Description thiamine zvinodhaka. Mirayiridzo yokushandisa

mushonga Thiamine inowanika Kamudzira chimiro kana intramuscular mhinduro. Zita wechipiri zvinodhaka - aneurine (usingachashandi.). Chinhu vitamin urwa mumvura. The fuma haana ruvara. Kana yakabikwa - raparadzwa. Thiamine hakusi soluble doro. Ko, zvino, ane dzichipfekeka unhu thiamine? Mirayiridzo yokushandisa anotsanangura chinangwa mushonga zvakadzama.

Mashandiro anoita thiamine

Vhitamini Thiamine aizivikanwawo vhitamini B1. It anoita muviri muviri kwemafuta uye makabhohaidhiretsi, pakudzikamisa kukura, kuvandudza kushanda kwomwoyo, zvomudumbu uye huta nehurongwa. Sezvo mumwe zvivako zvayo - ndiyo mvura soluble, kuti vhitamini hauna iiswe muviri uye asingauyi anoora kuti muchetura.

The kwaita Thiamine

Nyaya kunotanga apo musayendisiti Christiaan Eijkman kutanga vawana zvinhu zvakadai mavhitaminzi. Somugumisiro ake Zvakawanikwa mukurapa, akava akahwina mubayiro weNobel. Mumwe musayendisiti Casimir Funk, vhitamini vanozivikanwa se remubatanidzwa pamwe senitrogen kubva mupunga bran. Vhitamini sezvo rimwe mumiririri pakupedzisira akakwanisa muna 1926.

Mumuviri makemikari unhu

solubility anenge kunyatsonyudzwa mumvura. The asidhi aqueous mhinduro soro tembiricha asingadi kukanganisa fuma. The alkali fuma kana neshungu akaremara. The Morekuru ine pyrimidine uye thiazole zvindori inoumbwa methylene linkage.

Kupararira mumuviri

Funga kuti akaparadzirwa muviri thiamine. The Mirayiridzo kutsanangura pharmacokinetics zvinodhaka. Mushure achipfuura zvomudumbu turakiti zvinodhaka wefodya uye yaputswa zvomudumbu makemikari. Zvadaro, mukati maminitsi 15, inopinda ropa kare muna vasina kusungwa chimiro. Hafu yeawa Papera rinenge akaparadzirwa munyama siyana. In yakaisvonaka chimiro, thiamine ari plasma, uyewo phosphate esters - mune leukocytes uye erythrocytes.

Sezvo chikamu 50% thiamine iri striated tsandanyama, nhengo dzomukati chinoita vanenge 40% of vhitamini. Tsinga rinenge uye chiropa uyewo ane thiamine zvakakwana.

Tiamindifosfata - basa phosphoric Ester, ine thiamine. Mirayiridzo yokushandisa kunoratidza kuti Esteri zvinobatanidzwa zvakananga metabolic dzinotsanagura mafuta uye makabhohaidhiretsi. Output kubva muviri kunoitika nomukombiyuta itsvo uye ura.

shandisa

mishonga Kupinda kupiwa intramuscularly kana zvishoma nezvishoma nomutsinga 1 nguva pazuva. Standard mishonga nokuti vakuru - kubva 25 kusvika 50 MG. Marapirwo nguva ingabva mazuva 10 kusvika mwedzi mumwe.

Uyewo hypovitaminosis mishonga chisingaperi vanobviswa nomuromo 10-25 MG. The dose daily - kuraswa kana mapoka.

Mune zvimwe zviitiko, mushonga vakawedzera dose thiamine? Mirayiridzo kushandiswa pasi zvikuru hypovitaminosis dzinosiyana zuva dose 300 MG.

umboo

Mvumo makapiwa kushandisa panguva yepamuviri uye lactation. Chipimo chemushonga maererano yachiremba mirairo.

nemishonga

Thiamine kunogona kukonzera nhamba tsamwa siyana, pruritus, urticaria, angioedema, dzimwe nguva anaphylactic kuvhunduka kunogona kuitika. Pakati ishoma migumisiro - tachycardia uye diaphoresis.

Contraindications

Parizvino contraindications vasingakoshi. Kugadzirira thiamine kushandiswa Chinyorwa unorambidza kushandiswa vanenge hypersensitivity, ukuwo hadzi kubereka, kana encephalopathy.

mamwe mirayiridzo

Pane nhungamiro pamusoro kushandisa achishandisa thiamine. Mirayiridzo dzokushandisa haana yakarumbidza kushandisa mushonga sezvo kutsiva zvokudya, chete kana munhu RUBATSIRO RUNOTARISA kudya mushonga. Kana ingestion kunokonzera kuramba zvinodhaka (kurutsa hunenge, kuda kurutsa, achangobva kuvhiyiwa) vanobvumirwa parenteral yaitonga. Kana akawanikwa Wernicke kuti encephalopathy zvinofanira kupiwa dextrose vasati kutora mishonga iyi.