Masayendisiti vakagamuchira nemigumisiro yakanaka rebvunzo itsva zvinodhaka nokuda neleukemia

Masayendisiti akakwanisa kusika mushonga neleukemia, izvo kamwe zvakare vakaratidza kuti. Mumiedzo zvekuchipatara yakaratidza kuti bundu iri 71% varwere inouraya neleukemia kunoderedza kana kunyange anyangarika chose.

boka High ngozi

Kudzidza, vane zvibereko dzakabudiswa muna Journal of Clinical Oncology, zvinoitiswa chikamu 24 varwere chisingaperi lymphocytic neleukemia uyo dzimwewo nzira kunge isashande. Makore varwere ranged kubva 40 kusvika 73 makore. Uyezve, kuti ndiitewo chidzidzo chimwe nechimwe akagamuchira avhareji pakubhadhara shanu akasiyana yokurapa, kusanganisira pakurapa "Ibrutinib" - unoshandiswa zvikuru mushonga pamusoro kwakadai kenza. Izvi Vatori vechikamu pangozi yokuva ane pasi wokurarama.

miedzo zvekuchipatara

A chikwata kubva Research Center Freda Hatchinsona Cancer akashandisa mangwanani kurapwa inonzi immunotherapy timoralnogo Kanotokonya (CAR). With kwakadai yokurapa, pachake T masero murwere zvikaramba kubva ropa, uye kushandurwa muna murabhoritari ezvinhu. Muchiitiko chino, ivo chakagadziridzwa kuona CD19 - antigen pamusoro pemvura masero kenza.

Zvadaro, masero aya dzakachinjwa vari jekiseni kunyika murwere, zvichiita kuti arwe neleukemia, uye vachivhimei vachiwedzera masero kenza kuti antigen CD19. Vaongorori dzinoshuma kuti pashure pemwedzi mitanhatu uye nehafu 17 24 varwere bundu kunoderedza kana anyangarika chose.

"Kare hazvina kuzivikanwa kana zvichibvira kushandisa immunotherapy timoralnogo Kanotokonya T masero kuti pakurapa varwere chisingaperi lymphocytic neleukemia, uko nhengo boka ane ngozi - vakati kudzidza kunoita munyori Dr. Cameron Turtle, immunotherapy muongorori panguva Fred Hutchinson Center. - kudzidza Our kunoratidza kuti CAR T masero ari aizobudirira chaizvo pakurapa varwere pamwe CLL vasiri akakodzera kurapwa "Ibrutinib '."

Chii CLL?

Chirwere lymphocytic neleukemia - chirwere inotangira mumwongo kwevanhu (ari nyoro zvinyama mukati mapfupa apo masero eropa akaumba). In varwere CLL, mumwongo unobereka lymphocytes kanganisika vakawanda (zvemamiriro mhando ropa masero machena).

Sezvo chirwere mberi, masero aya kanganisika zvinogona dzikarongwa pamwe uye kukura node nodes, chirwatata uye chiropa. Ukuru "lymphoid anomera" akadaro kuyerwa vachishandisa-siyana kushanda pakuvheneka.

masero Healthy - ndiwo muviri paaizvidzivirira masero kuti anobatsira kurwisa utachiona, asi varwere CLL, havasi kushanda nemazvo uye mhirizhonga. Maererano American Cancer Society, chisingaperi lymphocytic neleukemia muna 2017 chichava chikonzero 4660 kufa. Also kutarisirwa zvinenge 20.110 itsva zviitiko chirwere.

nemishonga

New kurapa ane inokosha nemishonga, kunyange zvazvo vakawanda vavo vari reversible. Pakuongorora vanenge 83% wevarwere kwakaedzwa cytokine kusunungurwa chirwere, vanowanzochema kuomesa pashure kurapwa T-masero nezviratidzo akadai fivha, kuda kurutsa, chills, uye zvisinganzwisisiki shoma BP. Zvinosuruvarisa varwere vaviri vakanga muchipatara, uye mumwe akafa panguva kurapwa.

Mavhiki Four pashure kurapwa, vatsvakurudzi vakaongorora mwongo mimwe varwere 12, uyo nokuda kurapwa vari ruregerero, kuti aone kana akaramba ezvinhu pashure pokupedza mushonga. Ava, vanomwe vakanga vasina akaipa kenza.

Kudzidza ichiri chichiri kutanga, asi anotova wandei tarisiro. Marwadzo zvechokwadi dambudziko, asi uchabatsirwa yekudyidzana pfuura zvavo.