Analogue "chloramphenicol" manyoka (Mahwendefa). "Chloramphenicol" (ziso madonhwe) analogs

Vazhinji vedu vanoziva ehupfumi zvinodhaka "Chloramphenicol", iro raunogona kukunda zvirwere zvakasiyana-siyana. Zviri zvakabatsirawo gastrointestinal zvirwere, kusanganisira avo ayo achiperekedzwa manyoka, vari zvinowanzoshandiswa ophthalmic tsika iri kwemabhakitiriya etiology chirwere. Zvisinei, kwete nguva dzose wakarurama kushandisa zvinodhaka ichi, saka chiremba anogona vanonyorera analogue kuti "chloramphenicol". Asi chii zvekushandisa mhando inogona kurumbidzwa, edza kunzwisisa.

Pharmacological ehupfumi zvinodhaka "Chloramphenicol"

mushonga uyu ane chakarondedzera chiito, nokuda kwayo mafuta-soluble ehupfumi, nyore nyore chinopinda sero Kamudzira kuti utachiona uye zvaanoita ane fuma kwemabhakitiriya ribosomes. Mugumisiro zvakadaro migumisiro iri nyonganyonga pepdidnyh nokuumba zvisungo uye mapuroteni usage. Saka, zvinoita sokuti basa zvinodhaka fuma ane bactericidal uye bacteriostatic chiito.

"Chloramphenicol" rinoshanda pamusoro utachiona zhinji zvigare izvo husingakwanisi tetracyclines, sulfonamides uye penicillins. Asi pathogenic majemusi - Mycobacterium tibhii uye howa - mishonga, zvinosuruvarisa haana maturo.

Kupikiswa nzira iyi zvigare nezvechinhu zvishoma nezvishoma. Nokuda zvakadai zvinhu uyewo mukuru toxicity zvinodhaka anoshandiswa kurapa zvakakomba zvinotapukira iyo vane zvishoma toxicity antibacterial mishonga isashande.

Zvairatidza kuti kushandiswa uye kusunungurwa fomu

Sezvo chishandiso inoshandiswa munzvimbo dzakawanda mishonga, vemishonga vakatora vatarisire zvivanakire kushandiswa uye dzakabudirira zvikuru zvitatu siyana chezvinodhaka. First - zvinwiwa mhinduro iri rakagadzirirwa Outdoor kushandiswa. Zvinonzi nachiremba pakurapa venous nemaronda kuti murege kuporesa kwenguva refu, uyewo kutsva II uye III chechetere. Kazhinji varumbidzwa mushonga purulent ganda maronda, mamota uye wakatsemuka minyatso mu ekukurerai.

Drug mu piritsi fomu vari zano kutora varwere kutambura nezvirwere zvakadai nemanyoka, paratyphoid, sefivha, brucellosis, salmonellosis, tularemia, pfungwa pute, mabayo. Zvakafanana inoshanda mushonga kuti siyana Q nefivhiri, inguinal limfagranuleme, yersiniosis, psittacosis, biliary turakiti zvirwere, purulent peritonitis, chlamydia, septic vanga zvirwere, ehrlichiosis, purulent otitis uye Urinary turakiti zvirwere kwemabhakitiriya mavambo.

The chimiro wechitatu pomutumwa - eyedrops. Ivo zvinoshandiswa ophthalmic tsika nokuda kurapwa uye kudzivirira zvirwere zvakadai keratitis, conjunctivitis, blepharitis.

Side Migumisiro Ezvemutauro

Izvi mumiririri pharmacological, uyewo zvimwe zvinodhaka, asi zvakanaka pharmacological ehupfumi ane uwandu nemishonga kuti munguva mushonga.

Kushandisa zvinodhaka zviri pahwendefa muchimiro kungaita munhu dysbacteriosis, dyspepsia, kurutsa, kuda kurutsa, manyoka uye nokushatiriswa pamusoro pharynx uye dzaiita zvokutaurwa mhango. Bvuma nokugamuchirwa kunoreva may hematopoietic ezvinhu, iyo kunooneka pacharo muchimiro thrombocytopenia, granulocytopenia, erythropenia, reticulocytopenia uye leukopenia. Zvishoma kacho, murwere anogona kuva aplastic kupererwa neropa kana granulocytopenia. Kubva tsinga maitiro "Chloramphenicol" Mahwendefa angava peripheral neuritis, kuvhiringidzika, rinoonekwa uye auditory zvisipo, uye psychomotor nenyonganiso said.

Nenjodzi kuti kushandisa zvinodhaka pane mhinduro muchimiro zvinogona chisimbwa, richiratidzwa sezvo ganda mapundu kana angioedema.

Structural analogue zvinoreva

The chikuru vanoshingaira chezvinonhuwira zvinodhaka ndiko chloramphenicol. Naizvozvo, mukuru STRUCTURAL analogue "chloramphenicol" - mushonga pamwe chete zita "Chloramphenicol". Zvairatidza kuti kushandiswa ayo akafanana nevaya inorondedzerwa mirayiridzo kushandiswa "chloramphenicol" mirayiridzo.

The chishandiso anogadzirwa huru nhatu siyana. First - mahwendefa uye capsules ane 0.25 uye 0.5 g vanoshingaira musimboti. The fomu wechipiri 25% ziso madonhwe, wechitatu - madota akaronga kuti mhinduro kuti jekiseni.

Zvinokosha kucherechedza kuti, senzira "Chloramphenicol" analogs ane chloramphenicol, muri mishonga inorwisa mabhakitiriya uye zvinofanira kupiwa zvakananga chiremba. Muzviitiko okuzvibatsira kwokubatsira boka iri zvinodhaka kunowedzera mukana nemishonga.

Drug "Levovinizol"

Chimwe STRUCTURAL analogue "chloramphenicol", iro zvino inogona kutengwa chemishonga, anozivikanwa pasi kutengeswa zita "Levovinizol". Hwaro chishandiso nhamba akashandisa chloramphenicol uye Excipients. Available mushonga muchimiro ane aerosol, liniment, upfu kuti gadziriro yacho yapera mhinduro uye doro mhinduro.

Ipa vachishingaira mushonga mu siyana kwemabhakitiriya ganda zvirwere zvinokonzerwa muvamwe tusingaoneki. Uyezve, vanachiremba kakawanda kushandisa mushonga kurapa varwere vaiva neutachiona yakadzika uye zvachero Uchipisa, kumanikidzwa maronda, trophic maronda, achiporesa maronda, mamota, vanotiwo medicament lactating vakadzi wakatsemuka minyatso.

Kusiyana zvinodhaka "Chloramphenicol" ano analogues kuti kukamura uchishandisa chikumbiro, kunyanya zvinodhaka "Levovinizol" vane pfupi pakarongwa nemishonga, saka havagoni kunyange kushandiswa kurapa vana kubva pakuzvarwa.

Panyaya contraindications, ipapo naivowo, kwete zvokuti. Achishandisa kudzivirira vanhu hypersensitivity kuti zvinoriumba, chinovhiringidza kuti mwongo hematopoiesis, uyewo vaya vanotambura chakasimba inoratidza porphyria, kushayikwa shuga-6-phosphate dehydrogenase, renal kana hepatic insufficiency, psoriasis, fungal zvirwere zviri Epiderme e, eczema.

Rinoreva "sintomitsina"

Kuedza kugadzirisa mubvunzo chii chinodhaka "Chloramphenicol" anoreva zvakafanana uye analogues, iva nechokwadi kutaura medicament "sintomitsina". mushonga iri kazhinji ushandiswe varwere vane utachiona kutsva 2-3rd zvakaoma kwazvo, non-achiporesa trophic maronda uye siyana ronda zvirwere.

At mumwoyo zvinodhaka rakashandiswa kunoreva chloramphenicol. Ebetsero zvinoriumba kuumba chete chipimo chemushonga fomu vemishonga akashandisa vanhuwo mafuta Castor mbeu, sorbic acid, ndokunatsawo mvura, emulsifier № 1 uye carmellose yavaibvisa 70/450 "O".

Drug "Metronidazole"

Antiprotozoal uye antibacterial mumiririri zvaishandiswa muminda mushonga siyana. Iye akagadzwa sapamazuva protozoan zvirwere, hosha yacho mapfundo mapfupa, uye mune abdominal zvirwere kwemabhakitiriya etiology. Yakabudiswa vachishingaira mushonga muna mana makuru chipimo chemushonga siyana: muchimiro kusangana nekutsi kwemukadzi gel, aizomupa mhinduro, suppositories uye mahwendefa.

Izvi analogue 'chloramphenicol' kubva manyoka rinofanira kushandiswa chete mushonga, izvo Uchamisa nguva yose kuchirapa kosi uye uwandu husingakuvadzi. Zvikasadaro, mukana nenjodzi muviri kunowedzera yekudyidzana. Panyaya iyi, musimboti tsinga uchitambudzika, uye varwere chokunyunyuta pamusoro chinyamunhari chinorwadza, nomusoro, kurukutika, kushaya hope, dzungu, kushatirwa, hope, ataxia, kuvhiringidzika uye kunyange zvisipo. Uyezve, yakazvimirira achitora chinodhaka anogona achiipa murwere ezvinhu, anowedzera manyoka. Zvinogona kuratidzika kurutsa, kunzwa kuoma mumuromo, kurasikirwa kudya nezvimwe zvirwere zviri zvomudumbu gadziriro yakakwana. Naizvozvo, senzira "Chloramphenicol" mirayiridzo kushandiswa analogues rinokurudzira achitora chete mushonga. Izvi zvichakubatsira kudzivisa pamamiriro divi siyana uye nokukurumidza kubata aivapo dambudziko.

Rinoreva "Ciprofloxacin"

Chimwe analogue kuti "chloramphenicol" - Mahwendefa "Ciprofloxacin". mushonga uyu ane antibacterial kushanda uye rinoshanda pamusoro utachiona zvirwere zvizhinji genitourinary maitiro nemudumbu. The chipimo chemushonga zvinodhaka uye nguva yose kuchirapa kosi rinowanikwa nomumwe.

mushonga uyu haisi STRUCTURAL analoginen rinoreva "Chloramphenicol", asi pharmacological ehupfumi ava vaviri zvinodhaka rakafanana chaizvo. Uyezve, anogona kushandiswa manyoka, kunokonzerwa siyana pathogenic tusingaoneki. Maererano contraindication kushandisa inorwisa mabhakitiriya "Ciprofloxacin" kuti vazhinji vavo. Chekutanga, zviri zvachose hazvitenderwi mishonga inoshandiswa kurapa vana uye kuyaruka vasina kuwana makore gumi nemashanu. Chechipiri, hazvina yakarumbidza kushandisa mushonga vakadzi panguva yepamuviri uye lactation. Chikonzero ndechokuti analogue kuti "chloramphenicol" ari mumiririri quinolone nemishonga series, izvo zvinogona kuunganidza mu pfupa uye shwashwa rinenge aparadza mamiriro avo. Uye ngozi kwazvo kusimukira mafufu mudumbu uyewo mwana, ana amai achiyamwa.

Inorwisa mabhakitiriya "Amoxicillin"

Mumwe antibacterial mushonga, izvo akaratidza zvakakwana pacharo pakurapa zvirwere intestinal kuti manyoka, inzira "Amoxicillin". Sezvo mushonga "Chloramphenicol" analogues izvozvo zvinofanira kushandiswa chete pasi zvokurapa kurumbidzwaka. Pashure pezvose, vakawanda inorwisa mabhakitiriya vane marwadzo. Saka, mabasa murwere ane antibacterial mumiririri, imwe nyanzvi kwete chete anoti ari chipimo chemushonga zvinodhaka, asi kuzozivisa kubvuma mitemo. Zvinonzi zvakare kunodiwa kuti zvinyorwe zvakaoma kurapa pakati probiotics anogona kubatsira kuderedza asina kunaka zvinokonzerwa antibacterial mumiririri uye kuramba zvakajairika intestinal kasvisto.

Analogs "chloramphenicol" vana

Kana manyoka ratanga ari mwana, vaizviona - kwete mushonga wokugadzirisa dambudziko. Uye tisingatauri kuzvimirira kushandiswa antibacterial yomuchipatara uye haana kuita. Chinhu chokutanga kuita kuona nyanzvi rubatsiro. Chiremba tichaongorora mafufu, inotakura nhevedzano zvidzidzo uye taurira njodzi kuti murwere kurapa shoma. Chokwadi, kana zvikaonekwa kuti mhaka manyoka ane noutachiona, kurapa pasina nemishonga angangotadza zvinobvira. Asi izvi hazvirevi kuti chiremba achaita mishonga chete "Chloramphenicol". Analogs vana vakasarudzwa maererano nezera boka murwere, kwokuomerwa chirwere, uye maererano wacho unhu mafufu (chisimbwa, kusashivirira dzimwe mishonga uye zvinoriumba dzavo, chirwere chisingaperi, uye zvichingodaro. D.).

Most kazhinji Pakadaro, munhu chakaita zvokugadzirwa zvinodhaka "nifuroxazide," izvo zvinoreva kuti boka nitrofurans. Inowanika sezvo pahwendefa chimiro uye kuturika, ichi analogue "chloramphenicol." Mahwendefa kazhinji ushandiswe vanhu vakuru vana kuchikoro zera, asi iri mvura zvinoreva unogona kupa nokuvhuvha.

Than kutsiva mushonga mu ophthalmology?

Uchifunga ehupfumi zvinodhaka "Chloramphenicol" uye ayo analogues, havafaniri kukanganwa kuti ichi antibacterial zvinodhaka kunouya nenzira dzakasiyana-siyana uye kunogona kushandiswa mune dzimwe nzvimbo zvokurapa. Somuenzaniso, Madonhwe ziso vari zvinowanzoshandiswa ophthalmologic tsika nokuda kurapwa kwezvirwere zvinokonzerwa zvirwere zvinokonzerwa noutachiona. Mutumwa inogona raitongwa varwere vanenge conjunctivitis, blepharitis, keratitis, uveitis nezvimwe zvirwere.

Zvisinei, pasinei mukuru efficacy, mushonga haigoni akakurudzira vose, sezvo pamazita contraindications kuti mabiko yaro yakafara. Maererano ruzivo huri mirayiridzo kushandiswa, ari medicament iri zvaisambobvumirwa kuvana kuyaruka pasi pemakore 18 wevakadzi zera, pamuviri uye ukoti. Varwere nezvirwere ari hematopoietic gadziriro, renal kana hepatic insufficiency nezvimwe zvirwere systemic uye havagoni kushandisa zvinodhaka "Chloramphenicol" (ziso madonhwe). Vaya rine ngozi zvokubikisa mumamiriro ezvinhu akadaro - chete yakarurama chingaitwa kugadzirisa dambudziko. Zvichienderana nezera murwere uye kukomba kwechirwere chacho, chiremba ringavakurudzira Madonhwe akadai "sulfacetamide", "Okomistin", "Normaks", "Floksal" uye vamwe.

Drug "Albucidum"

Sezvo mushonga "Chloramphenicol" (mumate), imwe analogue "sulfacetamide" riri medicament tinazvo bacteriostatic kushanda. mushonga uyu ushandiswe varwere - pasinei nezera -. Nokuti kudzivirirwa uye vabatwe anogumbura zvinotapukira ziso zvakadai keratitis, conjunctivitis, blepharitis, etc. The chete chinhu chinodiwa kuti unyatsoteerera zvachiri kuti nekuda pakurapa vana rinoshandiswa 20% of zvinodhaka ichiputswa , asi zera mapoka vakura zvinoratidza 30%.

Kana tikafunga zvingakonzerwa nemishonga zvinodhaka, kazhinji, zvaitika chaizvo kashoma uye havana inoda symptomatic kurapwa.

Zvaunofanira kuziva pamusoro zvinodhaka "Chloramphenicol" yayo analogs?

Mishonga zvakafanana chivako kuti rinoreva "Chloramphenicol", kwete zvikuru. Asi pano ndiyo zvinodhaka dzakafanana pharmacological ehupfumi kunopfuura zvakakwana, uye izvo munhu kusarudza - kutsunga chete nachiremba. Chete nyanzvi, uyo akapedza nechirwere uye kuona kukomba kwechirwere chacho etiology, vangakurudzira murwere kugamuchira zvivako "Chloramphenicol".

Analogs (manyoka, somuenzaniso) wechinhu mapiritsi uye kuturika, zvakare, zvinofanira kutorwa pamusoro zano chiremba, zvakajeka kutevera dosing hurongwa. Izvi kuchaderedza ngozi nemishonga.