The mushonga "Leykostim": mirayiridzo kushandiswa, dzomuzana chaiwo

Chii chinodhaka "Leykostim"? Instructions, kusunungurwa chimiro, zviratidzo uye contraindications kuti zvinodhaka ichi kunzi pazasi. Nesuwo kukuudzai chii analogs anowanikwa chokushandisa ichi Rinowanikwawo ayo akafanana, uye zvichingodaro.

The chimiro, kavha, chikamu zvinodhaka

Wakadiniko anoita zvinodhaka "Leykostim"? Mirayiridzo dzokushandisa inoshuma kuti kushingaira medicament iri kugadzirwa sezvo mhinduro subcutaneous kana intravenous yaitonga.

The kushingaira chezvinonhuwira pomutumwa riri filgrastim. Zviri recombinant granulocyte nyuchi-mutange chinhu. 1 ml zvinodhaka mhinduro ingasanganisira 300 MG (mamiriyoni 30. Iu), 600 MG (mamiriyoni 60. Iu) kana 150 micrograms (mamiriyoni 15. I.U.) filgrastim.

Kana Excipients, ipapo kushandiswa dzavo mannitol, yavaibvisa acetate trihydrate, dextran, acetic acid, polysorbate, uye mvura kuti jekiseni.

Mune kavha inotoda kutengeswa "Leykostim"? Mirayiridzo zvokushandisa midzi mune makadhibhokisi bhokisi pamwe chete kana shanu ndiro zvinodhaka.

The ehupfumi zvinodhaka

Chii mashandiro kuita zvinodhaka mu "Leykostim"? Mirayiridzo yokushandisa, vanachiremba wongororo vanoti chinhu chinodhaka-immunomodulator. Chinhu zvikuru Yakanatswa isiri glycosylated mapuroteni kuti ane pamutemo simba pamusoro pokumuka uye sangano (kubva mumwongo kupinda ropa) dzichipfekeka neutrophils.

Pashure pakatanga zvinodhaka yekudyidzana kunowedzera nhamba neutrophils muropa uye chete zvishoma - monocytes. Izvi kunoitika mumaawa 24.

Kuwedzera ropa neutrophils riri dose-zvaanoda. Chizvarwa pakugadzira kushingaira mapuroteni, i.e. filgrastim, izvo normalizes kuwanda uye Kusiyanisa masero dzakashongwa utachiona kwemabhakitiriya Escherichia coli coli. Sezvineiwo, yokupedzisira, nokuda nezvaanogona hwemazuva kuvabereki engineering, nechimwe Gene granulocyte nyuchi anotokonya hwevanhu chinhu.

Maererano nenheyo vake kukuvara mumuviri mushonga hwakafanana granulocyte munzvimbo-anotokonya chinhu, iri rwokuzvarwa mavambo. The chete Kusiyana chokwadi kuti "Leykostim" (mhinduro) haina glycosylated, uye ane N-chinouraya amino iine acid vasara methionine.

Features zvinodhaka

Zvii rine mushonga "Leykostim"? Mirayiridzo Use rinoti kuti kushandiswa nechirwere kuti neutropenia mune vanhu vanosangana mishonga. Uyewo, mushonga uyu unoshanda chaizvo kuti chirwere neutropenia. Izvi imhaka yokuti iye anogona kudzorera Zvakanyanya Kunaka Panguva Yepamuviri nhamba neutrophils mumuviri womunhu.

Kushandisa Pfungwa nokuda kudzivirirwa, murwere anogona kuderedza kuitika neutropenia, uyewo kuderedza kunzwisisa aibuda uye nguva munguva chirwere. ekisiposha kwakadaro kunotadzisa kutapuriranwa matambudziko, kwakaderedza murefu urefu chipatara kugara, anobvumira mishonga pasina kubva mazwi kuti zvakatangwa mukuru Zano kurapwa.

Sezvo muviri womunhu anoita "Leykostim"? Mirayiridzo yokushandisa kunoratidza kuti kushandisa zvinodhaka zvinobatsira kuti vavatungamirire peripheral ropa masero risati hematopoiesis, yakanga yaunganidzwa kubudikidza cytapheresis (i.e. dzakaparadzana ropa mukati cellular pakuderedza nokubviswa vanosarudza) uye raitongwa murwere mushure kosi dzakakwirira-dose mishonga.

Uyewo, kuti jekiseni masero (hunde) Kuva hematopoietic basa, akaderedza masoja uye hematopoietic gadziriro, uyewo yekuzvidzivirira nekuomarara zvinotapuriranwa uye Hemorrhagic matambudziko.

mishonga chengetedzo

Zvinokuchengetedzai zvinodhaka evanhu "Leykostim"? Manual rinoti zvinodhaka izvi zvinogona kushandiswa vose vana nevakuru. Zviri zvakafanana wakachengeteka nokuda vanhu vose kugamuchira cytotoxic mishonga.

Varwere immunodeficiency utachiona chikumbiro mhinduro chinopa optimum pamwero neutrophils uye anopa mukana kutevera zvose zvavakabvumirana dosages ose yemaARV kana myelosuppressive kurapa.

Kana kushandisa chigadzirwa ichi kwekupararira kweHIV yaiitwa.

Pharmacokinetics

Chii pharmacokinetic zvinodhaka ane "Leykostim"? Instruction kunoratidza kuti wevasungwa yezviri wemafuta mumiririri uyu zvakananga novimba raitongwa dose.

Mushure subcutaneous Kutarisirwa, mukuru uwandu zvinodhaka muropa vakachengeta pashure maawa anenge 8-15.

The hafu-upenyu "Leykostima" rinoita zvinhu zviri zvitatu kusvika mana maawa. Filgrastim rinoita kuti peptides. About 1% yezviri zvinoriumba anooneka kuchinja mune weti.

Filgrastim kuunganidza mumuviri womunhu hakuitiki kunyange pashure kushandiswa kwenguva yakareba zvinodhaka (kana kurapa kwazvo mwedzi). In iyi yawo hafu-upenyu ndiyo chete.

zvairatidza

"Leykostim" The mushonga nachiremba zvinotevera zvinangwa:

• nokuti kuderedza ya neutropenia aibuda matanho 2-4, uye kuderedza kuitika febrile neutropenia muvanhu namamota nemieloproliferativnymi pashure mishonga pamwe cytostatic vamiririri;
• kuderedza kuratidzwa yematambudziko kuti simuka kana neutropenia, uyewo kuderedza nguva mukurwara muvanhu kuwana myeloablative mishonga pamwe mwongo transplantation pakushaiwa;
• Sero dzokugara dzapfuura hematopoiesis ari peripheral ropa nechinangwa kupatsanura uye transplanting navo pashure myelosuppressive mishonga;
• nokuti dambudziko neutropenia mune vanhu vane utachiona hweHIV (kusanganisira vaya vari azara) kuti yekuzvidzivirira zvirwere kwemabhakitiriya mavambo;
• nokuti mishonga echirwere neutropenia;
• Sero nzvimbo risati hematopoiesis, mune peripheral ropa utano vaipa kuti kuisirwa uye kuvaparadzanisa kurwara.

Contraindications

Ndezvipi contraindications zvinodhaka ane "Leykostim"? Reviews nenyanzvi rakashuma zvinotevera inorambidza:

• vakawedzera nomumwe aikanganiswa murwere kune basa uye zvimwe zvinhu zviri Kuronga zvinodhaka;
• vachiberekwa neutropenia, yakanyanya kuyerera pamwe cytogenetic zvirwere (Kostmann urwere);
• neonatal nguva (kunyanya mwedzi upenyu wokutanga).

Drug "Leykostim": mirayiridzo chikumbiro

mishonga Viewed inogona kupiwa nenzira mbiri:

• nomutsinga;
• subcutaneously.

Chipimo chemushonga uye nzira chourongwa "Leykostima" tinofanira kutsunga nenyanzvi, zvichienderana navanachiremba ezvinhu, munhu zvechadenga murwere uye chirwere. Zvisinei, zvinofanira kucherechedzwa kuti vanachiremba uchidzidzira Zvinosarudzwa subcutaneous kwokubatsira chezvinodhaka.

For intravenous achishingaira medicament iri wakasuduruka chinu parutivi sirinji, uye ipapo wakaradzikwa chinu 5% dextrose. The zvichiguma Kugadzirisa chinotarisirwa kuti murwere kwehafu yeawa.

Kushandisa 'Leykostim "? Instructions (analogues Mushonga uyu ichakurukurwa pazasi) rinotaura kuti mushonga anofanira kushandiswa hapana kwokutanga pane zuva yapera mishonga.

The mushonga mhinduro raitongwa zvichienderana murwere uremu. The dose neeSultan pamusoro 5-12 MG pa 1 kg uremu. Majekiseni anoteererwa rimwe zuva ine kakawanda kamwe pazuva.

ARV yakakurukura mushonga yaifanira sokuvapo nhamba neutrophils muropa regai kusvika zvakajairika siyana. Kazhinji, marapirwo nguva iri mavhiki maviri.

Panguva yaitonga nyanzvi vanofanira nguva dzose kuona nhamba leukocytes muropa. Kana nhamba mukuru 50,000 / microliter, nokuishandisa akapidigura.

Panguva mushonga, murwere anogona kutanga thrombocytopenia. Kana iri kudzokororwa assays ari platelet count ukoshi wakachengetwa pazasi 100,000 / microliter, ipapo anoongorora kwekanguva Kudzimwa zvinodhaka kana kuderedza uwandu husingakuvadzi kwayo.

nemishonga

Maererano nenhamba, mushonga "Leykostim" Kashoma kunokonzera nenjodzi. Zvisinei, izvozvo zvinogona achiri kubatsira kwaita migumisiro akadai:

• dysuria;
• kurwadziwa mapfupa kana tsandanyama;
• alopecia;
• hepatomegaly, splenomegaly;
• hypotension (inopfuura);
• vakawedzera kwevari uric asidhi uye alkaline phosphatase;
• simba, nomusoro uye nekuneta;
• neutachiona pakutanga kurapwa, izvo zvinowanzoitika pashure intravenous kwokubatsira chezvinodhaka.

Zvinofanira kucherechedzwa kuti kana ane jekiseni sizvo anogona kunokanganisa murwere kusanzwa panguva jekiseni nzvimbo.

zvinodhaka kwavatori

Asati kushandisa mushonga uyu, unofanira kufunga matambiro anowirirana nevamwe mishonga "Leykostim". Instructions (INN of mishonga unorira "filgrastim") rine mashoko zvakakwana kuburikidza:

• Medicament "5-FU" kunosimbisa neutropenia.
• Nokuti achikura masero myeloid vari nehanya chaizvo cytotoxic vamiririri, kugadza "Leykostim" vanofanira kuva zuva asati kana pashure kushandisa zvinodhaka izvi.
• Viewed medicament haawirirani yavaibvisa chloride.
• Kana tichishandisa mhinduro kutungamirirwa muvambi masero anotevera mishonga dzinofanira kuzokurukurwa kuti kunyatsoshanda zvinoderedza kana basa kuunganidza kushanda "carmustine" "Melphalan" uye "carboplatin".

chaizvo kurumbidza

Hazvina akakurudzira kupa "Leykostim" vanhu vane vasingadzoreki chiropa nerevane itsvo, sezvo filgrastim kuchengeteka uye efficacy pavarwere izvi harina kudzidza.

Varwere osteoporosis nemamwe mapfupa chirwere, vanoshandisa zvinodhaka nguva dzose kwemwedzi mitanhatu, unofanira kuitisa kudzorwa mapfupa arambe achirema.

Kubudirira mushonga mune vanhu vane shoma myeloid wokutsauka masero asina kudzidza. Zvisinei, vanamazvikokota vanoti varwere dzakadaro ukuru nokuwedzera kwenhamba neutrophils kunogona yekudyidzana yakaderera.

Efficacy uye kuchengeteka "Leykostima" mune vanhu vane chirwere myeloid neleukemia uye myelodysplastic chirwere vasina dzakatangwa. Nezvenyaya iyi, mune hosha dzakadai hakuratidzwi.

Monotherapy vaiona kwete zvinodhaka kunodzivisa kupererwa neropa uye thrombocytopenia, izvo zvinokonzerwa myelosuppressive mishonga. Zvinonzi kunodiwa kuona uwandu maplatelet uye hematocrit. Kunyanya kungwarira zvinofanira kushandiswa kana uchishandisa rimwe-chinoumba kana mubatanidzwa chemotherapeutic regimens, vanozivikanwa kwavo kukwanisa kukonzera zvakakomba thrombocytopenia.

Asati atanga kurapwa, "Leykostimom" zvakakodzera kuti uwane kuongorora ropa neumwe yakawanda platelet uye leukocyte Counts, uye dzinotibatsira karyotype uye mwongo mufananidzo.

Panguva kurapwa kunodiwa kuti nguva dzose kuongorora weti uye kukura chirwatata.

Drug "Leykostim": analogs uye mutengo

Analogues zvinodhaka vanonzi anotevera zvinodhaka: "Filergim", "Grasalva", "Granogen", "Neupogen," "leucite", "Neypomaks", "Mielastra", "Neyrostim".

Kana mutengo ipapo, "Leykostima" chaizvo. Kutenga mushonga uyu Pharmacies muMoscow uye mamwe maguta Russian rinogona 2500-4500 rubles. Mutengo mishonga iyi zvinoenderana noukuru uye uwandu ampoules por rongedza.

mishonga Reviews

Zvinosuruvarisa wongororo wevarwere uyo tora mushonga uyu, zvishoma. Maererano kuti pane, mishonga kazhinji ushandiswe nokuda zvirwere, uyewo cyclic neutropenia vana. Kubata mushonga zvirwere zvakakomba zvakadaro pfupi.

Zvinofanira kucherechedzwa kuti pane murwere uchapupu pamusoro kunotoda kushandiswa "Leykostima" muvana uye vakuru vane neutropenia chokuita kenza mishonga. Kugadzirira basa vacheche vari chipimo chemushonga 5 MG / makirogiramu pazuva, asi zvakanaka akashivirira.

Vamwe varwere vaifarira mubvunzo pamusoro kuti mhinduro mhando iri nani: "Leykostim" kana "Neupogen". Somugumisiro miedzo kurapwa kuti rwaiitwa kuziva tolerability uye efficacy pamusoro vamiririri izvi, zvinotevera mhedziso vakataurirwa: deadlines nokuti rakasungwa neutropenia pashure kushandisa mishonga kutaurwa havasi anokudzwa. Uyezve, havana zvakangofanana zviratidzo zviri efficacy uye tolerability.