Mirayiridzo yokushandisa - ampicillin

Yakati yapfuura, yakasvika pakuzivikanwa kuti huru mashandiro yokuva anochinjika dzakasiyana siyana utachiona kuti kwemishonga inorwisa mabhakitiriya ndiwo β-lactamase dzavo zvigadzirwa. Ndivo chaizvo pave nokuparadzwa unodzivirira zvindori mishonga uye anongoda chakunodzikisira dzavo kuchirapa kushanda. Kukunda ichi kunambwa, pokuikurukura uye kushanda agadzirwa makemikari inactivate β-lactamase anongofunga clavulanic asidhi Formulations sulbactam uye tazobactam.

yeimwe izvi zvinosanganisira sezvo zvinhu penicillin ingibitorozaschischonnyh dzinonzi - aibatanidza zvinodhaka, izvo zvinosanganisira kuti penicillin mushonga. Kuzivikanwa mienzaniso gadziriro dzakadaro ampicillin-sulbactam, amoxicillin, ticarcillin uye vamwe vanoumba boka penicillins. Kushandiswa yavo inoshanda uyewo nokuti vanogona kushanda sechikamu akasiyana-siyana mubatanidzwa pakati cephalosporin pakati III rudzi, apo kubudirira yezviri chirungiso inogara pane mumwe mukuru pamwero.

Panguva anofambidzana siyana, zvinoshandiswa zvinodhaka dzakawanda dzemazuva ano dzine munhu sezvamunoita mishonga uye FIs ose β-lactamase, pane chikuru basa patsva penicillins uye vari anenge zvachose kuzovazve dzavo kuchirapa efficacy pakurwisa ruzhinji rinozivikanwa staphylococci nhasi anaerobes uye giremu mabhakitiriya. Uyezve, mune Formulations yakadaro iri kuwedzera zvavo inorwisa utachiona chakarondedzera. mushonga kwakadaro ndokwevakavimbika ampicillin / sulbactam, izvo zvichienderana mugadziri vanongogona kubudiswa pasi mazita kana unazin Sulatsillin.

mishonga Izvi zvinosanganisira ampicillin uye sulbactam, izvo varipo vari nhamba 2: 1. Sezvinoratidzwa nemirayiridzo manual, ampicillin uye sulbactam pakugadzirira ichi kunze chaizvoizvo ichivharira β-lactamases vane kumbonyanya raidudzwa basa pamusoro Neisserial uye atsinetobakterov.

Kazhinji nokuti munyika zvinodhaka paakapiwa basa sultamicillin, rinoumbwa sulbactam uye ampicillin. Mahwendefa kana paakapiwa wefodya unopinda muviri. Ipapo zvakaitwa hydrolysis nokuitika zvabatanidzwa kuitika zvinodhaka ampicillin uye sulbactam, izvo runogonesa kuti bioavailability kuti ampicillin kunyange LEVEL kuti runowanikwa kana kugamuchira chinhu dose zvakayenzana zvetsika ampicillin.

Zvikuru akasiyana chakarondedzera basa, uye ichi zvinodhaka. Naizvozvo, kushandisa zvinodhaka vakawanda kunoratidzwa zvirwere kwemabhakitiriya kupi ttp, sinusitis zvitarisiko siyana uye etiology. The mushonga nezvaro nezvirwere repasi kufema turakiti: chisingaperi bronchitis, mabayo.

Maererano mirayiridzo kushandiswa, ampicillin pamwe sulbactam tigutsikane unoshanda pakurapa dzakasiyana siyana intraabdominal uye pelvic zvirwere, kusanganisira nyoro zvinyama utachiona, mapfupa uye vadyi utachiona, septicemia.

Kugadzirwa ampicillin pamwe sulbactam yekudyidzana zvikuru zvichienzaniswa amoxicillin / clavulanate pakurapa zvirwere kuti Kunotanga atsinetobakterom.

The chipimo chemushonga zvinodhaka kunotema murayiro kushandiswa. Ampicillin ari ushandiswe nemuromo wacho dose nokuti vakuru hwava 0,375-0,75 magiramu pasinei kudya kaviri masikati, kana hosha iri hunhu nyore. In zvikuru siyana mishonga akashandiswa 1.5-3.0 magiramu yose zuva kana kukuvadza rwuchiwanzwa, kuti chipimo chemushonga anogona ngazviwedzerwe 6.0 magiramu.

Vacheche mushonga wakawanda mune mishonga dzaona vanenge 50 micrograms pazuva paminiti imwe kilogram pakati kurema mwana. Rubvumo rinoitwa kaviri.

Release chimiro uye chipimo chemushonga zvinodhaka rinotsanangura nemashoko akadzama mirayiridzo kushandiswa. Ampicillin inogona kutorwa kunze mahwendefa muchimiro upfu kushandiswa kugadzira inokosha kuturika (kana nomuromo raitongwa). Uye akapa kushandiswa kwezvinodhaka nokuda jekiseni, uyu anogadzirwa upfu fomu. The solvent akapa vane mushonga mune rimwe pasuru.