SCC markers: test features. Chii chinonyanya kuratidza?

Vanomhanya ndivo zvinhu zvakabudiswa nemuviri panguva yekuvandudzwa kwemarara. Zita rokuti "tumor markers" rinoshandiswa zvakare. Vazhinji vese vanozivikanwa nevashambadziri vane hukuru hwekunzwa. Kuziva zvimwe zvirwere, somuenzaniso, carcinoma ye nzeve, nasopharynx, esophagus, mapapu nemukirini mukati mevakadzi, muedzo unoitwa panguva iyo squamous cell carcinoma antigen SCC yakavanzwa. Muchikamu chino tichakurukura nezvinyorwa.

Chii ichocho?

SCC markers ndeye glycoprotein. Iyo inogadzirwa mumasero epa epithelium flat ye nhengo. SCC-incomarker inonzi proteinaceous substance inoshandura chimiro chemasero anowanzoita, zvichiita kuti kupindira kweprotini kuburikidza nemumakumbo.

An antigen of squamous cell carcinoma ndeyemhuri ye inhibitor ye serine proteinases. Nhamba ye antigen muropa inopesana zvichienderana nesero rechirwere uye ukuru hwechirwere. Kana kusati kwatanga kurapwa kwehuwandu hwehutano hwekutsvaga ropa mumakadhi hwakanga hwakakwirira, izvo zvinotarisirwa hazvibatsiri kudarika pane zvingave zviratidzo zvishoma.

Nhamba yevanorwara nekenza muropa inowirirana zvakananga nehuwandu hwekukura kwechirwere, saka, maererano nemashoko aya, zvinokwanisika kunyatsotsanangura danga rekenza. Kuongororwa kweropa nokuda kwechirwere chevarume hakugoni kuitirwa kuongorora uye nokuda kwekuongorora chirwere chekutanga, kungoona kutarisa kwechirwere chinenge chiripo.

Ndeupi ruzivo runopiwa neCCC markers?

Muedzo wekenza zvirwere ndeyekubudirira zvikuru mukurwisana nekenza. Zvarinotaura uye zvizhinji muropa zvinopa mufananidzo wakakwana weboka rechirwere, kusanganisira danho. Uyezve, vatongi vanotibvumira kuti tione nzira yekuderera kwemasero ane hutano kuva masero emakemikari pachikamu chekutanga chechirwere.

Ndezvipi zviitiko kuongororwa kwakaitwa?

Kuti uwane chirwere chekenza, vanachiremba vanopa kuongorora kweCCC oncocomarker pamwe chete nedzimwe nzira dzokugadzirisa zvirwere zvakanyanya mumuviri. Sezvo mutemo, tsvakurudzo inotora kwenguva yakareba. SCC markers inoshandiswa nevanyanzvi kuziva chirwere ichi, kutarisa kuenderera mberi kwayo uye kutarisira kukura kwayo.

Muedzo pamwe nekushandiswa kwekugadzirisa zvinonzwisisika kuitwa maererano nevanhu vari panjodzi yekuva nemaronda akaipa. Iko inokubvumira kunyatsoongorora. Munguva yekurapa, antigen muropa anowanzokura, iyo inokonzerwa nokuparara kwemaitiro akaipa, izvo zvinoita kuti miviri yeatypical inopinda muropa. Nokuda kwechokwadi kwe data, zvinokurudzirwa kuti kuongorora kunowanzoitwa mushure mavhiki mana. Pane dzimwe zvirwere zvinopisa, zvinogonawo kuwedzera kuiswa muropa reAntigeni, somuenzaniso, muchirwere chetachiona, bronchitis, ARI, nezvimwe zvirwere zveganda.

Ndeipi muedzo?

Chiyero cheScC-incomarker chinoitwa:

• Kuchengetedza kupararira kwemasitasti kune dzimwe nhengo dzine kufambira mberi kwechirwere.
• Kuongorora kwekubudirira kwekurapa.
• Kudzora kwechirwere mushure mekurapa kusadzikazve.

Kugadzirira kwekuongorora kwera laboratory

Kuti zviitiko zvive zvakavimbika sezvinobvira, nyanzvi inofanira kufungisisa zvese zvinoshandiswa nemushandi uye kusabvisa zvirwere zvinogona kupisa.

Mamiriro akasiyana ehurongwa hwekuendesa kuongorora haadi. Ropa paCCC oncologist rinobva mangwanani, pane risina chinhu, musati wasati wanyatsoongorora, murwere anorayirwa kurega mafuta, fried uye zvokudya zvinonaka. Pazuva rekuongorora, haufaniri kusvuta kwehafu yenguva isati yatora ropa, uye shandisai tei nekofi. Kuti iite maitiro e laboratori, mukoti anotora ropa remurwere kubva mumhino muhuwandu hwemamiriyoni mashanu.

Tsanangudzo yemigumisiro

Kazhinji pazvikamu zvekutanga zvekuvandudza, maitiro akaipa haazviiti ivo pachavo. Nokudaro, kuenzanisa kweropa panguva yakakodzera nokuda kwemaantigen muropa kunowedzera mukana wehupenyu hunofadza.

Mune munhu ane hutano, huwandu hweAntigen muropa hahupfuuri hutsika hwe 2.5 ng / ml. Zvisinei, pane zvakaitika munguva pfupi yapfuura zvirwere zvinoputika, chiratidzo ichi chinogona kunge chakakwirira. Zvino iwe unofanirwazve kuitisa kuongorora ropa shure kwemavhiki matatu.

Nhamba yevanhu vanoona zviratidzo zveropa muropa inobatsira vasarudzo vanorongerwa kuti vawane maawa kana kuti kurapa kurapwa, pamwe nekugadzirisa kurapwa pakusatadza kwemigumisiro yakanaka kana kuipa kwemamiriro emurwere.

ICC oncologist (iyo inonyorwa inowanikwa munyaya yacho) inobvumira kufungidzira mune varume chirwere chesophagus, nasopharynx, nzeve nemapapu. Mukenza yemasophagus nemapapu, chiyero che antigen munharaunda ye 1.5 ng / ml chinowanikwa muropa. Muchiitiko chekudzidza kune vakadzi vane chirwere chekenza chechibereki uye kuonekwa kwezinga rakakwirira reAgengen, rinogona kunyatsochengetwa pamusoro pokudzoka kwechirwere ichi.

Ongorora mutsara. SCC mu squamous cell carcinoma

Kusvika iye zvino, chirwere chemukomero wechibereko chinokanganisa kwete vakadzi vese vane makore makumi mana, chirwere ichi chakatanga kukura mumusikana muduku kusvika kune makumi matatu. Chirwere chemukomero wechirwere chirwere chinonyanyisa, saka kurapa kwakakodzera kunobvumira mukadzi kuchengetedza nhengo dzebereki.

Kuti zviongororwe zvakajeka zvechirwere ichi, chiremba anoenda anofanira kufungisisa zvinhu zvose zvevarindi, kusanganisira nguva inotorwa kuwedzerwa ropa uye kururamisa kwekuchengetedza kwayo. Chiyero chevatengesi chinonyanya kunzwisisika, saka kuchena kwezvinhu zvakatorwa kunokosha zvakare. Kakawanda kaseti kana kutuka kunogona kukonzera kusvibiswa kwezvinhu zvakasikwa, uye izvi, zvakare, zvinotungamirira kusakarurama kwekuongorora.

Kuti mukadzi aongororwe ne "kenza yemumuromo wechibereko", zvidzidzo zvinodiwa zvinowanikwa kune vashandisi. Pakutsvakurudzwa kweropa muenzanisi we2,5 ng / ml pa onkomarker SCC - chimiro kana chiyero. Chirwere chemukombomu chinenge chichitanga kuitika pamusana wechiitiko chikuru kupfuura 2.5 ng / ml. Nokururamisa kwedheta, muedzo unodzokororwa mushure mememazuva makumi maviri. Kazhinji pane kuwedzerwa kunogamuchirwa kweSCC oncologist muropa remurwere, rinobatanidza nechirwere chinotapukira chinoitika.

Kukosha kwekuongororwa panguva yakakodzera yekervical malignancies

Kuita tsvakurudzo pamusoro pekuvapo kwevatengesi kune gorosi kunokosha kune zvikonzero zvinotevera:

• Zvirwere zvepachibereko zvekuberekwa kwemukadzi kunoderedza kubereka.
• Ichi chidzidzo chinoita kuti zvikwanise kuzivisa vakadzi vari pangozi uye kuongorora kubudirira kwehutano.

Pachitatu chechitatu chechirwere, nhamba yeantigens inodarika chimiro katatu. Sezvakawedzerwa kuongororwa chiremba anogadzira kombiyuta tomography, pamwe nekuongorora urine neropa.

Neine hutachiona hwehutano, panewo huwandu hwakareba hwekuti kenza yeCCC ichacherechedza pa squamous cell carcinoma. Mumamiriro ezvinhu akadaro zvakakosha kudzidza mumagetsi, uye nokuda kweizvi, kuwedzera kune kuongorora kwakakwana kwevakasvibiswa, kuongorora kwechirevo chekuongorora kwake kwezvinhu zvakakuvadzwa zvechirwere chinorwara chinoitwa.

Nhamba yezvipembenene zvinoratidza kuchinja mumamiriro emasitasisiti. Uyewo pahuwandu hwavo hunoita hukuru hwechirwere, nzvimbo yacho uye kukanganisa kwechigunwe chemaitiro chekenza masero.

Zvimwe zvakasiyana-siyana zvinorara zvinokonzera

Mhando ipi neipi yechipfuva inoparadzanisa mararamiro ayo akasiyana, ayo anoshandiswa kutsvaga rudzi rwakasiyana rwekenza:

• Cancer-embryonic antigen (inogamuchirwa - 3 ng / ml) - yakagadzirirwa kuonekwa kwe colorectal carcinoma pamwe chete neCCC mucarcinoma yemukati.
• Alpha-fetoprotein (inogamuchirwa yepamusoro - inopfuura 15 ng / ml) inonzi antigen ine simba kwazvo, iyo inoshandiswa kutanga kutarisa hepatocellular carcinoma.
• Iyo gastric cancer antigen (iyo inogamuchirwa inenge isingapfuuri 4 U / ml) inoshandiswa kudzora kubudirira kwehutano hwegastric carcinoma.
• Mucin-like glycoprotein (inogamuchirika yezinga - masero anodarika 28 / ml) - kazhinji kadhi iyi inoshandiswa kutarisa mugumisiro mushure mekurapa kwemafupa anonzi mammary gland formation.
• CA 19-9 (chikonzero chinotenderwa - pasi pe 37 U / ml) chiratidzo chekuona pancreatic carcinoma.
• SCC markers (iyo inowanikwa haisi kudarika 2.5 ng / ml) inoshandiswa mukuongorora mitsva yemakirinoma remishonga yemudumbu, nasopharynx, nzeve, nemapapu.
• CA 125 (iyo inogamuchirwa isingasviki 35 U / ml) inoshandiswa kudzora chirwere chechirwere uye kurapa kwecarcinoma yemakumbo.
• NSE (iyo inenge yakagamuchirwa isingasviki 12 ng / ml) inoshandiswa kuongororwa uye kuongorora kubudirira kwerapi yediki kemapapu mapapencinoma.
• HCG (inogamuchirwa muvanhu - 0-5 IU / ml) nemigumisiro yakawedzerwa mune varume nevakadzi vasina kukwana inoratidza kuvepo kwechirwere chakaipa.
• Chidimbu che cytokeratin-19 (chibvumirano chinogamuchirwa chiri pasi pe 3.2 ng / ml) chinoshandiswa zvakakodzera chediki-cell lung carcinoma uye squamous cell lung carcinoma.
• Prostatic specific antigen (inzvimbo inogamuchirwa isingasviki 4.0 ng / ml) inonyatsoshandiswa kuongorora prostate carcinoma.

Kukosha kwekuona chirwere ichi pakutanga

Kuti uzvidzivirire migumisiro yakaipa uye kuzvidzivirira kubva pakugadzirwa kwekenza yakaipa, zvakakosha kuonana nechiremba kana pane chero zvirwere zvepanyama, kunyanya kana paine maitiro ekenza mumhuri.

Kuongororwa kwechirwere pane imwe nguva yekutanga uye kurapwa kwakakodzera kunobvumira kuchengetedza hupenyu hwehupenyu, kudzivisa kukura kwezvinetso uye kupararira kwemasimasi. Nokudaro, icho chinonyanya kuzivikanwa nderopa rekuongorora ropa reSCC, iro rinogadzirisa sero kushanduka pazvikamu zvekutanga zvekenza.