Lyophilisate - chii here? Valium nokuti majekiseni. How ruchikonzera lyophilizate?

Kukura neindasitiri inogadzira mishonga kwakaita kuti aifanira kuva zvinodhaka kuti anogona kuva pasi akasiyana zvimwewo ezvinhu kuchengetedza semushonga ayo. Somuenzaniso, kugadzirira yakavakirwa unorapa. Zvechokwadi tusingaoneki zvinochengeterwa mudura gadziriro yakadaro? Storage imhaka kune itsva nzira kupwa zvoutachiona zvinoumba chezvinodhaka. Nzira iyi inodaidzwa nokuda lyophilization, uye fuma pacharo, kubatwa zvakadaro, anonzi "lyophilisate". Chii, umo zvinodhaka inoshandiswa, chine mugumisiro - unogona kudzidza zvakawanda nokuverenga nyaya ino.

Chii Ndinoda-kuomesa?

Zvechokwadi itsva budiriro iri mishonga indasitiri yaiva michina iri nzira Ndinoda-kuomesa. Rinoshandurwa kubva pane rechiGiriki rinoreva "kukurumidza", "pakaoma". The nzira ine iri kupera mvura mumuviri kunoita zvinhu wezvokurapa nokuda oma uye mimwe Vacuum nokuomesa nzira. Zvakanakira nzira iyi kugadzirira yenhengo kuti gadziriro yokurapa vari:

• Minimal akatakura physico-namakemikari pakurapa zvipenyu zvenyama, kuti anobvumira kuchengetedza unhu zvinokosha;
• panguva lyophilization kunoitika zvishoma Kuchinja marongerwo uye chimiro yokutanga zvinhu;
• ari pasherefu upenyu zvinodhaka kwawedzerwa yekudyidzana;
• nevazukuru okuchengetera zvinhu, zvakadai mukuru tembiricha kana mukuru mwando.

Kubva munhoroondo Ndinoda-nokuomesa nzira

Yakaitwa nekaupenyu achangobva lyophilisate. Chii, nyanzvi dzokurapa vakadzidza nguva yokutanga muna 1909. Panguva iyoyo masayendisiti akatanga kuti aiyanika nenzira iyi iri chimbwamupengo utachiwana. Papera chinguva vanogumurwa preform akaoma plasma kubudikidza lyophilization. Panguva imwe chete iyoyo, masayendisiti Russian zvave mudziyo wokutanga sublimation, uye ipapo -oma-nokuomesa yambokurukurwa zvikuru uye anoparadzirwa. Nzira iyi yava kubereka huru-siyana dzokurapwa zvinodhaka: plasma, kwemabhakitiriya vamiririri, hormone, nemishonga inorwisa mabhakitiriya uye nevamwe.

Basa Vacuum Ndinoda nokuomesa

Nzira yakadaro rokugadzirira yenhengo chinonyanya chinowanzoitwa neindasitiri inogadzira mishonga. Sezvo saizvozvo lyophilisate, chii uye kupi nzira iri kushandiswa? Yakadaro nzira nokuomesa yakabereka zvakasiyana siyana mishonga. Asi kunze uku, nzira yaishandiswa zvemakemikari uye zvokudya Mazinga. Made lyophilizates ngaunyatsobata chinobatsira ehupfumi, regai zvinoda inoomesera okuchengetera zvinhu, kuva refu pasherefu upenyu, vakaita njodzi sezvo zvinogoneka vatengi.

Mano kuti lyophilization

We kuva midziyo inokosha kubudisa lyophilisate. kushandiswa vakadaro mano kurairirwa zvinoda hapana hwokugadzira ruzivo chaiyo uye unyanzvi. Itariro hurongwa nokuti lyophilization rechiFrench kugadzirwa "Yuzifrua" "Hohvakumm" Chirungu "Edward," German American "singi". MuRussia, vakawanda mudziyo uri Czech-akaita "Frigerio".

Pfungwa kwemabhakitiriya lysates

Nokuti kugadzirwa immunostimulatory, mishonga antiviral lyophilizate kushandisa kwemabhakitiriya lysates. Ngationei chaizvoizvo rinomirira zvakadaro yakaoma zvokurapa mazwi a. First unofanira kufunga zvinotaurwa kwemabhakitiriya lysates. Ichi chimwe kunze utachiona nemaziso nezvimedu inoumbwa zvemaziso, kemikari kana chafariz migumisiro. Uye, naizvozvovo, vanova lyophilizates mune chaiyo nokuomesa kwacho.

Use kwemabhakitiriya lysates

Dried nokuda lyophilization lysates mabhakitiriya kushandiswa immunostimulants. The mashandiro chiito zvakafanana kubata mushonga. Kamwe mumuviri, utachiona hunokonzera kwaiita masoja vanhu maitiro kubudisa anodzivirira antibodies. Saka, kana kuti mamwe hweHIV utachiona hwakakura dzevanhu rokuzvidzivirira achapindura zvakasiyana pane chikuru chirwere. Kuvapo mumuviri anodzivirira antibodies, raikura somugumisiro ndechokuti murume akatora chokudzivirira nechiyero lyophilisate bacteria zvichaita kuderedza mikana chirwere kana chirwere chakakomba. In dzakawanda zvinodhaka zvakadaro nomukombiyuta kufema vakatakura prophylaxis ose nemavhairasi zvirwere.

Kushandiswa Ndinoda-kuomeswa chimiro

Mishonga - lyophilisates zvinowanikwa siyana, sezvo emulsions, mhinduro uye upfu yakaoma. Somuenzaniso, mushonga "Bifidumbacterin" - lyophilisate ari muchimiro upfu rakaoma, izvo zvinoda dilution pamberi kushandiswa. chipimo chemushonga Right uye nzira chourongwa vave chiremba.

The mhinduro yakanga Ndinoda-kuomeswa injectable

Kazhinji lyophilisates rakashandiswa jekiseni. For intramuscular uye intravenous mushonga zvakakodzera kugadzirira kuchipatara mhinduro. Zviri nani kana yakadaro nzira rinoitwa nyanzvi, sezvo zvikuru kuti zvakajeka kuchengeta kukura zvinhu uye maberekero rwokugadzira. Zvikasadaro, haugoni chete kukuvadza mushonga (nokuda kururama kubatana zvingaitika zvakadai nemakemikari sezvo oxidation), asi kukuvadza utano murwere. Mumwe mushonga dilution ine maitiro ayo uye kushanda.

Somuenzaniso, majekiseni dzinopiwa mishonga yakadai se "Longidaza", "hondrolon". How yokusima lyophilisate dzaizopiwa jekiseni? Funga nzira kushandisa zvinodhaka nokuda muenzaniso "Vfend" antifungal mumiririri. mushonga uyu upfu chakaoma, dzaizara mu chena mabhodhoro. Production mhinduro nokuti jekiseni rinoitwa muna 2 mumatanho: zvakananga nemukuparadzwa, uye ipapo vakawana Kuisa pfungwa pachinhu dilution fuma. Chinu kugadzirira zvazvichanyungudutswa 20 ml ari pave solvent. Ipapo aida mari imwe-nguva zvinodhaka Kuisa pfungwa pachinhu rakasanganiswa yavaibvisa chloride kana shuga mhinduro.

Immunomodulating zvinodhaka "Polioksidoniy"

"Polioksidoniy" - ndiwo mumwe muenzaniso mushonga rinoshandiswa muchimiro intramuscular kana intravenous jekiseni. The mushonga - lyophilisate. Mirayiridzo kushandiswa kwayo rinoratidza kuti akagadzwa kuva vana 6 mwedzi uye vakuru vari kwakatooma kutapukirwa noutachiona kufema, kana kuti chinangwa muzvidzivirire.

The chipimo chemushonga zvinodhaka riri chairayirwa kupinda chiremba kufungisisa zhinji zvinhu. Nokuti zvaAtemisi intramuscular mhinduro 6 MG pamusoro lyophilizate yakanyauka muna 2 ml yavaibvisa chloride. A kudiwa intravenous jekiseni 3 ml solvent, uye Kuisa pfungwa pachinhu rakasanganiswa 200 Rine mamiririta gemodeza kana dextrose mhinduro.

"Polioksidoniy lyophilisate" anogona kumutsa sema maitiro, uye haienderani navamwe zvinodhaka, saka vasati kushandisa bvunza chiremba wako uye verenga nokungwarira mirayiridzo.

Drug "Bifidumbacterin lyophilisate": mirayiridzo kushandiswa

Mishonga "Bifidumbacterin" - mumwe lyophilisate mabhakitiriya mhenyu. Available muchimiro yakaoma upfu kuti gadziriro nomumukanwa mhinduro.

Rinoshandiswa kudzorera intestinal microflora, somuenzaniso pashure kwenguva refu asingaurayiwi kurapwa kana vaduku dysbacteriosis. It zvinoratidzwa kuti zvirwere zvakadai:

• intestinal noutachiona;
• Gastric uye duodenal maronda;
• pfungwa nomuviri zvemwana asati;
• chepfu uye zvimwe zvirwere zviri zvomudumbu hurongwa.

Also kushandiswa topically "Bifidumbacterin lyophilisate". Mirayiridzo yokushandisa kunoratidza kuti chinoda kugadziriswa maronda anogona kumanikidza applique wakaita gauze zvakakangwa ari kugadzirisa Pfungwa.

Intravaginal kushandiswa kutyora kusangana nekutsi kwemukadzi microflora, rectally ari postoperative munguva.

The mushonga wacho ushandiswe, kunyange vachangoberekwa, unogona kuishandisa uye lactating vanamai. Panguva pamuviri, vasati kushandisa mushonga vanofanira kuona chiremba.

gadziriro upfu akanga zvazvichanyungudutswa shoma inodziya emura: mukaka zamu, nomukaka zvigadzirwa, facial, yakabikwa nemvura. The chipimo chemushonga kunobva murwere zera uye chirwere.

Zvakakosha kuyeuka kuti iwe haugoni kuvaka "Bifidumbacterin" iri rinopisa mvura, akatorwa kufanana antibacterial zvinodhaka, uyewo kuti achengetere rakasanganiswa powder.

Lyophilisate "Interferon"

Medicament Russian gadzira "Interferon lyophilisate" anouya upfu chimiro, mumapepa kupinda ndiro. The zvinoriumba zvaisanganisira mairi - iri dzinongoitika Arifa interferon uye ropa leukocytes. "Interferon" chiri antiviral mumiririri, uye anowedzera kurwisa muviri kuti siyana chirwere.

Nasally vakashandisa chinodhaka, kureva. E. vakaroverera kana sprayed nokuda chaiwo mano mune nasal mundima. Kuti aite nzira iyi, unofanira kutanga wokuparadza lyophilisate. Nokuti chinangwa ichi, buritsa chinu uye kuti zvakanga akawedzera noushamwari kwakadonhera mvura kusvikira yasarudzwa pamwero 2 ML. Zvino zvakafanira kuti kuzunungusa chinu wokuparadza pakaoma inoramba.

Solution vakaroverera kupinda mhino 5 madonhwe kamwe pazuva kana inhalation nzira akaita kushandisa chaiwo apparatuses.

Hapana chiitiko haafaniri kupiwa nomutsinga kana intramuscularly uye nomuromo ichi lyophilisate! Mirayiridzo kuti mushonga anotaura nzira nasal chete kushandiswa.

Kugadzirwa ndiyo Ndinoda-kuomeswa zvigadzirwa vakabatsira kuti chidzoke nevakawanda ano mishonga zvinodhaka. chimiro ichi zvinodhaka kwebhuku yekudyidzana kunoderedza mari uye anowedzera kuti pasherefu upenyu, uye chikumbiro haakonzeri vangaomerwa yakawandisa kunyange kumba. Asi, kufanana nemamwe mushonga upi, zvinoda risati rasvika kubvunza mumwe mazvikokota zvinodhaka-lyophilisate. Chii, chii zviitiko zvinokosha kugamuchira kwezvinodhaka ichi, akatsanangura zvakadzama chiremba chete.