"Korvitol": analogues, nhoroondo, mirayiridzo kushandiswa. Chii chinogona kutsiva "Korvitol 50" uye "100 Korvitol"?

Zvemwoyo ndivo rakajairika. Kuti nokukurumidza kudzibatsira, kuderedza kwemwoyo, kuderedza mamiriro angina pectoris, migraine, zvinodhaka kutora "Korvitol". Analogs yakagadzwawo kakawanda mumwe chikonzero kana mumwe. The mushonga une contraindications, naizvozvo pamberi kushandiswa, bvunza chiremba wako.

Release chimiro uye Kuronga zvinodhaka

The mushonga ndohwaJehovha Beta-blocker. It anogadzirwa muchimiro mahwendefa chena vane dzeraundi makavharidzira spigot, uye chamfer pangozi rimwe-mativi. Available mu dosages maviri:

• "Korvitol 100". Rine 100 MG ose vanoshingaira chirungiso metoprolol tartrate.
• "Korvitol 50". It ane Zvinoumba 50 MG yezviri chirungiso metoprolol tartrate.

Zvimwe zvokubikisa kwose chete nyaya uye vakapa lactose monohydrate, magnesium stearate, povidone K30, croscarmellose yavaibvisa, nesilicon dioxide, colloidal talc.

Mahwendefa vari mumapepa ari aruminiyamu Maronda akasiyana zvezvimedu 10. The pasuru zvingava 3 kusvika 10 Maronda akasiyana. To mishonga akapa mirayiridzo Chinyorwa.

Pharmacology uye pharmacodynamics

"Korvitol" riri cardioselective Beta-blocker, izvo zvinoratidza pasina sympathomimetic basa uye hapana Kamudzira pakudzikamisa ehupfumi. It hwaanahwo antihypertensive, antiarrhythmic, antianginal ehupfumi.

Kuchititadzisa duku shoma β1-adrenergic receptors mwoyo uye anoderedza paumbwe catecholamines kusashanda kumusasa ATP, kunoderedza intracellular karusiyamu Ion ano. Zvakaomarara BATM, chrono-, Drome uye inotropic simba.

TPR pakutanga kushandisa Beta-blockers kunowedzera, uye pashure pemazuva mashomanana vanoshandisa zvinodhaka vakadzokera yepakutanga vanochiva kana kushandiswa kwenguva refu ipfupi.

Antihypertensive pfuma anokonzerwa kuderera cardiac goho uye kwetunhu imwe renin chinovhiringidza pamusoro renin-angiotensin uye nechepakati huta hurongwa, baroreceptor utetsa kudzoreredzwa kutsemuka chematenga uye pakupedzisira kuderera peripheral tsitsi zvinofurira. It zvinoderedza kweropa pa zororo uye panguva mumuviri neuropsychic mutoro.

The hypotensive zvazviri kunokwanisika mumaminitsi. Saka systolic BP iri akatura pashure maminitsi gumi nemashanu pashure vaifanira maawa maviri. Kuvhiringidzwa kubudirira rinovapo kwemaawa matanhatu. Diastolic BP ari kuchinja zvishoma nezvishoma. Kudzikamiswa zvinogona kuwanika chete papera vhiki kurapwa.

Antiangialnye chatingatevedzera zvinodhaka akatsunga vasanyanye myocardial okisijeni kudiwa nokuda kuderera kwemwoyo. Akaderedza susceptibility kune migumisiro myocardial tsitsi innervation, nhamba nekuomarara angina kurwiswa. Anowedzera kutsungirira chaiko.

Antiarrhythmic ehupfumi zvinozarurwa apo achibvisa arrhythmogenic kuratidzwa achidzikisa excitation uye ectopic sinus mutinhimira, uye chinovhiringidza kuti AV-conduction. Kana kuratidzwa supraventricular tachycardia, atrial fibrillation chinowanikwazve uye kuziva miedzo sinus tachycardia chokuita chomwoyo uye hyperthyroidism, mishonga kunoderedza kwemwoyo. Dzimwe zviri kudzorera sinus mutinhimira. It Unotsigira migraine uye kudzivirira chiitiko yaro yemberi.

Kana rikashandiswa pamatunhu kuchirapa mishonga, kusafanana nonselective Beta-blockers, ine zvishoma raidudzwa sei nhengo ine β2-adrenergic receptors, uye carbohydrate muviri. Kana kushandiswa guru mishonga (100 MG pazuva) ane ichivharira kubatsira vose β-adrenoceptor subtypes.

Metoprolol 95% wefodya kubva mudumbu uye ura. The kunonyanyisa yeplasma wevasungwa aona pashure pemaawa 1-2. Nokuti rinoita kuti muviri kana kutanga kutora zvinodhaka bioavailability ndiyo 50%. Pamusoro kushandiswa dzairamba zvinodhaka, izvozvo kunowedzera 70%. Kudya zvokudya nguva dzose kunowedzera bioavailability pamusoro 20-40%.

"Korvitol 'kunofambidzana ropa rive kubudikidza 10%, Vd - 5,5 l / makirogiramu. Nepano ari BBB uye plantsentarny nokuidzivirira. Yabudiswa muna mukaka mu mishonga diki.

Anenge mushonga zvose rinoita vari chiropa. Two metabolites chikuru vatatu hwokuratidza Beta-adrenoceptor ichivharira pfuma. The muviri zvinodhaka anotora chikamu isoenzyme pakati cytochrome P450 (CYP 2D6). Excretion kunotora maawa anenge 3,5. The mushonga inenge yabudiswa muna weti, uye 5% anoenda kuzochinja.

cheitsvo tunodzivisa muviri kuti metoprolol. Sezvineiwo inowedzera bioavailability mu cirrhosis. The rinobata fuma haisi asunungurwa kubva muviri panguva hemodialysis.

Zvairatidza yokushandisa zvinodhaka

"Korvitol" unofanira chete kushandiswa pane mushonga mu neBP. Rinoshandiswa sezvo monotherapy kana akabatana nevamwe antihypertensive nevamiririri. The chiratidzo kushandiswa iri tachycardia, nechirwere chemwoyo, myocardial infarction. Kazhinji kushandisa "Korvitol 100", analogues kudzivisa kurohwa uye mwoyo mutinhimira zvinetso, ekudzivirira migraine.

Contraindications

"Korvitol 50", uye mushonga ari chipimo chemushonga 100 MG kutorwa mu cardiogenic kuvhunduka. Contraindication anoshanda AV-chezvakaipa II uye III dhigirii uye sinoatrial misa. Regai kutora mushonga ari chirwere varombo sinus bradycardia. Ban vari peripheral kweropa kukundikana uye mwoyo nokukundikana. Mahwendefa usanwa angina, chenjera myocardial infarction uye arterial hypotension.

Haukwanisi nokubatanidza mishonga "Korvitol 50" (akafanana, kana zvakakodzera, ichakubatsira kusarudza kurapa chiremba) nokushandiswa monoamine oxidase FIs uye intravenous majekiseni "Verapamil".

The mushonga hakuratidzwi panguva uchiyamwisa, vanhu pasi gumi nemaviri, uye vanhu vane hypersensitivity kuti metoprolol, mamwe zvinhu sezvo chikamu nzira.

With chinokosha Yambiro mushonga cheshuga, Árbol asima, emphysema, metabolic acidosis, chisingaperi obstructive bronchitis mu chimiro. Chete pasi zvokurapa achitarisirwa vanofanira kudya mushonga vanhu vane peripheral vascular chirwere, renal kana hepatic insufficiency. Vakangwarira pakushandisa mahwendefa 'Korvitol "vanofanira kuva varwere myasthenia gravis, AV-blockade pamusoro I dhigirii, uyewo pheochromocytoma, kuora mwoyo uye hyperthyroidism. With kutarisira varwere muna psoriasis uye varwere vakwegura.

Panguva pamuviri "Korvitol" piritsi mishonga chete vanenge kukurumidza, kana paine fetus bradycardia, hypotension, yomuropa. Panyaya iyi, apore anofanira kutora nzvimbo pasi pedyo pokudzora chiremba. Mune ramangwana, kutungamirira tisanzwa kutarisira achangoberekwa panguva maawa 48-72 mushure pakukurukura.

Metoprolol kubatsira mazuva vomwana upenyu chokutanga Hazvizivikanwi, saka vakadzi vanoshandisa chinodhaka, riri zano kurega achiyamwa.

"Korvitol": kushandiswa Recommended mishonga

The kuchirapa kosi nerimwe murwere pakutsvaga chiremba, uye zvinoenderana weboka chirwere. Chete nyanzvi anofanira akagadzwa mabiko uye chipimo chemushonga zvinodhaka "Korvitol". Mirayiridzo yokushandisa (analogs zvinodhaka kubva vagadziri Russian vari isingadhuri zvikuru) anorondedzera chete chaiwo regimens mune zvimwe zvirwere.

Saka, muna neBP uye angina kushandiswa kwezvinodhaka mukati 100 MG kamwe zuva kana 50 MG kaviri pazuva. Kana zvakakodzera, chitsama zvinodhaka ichiwedzerwa kusvika 100 MG, wakatorwa kaviri daily. Kufadza zvichibvira zuva nezuva dose iri 200 MG.

Functional kusagadzikana mwoyo, Nokumukira kwaita tachycardia, ari kugamuchira kwokutanga chinotarisirwa mune imwe mari 50-100 MG pazuva. mari iyi inogona kuva huviri nguva. Sezvo zvaida dose daily yakawedzera kusvika 200 MG.

Kuti adzivise migraine zvinodhaka chairayirwa 100 MG kamwe pazuva, kana 50 Rine mamiririta mangwanani uye manheru. Kana mishonga zvazviri kunokwanisika, kuti dose anofanira kuderedzwa. Izvi zvinofanira kuitwa zvishoma nezvishoma uye pasi pedyo zvokurapa achitarisirwa.

Older vanhu vane chirwere cheitsvo uye hemodialysis nezuva dose haisi ipfupi. In chiropa kukundikana nezuva chitsama zvinodhaka ipfupi, kufunga pamusoro murwere ezvinhu.

In ose pamusoro apa, "Korvidol 'rinoshandiswa zvokunwiwa, pashure kudya uye ndikandoshamba pasi zvishoma mvura. Mahwendefa zvinofanira kumedzwa pasina kutsenga. Kana mushonga wakadhakwa ose zuva, kuushandisa vauye mangwanani. Kana kushandiswa kaviri hwendefa kubatwa mangwanani uye manheru.

ovhadhozi

Medicine "Korvitol" iri nyaya ovhadhozi pakarepo kunwa. Zviratidzo kushungurudza nzira protrude sinus bradycardia, kuda kurutsa, dzungu, kunoderedza BP, gag dzepanguva, cyanosis, arrhythmia, bronchospasm, kufenda, ventricular arrythmia.

Chenjera ovhadhozi dhigirii rokugadzirira "Korvitol" (analogues muRussia unogona kutenga chero chemishonga kubva rubles 30 uye pamusoro) hworatidza sezvo cardiogenic kuvhunduka, pakoma, AV-blockade, kurasikirwa kuziva, cardialgia. Kazhinji, zviratidzo kunyanya kushandisa zvinodhaka okutanga vape- pashure maminitsi 20 - 2 maawa pashure kutarisira.

Chinhu chokutanga murwere ukashambidzwa dumbu uye ushandiswe zvinodhaka adsorbent. Kana paiva nomusiyano ichidonhedzera BP, munhu anoiswa mukati Trendelenburg chinzvimbo. Kana kumanikidzwa anodonhedza kuti yakaoma pamwero uye pane mwoyo kutadza, bradycardia, ipapo dzakabatwa nomutsinga panguva zvikamu maminitsi 2-5 Beta adrenostimulyatorov. The nzira rinoitwa pamberi zvakanaka mugumisiro. Intravenous majekiseni inogona kuitwa panguva dose kuti 0.5-2 MG "Atropine sulfate."

Kana aida kushanda isina kubudirira, kushandisa zvinodhaka zvakadai se "Dopamine," "Norepinephrine", "Norepinephrine" kana "dobutamine". Dzimwe nguva achiita 1-10 MG kuti "Glucagon" kana kuisa transvenous intracardiac pacemaker. In zvinoitirwawo bronchospasm jekiseni kuva tsinga Beta adrenostimulyatorov. Kana pfari kuitika, yozononokera kuita jekiseni rive tsinga "Diazepam". Hemodialysis muchiitiko ichi haashandi.

nemishonga

Constant kugamuchirwa gadziriro "Korvitol" (mapiritsi) anogona kukonzera chikamu Central tsinga nemusoro, tsandanyama simba, kunyanya kurukutika, dzungu, chikonzero chinovhiringidza chepfungwa uye vasiri kuita, paresthesia maoko netsoka. Akaratidza mwoyo, kufunganya uye kutya, vakanetseka yevasungwa. Ndainetseka Hope, kunaka hope, kushaya hope, kuvhiringidzika, pfupi rokuti kuyeuka. Asthenic chirwere zvingaitika.

"Korvitol" uye ayo analogs zvingakonzera madzerere, kuoma uye soreness kwameso, zvinoderedza kuti misodzi Urume kugadzirwa. Mune zvisingawanzoitiki kacho pane conjunctivitis, rhinitis. Kune ruzha munzeve.

The mushonga kungaita atadze kushanda zvakanaka pakati kumwoyo sezvo sinus bradycardia mhando, mukuru kwemwoyo, kungoerekana kumanikidzwa rutapudzo, hypotension, orthostatic hunhu. Mune zvisingawanzoitiki kacho, vasanyanye myocardial contractility, kuwedzera mwoyo kukundikana, arrhythmia, vasoconstriction. Kushushikana patency infarction. kardialgiya unomuka.

With kushandiswa kwezvinodhaka dzose dzakanga vakachengeta dysfunction pamusoro nemudumbu, kwaakaita muchimiro kuda kurutsa, kurutsa dzepanguva, marwadzo mudumbu, manyoka, muromo yakaoma. Vamwe varwere akaona kuchinja zvadzinofarira, kuwedzera rinokosha webasa chiropa makemikari. Mune zvisingawanzoitiki kacho akaratidza hyperbilirubinemia.

Somugumisiro yokurapa vakanga akacherechedza dermatological siyana. psoriasis ichi uye kusembura yayo, akatsvuka, mapundu. kunyanya vangadikitira, yakanga kucherechedzwa, alopecia reversible mhando uye photodermatosis.

Respiratoria divi migumisiro vasangana muchimiro dyspnea uye kuzara pamusoro nasal ndima. Vamwe varwere akatambura kupfupika mweya.

Dzimwe nguva paiva yomuropa uye hypothyroid mamiriro. Varwere vavhiringidzike thrombocytopenia, leukopenia, uye agranulocytosis. Kune chisimbwa muchimiro yakafunuka, mikoko uye rashes. Zvakaonekwa musana marwadzo (majoini), kufuta, kurasikirwa libido, potency.

Zvokungwarira

At kushandisa zvinodhaka atakure chinokosha kudzora mwoyo zvazvingava, BP uye shuga yomuropa, kunyanya pavarwere vane chirwere cheshuga mellitus. Mukupera zvazvingava, dose anosarudzwa maererano nomufananidzo chirwere.

Zvinofanira kudzidzisa murwere wacho nzira kukarukureta mwoyo mwero uye kudiwa rokurayiridza zano chiremba kana mwoyo mwero idukusa 50 u. / Min.

Kana vakagadzwa mukuru-dose (200 MG pazuva), akaderedza cardioselective. In varwere mwoyo nokukundikana kurapa rinoitwa panguva muripo.

Kungawedzera kwokuomerwa hypersensitivity siyana (pamwe zvinowedzerwa sema nhoroondo) uye kushaya mugumisiro pakatanga kwakajairika mishonga kuti "Epinephrine".

On pakanyorwa zvinodhaka anogona achiipa zviratidzo peripheral arterial kutenderera.

The abolition of kurapwa pavaiita zvishoma nezvishoma, achidzikisa dose kusvika rakadzikadzika kwamazuva gumi. Regai payakakurudzirwa kukanzura chinodhaka, sezvo zvinogona kukonzera angina uye BP.

In varwere angina dose anosarudzwa kuti mwoyo mwero akaenzana 55-60 u. / Min uye asingauyi kupfuudza 110 bpm panguva kurovedza muviri. / Min.

Vanhu vane kuonana lenses kuziva kuti munguva yokurapa, Beta-blockers anogona kuderedza kugadzirwa kukuvara mvura.

Metoprolol mune zvimwe zviitiko masiki zviratidzo hyperthyroidism. Varwere thyrotoxicosis contraindicated chimbichimbi kurega zvinodhaka, sezvo ino chete kutowedzera chirwere.

Varwere chirwere cheshuga haagoni pakarepo kuzviona tachycardia wakatsamwisa yomuropa. "Korvitol" kwete kuwedzera jekiseni Kutemeswa yomuropa kana kunonoka kupora ropa shuga chaiko nhanho.

Vakwegura vachitsigira mishonga vanofanira kuramba kuongorora itsvo basa, uyewo varwere renal insufficiency.

Kungwarira vanofanira kutora mushonga munhu ane mwoyo mamiriro, sezvo mahwendefa anogona kuwedzera kukomba kwechirwere chacho.

Panguva kurapwa haafaniri kutyaira uye kumisa mabasa chokuita wevasungwa hanya, yaingoda akurumidze mhinduro.

Panguva kurapwa vanofanira kupfeka namahwindo mbatya, nokuti mushonga kunogona kukonzera photosensitivity.

Chii chinogona kutsiva "Korvitol"?

Mune zvimwe zviitiko, zvinodhaka kungaita zvakasiyana-siyana nemishonga kana havambokwanisi kuuya pamusoro chiito, saka chiremba anogona kuisa "Korvitol". Analogs vane ehupfumi zvakafanana, kupa zvakafanana kuchirapa kushanda uye akaumbwa metoprolol tartrate. Vane mukurumbira chaizvo uye vanotengeswa kunenge kwose chemishonga uye mutengo vamwe vavo haawanzotauri dzisvike 50 rubles.

Zvinotevera vanokwanisa kutsiva "Korvitol" analogues pamwe chete vanovapo chirungiso:

• "Betalok".
• "Egilok".
• "Metozok".
• "Metoprolol".
• "Serdol".
• "Vazokardin".
• "Lidalok".

Similar migumisiro vane zvinotevera Formulations: "Aritel", "Estekor", "Bisomor", "Binelol" "Atenolol", "Kordinorm", "Betacam" "Biol" "Nebilet", "Bisogamma" uye zvimwe zvinodhaka.

Kana kutsiva mumwe mushonga mumwe, ziva kuti analogue hakuwanzoshandi sezvo zvakanyanya sezvo yepakutanga chinodhaka, vakapfuura dzakatevedzana miedzo uye yakawanda tsvakurudzo.

Mari chinodhaka, wongororo

Zvaiwanzoita unogona kutsiva "Korvitol" dzomuzana? Testimonials vanoti kuti zvakaoma kuwana mushonga pamwe chete nguva basa, pasinei nokuti rakabudisa zvakawanda zvigadzirwa ane zvakangofanana unorapa. Medicine kazhinji ndiyo Sevamiririri anodhura, asi, sezvo ruzivo akaratidza, muri zvishoma nyatsoshanda dzomuzana. Reviews anoratidza kuti "Korvitol" zvinobudirira lowers BP uye kunoita kukura migraine.

mahwendefa 50 100 MG arasikirwe 250-300 rubles, zvakafanana mune chipimo chemushonga 50 MG ndiko sezvakarayirwa 220 -250 rubles.