estrogen. Mushure mwana anoberekwa uwandu inonzi estrogen kunoderedza zvinoshamisa.

Panguva iyi kugadzirwa prolactin iri nekugadzirwa munyatso kweiyi mechanoreceptors. Dzavo vanoshingaira kukambaira achiyamwa kunokonzera kusunungurwa oxytocin, iyo vakasamukweva mukaka. Kureva prolactin zvinosimudzira mukaka kugadzirwa uye ayo kuunganidza ari mubhokisi, asi ari muitiro allocating mukaka vanosangana oxytocin.

Kuitwa prolactin panguva pamuviri zvinogona nemaziso kuonekwa pamusoro rusvava. High kuwanda kemikari anokomba zvakakanganwika mwana. Mazuva mashoma pashure pokuberekwa chipfuva mwana, zvakare, unogona kuva samafuta zvinoerera kuti haatarisiri okuwedzera kupindira yakazvimiririra vaedzwa muvhiki upenyu chokutanga.

Other ehupfumi luteotrophic kemikari:

• chinovhiringidza kuti ovulation;
• kuwedzera nguva kuvapo corpus luteum mbeu;
• kudzivirira mumwe pamuviri;
• duku unonyaradza marwadzo chaizvoizvo;
• munyaya paumbwe surfactant;
• nechokwadi zvirwere kubvumirawo zvimwe embryo;
• kupindurawo nechokwadi zvepabonde.

The mashandiro chirwere kukura

In varume utano uye vasiri pamuviri mukadzi asina zvoutano, prolactin hwakaipa nokuda kushingaira fuma dopamine. Zvinonzi synthesized mune hypothalamus. Chero pathologic ezvinhu ari chibharo ukama pakati hypothalamus uye pituitary shwanu, zvichiguma adenohypophysis masero synthesize luteotrophic kemikari uye kuwedzera ayo mumatunhu ari serum.

Makroprolaktin - chii here?

Ichi chimiro prolactin iro rine yakakwirira samolecular uremu. It chiri muviri zvishoma. The peculiarity nzira - yokukurukurirana hormonally kushingaira fuma immunoglobulin.

Prolactin uye makroprolaktin mune mari pamusoro ndozvakajairwa kunofanira kuvapo chete vakadzi vane pamuviri uye lactating. zvimwe zvose zviitiko vanoonekwa kuti pathological.

Makroprolaktinu kuva yepamusoro samolecular uremu, vanowanzotevedzera kuunganidza mumuviri. Vamwe vanoumba luteotrophic kemikari goho nokuda nokukurumidza prices yakaderera samolecular uremu.

Makroprolaktin, mwero izvo dzichakurukurwa pazasi, ane pasi zvipenyu basa, uye nokudaro, kuchinja diki pamuviri wake zviratidzi varege kupindura. The kunotoda mufananidzo simba, kana ari achiperekedzwa vachivavhiringidza kumwedzi, zvisina chairo chokukomborerwa zvokurwara.

The vamiririri munhurume kuripowo synthesized nokuda kemikari ichi. Ndiye anokonzera kugadzirwa dzisingaoneki, basa ravo uye kwetunhu testosterone. Men makroprolaktina nhamba dziri kudzika zvikuru pane vakadzi.

Munhu akaidza nokuda kwevari kemikari kudzidza, uyewo yaro Qualitative uye quantitative unhu tanzi kana mazhinji kushaya mbereko chirwere zvinangwa.

Gipermakroprolaktinemiya

Kana makroprolaktin vanomutswa, ipapo ezvinhu akadaro anonzi gipermakroprolaktinemiey. zvokurwara ichi haisi precipitating chinhu kukura nyanyisa anomera ose nebandauko osteoporosis sezvo kuenzaniswa mamiriro kuwedzera uwandu kwomuzvarirwo prolactin.

Zvinofanira kurangarirwa kuti unopinza kuwedzera mahomoni mu asiri kuyamwisa inoti kutyorwa mubasa iri hypothalamic-pituitary hurongwa. Kuvapo zvaikosha mari makroprolaktina vangapikisa sezvo dysmenorrhea, dzimwe nguva kuva chinokonzera kushaya mbereko.

prolaktinoma

Shoko rokuti "prolaktinoma" rinoreva benign mapundu pamusoro pituitary, inova zvakakurumbira kugadzirwa luteotrophic kemikari. Adenomas munogona vose vakadzi nevarume. Etiology chidzoke prolactinoma ichiri kwete pachena. Pane pfungwa nhaka kubatwa, uyewo kuti namamota kuitika zvakafanana pamwe zvokurwara nedzimwe nhengo dzose kwemakemikari anobudiswa hurongwa.

Two Mhando anomera Classified maererano nokukura kwavo uye nzvimbo:

• intrasellyarnye kwete vawedzere mhiri ari sella turcica , uye une dhayamita kuti asingasviki 10 mm;
• ekstrasellyarnye vawedzere mhiri sella turcica, uye une dhayamita kupfuura 10 mm.

Kuwedzera huru syndromes uye kuratidzwa, pamusoro izvo nyanzvi vakagadzwa nechirwere uye prolactin makroprolaktin, pane zvimwe zvekuchipatara zviratidzo chirwere:

• kuderedza ari kutarisana munda;
• rakapinza kuderera kutarisana acuity;
• Wakapamura mumaziso;
• nekusagona kushandisa peripheral chiratidzo;
• kurwadziwa nemusoro;
• kuora mwoyo;
• kufunganya uye kugumbuka;
• muna Muzviitiko zvakaipisisa, zvachose upofu.

Kunze Murabhoritari Diagnostics, kuisa zvakarurama nechirwere, kushandiswa CT uye MRI uropi, kurudziro nemiedzo (hormone) uye densitometry (mapfupa arambe achirema kufungidzira yaishandiswa Kusiyanisa).

Diagnostics Features

Analysis pamusoro makroprolaktin - chii? Ichi chirwere nzira immunohemilyuminestsentnoy maitiro, izvo ushandiswe varwere vose akakwidziridzwa kwevari prolactin pamuviri.

The Kuongororwa ndechimwe itsva nzira. Kana anoomerera mamorekuru kemikari "podselyayut" inoramba fluorescent iyo, nokusunga kuti prolactin kujekesa migove vachibatwa ultraviolet nemwaranzi. Padanho luminescence kunoyerwa luminometer - chaiwo inotakurika namano.

Quantitative zviratidzi makroprolaktina vakatsunga kushandisa polyethylene glycol. Ivo dzakaitisa deposition kuti masoja zvivako. Kana mushure kwacho ari serum akatsunga asingasviki 40% of zvachose luteotrophic kemikari pamwero, ichi zvinoratidza kuti zvinokosha nhamba iri kuongororwa zvinhu makroprolaktina.

Zvairatidza kuti kuongorora chirwere

Kune akawanda ezvinhu umo nyanzvi basa vamwe Qualitative uye quantitative zviratidzo zviri prolactin yayo nezvimiro. Analysis pamusoro makroprolaktin kuitwa zvinotevera nyaya:

• Galactorrhea - zvemamiriro secretion mukaka kana colostrum;
• Kuvapo prolactin - namamota adenohypophysis iyo synthesize ane kunyanyisa yakawanda kemikari fuma;
• vafirwa wokuratidzwa;
• kushaya mbereko;
• kusavapo kumwedzi kupfuura mwedzi mitanhatu;
• uterine ropa pamusoro asingazivikanwi etiology;
• kudzidza zvokurwara of pituitary;
• dzose kushaya ovulation;
• osteoporosis;
• zamu;
• tinyatsonzwisisa kubudirira prolactin mishonga.

Norma waivako dzakasiyana nguva

Number detectable prolactin (kunoguma mkIE / Rine mamiririta):

• mukono zvazvingava - 44,5-375;
• munhukadzi wokuyera - 59-619;
• postmenopause - 38-430;
• vana - 205,5-4420.

Makroprolaktina kuonekwa zvabuda zviri nokududzirwawo embodiments dzakadaro:

• chinokosha uwandu makroprolaktina;
• makroprolaktin asina kuzivikanwa;
• chinokosha nhamba makroprolaktina mubvunzo.

zvakanaka mugumisiro

Gipermakroprolaktinemiya akatsunga tikafunga zvinotevera pathologies:

• hypothalamus anomera;
• hypophysis mota pezvakaitwa;
• thyroid chirwere (kuderera pamusoro hormone secretion);
• polycystic ovary urwere;
• renal kukundikana;
• chiropa chirwere;
• anomalies adrenal shwanu, adrenal insufficiency ;
• chinonzi systemic lupus erythematosus;
• dzinonzi rheumatoid arthritis mhando;
• pyridoxine vhitamini kwokusakwana.

A chinokosha uwandu hwokuvapo makroprolaktina zvinoreva zvakare kuti murwere aigona kuva nguva refu kuti mushonga zvinodhaka.

The pamwero hormone simba:

• antihistamines;
• antipsychotics;
• diuretics;
• antihypertensives;
• antipsychotics;
• zvokuudzwa nhumbu;
• antidepressants;
• antiemetic akawanda uye kushandiswa kwenguva refu.

neb tsika

Mune dzimwe inoti makroprolaktin, mwero vakadzi izvo dzinosiyana-siyana zvichienderana nenguva upenyu zvingava zvishoma pane Zvakanyanya Kunaka Panguva Yepamuviri unongotaura. mugumisiro Izvi maitire zvinotevera nyaya:

• pituitary infarction, kuitika pamusoro colour rimwe hombe ropa kurasikirwa pakusununguka;
• perenashivanie pamuviri (kupfuura 41-42 mavhiki);
• Kushandisa zvinodhaka kwenguva refu kuti tikurire kugwinha, "calcitonin", hormone nzira, "Morphine", "rifampicin", "Nifedipine".

Ndiani anoita kudzidza uye apo kuzvipira

A kudzidza anogona kutumira vamwe vanachiremba: gayinakorojisiti, chiremba wezvedundira kana endocrinologist. Analysis rendi mumarabhoritari pamusoro unyanzvi dzokurapa makiriniki uye kuronga mhuri nzvimbo. Nokuti nechirwere rimwe venous ropa chinodiwa.

Migumisiro kuti kushanda, murwere unofanira kugadzirira kuongorora makroprolaktin:

1. maawa 12 asati wakurukura kuramba chikafu.
2. Mazuva mashoma asati nokugamuchirwa haana kushandisa zvinodhaka nokuda estrogens uye androgens. Mazvikokota, uyo akapa mirayiridzo, anofanira kuudza murwere nezvazvo.
3. Kwemaawa 24 kumisa mishonga zvachose.
4. Kwemazuva akawanda asati ongororo ushe kubva chero kurovedza muviri uye kudzivisa anoshungurudza ezvinhu.
5. Pazuva chokuendesa ari kuongorora unofanira kurega kusvuta.

mhedziso

Mumwe chimiro ari makroprolaktin luteotrophic kemikari. Chii, chii vari zvinhu pokutarira yepamusoro kwayo uye uwandu - mashoko anodiwa vakaroorana kuti anoda kuva vabereki mune ramangwana, kana ari mubishi kwekuronga pamuviri.