"Capecitabine": mirayiridzo kushandiswa, dzomuzana chaivo, kusunungurwa chimiro, ari mugadziri. "Capecitabine-TL": okuti

Capecitabine (. Latin Capecitabinum) - iri fuma ari fluoropyrimidine carbamate rinobva. Nderake boka antimetabolites - dzakananga yeimwe vakakwanisa tunodzivisa ikure nyanyisa anomera. The kufarira kwakadaro zvinhu zvakatanga muna 1960 g. Okutanga nemigumisiro yakanaka avapo nezvidzidzo zviri mbeva. Papera nguva yakanga yakawanikwa kubudirira kwayo pakurapa mamwe zvirwere kenza muvanhu.

Nhasi, mishonga yakawanda anticancer ane zvinoshingaira fuma capecitabine. Reviews wevarwere vakawanda vanoti pamusoro kubudirira kushanda munowanika mu anticancer mishonga.

Kuchirapa uye zvivako

Formula capecitabine - 5'-deoxy-5-fluoro-N - [(pentyloxy) carbonyl] cytidine. Antimetabolites boka mushonga inomiririrwa zvinoverengeka zvinhu kuti akafanana zvakasikwa kuti zvibereko muviri (muviri) munhu. Vanokwanisa kuita metabolic siyana, uye kugadziridza kuti sipidhi dzimwe nokukanganisika kwendangariro. Saka pane atadze kushanda zvakanaka mune kunokosha bundu masero uye chinovhiringidza kukura kwavo kana kushandisa gadziriro yakavakirwa fuma capecitabine. Reviews vanhu vari kutaura kuderedza kukura anomera. mashandiro ichi chiito inonzi cytostatic.

ehupfumi izvi kubvumira kushandisa zvinhu antimetabolitnyh navo anticancer mishonga. dzavo nekusimba efficacy pamusoro nyanyisa mapundu pamusoro nemudumbu uye mammary mumasero. Muchiitiko chino, wakanaka mugumisiro anopa zvose monotherapy uye akabatana nevamwe vamiririri. Pari, pahwaro Anti-metabolites zvakasikwa anopfuura 800 zvigadzirwa, asi achiri anoramba kutsvaga mapoka itsva yeimwe.

mashandiro chiito

Capecitabine Activation rinowanikwa munyama pakati bundu, pashure pacho rinotanga kushanda kwayo hunokachidza zvainoita masero (cytotoxic mashandiro). fuma iyi rinobatanidzwa muviri nemapinduriro uye zvinotungamirira ndechokuti utano uye bundu masero vari dzikwanise cytotoxic analogs. Saka pane kutyora urwu fuma zvakakodzera kuti DNA usage uye, naizvozvo, weboka rikurumidze.

Sezvo masero kurega kuwedzera nhamba dzavo. Mune imwe Muchiitiko, pane "kuzvitsinhanisa" mumwe nomumwe fuma, mauri puroteni usage akashatirwa kana kushandisa zvinodhaka yakavakirwa capecitabine akakura. Guide rinotsanangura nemashoko akadzama izvi.

The mashandiro tishandurwe ichi waanodzikisira mukana kukuvara masero utano. Capecitabine zvikuru kusimbiswa bundu pacharo, pane ari dzakapoteredza munyama. Pakanzi yakadaro zvishoma kukuvadza muviri kana munhu ari kurapwa kuti mushonga inobva pfuma capecitabine. Mirayiridzo dzokushandisa rinokurudzira kugamuchira mari mu mishonga zvachose kunorondedzerwa kuti takatsunga ne kupinda chiremba.

Rambira fuma mumuviri

Pamusoro kugamuchira capecitabine raro nokukurumidza Absorção de Água ari nemudumbu. Kana muchidya panguva ino, muitiro zvishoma pasi. Saka, pana nokugamuchirwa antimetabolite zvinodhaka rinoitwa mushure ingestion. Uyezve kushanduka kunoitika muna chiropa fuma, mumwe uwandu capecitabine uye metabolites ayo kusungira kuti mapuroteni (semuenzaniso, sealbumin). Yepamusoro serum yomuropa runowanika pashure 1.5 -3 maawa pashure kushanda zvinodhaka. Izvi anotaura kuti mushonga "Capecitabine" mirayiridzo. Analogs vane pharmacokinetics zvakafanana.

Vazhinji fuma iri yabudiswa muna weti, dzakaderera - pamwe mutsvina yadzo. Uyezve, kwete chete anobva capecitabine muviri kuchinja (anenge 3%), asi nezvinogadzirwa nomukaka. Vamwe vari rinoita kuti sekwaserera yeimwe. The dzokugara uye kuchinja capecitabine mumuviri havasi kukanganiswa munhurume, zera, rudzi.

Kana achiita?

Capecitabine kupinda Formulations siyana raitongwa varwere vane kenza yemazamu, kusanganisira metastatic pechikuva. Panyaya iyi, mashoko anoshandiswa kuumbwa oga, kana kukabatanidzwa kurapwa pamwe contraindications kana kusava efficacy kuti mishonga. Kakawanda, capecitabine pamwe docetaxel.

Zvinonzi zvakare ushandiswe varwere vane kenza muura, yegurokuro, dumbu, rwatata, colorectal kenza, vaviri vari munharaunda kuparadzirwa pachikuva, uye panguva metastasis. Pakurapa kenza muura anopiwawo "capecitabine". Mirayiridzo yokushandisa kunyatsoongorora kutevera rakarumbidza chipimo chemushonga uye kuomerera zano kupinda chiremba.

Kudyidzana nevamwe zvinodhaka

Kana mishonga akaratidza basa, imwe oncology nyanzvi anogona mishonga mubatanidzwa kurapwa, iyo ichashandiswa "capecitabine". Mirayiridzo dzokushandisa inopa mazita zvinhu, izvo zvinoita kuti abudirire kusangana.

Somuenzaniso, ne "docetaxel" - zvinodhaka cytotoxic chiito mhando ane muriwo mavambo. It anokwanisa kuramba kwenguva refu ari mumasero zviri kumusoro kuwanda. Zvisinei, izvozvo mubatanidzwa vamiririri iri contraindicated vanhu vane uwandu maplatelet uye neutrophils 100,000 / Ul uye 1500 / L, ukuwo. Uyewo "Docetaxel" hairevi varwere yakawedzerwa mwero bilirubin. Panyaya iyi, kuti zvinobvira kuva nemigumisiro isingafadzi. Kana "Docetaxel" nokuda kwechikonzero "kuwa 'ari kurapwa zvaiitwa, ramba kurapa" capecitabine ", asi panguva kwakaderedza mishonga.

In zvinoitirwawo hypersensitivity siyana kurapa "capecitabine" uye "docetaxel" vanorega uye kubvisa zviratidzo akaita. Scheme aibatanidza supplementation hwapedyo oncologist unyanzvi Artisan. zano iri kugadziridzwa mune chiitiko chepfu migumisiro.

"Capecitabine" harigadzwi panguva imwe chete "Sorivudinom" - ane antiviral mumiririri. Kubatana uku kungawedzera toxicity wokutanga zvinodhaka. Kushandiswa antiepileptic zvinodhaka "phenytoin" kubatanidzwa kunowedzera wevasungwa neyokupedzisira muropa plasma. Zvinogonekawo ropa chirwere pakushandisa coumarin anticoagulants uye nzira, apo mukuru zvinoriumba - capecitabine. Mirayiridzo yokushandisa zvinonyevera pezvingazoitika, saka unofanira kutanga uzive nacho.

Ndianiko contraindicated?

Chikonzero kuti contraindicated kana ari kungogumira mushonga kungava:

• High utetsa (hypersensitivity kuita).
• Kuvapo kwazvo renal kana hepatic insufficiency.
• Various zvokukura pamuviri (mushonga kunokanganisa muchero), pamwe kunze zviitiko apo upenyu amai chiri kuiswa pokutanga;
• Feeding achangoberekwa dzichifura.

Uyewo kugamuchira capecitabine muganhu nokuti vanhu vane nechirwere chemwoyo (CHD), kana mamiriro yakawedzera Kuwanda bilirubin muropa, chiropa chirwere metastatic kuti kutyora zvayo zvinokosha mabasa. hapana kugadzirira pachii yevana uye vakwegura. Izvi inosimbisa zvinodhaka "Capecitabine" mirayiridzo. Testimonials taura pamusoro siyana nemishonga uye chepfu migumisiro yokurapa. Naizvozvo, capecitabine kurapa kunoitika pasi kuzviomesera pokudzora nyanzvi oncologist.

Pane nemishonga?

Mushure kutora mushonga kunogona kuva nemusoro, mamiriro nokuneta, lethargy, utera. Hope zvingaitika, kana vakutarisire - hope. Mune zvisingawanzoitiki Muzviitiko - kurasikirwa kufambisa nokudzikama, kuvhiringidzika.

Side migumisiro kumwoyo iri kupererwa neropa (kupererwa neropa). To muduku zvakadini zvingava kukonzera angina, myocardial ischemia, sitiroko, mwoyo nokukundikana uye nevamwe. Kana muitiro womunhu kufema nadzo vanobatanidzwa, pangava kupfupika mweya, kwazvo nepahuro, chikosoro. Very kashoma - pulmonary embolism, zvemapapu kurwadza kwacho.

Kana kushandiswa murwiyo chete kana kubatanidzwa kurapwa zvingangoitwa migumisiro pamusoro zvetsandanyama nemapfupa hurongwa. Kunoratidza pacharo nokurwadziwa ari makumbo uye chiuno, usimuke hypertonus tsandanyama (myalgia), kurwadza kwemajoini (arthralgia).

The ganda rinogonawo sei. Zvingakonzera dermatitis, erythema, kunyanya kuoma ganda, akatsvuka, tingling, chiveve, peeling, kuvaviwa, wakawedzera pigmentation, kukuvara kunokanganisa nezvipikiri. Mune zvisingawanzoitiki kacho pane ganda makatsemuka, hypersensitivity kuti ultraviolet nemwaranzi, peeling ikawanda fragility kuti chipikiri kwamahwendefa.

Zvimwewo yaivhuvhuta zviitiko zvingaitika kutapuriranwa pezvakaitwa nokuda kudzikisa muviri dzokuzvidzivirira. Pashure zvinodhaka kurapa kunokonzera vasanyanye maplatelet ropa uye ropa masero machena. kuratidzwa kwakadaro rinorondedzera medicament "Capecitabine" mirayiridzo Chinyorwa. Analogues kupa zvakafanana migumisiro.

mushonga

"Capecitabine" zvakakodzera chete pezviri kushandiswa. Kazhinji okumavirira pasi nemvura pashure hafu yeawa pashure kudya, asi kwete paya. The daily dose iri pakutsvaga kupinda oncologist, zvichienderana nekukura namamota, pave pachikuva, uye yose muviri pamusoro nharaunda. Hazvina chinodiwa kuti chiremba ane kare unyanzvi kushanda kwezvinodhaka ichi. Inonyanyoshandiswa ushandiswe kaviri-nezuva - mangwanani uye manheru. Panyaya iyi, yose kosi runogara masvondo maviri, uye ipapo - kuregawo kwemazuva manomwe, zvichiteverwa dzokororo kurapwa.

Nokuti varwere renal insufficiency, nezuva mishonga ipfupi. By kuderedza leukocytes (leucopenia) uye neutrophils (neutropenia) muropa rambai achitora zvinodhaka. Saka rinokurudzira senzira "Capecitabine" mirayiridzo Chinyorwa. Anoreva zvakafanana kana analogues raitongwa panguva chirongwa yacho kupinda chiremba.

toxicity

Kune madhigirii akawanda, maererano izvo kuva chepfu Migumisiro zvinodhaka "capecitabine" (Mirayiridzo Use). Reviews vanhu vazhinji vanoti kuti izvi Munhu chichingoitwa.

Pane mwero anoverengeka toxicity:

• 1 dhigirii. Kune vashoma nemishonga.
• 2 dhigirii. The zvikuru manyoka (kusvika 4 kanomwe pazuva) vakatevera muzvidimbu kuzvimba, akatsvuka, basa wenyonganyonga, rakapinza kuwedzera bilirubin. Panguva iyi, mabiko zvinodzongonyedza capecitabine kusvikira zviratidzo toxicity kuti pachikuva 1.
• 3 dhigirii. Manyoka unoraramisa kusvika 9 nguva pazuva. It kunoitika malabsorption (sprue). Kana uyu akaona ganda simba peeling, akatsvuka, Maronda akasiyana uye maronda. Pane yakapinza kurwadziwa ari wamativi, ndokuramba unongotaura. Bilirubin ari yakawedzera ka3. Panguva iyi yokurapa iri kwakaregwa, uye nekuratidzwa toxicity 1 dhigirii kuramba kugamuchira nzira panzvimbo dzapasi dose.
• 4 dhigirii. More kakawanda manyoka - kusvika 10 nguva pazuva. Chitsiko neropa. Pane kudiwa pakatanga zvinodhaka, pavaigona kutora chikepe chaienda ari nemudumbu. Kana zviratidzo dhigirii iyi kurapwa zvinofanira akamira uye haana tatangazve.

Ndezvipi zviyero vanofanira kuchengeta kuchengeteka?

Yawapiwa zvinofanira kuitika pasi pedyo zvokurapa achitarisirwa. Mazvikokota anofanira rakakodzera wanikidza chepfu kuratidzwa -. Pasinei kuda kurutsa, manyoka, etc. Pamusoro vasabatwa ava features, kurapwa iri kugadziridzwa. Kana zvakakodzera, kubvisa zviratidzo, kuderedza nezuva dose, kuregawo. Treatment chinofanira mberi, kana zviratidzo toxicity regai vangangokukuvadza upenyu.

Nokuti vanhu vane nechirwere chemwoyo zvokuongorora nyanzvi kunofanira kunyanya kwazvo. Muchiitiko chino, unofanira nguva kuzivisa inokanganisa kumwoyo uye nguva kuti urongwa sezvinodiwa.

Nyanzvi varege kushandisa pfuma iri chiremba tsika. Kubudirira kushandiswa kwayo haina dzakatangwa vana. Kana marapirwo ari pasi mukadzi zera, iye anofanira zvekuita matambudziko capecitabine pamusoro azvarwa. Paaiita yokurapa, iye anofanira kushandisa yakavimbika pamuviri.

Kugadzirira uye analogues

Pane zvigadzirwa akawanda nemhaka capecitabine. In musika wokuRussia pane 7 zita chinodhaka, zvinoberekwa mudzimba uye vatorwa makambani akawanda kutengeserana. Somuenzaniso:

• "Capecitabine".
• "Capecitabine-TL".
• "Tutabin".
• "Xeloda".
• "Kabetsin".
• "Kapetsitover".
• "Kapametin FS".

Sezvo nheyo zvose nzira idzi mumwe chete rinoita chirungiso - capecitabine, nekuraira kwavo kuchava zvakafanana. Kazhinji inoratidza tafura pakuverenga kuti chipimo chemushonga kupiwa muviri uremu uye kurapwa kururamisa redunhu kana chiratidzo kunosiyana inosiyana toxicity.

Zvakakosha kunzwisisa kuti chinhu chokutanga kuverengwa, kana iye akagadzwa Somuenzaniso, "Capecitabine TL" - nokurairirwa. Mashoko mairi haisi akakodzera kuzvidzora vaitarira Ezvemutauro! Masvomhu All chokuita dose uye kurapwa zvaiitwa, unobereka chiremba - oncologist ne kugona yakakwana panyaya iyi. Self-kwokubatsira anticancer nevasori kukonzera irreparable kukuvadza muviri.

Ngatikurukurei zvimwe zvinodhaka.

Description kugadzirira

• "Capecitabine - TL" anoita Russian OOO kambani "Technology mishonga." Chinhu chinokosha pakuderedza - capecitabine. Mirayiridzo kushandiswa, kusunungurwa chimiro mubereko vakawanda. Funga mashoko. Hwendefa iri, film-zvemapuranga. Zviri vanoshingaira fuma - 150 kana 500 MG. Upiyona zvinoriumba: cellulose, lactose, croscarmellose yavaibvisa, hypromellose, magnesium stearate. Mumwe pasuru kungava 60 kana 120 pamahwendefa, zvichienderana chipimo chemushonga zvinodhaka "Capecitabine - TL". Instructions vanofanira ane kwemashoko akazara pamusoro kushandiswa mari.
• "Capecitabine" - mumhuri chigadzirwa pamwe chete rinoita chirungiso. Kurondedzera kwake zvakafanana nzira dziri pamusoro. Release chimiro zvinodhaka "Capecitabine" - Mahwendefa. Mirayiridzo dzokushandisa dziri akanyudzwa mukati pasuru.
• "Kabetsin" - anticancer mutumwa Russian gadzira ( "Company" deco "). Product fomu - mahwendefa firimu zvinenge zvakazara 150 kana 500 MG kuti basa fuma. Secondary zvinhu: microcrystalline cellulose, crospovidone, starch, magnesium stearate. Siya kubva Pharmacies chete mushonga.
• "Kapetsitover" - inogadzirwa Russian kambani OJSC "Veropharm". Izvi anticancer mumiririri rinowanikwa pamahwandefa 150 kana 500 MG 60 - 120 zvidimbu. Kunze capecitabine, mukugadzirwa kunosanganisira lactose, cellulose, croscarmellose yavaibvisa, yavaibvisa stearate, uye hypromellose.
• "Kapametin FS" - zvinoberekwa Russian kambani "Nativ" - chinoshingaira ubatanidzwe purogiramu imupota kuzvitsinhanisa zvinodhaka. "Kapametin FS" kukusunungurirai chipimo chemushonga ine 150 - 500 MG vanoshingaira mumiririri - capecitabine. Mirayiridzo dzokushandisa (uyewo mugadziri Set mariri) vachakuudza mangani mapiritsi por rongedza - 60 kana 120.
• "Tutabin" - vatorwa chigadzirwa pahwaro capecitabine. Inobereka ive Argentine kambani Laboratorio VARIFARMA SA, riri mabharani pomutumwa. "Tutabin" anogadzirwa muchimiro mapiritsi pamwe chinoshingaira chirungiso zviri 500 MG. Kavha - kabhodhi bhokisi nemirayiridzo yawapihwa.
• "Xeloda" - imwe antitumor mumiririri. Yakabudiswa muSwitzerland ne "naF Hoffman La Roche" uye ayo subsidiaries uye mumiririri Mahofisi dzimwe nyika - Mexico uye United States. In musika wokuRussia mune 5 zvinodhaka pamwe kutengeserana zita. Product fomu - mahwendefa (150 - 500 MG) pa 60 kana 120 zvidimbu. mune imwe chete pasuru.

Reviews

Reviews basa pachishandiswa zvakasiyana siyana zvinodhaka capecitabine. Vazhinji vavo zvakanaka, asi panewo kunaka wongororo. Zvisinei, izvi hazvirevi unhu mari idzi sezvo zvakanaka kana zvakaipa, nekuti nguva dzose unofanira kufunga munhu akazvimiririra muviri mumwe nomumwe. Kugamuchira nzira chete vanhu vakasiyana kutongondipa zvakafanana mugumisiro. Zvikuru ndechokuti iyo muviri yakarohwa neoplasm rinhiko zvakanga zvichiitika.

Vanhu vakatora mushonga, anodaro mumwe simba hunokachidza mugumisiro pashure mazuva anoverengeka rubvumo. Zvisinei, vakawanda dzinoshuma zvinokosha nani avo ezvinhu uye kunyange kupinda kanganwiro. ezvinhu rinokosha kuti mushonga zvinoshanda uyewo kuti kuroorwa, munhu Consulting oncologist uye kunyatsotevedza mirayiridzo yake chokuita kurapwa.