"Nimesulide" mapiritsi. Mirayiridzo yokushandisa, dzomuzana chaiwo

Marwadzo - rudzi yokuedza muviri kuti atambudzwe munhu, mudane rubatsiro. Saka chakaipa kuti chinhu "iri Danish umambo", uye zviwanikwa muviri kukwana kugadzirisa dambudziko, tinoda rubatsiro kubva kunze.

Consumer mishonga musika of Russian Federation akauya mazana zvinodhaka kubatsira vanhu kukurira kurwadziwa. Mishonga All siyana sezvamunoita, kukura uye mashandiro kuti simba. Mumwe inonyatsobudirira ndivo zvinodhaka kubva boka vasiri steroidal Anti-anogumbura zvinodhaka. Pakati pavo pane kuturika uye mahwendefa "Nimesulide".

Mamiriro uye Kuronga

Round mahwendefa vane lenticular chimiro. In ruvara kungava akacheneruka yero kana kungoti tsvuku. Huru kushingaira zvinoriumba - imwe pfuma Nimesulide neimwe piritsi - 100 MG. Kubva nhamba anganzi yokuwedzera microcrystalline cellulose, starch (chibage), yavaibvisa starch glycolate, colloidal nesilicon dioxide.

Mukuwedzera, mushonga wacho aida vatengi muchimiro Nezvakakuyiwa kuti kumisa "Nimesulide." Kuronga kwakafanana kuti mahwendefa, mumwe 100 MG sachet chikuru kushingaira zvinoriumba.

pharmacodynamics

Nimesulide zvokusarudza kuchititadzisa cyclooxygenase-2, cyclooxygenase-1, rawo riri kuti zvikuru muduku papi. Panyaya iyi, chinovhiringidza pamusoro prostaglandins kwetunhu kwakacherechedzwa wakatsamwisa anogumbura kuita. Zvisinei, paumbwe prostaglandin-mhando pamutemo nimesulide rine haawanzotauri oneka zvazviri, zvichiguma usingashandi rubatso zvinoratidza zvomudumbu hurongwa.

Mukuwedzera, zvokurwisa zviito nimesulide richiratidzwa chinovhiringidza pamusoro inotungamirwa chokusarudza radicals. Zvisinei, ivo dzinotsanagura hemostasis uye phagocytosis hakurevi kutambura migumisiro nenhumbi ichi. The mashandiro pamusoro Anti-anogumbura mugumisiro ndikazoti medicament anopindura wandei nzvimbo uye kukwanisa kwayo kudzvinyirira kusunungurwa myeloperoxidase (mu anogumbura zvirwere zvakawanda zvinogona kukonzera kukuvara rinenge ndiyo imwe yakarurama kwazvo chirwere maitiro anoratidza zvingakanganisa mwoyo kurwisa kana nesitiroko).

Zvairatidza yokushandisa

Wide zvezvinotaurwa zvakakwana zvinodhaka "Nimesulide". On chii chinoita chinodhaka ichi? Nokuti mushonga une pamusoro kuoma kwevanhu chaizvoizvo - antioxidant, unonyaradza marwadzo, antipyretic uye kuvengwa - ipapo riri basa pamwe zvinoverengeka anogumbura zvirwere. Inoshanda zvinodhaka uye pamberi osteoarthritis (chisingaperi kwemajoini chirwere pakutanga ichaparadzwa articular shwashwa), tendinitis (kuzvimba mudzira uye zvinyama degeneration), bursitis (kuzvimba mucous mabhegi, muzvinhu majoini).

Migumisiro yakanaka inoratidza "nimesulide" pakurapa dzinonzi rheumatoid arthritis, nemamwe-articular rheumatic zvirwere. Zvinobudirira kurwisa zvirwere kuti pamwe anogumbura kwendangariro. Kazhinji, "Nimesulide" piritsi kushandiswa Gynecology, mishonga kukuvara dzakasiyana mavambo. Varwere vanoti chinobudirira kubviswa marwadzo panguva postoperative vapore.

Contraindications "nimesulide"

Sezvo medicament rinoreva boka National ano Musangano Square, ane zvikuru chaizvo mazita contraindications. "Nimesulide" (kubva chii anobatsira mushonga - rave inokurukurwa kare) hazvifaniri kutora vanhu vane hypersensitivity chero chezvinonhuwira wayo sezvamunoita. No mushonga raitongwa varwere ivavo vane nhoroondo kuoneka hepatotoxic siyana uye hypersensitivity siyana sezvo rhinitis, bronchospasm, urticaria (pamwe asipurini kana nevamwe NSAIDs vamiririri veboka).

Contraindications kuti kushandiswa medicament ndiko kuva chero erosive-ulcerous maronda ari zvomudumbu ino, muitiro kuva ropa chero kupi (t. E. Variations ari kushanda kweropa).

Medicine "Nimesulide" mirayiridzo unorambidza varwere renal, hepatic, cardiac insufficiency. Varwere "asipurini" asima, doro uye zvinodhaka nedoro uye regai kutora zvinodhaka.

Regai mishonga idzodzo nguva, kana murwere ichiwedzerwa muviri tembiricha kana mamwe dzihwa-zvakadai zviratidzo zvinochengetwa. Uyezve, zviri zvisingagamuchirwi kutora "Nimesulide" vana, nepamuviri uye lactating vakadzi.

Possible divi Maitiro "nimesulide"

Pokushandisa medicament kunogona kukonzera zvinoverengeka divi anokonzerwa kubva siyana nadzo uye mugadziriro yomuviri.

Rakajairika siyana vari akanyorwa zvomudumbu maitiro, uye vari kunoratidzwa kuda kurutsa, kurutsa, manyoka, flatulence, uye kukura gastritis. Zvishoma zvinowanzoitika gastrointestinal ropa, nemaronda kusvikira perforation. Apo neapo unogona kunzwa dyspepsia, stomatitis, abdominal marwadzo.

Anogona kukonzera "nimesulide" divi chiito nokuda hepatobiliary hurongwa, kazhinji richiratidzwa yakawedzera chiropa enzayemu yomuropa, dzinenge - kukura nehepatitis (kusanganisira fulminant ..), Cholestatic jaundice.

On zvakaitwa kumwoyo angati, kana pane rakadzikama kuwedzera BP, varwere Kashoma kunetseka mwoyo palpitations, ropa, Flushing, BP akasvetuka.

Urinary Hurongwa anogona kupindura chimiro edema (kwete kazhinji), kashoma - Urinary chengetedzo, hematuria, dysuria. Very kashoma zvinogona kuva renal kukundikana, interstitial nephritis, oliguria.

Possible zvinoitwa CNS kakawanda kunoratidzwa dzungu, zvakawanda zvive, asthenia. Nezvahwo rinogona kunzwika nomusoro, somnolence kukura (zvakafanana hypnotic hope), Reye kwakaita syndrome (encephalopathy), hypothermia (muviri tembiricha kuderera pazasi padanho kunodiwa kuramba zvakajairika muviri). Apo neapo unogona kunzwa pamusoro pezvaakaita akadaro "Nimesulide", sezvo kutya, kuzvidya mwoyo, kurota zvinotyisa.

Panyaya nhengo dzinobudisa maitiro uye hematopoietic gadziriro, "Nimesulide" (Instruction, vakashinga wongororo vanosimbisa mashoko aya) anogona kashoma kutsamwisa kupererwa, eosinophilia, asi kashoma kuti vave thrombocytopenia purpura pantsitopenicheskaya.

Kashoma, asi unogona kunzwa pamusoro metabolic vachivavhiringidza (hyperkalemia), rokuzvidzivirira (hypersensitivity, anaphylaxis), kuti nhengo zvaakaratidzwa (madzerere, dzisavhiringidza nokuruwa), kufema, mediastinum (dyspnea, bronchospasm, asima kurwiswa). Paiva zvinoitwa ganda uye subcutaneous zvinyama (vangadikitira, kuvaviwa, dermatitis, urticaria, erythema, zvikuru kashoma - chepfu epidermal necrolysis, Stevens-Johnson urwere).

dosing uye kushandisa redunhu muoti

Adult varwere Mahwendefa "nimesulide" vakayambira kutora rimwe panguva (100 MG) kaviri daily. Zviri nani kuita kudaro pashure zvokudya uye inwa mvura yakawanda kuti mushonga. Kana chiri upfu kuti kumisa, ipapo zviri imwe sachet rakasanganiswa muna 100 ml mvura. Kuyaruka pamusoro makore 12 hapana chikonzero kushandura dose, uye vana mushonga uyu kugamuchira wairambidza. Kana pakurapa varwere vakwegura munhu dose kugadziridzwa haisi akaita.

Nokuti vanhu vachitambura kubva hepatic insufficiency, creatine Clearance iri kuwanda 30-80 Rine mamiririta / min., The chipimo chemushonga handizvo. Kana chinoratidza iri kutura (30 Rine mamiririta / Maminitsi zvichidzika.) - rambidzwa kugamuchira medicament.

Ndivo mukuru kurumbidza kuti negashiro zvinodhaka "Nimesulide". The chipimo chemushonga anosarudzwa zvishoma inoshanda, uye nokuda pfupi zvinoita nguva, izvo zvichaita kuderedza mukana nemigumisiro. Kunonyanyisa nzira yokurapa nokushandiswa kwe "Nimesulide" haafaniri kupfuudza mazuva 15.

Kunwisa chipimo chemushonga: Zviratidzo, Treatment

Kutora piritsi "Nimesulide", zvakakodzera kuomerera mishonga yakarumbidza mumirayiridzo kana kusarudzwa nokuda kupinda chiremba. Self-kwokubatsira medicament uye (kana) kusingadzoreki kushandiswa kwayo kungaguma ovhadhozi. Inonyanyoshandiswa vakachengeta zvinotevera zviratidzo: svoto, kurutsa, ropa, nemudumbu, hope, lethargy, BP (BP), chinovhiringidza ari kufema basa, chenjera renal kukundikana.

Treatment pakuparwa ovhadhozi symptomatic, ari kutsigira hunhu. Mushonga nimesulide iri parizvino chinoshayikwa. Kana kubva overdosing kana kutora refu dose pamusoro medicament haina vakapfuura anopfuura 4 maawa, murwere ane chipatara gastric lavage yakarumbidza kugamuchirwa absorbent (semuenzaniso, kusashanda kabhoni iri uwandu 60-100 MG munhu mukuru) uye dzimwe mhando osmotic laxative zvinodhaka.

Munguva yose nguva kurapwa kunofanira nokungwarira kuongororwa noutano nyanzvi kushanda chiropa uye itsvo. Information nezvomukana nokubviswa nimesulide kubva muviri hemodialysis isipo. Nokuda anokudzwa zvinodhaka tichisunga kuti mapuroteni kumanikidzwa diuresis hakusi inobudirira.

mirayiridzo Special

"Nimesulide" kuva mushonga kubva Pharmacies zvisina kuitwa, inofanira kubatwa nokungwarira. Rega zvinofambirana pokushandisa medicament uye zvimwe vasiri steroidal Anti-anogumbura vamiririri, analgesics mushandi. With kukura zviratidzo varwere, chiropa kukuvara maitiro (kuda kurutsa, kurutsa, zvinetso zvokudya, rima weti) kana kuwedzera huwandu hepatic transaminases chikumbiro "nimesulide" anofanira kusiyiwa. Kana paine nefivha kana chikosoro-kufanana zviratidzo, kurapa anofanira vakarega pakarepo.

Iteerere varwere vake vanofanira kuti zvakafanana ne "Nimesulide" achitora mishonga kuti zvinowedzera mukana gastrointestinal maronda uye ropa. Zvokungwarira akamuraira mushonga vanhu vanotambura maronda colitis kana Crohn, chirwere nemaronda vane nhoroondo varwere vakwegura.

Vanhu vanofanira kutora "Nimesulide" pamwe asipurini mu cardiac mishonga vanofanira kupiwa mubatanidzwa marapirwo pamwe gastroprotectives.

Kushandiswa "Nimesulide" (kana zvimwe NSAID) akawanda uye pamusoro yakareba nguva kunotungamirira kuwedzera duku nengozi tsaona thromboembolic (sitiroko, myocardial infarction, uye zvichingodaro. N.).

Varwere siyana zvemwoyo matambudziko "Nimesulide" mamiriro anogona vakagadzwa chete kana kuti zvinotarisirwa kubatsira akapfuudza mukana nemishonga.

The medicament ane zvainoita mwero platelet basa. mashoko ichi zvakakosha kuti varwere vanenge Hemorrhagic diathesis. Chakakomba maronda ganda unowanzosangana kuva munguva refu kushandiswa "nimesulide". Kamwe ganda rashes kuoneka, anova kuti munhu kukuvara mucous membranes kana zvimwe wakaiswa kuratidzwa asingashiviriri, mishonga kurapa zvinofanira vakarega.

Kushandiswa "Nimesulide" vakadzi vane pamuviri kungamutsawo kuvhara arterial mutsinga dzinofamba nemukaka isati unodiwa, kuderedza inzwi pakati Líquido amniótico. Possible mikana yakawanda intrauterine ropa, kwakaderera basa, zvakafanana edema. Nezvikonzero izvi, vanaamai pamuviri panguva yokutanga uye chechipiri trimesters pamuviri kugamuchira "Nimesulide" haina inokurudzirwa.

Zvinofanira kuva mhinduro yomubvunzo wokuti kana tinogona kutora "Nimesulide" panguva imwe chete uye doro, zviri pachena: zvakadai mubatanidzwa hazvibvumirwi!

analogs

Under analogs "nimesulide" rinoreva zvinodhaka kubva mumapoka NSAID ine sechinhu chikuru vanoshingaira chirungiso nimesulide (mutengo nokuti pavo oscillate panenge chete siyana asi zvishoma pazasi it). Kupfuura kuzivikanwa uye anowanzonzi ushandiswe wezvokurapa mudonzvo analogs zvinosanganisira zvinodhaka "naiz" (gel, piritsi, kuturika), "Nimesil" (Nezvakakuyiwa) "Niemiec" (Mahwendefa) 'nimulid "(gel, mapiritsi, mapiritsi kuturika nokuti yakayamwa) .

analogs All nhaka Kushanda zvakakwana uye basa kubata akasiyana-siyana zvirwere, anogumbura akapfeka hunhu.

mutengo dungwerungwe

Mitengo pachake "Nimesulide" uye ayo analogs ndiwo inenge imwe, kunyange isu vaiona zvinodhaka mutengo nyore kune zvakasiyana-siyana vatengi. Mahwendefa "Nimesulide" (20 hrs. Mune rongedza) achaita mari 85-90 rubles por rongedza. Chete nhamba mahwendefa "Naiza" achaita mari 110-140 rubles, "Niemiec" (uyewo 20 hrs.) - iri 115-134 rubles. Kavha "nimulid" kuti mapiritsi 30 kunodyira 180-220 rubles. Vhoriyamu zviri huru vanoshingaira chirungiso (Nimesulide) mu analogs zvose chete - 100 MG.

Asi mapiritsi "Nimesulide" (rakadzika mutengo) inogona kutengwa Somuenzaniso, imwe slurry "naiz" mari 200-300 rubles 60 Rine mamiririta kana "nimulid" - 75-105 rubles nokuti zvakafanana zvinodhaka. Uyewo dziripo zvakawanda yevatengi lozenges "nimulid": migove 20 nemutengo 130-155 rubles por rongedza.

Zvichida chimiro kupfuura kudhura pakati kusunungurwa mushonga chete nimesulide sechinhu chikuru chinoumba - upfu 'Nimesil ". 30 zvikwama (pasuru) achaita mari mutengi iri uwandu kubva 560 kusvika 645 rubles.

Nokuti kukamura uchishandisa Chikumbiro dzinobudirira gels pamwe nimesulide. Saka, "naiz" achaita mari 120-145 rubles nokuda chubhu 20 d kana 215-275 rubles (50 g). Gel "nimulid" zvishoma isingadhuri: 115-150 rubles por chubhu Vhoriyamu '30

In mhedziso ndinoda kutaura zvinotevera. Chisarudzo kushandisa "nimesulide", chero analogue kana zvimwe NSAIDs zvinofanira rakatorwa kupinda chiremba. Chete hutano nyanzvi inogona zvakanaka kuongorora kwokuomerwa utano hwavo varwere, kufunga kufanana nechirwere zvose, sarudza zvinodhaka chipimo chemushonga kuti kusarudza uye kutanga kurapwa urongwa kuitira kurerutsa mukana wokuti nemishonga uye kuti chinonyanya yakanaka.