A mushonga tibhii. New Anti-TB zvinodhaka: zita, mirayiridzo

Tiibhii chirwere chinonzi chirwere hunhu, zvinokonzerwa Mycobacterium (seinä Koch) pamwe inonyanya kuoneka pulmonary localization. kurapwa chirwere inofanira nzwisisika, chinoenderera, zvinosanganisira mishonga anoverengeka Anti-TB, akapa aikanganiswa pakati nayo utachiona.

zvinodhaka boka

Mumwe TB mushonga chikamu dzakananga boka zvinhu. kuparadzirwa iyi inobva makemikari anoumba, ari kurapwa basa uye tolerability wevarwere:

• dzakatevedzana yokutanga ( "INH" "Rifampicin") - inonyatsobudirira;
• Napamusara wechipiri ( "streptomycin yakawanikwa", "Kanamycin") - avhareji kunyatsoshanda;
• mumutsara wechitatu ( "Thioacetazone" "Pas") - zvisinganyanyi inobudirira.

zvinodhaka zvikuru inobudirira rinowanzoshandiswa Nokuva mumwe nomumwe navo achishandisa mamwe mapoka. The dzasara mahwendefa tibhii rinonzi negadziriro yeparutivi. Ivo zvinoshandiswa zviitiko apo nayo utachiona ndiyo nemishonga unorapa ari nekabhunakeri.

"INH"

The mushonga "INH" rinoshandiswa pakurapa vakuru nevana. chiito Its inoendeswa vanoshingaira chimiro nayo utachiona. Panyaya mycobacteria vachingotya zororo, iye isashande. The Kuronga goko Koch seinä inosanganisira mikolievaya acid, ane kwetunhu iri nokuita zvinodhaka.

"Isoniazid" - mushonga tibhii munzvimbo dzose uye nezvimiro. The chipimo chemushonga iri kugadziridzwa nomumwe, zvichienderana sei, pamwe chii kunoreva kuti nyanzvi anokurudzira kugadzirira rakabatanidzwa.

1. "Isoniazid" + "Rifampicin" - mararamiro kurapwa kunoitika pamusoro 6 kana 8 mavhiki. The mushonga chinobviswa kamwe zuva mangwanani usina chawadya.
2. "Isoniazid" + "Thioacetazone".
3. "Isoniazid" + "Rifampicin" + "pyrazinamide" - zvakadaro mubatanidzwa mudziyo unonzi "Rifater". Kushanda 2 months zuva nezuva, kuwedzera kubudirira kurapwa, "streptomycin yakawanikwa" kana "ethambutol".
4. "Isoniazid" + "Ethambutol" - TB somushonga Nokuraramisa mishonga.

"Rifampicin"

Features zvinodhaka "Rifampicin": mirayiridzo kushandiswa (zvinoreva mutengo - vanenge 200 rubles) zvinoratidza kuti fuma inobudirira pamusoro mycobacteria Munzvimbo, richisvika vaifanira yevasungwa ikoko. TB utachiona vanowanzotevedzera nokukurumidza ajairire payo, nokuti izvo zvinodhaka ishoma. Not kushandiswa paanenge achiyamwa, nokuti ane pfuma yakawanda kupinda zamu mukaka.

"Rifampicin", mirayiridzo kushandiswa, mitengo izvo dziri kushandiswa mishonga nzvimbo vane divi migumisiro, rinoratidza zvinotevera inoti:

• cephalalgia (kurwadziwa nemusoro);
• reversible renal kukundikana (renal oparesheni anonaya mushure zvinodhaka kutarisira);
• neutachiona;
• dyspeptic zviratidzo - kurutsa, manyoka, bloating;
• madzerere;
• kuchinja murabhoritari parameters pamusoro peripheral ropa.

ya-aminosalicylic asidhi

"Pas" - mushonga tibhii kwakavakirwa amino salicylic acid. It anogadzirwa muchimiro mapiritsi, kugadzirisa, granules. The daily chipimo chemushonga rakakamurwa kuva 3 mishonga iri wokurera, kunwa mukaka, chicherwa mvura, simba pasoda mhinduro. Mune zvimwe zviitiko, chiremba prescribes zuva dose rimwe danho.

A gadziriro iri yokuzviranga ravakapiwa kwete chete akabatana nevamwe Anti nevamiririri. Valid chete pamusoro nevasori, vari kushingaira ezvinhu. Kupikiswa kuti mycobacteria kuti basa fuma iri kushanda kwete yakatanga.

"Pyrazinamide"

Mahwendefa tibhii chokuita chakaita zvokugadzirwa wechipiri-mutsetse zvinodhaka. Rinoshandiswa mubatanidzwa Mabatirwo tibhii chero localization. Kushandisa "pyrazinamide" panguva pamuviri uye lactation zvinobvira, chero kuti mycobacteria husingakwanisi zvimwe zvinodhaka tibudirire.

Kamwe chete pamwedzi anofanira kuongororwa transamiaz sandara uye kuvapo uric asidhi muropa panguva kwenguva refu kurapwa mumiririri. Contraindications pakushandisa ndiwo:

• nomumwe hypersensitivity kune chinoshingaira fuma;
• zvakakomba renal hurongwa;
• Organic zvokurwara chiropa.

fluoroquinolones

Drugs boka rinoshandiswa senzira causal kurapwa. Mari vane bactericidal chaizvoizvo, bata mycobacteria pa zororo uye panguva basa.

"Ciprofloxacin" inokurudzirwa akabatana nevamwe Anti-TB zvinodhaka. Kunonyanyisa wevasungwa mumuviri kunokwanisika mumaawa mashomanana kubva panguva womuchato. Kunogona kukonzera chemanyoka zvinetso, cephalalgia, kufunganya, neutachiona, ungaderedza kutarisana acuity.

"Ofloxacin" - mushonga tibhii, hunobata nzvimbo DNA iri mumasero nayo utachiona. Inowanika mapiritsi uye mhinduro kuti aizomupa. The daily dose chichigamuchirwa matanho maviri ane 12-awa zvikamu. Izvi zvinoita kuti tikwanise kuramba kuramba zvakakodzera wevasungwa kuti "ofloxacin" mumuviri.

"Lomefloxacin" - anobudirira mushonga kuti ane anenge 100% bioavailability. Rinoreva "vachivhiringidza" iri muDNA nayo utachiona chains ini ayo nzvimbo muchitokisi. Contraindicated panguva pamuviri, lactation, vana pasi pemakore 18.

zvinodhaka itsva

Zvakagadzirwa mumunda TB chokuita kukura zvikuru inoshanda Anti-TB zvinodhaka, asi nehanya kuti utachiona kuti vasingadi kuderera pamusoro yakareba nguva.

zvinodhaka New pamusoro tibhii:

• "Perchlozone" - zvisinei, nefuma ane pasi toxicity kuti muviri, ndizvo chaizvo kushingaira pamusoro mycobacteria. Contraindications zvinosanganisira pamuviri, lactation, paucheche, nomumwe hypersensitivity, itsvo uye chiropa zvokurwara.
• "Mikobutin" - yaiwana antibacterial mumiririri rifabutin yaishandiswa kurapa chirwere siyana hosha iri varwere husingakwanisi "Rifampicin". Rinoshandiswa kwete chete sechinhu kurapa, asiwo kudzivirira zvirwere.
• "Bedakvilin" ( "Sirturo") ane nzira itsva nzira kudzivisa kugadzirwa makemikari ose Mycobacterium tiibhii zvinokosha. Inoshanda pashure 3 months kurapa (ichienzaniswa nezvimwe zvinodhaka anoratidza mugumisiro mumakore 1.5-2), achipa kunaka pakuongororwa.

Side migumisiro yokurapa

The panowanikwa divi anokonzerwa nokuti kuti mishonga inoshandiswa yekudyidzana zvinokanganisa metabolic pezvakaitwa kuti atore nzvimbo murwere, uye kukonzera kuvandudzwa hypo- kana kukanganisika zvirwere, nyonganyonga redox kwendangariro.

The inonyanya divi Marwadzo:

• kunzwa kurasikirwa;
• peripheral polyneuritis;
• vanotaura pamusoro mashandiro mikuru nadzo uye nehurongwa;
• neutachiona;
• goiter;
• candidiasis;
• dyspeptic zviratidzo.

A dzakananga kuratidzwa mumwe Jarisch-Herxheimer maitiro - achipindura murwere kuti hombe kuparadzwa mycobacteria mumazuva mashoma okutanga pashure kutangisa kurapa.

Folk mishonga tibhii

With kurapwa kwenguva refu wevarwere achida kuedza chero nzira, chero bedzi mhanyisa apore. A zvinoverengeka Quick kuti tiwedzere zvinodhaka mishonga.

Spoon Birch Mafundo dira 2 Makapu rakasanganiswa doro kana vodka. Vanoomerera kusvikira kusvikira mhinduro achava cognac ruvara. Tora spoon 3 kanomwe pazuva panguva yose yawapiwa.

Reed kunosiya kuwacha, yakaoma uye ngaakuyire, vakabva 3 spoon. Dururirai 2 makapu mvura, bikai kwemaminitsi 5-7. Kuti vanosimbirira uye epfungwa. Inwa 1/2 mukombe emura usati wadya kudya.

Ematenhe mafuta, uchi uye fruit - chevarwere mishonga tibhii, kubudirira iyo kunoenderana kurudyi mubatanidzwa. Yakapwanyika nzungu, uye mafuta peretaplivaetsya. zvinhu zvose zviri kusanganiswa zvakaenzana zvikuru. Musanganiswa anoiswa nomuromo uye kusimudzira kusvikira iye chakambopfavisa.

Pine kana spruce muto akadurura doro 2-2.5 masendimita kumusoro uye dzavhara. Mazuva mashoma gare gare mushonga anova homogeneous. To izvi vakawedzera yakanyauka mafuta uye madota uchi zvakaenzana. Tora yetea katatu pazuva kwemwedzi mitanhatu.

Zvinofanira kurangarirwa kuti kushandiswa angambosvika uye kugadzirira zvinofanira kuitika pasi pokudzora anokwanisa nyanzvi.