Buserelin dhepoti - tsananguro uye kushandisa mamiriro

Kusarudza hormone zvinodhaka rinofanira kubva kunyatsodzidza zviratidzo nokunyatsoongorora kuziva pangozi nemishonga.

Kugadzirira "Buserelin dhepoti" anoenzanisa zvakanaka nevamwe vayo yakakwirira kunyatsoshanda uye pasi mukana kumuvengi zviratidzo. Ndiye nhengo hormone anticancer nevamiririri.

The pharmacological zviito zvinodhaka

The chiito chine buserelin antigonadotropnym, Anti-androgenic, Anti estrogen, Anti bundu anokonzerwa. Drug fuma "Buserelin dhepoti" by makwikwi sunga kuti receptors masero secreting gonadotropin-kusunungura chinhu (vari nemamiriro Anterior akafukidza pituitary gland).

In wokutanga Danho zvinodhaka chiyamuro iri akaona zvinopfuura kuwedzera wevasungwa pamusoro LH uye FSH (gonadotropic kemikari), dzinounzwa nokuda pituitary, iyo inotungamirira vawedzere dzokubereka nadzo Gomonov kugutsikana. After 14 - 21 mazuva ichivharira kunoreva gonadotropic mashandiro kuburikidza kunaka feedbacks, iyo inosvitsa chinokosha rutapudzo pamusoro LH uye FSH, uye, somugumisiro, uye kuderera kugadzirwa bonde mahormone. Saka, varume testosterone wevasungwa zvinoderedza, wasvika pamwero iyo chinosimbiswa pashure orchiectomy (zvokurapa castration). Women zvinodhaka maturo "Buserelin dhepoti" iri kutura kuna padanho kugadzirwa estradioda aivapo posklimaktericheskom munguva.

Kushandisa zvinodhaka "Buserelin dhepoti"

It rinoshandiswa pakurapa kenza yeprostate, mune zvimwe zviitiko, vakashandisa kudzvinyirira testosterone kugadzirwa ari testes. Also kushandiswa pakurapa kenza yemazamu (kemikari-nemataundi zvirwere, iyo inozivikanwa nokuva yakakwirira kugadzirwa estrogens kana rinowanika endometriosis). Zvimwe zvirwere, kurapa "buserelina dhepoti": uterine fibroids, endometrial hyperplasia isiri yekenza, kuitisa kuti IVF chirongwa mukurapa kushaya mbereko.

Contraindications uye anokosha audzwa

Hypersensitivity, orchiectomy, pamuviri, lactation. Zvokungwarira kutora mushonga ari zvokurwara nezvezvimwe zvinetso zvedundira turakiti pachiyero vertebral metastasis, BP, chirwere cheshuga, uye kuora mwoyo. Buserelin dhepoti uye pamuviri - sawirirana pfungwa.

nemishonga

Murwere anganyunyuta kuti zvakawanda zvive pamusoro chikamu chinokosha tsinga muchimiro musoro, kutya, kushaya hope, kukanganwa, ungaderedza wevasungwa, dzungu, kusagadzikana mupfungwa, uye dzimwe nguva kuora mwoyo. Inogona akanzwa tinnitus kana kumanikidza yeziso, madzerere kana kunzwa. Kazhinji zvinogona "kupiswa." In vhiki yokutanga kurapwa vakadzi vakachengeta psevdomenstruatsiya, ipapo akaisa kusangana nekutsi kwemukadzi kuoma, zvinoita mapfupa demineralization, ungaderedza libido. Varume, chirwere chinogona yakawedzera pakutanga 2 - 3 mavhiki, kana kuonekwa gynecomastia, akaderedza potency. Chairo chete kunogona kuitika: kudya dyspeptic zvirwere. Buserelin dhepoti uye doro haawirirani. In varwere neBP kungawedzera kumanikidzwa, kwemwoyo. Kubva neutachiona kuitika: kuvaviwa, mapundu, bronchospasm, anaphylactic kuvhunduka. Kuchinja rabhoritari zviratidzi: dyslipidemia, hyperglycemia, kuwedzera transaminases uye bilirubin, thrombocytopenia uye leukopenia.

Misimboti zvinodhaka

Intramuscular Kutarisirwa: raitongwa pakarepo pashure gadziriro yacho kuturika.

- kana prostate bundu ose 4 mavhiki 4.2 MG.

- Endometriosis - hunosumwa mukati 4 months.

- pamwe uterine myoma -3 mwedzi.

- kushaya mbereko - 4.2 MG.

Intranasal Kutarisirwa:

- nokuti pakurapa munhukadzi zvirwere pamusoro apa - raitongwa kuti nasal mhango 900 MG / zuva (rimwe dose, 3 kanomwe pazuva), kubva 1 - 2 mazuva kumwedzi.

- kushaya mbereko 600 MG / zuva, 1 dose ari nasal mhango kanokwana pazuva. Kana zvakasimba akaratidza blockade dzokubereka nadzo, kuti dose ipfupi 2 nguva.

Vamwe manotsi:

- Treatment kenza yeprostate unotakurwa hwose;

- Anti-androgen mishonga raitongwa nokuda 2 weeks. uye kuti 2 weeks. kurapa pamwe buserelin, kunotadzisa yematambudziko kuti zvingaitika muvhiki kurapwa rokutanga;

- pakutanga nguva kurapwa mune vakadzi kuonekwe ovarian chikofu;

- vanofanira kudzivirira pamuviri uye nhumbu kugamuchira mushonga kubata buserelin, asi 2 months wokutanga zvakakodzera kushandisa non-hormone nzira muzvidzivirire;

- yakanaka chaizvo zvinodhaka Mabatirwo endometriosis surgically Akaroromesawo kakawanda zvazvo.

Kudyidzana nevamwe zvinodhaka

Buserelin akazoita mugumisiro hypoglycemic zvinodhaka. Zvingaita kuti ovarian hyperstimulation, kana kushandiswa pamwe zvinodhaka dzine bonde mahormone.