"Azathioprine": analogues, mutengo, mutungamiriri uye wongororo

Autoimmune chirwere - boka pathological ezvinhu umo ichiwedzerwa basa zvirwere muviri wake pachake. Kuti kuderedza zvirwere mhinduro, ushandiswe mishonga kuti vasaziva zvirwere. Ichi boka zvinodhaka rinokosha transplantation kudzivirira batanidza kurambwa. Ngatimboonai imwe mushonga akadai, sezvo "Azathioprine" analogs zvinodhaka, uye mirayiridzo kushandisa mamiriro ayo.

pharmacological characterization

Muchikamu wake zvinodhaka "Azathioprine" rine basa wemafuta chete zita. Uyu mushonga remubatanidzwa rinobva nezvinhu zvakakodzera kuti kwetunhu DNA uye RNA. Mumuviri, azathioprine anopa DNA usage uye, naizvozvo, kuchititadzisa sero nokupesana pezvakaitwa vari munyama. Kuderedza basa zvirwere zvinokonzerwa pokudzora kwomudzimu zvinodhaka "Azathioprine" iri lymphoid tishu.

Saka pane chinovhiringidza foni weboka pezvakaitwa uye cellular masoja norudaviro. Pashure pakatanga "Azathioprine" gadziriro iri muviri zvemamiriro zvinoderedza uwandu phagocytes uye kuderedzwa immunoglobulin usage. Ngatiteererei mamwe kuongorora ruzivo: chii vari zvechadenga "Azathioprine" chinodhaka analogues, mutengo, mirayiridzo kushandiswa.

Pharmacokinetics

The mushonga ari chaizvo zvakanyanya wefodya unopinda systemic kuparadzirwa, uye ayo kunonyanyisa yevasungwa aona pashure maawa 2 chete pashure nomumukanwa yaitonga. The mushonga haasi kunyanya mudungwe munzira kuti mapuroteni eplasma: yayo tichisunga kwavari 30%. For azathioprine mamirire mugumisiro chepuraimari metabolic kana kutanga Pfuurai chiropa.

Achipfuura hepatocytes, mushonga rinoita kuti basa mukomboni - mercaptopurine, uye ine pharmacodynamic migumisiro. Pfungwa yabudiswa zvinenge zvakakwana bile. The weti yabudiswa asina kupfuura 2% kuti medicament.

zvairatidza

Kugadzirira "Azathioprine" analogues pamwe chete vachishingaira fuma zvinoratidzwa kushandiswa mune transplantation kudzivisa batanidza kurambwa kuita.

Uyewo, kuti mushonga wacho zvinobudirira kushandiswa rheumatological tsika yokurapa dzinonzi rheumatoid arthritis uye autoimmune zvirwere zvakadai chiropa, chinonzi systemic lupus erythematosus, psoriasis, thrombocytopenic purpura, pemphigus, uye vamwe vakawanda.

Contraindications

Drug "Azathioprine" iri contraindicated pavarwere vane hypersensitivity kuti chikamu zvinodhaka. Nokuti kuti chinodhaka kuchititadzisa ose utachiona ropa, "Azathioprine" iri contraindicated mu nezvirwere ropa (kupererwa neropa leykotsito- uye lymphopenia, thrombocytopenia), uyewo pamuviri uye ukoti.

Shandisa panguva pamuviri uye uchiyamwisa

The rinoita fuma zvinoenda mukaka uye kuburikidza gematoplatsentarny nokuidzivirira. Panyaya iyi, kushandiswa hauna anokurudzirwa pamuviri uye uchiyamwisa. Kana zvakakodzera, kugadzwa zvinodhaka kana ayo analogues vari muchikwata ichi vanhu zvakafanira kuongorora ngozi kubva kushandiswa kushandiswa kwezvinodhaka uye zvinogona kukuvadza kuna amai uye mudumbu. Kana rakavapa nevasori paanenge achiyamwa ichangopfuura kudzima.

Zvakakurukurwa kushanda

The mushonga wayo analogs zvinofanira kushandiswa nokungwaririra pavarwere kutambura chibhokisi, uye vari varwere kushayiwa xanthine oxidase.

nemishonga

The chikuru Boka kurutivi migumisiro chokuita chinovhiringidza kuti mwongo chinosara basa masero matsvuku eropa. In kushandisa analogs ane azathioprine, kuwedzera kukura masero muropa, zvinoderedza pamusoro leucocyte count, platelet kuverenga, kupererwa neropa.

Nokuti chikamu zvomudumbu turakiti vakawanda nemishonga dzinosanganisira: ungaderedza kudya, chetsoka zvirwere, havachanyatsogoni hepatic basa, maronda maronda ari nemudumbu. Possible kurasikirwa hepatocytes, zvichiteverwa kuwedzera bilirubin kana mamwe chiropa kushanda miedzo. In varwere achirapwa kuvhiyiwa nhengo kuisirwa uye zvinyama zvingamuka pfungwa nomuviri zvemwana asati, maronda maronda mudumbu, ura, budiriro chepfu chiropa.

Neutachiona kuitika chaizvo kashoma kana raitongwa zvinodhaka "Azathioprine" analogs anoritsanangura (semuenzaniso, "Azathioprine"). Kuratidza kwete vakanyorwa, kunyanya nokuda ganda nekumhanyirira kana kwokupisa inoti.

Pakati mhiri migumisiro zvinofanira kuzivikanwa kukura yechipiri zvinotapukira pezvakaitwa mumuviri, chitarisiko tsandanyama uye kurwadza kwemajoini, chenjera renal dzichipfekeka insufficiency. Mune zvimwe Muzviitiko zvakaipisisa, mushonga "Azathioprine" analogues pamwe chete vachishingaira fuma zvinogona kukonzera hemolytic kupererwa, kupa zviratidzo kubva nechepakati tsinga. Azathioprine somunhu pharmaceutically kushingaira fuma, chikamu chimwe chete zita zvinodhaka uye ayo analogues, ane raidudzwa simba pamusoro azvarwa (teratogenic uye mutagenic nemigumisiro) uye anogona Nokumukira chitarisiko bundu pezvakaitwa uye kwavakazoita malignancy. Saka, zvinokosha kuti tiongorore kugadzwa zvinodhaka "Azathioprine" (Mahwendefa) wongororo, rondedzero, zvinodhaka analogues nokusanangura zvakanaka mazano. Achitarira mberi, tinoona kuti sezvo yezviri chirungiso azathioprine rine kwaibatsira pamusoro mukurwara, maererano zviratidzo. Izvi zvinoratidzwa kwete chete vanachiremba asiwo varwere pachavo.

"Azathioprine" - anoreva zvakafanana, analogs

Azathioprine - yakasiyana yazvo nzira fuma ane immunosuppressive chiito. Tichifunga mishonga musika haasi kunyatsonaka kumiririrwa gadziriro ane azathioprine. Analogs "azathioprine" anogona kupiwa mune mushonga wakadaro, sezvo ari "Azathioprine".

The mushonga inowanika piritsi muchimiro zvakafanana kugutsikana azathioprine. The chete nuance ndiyo mari "Azathioprine" zvinodhaka, izvo unogona muna 4-5 nguva mari "azathioprine" Russian kugadzirwa.

Chepfu uye ovhadhozi

Drug ovhadhozi "Azathioprine" ayo ishamwari "Azathioprine" akaratidza zvinetso zviri nemudumbu, kudzvinyirira kuti mwongo basa, uyewo yakawedzera chiropa shanda nemiedzo. chepfu kurapwa sezvo mushonga pacharo uye ayo analogues riri symptomatic, nechinangwa panguva kunokurumidza kubviswa pakati zvinodhaka mumuviri. No chaicho mushonga. Dialysis detoxification nzira dzinobudirira muchidimbu nokuti rinoita fuma kuburikidza navo yabudiswa kwete zvachose.

Zvokungwarira

The mushonga wayo analogs hadzina kurumbidzwa kushandiswa kwenguva refu. Pakutanga mishonga kunoda kuramba zvichiongororwa Masero peripheral ropa, uyewo richiona kuti chiropa makemikari.

Mune ramangwana, nezuva kudzora ngavabude, kuitisa zvichiongororwa zveBhaibheri kamwe kana kaviri pamwedzi.

mhedziso

The mushonga wayo analogs vanogona kunan'anura chete ane ruzivo nyanzvi. Asati kutora zvinodiwa kuti vanochinja kuongorora zvizere uye zvimwe zvidzidzo yokuzvigadzirisa mishonga. Kuti uwane mamwe mashoko, inoita kugadzwa "Azathioprine" gadziriro mirayiridzo kushandiswa. Price, analogues ino mudziyo sechikamu sefungu varwere. Saka nemutengo wakaderera mahwendefa 50 ari munzvimbo 250-300 rubles, uye pamusoro analogues vataurwa pamusoro. Usati kutora unofanira kuyera "zvayakanakira" uye "nezvayakaipira" uye kutanga kurapwa.