Anti-TPO - inonyatsoshanda muedzo nechirwere ose autoimmune thyroiditis

Pamwe zvirwere kumwoyo mberi kukura uye kwemakemikari anobudiswa zvirwere - chirwere cheshuga uye thyroid maronda akasiyana-siyana.

Pakati yokupedzisira anopindura rinokosha nzvimbo hypothyroidism, kubva kwayo chitarisiko pauduku kunokonzera kushaya pfungwa uye kwomuviri mwana. Kakawanda, vanonzi autoimmune thyroiditis kana Hashimoto vake. In chirwere ichi chinogona kuitika muna zvitatu zvekuchipatara siyana. hypertrophic ichi, rokuti compensatory hyperplasia isiri yekenza pamusoro thyroid shwanu, atrophic, kukudziridza dariro wechipiri chirwere uye kunoratidzwa yaitsiva dzose connective zvinyama mamiriro, uye alopecia panguva iyo lesion rinotaura mugove muviri mumwe chete.

ukoshi ongororo

Kazhinji, chete yakarurama uchapupu chirwere iropa kuziva miedzo Anti-TPO, i.e. antibodies pamusoro thyroid peroxidase - chikuru enzayemu inotungamirwa triiodothyronine uye thyroxine.

Nemhaka yebasa ravo riri kwakakanganiswa iodination pamusoro thyroglobulin, STRUCTURAL mapuroteni thyroid kuti inoperera kwetunhu mamwe zvokukura mahormone ayo. Sezvo izvi ndiyo vasanonoka bvunzo mu nechirwere kuti Hashimoto kuti goiter, ipapo chiremba vaifungidzirwa kuva maperembudzi basa hormone bvunzo ropa. Anti-TPO kune zvakanaka mugumisiro achawedzerwa, uye ipapo chirwere hunoratidzwa chose. Chete iyi, chiremba vachava nekodzero kutokurudzira zvakakodzera kurapwa uye kupa mukana fungidziro murwere. Kukosha ndechokuti muedzo kuvakadzi vane mimba, t. To., Kana inoratidza Anti-TPO, rinotaura pamusoro dzakakomba pangozi yokuita postpartum thyroiditis uye pernicious kuchinja chirwere pamusoro azvarwa. The pamwero antibodies izvi dzinowanzoona 0-5,6 Iu chete milliliter pamusoro serum, uye kuderera anogona kuonekwa vanhu utano pasi makore 50. Asi zvakanaka (Anti-TPO kupfuura dzose) Muedzo kuve nezvimwe zvirwere thyroid shwanu, saka nechirwere pakati pathologies izvi zvinofanira kuitwa hazvo kunzwisisa, pamwe kuongorora pamusoro T3, T4 uye TSH.

kunzwisisa tsvakurudzo

chirwere Hashimoto raMwari rinooneka kana kukundikana iri zvirwere, kureva, kana zviri kunyanya kupindura kana kuderedza T-suppressor basa. Saka (pamwe Anti-TPO) neropa varwere inowanika mamwe antibodies: chivako sezvo thyroid (thyroglobulin microsomal chakapatsanurwa) uye dzimwe nhengo zvachose. Izvi zvinoita kuti kuwadzana nevamwe, kwete kwemakemikari anobudiswa, pathologies ose autoimmune mavambo. Kuwedzera Kuongororwa Anti-TPO uye mahormone, anodiwa chokushandisa simbiso goiter Hashimoto. Saka, panguva Ultrasound kuzviongorora thyroid shwanu anogona kuratidza heterogeneity ayo mamiriro, hypoechogenicity zvimwe zvikamu, kuvapo calcification uye thickening yacho Kamudzira. More zvakakomba fungidziro anova Muzviitiko apo nhengo vachava nodes sezvo vanenge 5% kubva muzviitiko ozlokachestvlyayutsya.