Protamine sulfate: Description uye User

Ndechipi mushonga fuma sezvo protamine sulfate? mirayiridzo kushandiswa kwayo, uyewo chimiro uye neuchapupu mari achaiswa pasi apa.

Zvinoumba, tsananguro, chimiro

Chii protamine sulfate? Izvi mhinduro yakanga asunungurwa somunhu yellowish kana Hauoneki läpinäkyvä mvura dzaizopiwa intravenous yaitonga. Kugadzirira kwakavakirwa zvinodhaka ichi ane zita iroro, uye mberi unotora mvura jekiseni.

In kutengeswa "Protamine sulfate" iri yaipiwa mu ndiro kuti anoiswa muchitokisi pepa rehurukuro kubva polyvinyl chloride firimu, izvo vari kugara mumabhokisi makadhibhokisi. Uyewo ari pasuru anoiswa mirayiridzo kushandiswa uye ampoule opener.

Drug chiito

Chii protamine sulfate? Guide anoshuma kuti ichi heparin antagonist (chaicho). 1 MG venhumbi inokwanisa neutralizing ropa murwere anenge 80-115 Iu pakati heparin.

Action haberleri zvinoreva pashure intravenous jekiseni kunotanga pakarepo uye rinovapo kwemaawa anenge maviri. Complexation zvinodhaka nokuda kwokuwanda cationic mapoka kuti vasunge kuti anionic nzvimbo heparin.

Maererano mirayiridzo protamine sulfate muvanhu iri complexed heparin-protamine, iyo inotanga kusunungura yokupedzisira.

In ovhadhozi ichi zvinoreva murwere anogona yekudyidzana kuderedzwa kweropa, sezvo vaiona rinoita mumiririri Pfungwa akava mukuru anticoagulant basa.

Pharmacokinetics zvinoreva

Chii ane kinetic ehupfumi ari heparin protamine sulfate? Maererano nenyanzvi, ane pharmacokinetic ehupfumi zvinodhaka vasina kudzidza. Saka, havana kumiririrwa mu redzidziso.

Zvairatidza kuti mhinduro

Mune zvimwe zviitiko, murwere intravenous mhinduro "Protamine sulfate" unogona kupiwa? Kushandiswa pachishandiswa ichi kunoratidzwa:

• vasati kuvhiya vanhu achitora heparin nokuda kuchirapa zvinangwa;
• panguva hyperheparinemia;
• nokuti ropa yokuvamba nokuda heparin ovhadhozi;
• avhiyiwa pamidziyo ropa uye mwoyo pamwe extracorporeal kutenderera.

Inorambidza kuti rwendo mhinduro

Drug "Protamine sulfate" (mushonga kutenga tinofanira mishonga chiremba) iri contraindicated anotevera nyaya:

• pamwe thrombocytopenia;
• soro aikanganiswa pezvokuvamba zvinodhaka;
• zvakakomba hypotension;
• vachiberekwa kana idiopathic hyperheparinemia (mu mamiriro uyu mushonga haushandi, uye zvinogonawo yekudyidzana kuvandudza svota);
• Vanotarisira insulin uye zvimwe zvinodhaka ine protamine sulfate;
• neutachiona kuti zvigadzirwa hove, kusanganisira nhoroondo;
• adrenal insufficiency.

Hatigoni kutaura kuti zvakaitika kushandiswa vezvokurapa kuti chokushandisa ichi muvana ipfupi.

Panguva pamuviri uye lactation "Protamine sulfate" anogona kushandiswa. Zvisinei, izvi zvinofanira kuitwa chete kana, kana kubata mishonga zviri kupfuura kunge ngozi kuti mudumbu kana mwana.

Kugadzirira "Protamine sulfate": mirayiridzo kushandiswa

Viewed mhinduro inofanira kutarisirwa kunonoka IV donhwe kana bolus. Saka mwero chourongwa haafaniri kupfuudza 5 MG paminiti. Nokukurumidza sumo zvinodhaka kungaita murwere anaphylactoid zvakaitwa.

Chipimo chemushonga of medicament kunoenderana nzira chourongwa. The akaverenga dose ikaparara muna 300-500 ml 0,9% simba yavaibvisa chloride mhinduro. Zvinonzi zvaisambobvumirwa kupinda MG anopfuura 150 zvinodhaka kwemaminitsi 60.

• With bolus jekiseni chipimo chemushonga pamusoro protamine sulfate ipfupi zvichienderana nguva yakapfuura kubva kwokubatsira heparin. Izvi imhaka yokuti ekupedzisira iri kuramba kubviswa dzemuviri.
• Kana heparin chinotarisirwa intravenous donhwe, zvakakodzera kumisa aizomupa uye kushandisa anenge 20-30 MG kuti protamine sulfate.
• Kana subcutaneous jekiseni heparin chipimo chemushonga kuti protamine sulfate 1-1.5 MG 100 Iu heparin. Saka 25-50 MG wokutanga kunofanira zvishoma nezvishoma wakawanda nomutsinga, uye vanosara uwandu - intravenous donhwe kwemaawa 8-17. Zvinogonekawo inoratidza kutarisira asi zvinoda kuomesa richiona nezvezvabuda APTT.
• Kana nokukurumidza kupindira pakuparwa extracorporeal kuparadzirwa mhinduro vaiona chipimo chemushonga iri 1.5 MG kuti 100 ME heparin.

The kunonyanyisa nguva yokurapa pakati mari ndiyo 3 days.

Action ne-hunhu

ari protamine sulfate kunogona kukonzera nenjodzi? Manual rinoti vakawanda zvinodhaka izvi tichishandisa zvakanaka akashivirira nevarwere. Zvisinei, mune zvimwe zviitiko, zvinogona zvichiri kukonzera nemigumisiro pamusoro chikamu masoja, zvemwoyo uye zvomudumbu enyika, uyewo ganda:

• bradycardia, zvinoderedza BP;
• kurutsa uye svoto;
• kuvaviwa, ganda mapundu, kuvandudzwa anaphylactoid siyana;
• kunzwa kupisa, vachifunga pfupi mweya, uye Flushing ganda.

Wakawandisa uye kudyidzana nedzimwe zvinodhaka

Viewed mhinduro zvarakanyorerwa intravenous Kutarisirwa hakupindirani nemitemo penicillins uye cephalosporins. Sezvo chiri antagonist, pasi samolecular uremu heparins, kushingaira zvinodhaka kungawedzera nguva uye kusimba chiito vasiri depolarizing tsandanyama relaxants.

An ovhadhozi zvinodhaka vangava nechokuita ropa. Izvi imhaka ndechokuti fuma iri mubvunzo ane mukuru anticoagulant basa. Muchiitiko chino, dzinoita symptomatic kurapwa kunodiwa.

chaicho mashoko

Zvaunofanira kuziva usati pamunopinda mhinduro dzakadai protamine sulfate? Nyanzvi dzinoti kushandiswa kwezvinodhaka ichi kunofanira kunyatsoongororwa zvazvaiita nachiremba vanofanira kugara kuongorora ropa pakugwamba murwere.

Pamberi pakatanga zvinodhaka anodiwa kuitira ropa zvakakwana romurwere vhoriyamu. Izvi imhaka yokuti hypovolemia yekudyidzana kunowedzera ngozi kuchidonha.

Storage mamiriro ezvinhu nerubatsiro Pharmacies, ari pasherefu upenyu

Kana akasununguka inotengeswa Pharmacies zvinodhaka "Protamine sulfate '? Recipe mumutauro wechiLatin kana Russian, iva nechokwadi kuratidza mishonga, zvimwe zvinodhaka asunungurwa.

Kuchengeta nzira vaiona zvakakodzera mune pasingasvikire vana uye waidzivirira kubva chezuva apo mhepo tembiricha iri pakati 4 uye 10 madhigirii. Zvinofanira kucherechedzwa kuti intravenous mushonga "Protamine sulfate" chero zvazvingava hamufaniri chando.

Pasherufu upenyu zvinodhaka iri 4 makore kubvira musi gadzira. Usashandisa mhiri yapfuura iyi kumwedzi.

Drug analogues wongororo nezvazvo

Analogues ari nhau zvokushandisa havasi vazhinji kwazvo. The intravenous mhinduro inogona kutsiviwa zvinodhaka zvakadai se "Protamine" uye "Protamine-Verein".

Panyaya nevatengi ongororo, inenge vose akanaka. "Protamine sulfate" - iri vakarongeka chaizvo uye inobudirira nzira iripo wose. Zvinonzi pfungwa iyi vaiita vazhinji wevarwere. Vanoti mishonga iyi haapi heparin kutitadzise chirongwa kweropa, kuvandudza murwere munguva rinorema kubuda ropa.

Kana zvemashoko zvinodhaka ichi zvinosanganisira kwayo nokukurumidza uye kwenguva refu kushanda. Uyezve, kuti apore anzwe kuti murwere runodiwa kuita kurapwa kwenguva refu. The kunonyanyisa Nguva kushandiswa kwezvinodhaka izvi kwamazuva matatu.