Lipid-richikwidibira zvinodhaka "Rosuvastatin": mirayiridzo kushandiswa

Medicine "Rosuvastatin" mirayiridzo Chinyorwa anotsanangurwa hypolipidemic zvinodhaka kuti statins. Kushanda ichi nzira zvokusarudza ndiko yemakwikwi chinovhiringidza pamusoro HMG-CoA reductase. Kushandisa gadziriro "Rosuvastatin" (mirayiridzo kushandiswa izvozvo zvinoratidza) kakawanda wakawedzera LDL catabolism, vakawedzera mwero hepatic LDL receptors uye uwandu VLDL ipfupi. Pamusoro pharmacokinetic ehupfumi zvinodhaka lipid-achideredza, asi akazivisa kuchirapa mugumisiro kugamuchirwa yayo kuchengetwa kwamazuva manomwe pashure pakutanga yokurapa, richisvika mugumisiro wayo zvakanakisisa mavhiki mana.

Tora piritsi "Rosuvastatin" mugadziri anokurudzira kuti vanhu vachitambura kubva yakavhenganiswa chimiro hypercholesterolemia (kutaipa IIb) hypercholesterolaemia kana IIa (kusanganisira heterozygous) ive adjunct kuti zvokudya.

Saka inonyanya kunyatsoshanda hypolipidemic vanoshingaira zvinodhaka riri nyaya apo dzimwe kurapwa nzira (kurovedza, zvinoderedza kurema muviri) haanamati kuti kuwana yakakodzera kuchirapa mugumisiro. Uyezve, kushandisa mumiririri haangotongi "Rosuvastatin" mirayiridzo Chinyorwa anokurudzira webetsero zvinodhaka panguva kurapa homozygous hypercholesterolemia mhuri mhando.

Ipa mahwendefa aya ari zvaisambobvumirwa mu Kana murwere nokushayiwa chiropa zvirwere, myopathy kana zvirwere kwakunoitwa itsvo. Panguva pamuviri, uyewo havafaniri kutora zvinodhaka lipid-richikwidibira "Rosuvastatin." The mushonga contraindicated mune lactation nguva. Uyezve, hazvina varumbidzwa kutora mapiritsi aya Panguva pamwe cyclosporine kana hypersensitivity kuti yenhengo dzavo. Persons vasina kuwana makore gumi nemasere, uye harisi zvakakodzera kugadza mumiririri anyatsosarudza "Rosuvastatin." Mirayiridzo dzokushandisa havasi vakayambira kuti uiite nyaya doro nedoro akasimbisa renal kukundikana kana chiropa zvirwere.

Nokungwarira zvikuru kushandisa zvinodhaka lipid-achideredza vanofanira kuva vanhu kutambura electrolyte, kwemakemikari anobudiswa uye metabolic zvinetso, hypothyroidism kana hypotension. In sepsis, kusingadzoreki pfari, proteinuria, chikuru kunotevera uye zvomusejari kupindira uyewo vanofanira rega kutora zvinodhaka, "Rosuvastatin." Uyewo, hama contraindications vari nhaka tsandanyama zvirwere uye zera mukuru kupfuura makumi matanhatu nemashanu.

Mukugumisa, zvinofanira akati pamusoro zvichibvira nenjodzi, panowanikwa izvo zvinogona kukonzerwa nokugamuchirwa rinoreva "Rosuvastatin." Somuenzaniso, varwere vakawanda chokunyunyuta pamusoro abdominal marwadzo, kupatira, dzungu uye svoto. Uyezve, hapana ngozi myopathy, proteinuria, asthenia , uye myalgia.