Bundu zvechinguvana HE4: decoding uye zvazvingava chakarurama

Oncology - dambudziko ngozi. Gore negore nokuda kwechirwere ichi inouraya vanhu vakawanda. Chechina-anozivikanwa chinokonzera rufu nekenza ovaries. Uyezve, mwero wokufa kwevanhu ndiko soro iri dzakabudirira munharaunda. Kenza inogona kurapika kana kuzivikanwa vachiri padanho kwayo kukura. Izvi zvichabatsira epithelial bundu zvechinguvana HE4 ovarian kenza. Chii mwero indekisi ichi kunzi pazasi.

Tichishandisa chimiro ichi kenza

Zviratidzo kazhinji vanoziva kwakaoma, sezvo vari chokuita zvakananga bundu inotungamirwa mu zvinoshandiswa uye saka kujeka. Maererano mashoko neInternational Agency for Research pamusoro Kenza, mashanu gore kupukunyuka mwero ovarian kenza muvarwere pakupedzisira mumatanho vanenge 46%. Asi kana ukaona hosha iri tanga, wokurarama yakawedzera kusvika 94%. Kutsvakurudza Modern akapa vanhu mukana kurwisa chirwere ichi. Wanikidza kutanga malignancy muna tanga nebundu zvezvinangwa pakudzidza. With kuwedzera kwavo pamwero vanachiremba vari achiyambirawo. Munyaya ino tichakurukura bundu zvechinguvana HE4.

Kutsunga mota zvechinguvana

Mumuviri womunhu mune zvinhu vari vhoriyamu duku, makatumidzwa bundu zvezvinangwa. Ivo vari muzvitendero zvakasiyana-vasiri uye nokukanganisika masangano uye havasi ngozi uwandu zvakajairika. Zvose zvichava zvakasiyana, kana inzwi ravo achatanga kuwedzera. Izvi zvinoratidza kuti ndingangokuvara malignancy. Somuenzaniso, kuziva ovarian kenza, anowanzodanwa kushandiswa bundu zvechinguvana CA-125. Asi gare gare Zvakazoitika kuti bundu zvechinguvana HE4 zvakanyatsorurama marondedzerero oncology.

Izvi serous mapuroteni kuti inoperera ari enzayemu runovharidzira mamwe, rakashandurwa rinoreva "munhu puroteni munhu -. Zvina manda" The zvaida shoma zviri testis uye urume basa iri Pfungwa. Uyewo chinhu nemamiriro kufema, fallopian chubhu, uye mune mucous membranes. Asi chaizvoizvo mashandiro uye sei kunokanganisa munhu pepsin, zvichiri kwete pachena.

Zvairatidza kuti ongororo chinangwa

A shoma bundu zvechinguvana HE4 anogona kuva mukadzi upi. Its vhoriyamu kunowedzera zvirwere zvakadai:

- Ovarian kenza.

- Oncology endometrium.

- kenza yemazamu.

- kenza Lung.

kunobatsira HE4

Saka oncomarker HE4 zvinoreva kare akaipa muitiro. Hahugoni kutsunga pamwe benign muitiro, kana kuzvimba ovaries. Izvi zvinoratidza kuti inoshanda HE4.

nowakautangira Its, bundu zvechinguvana CA-125, anonziwo zvainanga kuziva kenza, asi ine duku nzvimbo kururama. Ndiko, uwandu CA-125 anova mukuru okupedzisira matanho zvakarurama zvawanikwa. A HE4 vhoriyamu inowedzera munenge matatu asati chaiwo tsanangudzo chirwere.

Saizvozvowo, nokuongorora kenza anogona kuonekwa vachiri Danho, uchigere dzakabudirira zviratidzo. Pasinei neizvi, inopangidza kuti bundu zvechinguvana HE4 harishandiswi yokutsvakurudza masangano munzvimbo yacho ovaries. Haafaniri kucherechedza utachiona uye mucoid siyana kenza.

HE4 inoshandiswa kuongorora kurapwa vakadzi Wakatotanga. Saizvozvowo, kana kuongorora marapirwo haangazodzingi kuita, akabva ashandisa kurapa dzapera.

Maererano nenhamba bundu zvechinguvana anogona kuona paumbwe yechipiri foci kuti bundu masero zvichikonzerwa kusiyana chepakuvamba yatanga muna pedyo nyama kana kuvandudzwa.

Kuita assays HE4

Kukonzera ndufu nokuda kenza ndiko kuziva chirwere okupedzisira mumatanho vayo kukura. Tichibatsirwa HE4 ari kuongorora anogona kuziva vachiri padanho kenza, nokudaro kuderedza mukana wokuti rufu. Bundu zvezvinangwa anogona kuonekwa muropa wakatorwa kubva tsinga. For zvakakodzera chokuendesa ari kuongorora vanofanira:

• Dhoneta ropa riri zvachose usina chawadya kana mushure mana shanu maawa pashure zvokudya. Unogona kunwa mvura, asi kwete pachii kofi kana muto.
• Kana zvichibvira, mazuva mashoma (mazuva 3-4) asati chokuendesa ari kuongorora haana kutora chero mushonga.
• Usati chinhu kuongorora hakuiti kunwa kana kuputa.
• Kutanga kurapwa mukadzi ruoko pamusoro kuongorora kamwe ose mitatu. Mune remangwana, zvakakwana chete - nguva mbiri ongororo.

Mune zvimwe zviitiko, imwe ongororo dzakabatwa vana. Vanofanira chinomwiwa akabika mvura kwehafu yeawa pamberi chokuendesa mashoko ongororo. Avhareji Vhoriyamu akadhakwa mvura inofanira kuva 150-200 Rine mamiririta.

Vakadzi vanofanira kuti kuedzwa kana paiva kurwadziwa vari pelvic nzvimbo, kwakakanganiswa kumwedzi, akaderedza kudya.

Munguva yokudzidza zvakakosha kuziva yakakwirira azvipire bundu zvechinguvana.

Bundu zvechinguvana HE4: inopangidza

Norm kunobva bonde, zera murwere. Pashure bvunzo ropa akapinza, unofanira kumirira. The Zvichaguma wakagadzirira pezvizuva.

Volume HE4 vanoziva ane chemiluminescent kudzidza chinokosha.

Chinonyanya kukosha ndechokuti ichi: pane maitiro akanzi yeimwe uye aida 4-fung mapuroteni. Zvadaro pane kuchinja zvavo tinoberekwa zvivako. Nokuva gombedzero zvinokonzera kuti luminescence zvakaitwa. Zvino uchibatsirwa paku nzira zvikavengwa ngaaverenge padanho bundu zvechinguvana.

Dzemunharaunda varume nevakadzi

A zvinoitika uwandu mapuroteni-4 vakadzi panguva pre-kubereka haasi mukuru 70 pmol / L, uye pashure kubereka - zvishoma pane kana kuenzana 140 pmol / L. The zvakawanda zvairatidza izvi, chikuru mukana wokuti kenza ovarian chirwere.

Asi iwe unofanira zvechokwadi kuziva kuti pane zera dzemunharaunda, kureva, mashoko nechakatsinhiwa zvichienderana nezera. Naizvozvo zviri nani kuwana mashoko ose kubva nachiremba wako. Izvi ndizvo zvinoratidza bundu zvechinguvana HE4.

Tine zvinotevera dzinonakidza chokwadi. Kana vakatapwa HE4 inopangidza, unowana zvinotevera mashoko: chetatu hadzi hafu yevanhu yakawedzera dziine bundu zvechinguvana, asi CA-125 kazhinji anoramba ari bvumidzwa ndozvakajairwa.

Chii mwero kuti varume? Zviri pachiyero 4 kumar / Rine mamiririta uye pasi. Zvinofanira kuva vasingafariri kuna kana vakawana simba chaizvo unongotaura. Inogona kutaura kukura kenza mumuviri chirwere ane ngozi.

Pane kuchinja nezera dzemunharaunda. Pashure pemakore makumi mana vari varume mwero 2-2.5 kumar / ML, pashure pemakore matanhatu - 4.5-6.5 kumar / ML.

Nhamba dzinoratidza kuti vakawanda nevarume vose dzinovuya kurapwa. Vakaunganidza bundu zvezvinangwa muropa uye ane zvokurwara kweprostate gland.

kukanganisa kuongorora

Zvinofanira kurangarirwa kuti kuzvida kuongorora kuti bundu zvezvinangwa haisi chikonzero kusimbisa kana ndeyenhema oncology. Nemazvo asi shandisa HE4 nezvimwe Analyses. Zvakanakisisa kuongorora izvozvo pamwe CA-125. Uye kuchiita-siyana Diagnostics, sezvo mumarabhoritari uye richishanda.

Dzimwe nguva refu ukoshi bundu zvezvinangwa HE4 kushaya malignancy. Isu ichaongorora yakanaka chenhema mugumisiro nokuda:

• kuvapo systemic enhaka chirwere, iro rinotsanangura kuchinja transmembrane regulator Gene;
• Kuvapo kwevamwe urogenital inflammations mamiriro;
• chisingaperi renal kukundikana;
• ovarian chikofu;
• myoma.

Sei kuziva zviratidzo kenza?

Kuchangotanga kuvhiringidzika muviri zvakakodzera chiremba. Iye achagadza ongororo pamusoro epithelial bundu zvechinguvana HE4 ovarian kenza. Regulation kana yakatsauka kubva acharatidza nokukurumidza. Pakutanga zvingaratidza kuva aisatombowanika. Asi chero zvakadaro, ongororo haafaniri kupedza pa:

• kutyorwa ari ovaries uye matambudziko kumwedzi vakadzi;
• kurwadziwa ari pelvic nzvimbo;
• kudzikira vakawanda utano ane kuderedzwa havi;
• utsinye uye asinganzwisisi uremu;
• nokusakendenga.

Pamusoro kusimbisa nechirwere havafaniri kutya, nokuti kenza ari kukunda kurapwa nhasi. Chokwadi, ichi ndicho bvunzo, asi chinogona kukurirwa ubude kurwa vakakunda.

Self-mushonga isanzwiwa kuvimba akamira oga kunenge nenyanzvi.

Zvichatora murefu uye simba, nekuti dzokurapa - ibasa rakaoma, iro rine refu uye kusingafadzi hunhu.

mhedziso

The yakakanganiswa Zvingaguma, kana bundu asingadi vaunze HE4 kana richiwanikwa kukwana akawanda kuti asarudze.

Pasinei nokuti nenyaya acharatidza, hazvina zvakakodzera kuva agumbuka mberi nguva uye uchiita kuti chirwere. Vanachiremba vanogona kuziva chirwere uye taurira kurapwa, asi chete pashure kuongorora zvizere.