"Sumatriptan": mirayiridzo kushandiswa, wongororo. Drug analogues "Sumatriptan"

Chii chinorehwa zvinodhaka "Sumatriptan"? Mirayiridzo kushandiswa kwezvinodhaka, ayo pharmacological chiito, uye chimiro murwiyo zvichakurukurwa zvishoma mberi. Uyewo, munyaya ino isu achakuudza pamusoro zvinodzidziswa contra-zvairatidza uye divi migumisiro zvinodhaka uyu, chii chacho nzira chikumbiro uye chipimo chemushonga, kana akanga chero analogues nezvakadaro.

The Kuronga mushonga wayo Kuronga

Pari, chete mapiritsi anogona kuwanikwa Pharmacies uye nasal mwaya "Sumatriptan". Mirayiridzo Kushandiswa chokushandisa ichi rinopa mashoko zvakakwana pamusoro Kuronga zvinodhaka. Familiar nayo iwe uchagona ikozvino.

A firimu zvemapuranga mahwendefa ane basa fuma yakadai sumatriptan succinate. Panyaya upiyona okunze, izvi zvinosanganisira zvinotevera: karusiyamu rehydrogen phosphate dihydrate, microcrystalline cellulose, giproloza (Klutsel kana hydroxypropylcellulose LF), magnesium stearate, mannitol (kana mannitol), croscarmellose yavaibvisa (kana primelloza).

The rinoita chirungiso nasal mwaya "Sumatriptan" uyewo anoshanda sumatriptan. Kana ebetsero zvinoriumba, vanogona kuchinja maererano Maumbirwe medicament kusunungurwa. Zvinofanira kucherechedzwa kuti pfapfaidzo inoshandiswa kurapa kure ishoma pane mahwendefa. Zvisinei, vane vatengi vavo. Kazhinji, izvi ndizvo varwere vasiri akasununguka kutora mushonga nomuromo.

The pharmacological zvechadenga zvinodhaka

Zvii zviri "Sumatriptan" pamahwendefa, izvo akaongororazve tinotarisira mberi?

Akati gadziriro iri protivomigrenoznoe rinoreva. Chinhu yakananga uye kusarudza agonist 5-HT1-kweserotonin receptors, izvo vemunyika muropa nemidziyo uropi. Zvinofanira kucherechedzwa kuti mushonga haana sei dzimwe subtypes 5-HT-kweserotonin receptors.

Mushure kutora mushonga kwahunokonzera vasoconstriction wokwavo carotid arterial mubhedha. Saka, mashoko medicament "sumatriptan" (Mahwendefa) anopa ropa intracranial uye extracranial munyama. Zvinofanira kucherechedzwa kuti meningeal vasodilatation, uye avo kuzvimba uye zvinokonzera migraine muvanhu.

Hatigoni kutaura kuti pashure kuitwa chokushandisa ichi pasina chinokosha chaizvoizvo (kunaka) pamusoro ropa riyerere chepfungwa. Mahwendefa chete tunodzivisa Kanotokonya basa afferent fibers (harinzwi dzavo) ari trigeminal etsinga, riri munzvimbo reDhura. Izvi kunoitika nokuda kuderera kuti kutsinga dzinouya neuropeptide kusunungurwa.

Zvinofanira akati kuti zvinodhaka "Sumatriptan" uye "Sumatriptan din email" kubvisa zvachose photophobia uye kuda kurutsa, izvo kwakabatana migraine kurwiswa zvakananga.

Kubudirira mushonga

Mugumisiro pashure kuitwa pakati "Sumatriptan" chinodhaka nokukurumidza sei anouya? Testimonials pamusoro medicament ichi ane ruzivo kuti zvinodhaka anotanga kuita maminitsi chete pashure 30. Saka murwere vanofanira dose 100 MG. Sezvineiwo, muna 50-70% dzevarwere vari kukurumidza yakapedza migraine kurwiswa pashure kushandiswa 25-100 MG zvinodhaka. Masikati pa 1/3 varwere kuitazve, izvo zvinoda kushandiswa akadzokorora zvinodhaka.

Pharmacokinetics

zvinodhaka "Sumatriptan" rini kunyura? Mhinduro yomubvunzo uyu inowanikwawo mune mirayiridzo kushandiswa mari. Agamuchira mushonga mukati, akapotsa pakarepo kunakidzwa nema- turakiti. Mushure maminitsi 45 wevasungwa zvinodhaka ari ropa serum rinosvika vanenge 70%.

Nokuda kukwana Absorção de Água uye vokutanga-vanopfuura muviri, Mhedziso bioavailability zvinodhaka kana raitongwa paavhareji 14%. Pamusoro ndichisunga kuti plasma mapuroteni, zviri pasi kwazvo (anenge 15-21%). The hafu-upenyu nguva anenge 2-kwemaawa. Kugadzirira yaiwana runonyanya kuburikidza neitsvo.

Absorbability zvinodhaka iri chaiyo zvekuchipatara ezvinhu

Maererano unyanzvi, migraine kurwisa regai yekudyidzana kukanganisa absorbability yezviri mumiririri sumatriptan (by ingestion kana intranasal kutarisira).

Kana murwere anetseka chiropa basa, shure kushandisa mishonga anogona kuona yakawedzerwa pamwero basa pazvokudya plasma. Izvi kunoitika pamusana mukuderedza yomuzana zvichipfuura Clearance.

Zvairatidza kuti kushandisa mishonga

Mune zvimwe zviitiko, prescribers "Sumatriptan"? Mirayiridzo kushandiswa kwezvinodhaka rinoti inofanira kutorwa chete kuratidzirwa migraine (pasina Aura kana wake).

Contraindications pakushandisa

Kana pane zvarakasiya zviri zvaisambobvumirwa kutora mushonga "Sumatriptan" analogs zvinodhaka ichi? Ndinoda kuratidza kuti panhau iyi mumirayiridzo pane yakawanda mashoko. Ndokusaka asati atora mushonga nacho, iva nechokwadi kuti kuverenga.

Saka chii vari contra-zvairatidza Rakaratidza zvinodhaka? Funga zvawanyora izvozvi:

• zvakawedzera aikanganiswa murwere kuti pezvokuvamba Pfungwa;
• Varwere vakwegura (anopfuura 65 years);
• basilar, kana oftalmoplegicheskaya chimiro hemiplegic migraine;
• mawa negashiro imwe medicament pamwe medicaments ane ergotamine nezvinogadzirwa nomukaka siyana, uyewo Mao FIs (airambidzwa kubvuma kunoreva asati mazuva 14 mushure caffeine pamusoro vakati zvinodhaka);
• nechirwere chemwoyo, uye vanofungidzirwa nayo;
• kuyaruka uye vana zera (Makore 18);
• angina, kusanganisira Prinzmetal angina ;
• pamuviri uye achiyamwa;
• myocardial infarction, kusanganisira unoyerera munhau;
• neBP (kusingadzoreki mhando);
• neBP (pehurumende mhando);
• occlusive peripheral tsinga chirwere;
• pfari, kusanganisira chero pathological ezvinhu chokuita pasi zvipusha pachikumbaridzo;
• renal kana hepatic kukundikana;
• Kurohwa kana zvinopfuura ezvinhu ropa aibuda chepfungwa, kusanganisira kubuda kare.

Sezvataurwa pamusoro apa, mushonga "Sumatriptan" haafaniri kushandiswa panguva yepamuviri. Asi kana ngozi kuti mudumbu idukusa zvinobatsira kuti mai, uchiri ushandiswe kuti vakadzi vari rehurumende uye ekukurerai. Zvisinei, kuita izvi kuti chete ruzivo nyanzvi ane (mushonga chinobviswa kunoparirwa pasi yayo cherechedzo). Nenzira, haisi varumbidzwa kudyisa wako mwana zamu mukati rimwe zuva pashure pakugamuchira akati mahwendefa.

Drug "Sumatriptan": mirayiridzo kushandiswa

mushonga uyu akatorwa nemuromo zvisinei zvokudya yaunodya. Chipimo chemushonga muchiitiko ichi anofanira kuva akaenzana 50 MG (kana zvichidiwa - 100 MG).

Kana ukasarudza kushandisa nasal medicament "Sumatriptan" (pfapfaidzo), ayo dose ndiyo 20 MG mumwe pamhino. Akadzokorora kwokubatsira mushonga anobvumirwa kwete kwokutanga pane pashure 2 hr.

Kufadza daily chipimo chemushonga nokuti mukanwa Kutarisirwa ndiwo MG 300. Kana kushandisa intranasal Pfungwa, zviri akaenzana mishonga vaviri 20 MG.

Features mishonga

Zvino kuti munoziva kuti kuhwina migraine. "Sumatriptan" (Mahwendefa uye pfapfaidzo) kuzvigona zvakanaka basa. Zvisinei, zvinofanira kucherechedzwa kuti medicament hauna chinangwa nokuda prophylaxis ose akati kutsauka.

Kushandisa zvinodhaka zvinogoneka chete panyaya apo nechirwere iri kupokana. Pamberi kugadzwa zvinodhaka "Sumatriptan" varwere atypical uye kwete kare nechirwere migraine, chiremba anofanira kuva nechokwadi kuti atonge vamwe ezvinhu chetsinga ngozi. Zvinofanira kurangarirwa kuti varwere chirwere pashure kuitwa akati mahwendefa zvingamuka cerebrovascular zvirwere.

Kuvapo abnormalities munyika kweropa ino (mu varume vakuru kupfuura makore 40 uye vakadzi postmenopausal) chinoda rokutanga kuongororwa kuti asava abnormalities kwemwoyo uye ropa midziyo.

Pari pane ruzivo pamusoro panowanikwa kutyorwa kufambisa, simba uye hyperreflexia pashure atora chinodhaka, "Sumatriptan" uye zvimwe zvinodhaka kubva boka FIs anyatsosarudza.

Asati uye panguva kurapwa pamwe mushonga wataurwa Zvinoda kuramba chikafu yaunodya, uyewo kuomerera vaitofanira kudya. Saka, murwere unofanira kubvisa kubva zvaunodya zvokudya zvine tyramine fuma (chocolate, maranjisi, but, celery, nzungu, chizi, bhinzi, uye madomasi). Uyezve, zvinokosha kuti asiye kudyiwa doro, kusanganisira mutsvuku, ikapenya uye akaoma waini, Champagne, doro.

Exercise uye tirambe tiine utano hwakanaka zvavo (kufamba, kushambira, Skiing), uyewo kuvapo chero chitandadzo pave kwaita pfungwa, izvo kunotadzisa kukura murwere ane migraine kurwiswa kwevanhu.

Mirayiridzo kushandisa nasal pfapfaidzo

zita pfapfaidzo pamwe yezviri fuma sumatriptan Trade unorira "Imigran". chinodhaka ichi une zvikamu:

• chinosimudzira minwe;
• zano;
• zvitema bhatani.

Zvinofanira kucherechedzwa kuti rwebhuruu bhatani iri kusashanda nokukurumidza uye kamwe chete. Panyaya iyi inokurudzirwa kusamuendesa pamusoro payo kusvikira muromo iri apinda nasal ndima. Zvikasadaro, rizere dose zvichange zvisisipo pasina.

Kushandisa nasal pfapfaidzo, murwere vanofanira wakasununguka nzvimbo, akarara pasi, akamira kana akagara. Nenzira, pashure murwere nasal mhango inokurudzirwa kucheneswa pamwe donje swabs.

Dzichibvisa mhoni rongedza uye dzichibvisa zvinodhaka nokuda nasal kushandisa, mushonga inofanira kupinda chimwe pamhino. Kana mamwe ndima nasal, inofanira chakatsindirwa munwe kuti nasal septum. Panyaya iyi, murwere unofanira kufema achishandisa muromo.

Dzinoisa muromo kupinda pamhino nasal Pfungwa inofanira kuva 1 sendimita. Musoro murwere vanofanira kuchengeta yakarurama, kwete kupotsera shure shure. Pashure paizvozvo, murwere unofanira kuvhara muromo wake uye kuita wakanyarara uye anononoka kundosvikira kuburikidza mhino, ane mawa kuedza tinya rwebhuruu bhatani ane thumbs wako. Muchiitiko chino, munhu anogona sokuti bhatani chanyatsosunga chaizvo. Asi ichi handizvo. Munguva jekiseni zvinodhaka kupinda nasal mhango murwere vanofanira kunzwa simba nekudzvanya inzwi. Izvi zvinoreva kuti bhatani yakabudirira akashanda.

Pashure nzira iyi, murwere kuvhura muromo wake ufuridzire zvishoma nezvishoma napo. Head vanofanira kuramba kuchengeta twasu. Zvadaro, murwere anofanira yakanyarara mweya kubudikidza nasal mhango, uye nokuda ipapo exhale - achishandisa muromo (nokuti 10-20 seconds). Zvinokurudzirwa kwete kufema chaizvo.

Kana nzira iri paakapedza jekiseni zvinodhaka, munhu anogona kunzwa pamberi mwando mumhino, uye murombo kuravira. nezvekufadza izvi hazvisi ngozi dzoutano uye chaizvo kutsanya zvakaitika nomuzvarirwo. Pashure chete pokushandisa dispenser anogona kuraswa.

Rinotinyevera kana kushandisa

Drug "Sumatriptan din email", wongororo zvacho zvakanaka kune mukuru zvakadini, tinofanira kubatwa nokungwarira hwakanyanya vatyairi motokari, uyewo nevaya vari kuita mabasa ngozi zvinoda zvakawedzera mwero kuita uye kutarisirwa.

nemishonga

Kungakonzera divi migumisiro mishonga "Sumatriptan"? Kugadzirira izvi mhando kunogona kukonzera kukura munhu kumbonyanya vakawanda kunaka mananara. Ngationgororei navo zvakadzama:

• munhu kweropa hurongwa. Pamusoro chikamu ezvinhu mune murwere pasi BP zvinogona kuonekwa, myocardial infarction, chakamboti BP (kazhinji nokukurumidza pashure ingestion), tachycardia, bradycardia, tachycardia, uye mune zvimwe zviitiko, arrhythmia, kurwadza kwacho ari coronary arteries, inopfuura ECG kuchinja Raynaud kuti syndrome.
• Tsinga uye pfungwa nenyere. Paakatyaira mushonga munhu tinganetseka kurukutika, dzungu, simba uye hope. Mune zvimwe zviitiko, mushonga hunokonzera diplopia, nezvipusha, panowanikwa kudzima rinobhururukira pamberi ake, nystagmus, ungaderedza kutarisana acuity, scotoma uye haasaruri zvinopfuura kurasikirwa zvaakaratidzwa.
• The zvomudumbu turakiti. Kubva kugaya murwere kazhinji kuonekwa kurutsa, dysphagia, kuda kurutsa, uye kuwedzera (minor) nezvebasa chiropa makemikari, abdominal kusagadzikana uye ischemic colitis.
• Chisimbwa. Mushure kutora mushonga, vamwe varwere yakashuma chakaita pruritus, mapundu, urticaria uye erythema. Uyewo, pane anaphylaxis, kunzwa kupisa, tingling uye marwadzo ari musoro, kufundumwara, kumanikidzwa, Flushing, uye myalgia. Intranasal kwokubatsira mushonga munogona muchimiro omunzvimbo siyana yemapapu zvinopfuura kutsamwa kana nokupisa manzwiro ari huro uye nasal mhango uye nasal ropa.

Kudyidzana nevamwe zvinodhaka

Sei vamwe mishonga iri kubudirira uye kwechirwere ari "Sumatriptan" chinodhaka kuitei? Instructions, mhinduro kubva nyanzvi panyaya iyi ane ruzivo inotevera. Tiine mawa kushandiswa kwezvinodhaka pamwe medicament "Ergotamine" uye rinoreva murwere ergotaminsoderzhaschimi zvichibvira refu vasospasm. Panyaya iyi, chinguva pakati mishonga zvinodhaka izvi zvinofanira kuva maawa anenge 24.

Maererano nokutsvakurudza, pane kudyidzana pakati zvinodhaka "sumatriptan" uye Mao FIs. Saka nhamba metabolic iri kutanga ipfupi, uye ayo yevasungwa inowedzerawo.

With mawa Kushandisa vakati Anti-migraine zvinodhaka, uye aiva haangotongi kweserotonin reuptake FIs, murwere anogona kuva simba, hyperreflexia uye vachanetseka Kufambisa nemafambiro.

Ovhadhozi zvinodhaka (zviratidzo, kurapwa)

Chii chinoitika kana musingadi zvinoenderana chipimo chemushonga ndakarumbidzwa nachiremba wako? Kana kunyanya kushandiswa rekugadzirira "sumatriptan" varwere kungawedzera pamusoro divi zvavaifunga. Panyaya iyi, avo ezvinhu kunoda anokosha akataurwa kwemaawa 10.

Kana zvakakodzera, imwe ovhadhozi murwere aibatsira muchimiro symptomatic kurapwa.

Drug "Sumatriptan": analogues zvinodhaka mutengo

Kuwana chishandiso chero chemishonga. Zvinofanira kucherechedzwa kuti mutengo "Sumatriptan" zvinodhaka, zvichienzaniswa nedzimwe, vachiri pasi. Saka, firimu zvemapuranga Mahwendefa pamusoro 50 Uchazoti kubhadhara rubles Russian 170-200 chete. Kana nasal zvinoreva kuti mutengo wayo uri pamusoro chete.

kana dzomuzana vane mushonga "Sumatriptan"? "Amigrenin" - mushonga kuti anowanzodanwa vawana kubvisa migraine kurwiswa kana pamusoro zvinoreva kusava chemishonga. Kunze kwayo, analogues medicament "sumatriptan" kuti basa fuma ndedzinotevera zvinodhaka: "Sumarin" "Imigran", "Sumitran", "Migrepam", "Sumatriptan-din email", "sumatriptan succinate", "sumatriptan Pfizer", "sumatriptan Adifarm "" Sumamigren "," Trimigren "uye zvichingodaro.

Uyewo, sezvo ari nasal decongestants yakafanana, vamwe vanamazvikokota dzinorumbidza kushandisa pfapfaidzo "Imigran".

Storage mamiriro uye sherefu upenyu

Nechipiriso mushonga zvinofanira kuchengetwa chete rakaoma uye kudzivirirwa chiedza chezuva nzvimbo. The tembiricha mukamuri hakufaniri anopfuura 25 inegumi. The pasherefu upenyu zvokurapa zvivako ndiyo 3 years. Shure iyi, mushonga haafaniri kushandiswa.