"Fliksotid": mirayiridzo kushandiswa, wongororo. zvinodhaka analogues

Unoziva here kuti "Fliksotid" kugadzirira ndeipi? Mirayiridzo yekushandiswa kwemishonga iyi, zviratidzo zvayo, hutano, migumisiro yehupenyu uye mafomu ekuregedzwa icharondedzerwa zvakadarika pasi apa. Mukuwedzera, tichakuudza kana iyi mishonga inopesana, chii chichaitika kana kuwedzeresa, izvo zvinoshandiswa mune zvemishonga, nezvimwe zvakadaro.

Kuumbwa uye chimiro chemishonga

Ndezvipi zvingabvira kutenga mari yekugadzirira "Fliksotid", murayiridzo wekushandiswa kwokuti inosanganiswa nechibereko? Parizvino, iyi mishonga inotengeswa chete nenzira ye inhalation aerosol. Icho chikuru chinoshandiswa chinhu chinonzi fluticasone propionate microionized. Kugadzirira kunosanganisirawo chimwe chikamu, chakadai se tetrafluoroethane.

Mishonga inobudiswa musimbi inhaler ine chinyorwa che concave uye chigadzirwa chinoparadzaniswa chakagadzirwa nesipiritsi. Mukati megiyo pane kumira kwemuchena kana kuti mutsvuku. Paunenge uchitenga chigadzirwa ichi, iwe unofanirwa kugara uchitarisa kumusoro weiyo inhaler. Ivhavharo yaro haifaniri kunge iine maitiro asina kuoneka.

Mhando dzeaerosol mishonga yemiti

Zvichienderana nehuwandu hunoshandiswa huripo huripo pakumiswa, mitatu yemishonga iyeyo inozivikanwa. Mazita avo ndeaya anotevera: "Fliksotid Diskus", "Fliksotid Nebula" uye "Fliksotid Evohaler".

Zviratidzo zvepamusoro zvechirwere

Chii chiri kugadzirira "Fliksotid"? Iyo mirayiridzo yekushandisa inotaura kuti inoshandiswa iyo inoshandiswa ndeyeboka rezvizvarwa zvemunharaunda. Nekudzivirirwa kwekutengesa, chinhu chinoshanda chinobereka zvinonzi anti-allergen uye anti-inflammatory effects. Somugumisiro, kuoma kwezviratidzo zvakaderedzwa zvakanyanya, sezvinoitwa nguva yakawanda yekuwedzerwa kwehutachiona hunoendeswa nekudzivirira kwemhepo (semuenzaniso, chirwere chisingaperi chisingagoneki, chirwere chechirwere chechirwere uye emphysema).

Nheyo yekuita kwemishonga (aerosol)

Ko kugadzirira "Fliksotid Nebula" uye mamwe maitiro emushonga uyu unoshanda sei? Icho chinhu chikuru chinodzivisa kupararira kwemasero emasero, macrophages, eosinophils, neutrophils uye lymphocytes, uyewo kunoderedza kushandiswa uye kunounza mutevedzeri wezvinyanyisa uye zvimwe zvinhu zvinoshandiswa zvehupenyu (zvakadai se histamine, prostaglandin, leukotriene, cytokine).

Muchirwere chisingaperi chisingabvumirwi nehutachiona, kune huwandu hwakakosha hwechirwere ichi pamhepo yekufema, kuitira kuti zviratidzo zvive zvishoma kududzwa, kuwanda uye kuoma kwekuwedzera kunowedzera, uye kudiwa kwemapiritsi eSGC anowanikwa. Somugumisiro, hutano hwomurwere hunovandudza.

Izvozvo zvinokonzerwa nemishonga iyi hazvisi zvishoma. Panyaya iyi, mumatare ekurapa, hazvina maturo pane hypothalamic-pituitary-adrenal system.

Iyo "Fliksotid" mishonga, iyo yakafanana iyo ichanzi pasi apa, inokurumidza kudzorera mhinduro yemurwere kune bronchodilators, kuderedza nguva dzavanoshandisa.

Kurapa kwekutapedza mushure mekushandiswa kweaerosol inhaler inotanga mukati maawa makumi maviri nemasere uye inosvika pakakwirira kwevhiki mbiri kana kupfuura. Chigumisiro chacho chinochengeterwa kwemazuva mashomanana mushure mokunge mishonga ichibviswa.

Pharmacokinetics of aerosol

Mushure mokunge aerosol "Fliksotid" yakashandiswa nokuda kwechinangwa chayo, chinonzi bioavailability chaicho chakashanda chiri 8-11%.

Kushandiswa kwemishonga kwechirwere ichi kunowanzoitika mumapapu. Nenzira, pakutanga kunyorera kunoitwa nokukurumidza, uye zvino kunonoka. Panguva yekugadzirisa, chikamu chekumiswa kwemukati kunogona kumedzwa nemurwere. Zvisinei, iyo yakagadziriswa inogadziriswa nekuda kwekusagadzikana kwehuwandu hwemishonga mumvura, pamwe chete nemasabolism ane simba kana achipfuura muchiropa.

Izvo zvinosungirirwa kumapuroteni eplasma mune izvi zvinodhaka zvinoenderana nepamusoro uye inenge 91%. Icho chinoshingaira chechirwere chacho chinoshandiswa mumagetsi muchiropa pamwe nekubatanidzwa kweYP3A4. Somugumisiro, metabolites isingashandisi inoumbwa.

Mushonga we "Fliksotid", kuongororwa pamusoro peiyo inonyanya kukosha, une rusununguko rwepamusoro peplasma. Iyo hafu yehupenyu nguva inenge maawa masere. Iyo yakanyanyisa mumhando ye metabolite pamwe nemuyo.

Zviratidzo zvekushandisa kweaerosol

Munoshandisa zvipi zvinodhaka "Fliksotid"? Mirayiridzo yekushandiswa inozivisa kuti mishonga inorayirwa kurapwa kwevarwere vanotambura nehuputi hwechirwere, kuitika muhurukuro yakaoma kana inonyoresa. Uyezve, mishonga inoshandiswa kudzivirira kugumburwa paunotora systemic glucocorticosteroids.

Mukuwedzera, mishonga inoratidzwa kune varwere vane zvirwere zvisingaperi zvepapupa. Shandisa iyo kuti kuderedze kushandiswa kwechibhakera, pamwe nekuvandudza basa rekudzivirira mukati remuviri wekupumha.

Contraindications kushandiswa kweaerosol

Ndezvipi mumamiriro ezvinhu chero ipi zvayo hazvibviri kushandisa inhaler "Fliksotid"? Contraindications ndeizvi:

• Hypersensitivity yemurwere kune chero chikamu chechirwere;
• Aconcho bronchospasm;
• Izvo chinonzi asthmatic (sekugadzirisa kwekutanga);
• Zera kusvika 1 gore.

Inofanirawo kutariswa kuti mishonga iyi haifaniri kushandiswa pakuburitswa kwekurwadziwa kwechirwere chinoputika.

Kunyatsoshandiswa kwechirwere

Ndezvipi mumamiriro ezvinhu anonyatsorongedzerwa kugadzirira "Fliksotid"? Vanachiremba vanoti chirongwa chino chinofanira kushandiswa zvakasimba pasi pekutarisa kwevanyanzvi mu glaucoma, chiropa cirrhosis, pulmonary tuberculosis, hypothyroidism, pamuviri, systemic zvirwere (bhakitiriya, fungal, parasitic kana virasi), uye munguva yeactro and osteoporosis.

Kugadzirira "Fliksotid" kwekudzivirira: murayiridzo

Zvichienderana nerudzi rwekugadzirira, nzira dzaro dzokushandisa uye dhizi dzinogona kusiyana zvikuru. Semuenzaniso, kuti uwane zvinodiwa, iyo aerosol "Flixotide Diskus" inofanira kushandiswa nguva dzose, kunyange munguva yekuregererwa.

Nguva yehutachiona uye mukana wakakwana wemishonga inofanira kuongororwa chete nachiremba, achifunga nezvechirwere chemu murwere uye chechigarire chimiro chemufananidzo. Kune vanhu vakuru, muyero uri 100-1000 μg 2 pazuva pazuva. Kushandiswa kwemishonga inotanga neine zvishoma zvinokonzera kurapa. Kana zvichidiwa, muwandu wemishonga inoshandiswa inogona kuwedzerwa. Nhamba yepamusoro yezvinodhaka haifaniri kudarika 2000 mcg.

I "Fliksotid" mishonga yevana kubva pamakore mana anotambura nehuponi hwechirwere inorayirwa muwandu hwe50-100 μg kaviri pazuva. Kana zvichidiwa, ichi chiyero chinowedzerwa kusvika ku 400 μg pazuva. Kana vari vakuru vane zvirwere zvisingaperi zvepapu, vanowanzopiwa 500 μg yemishonga kaviri pazuva.

Nzira yekushandisa sei chirwere "Fliksotid Evohaler"?

Ichi chishandiso chinofanira kushandiswa nguva dzose. Usati washandisa, mushonga unofanirwa kushandiswa kazhinji kuti uwane mufananisi weunifomu. Uyewo chidimbu chekumiswa chinofanira kuzununguswa nesimba. Pakurasira iyo aerosol, murwere anoda kutora kupera. Munhu anotaura anofanira kucheneswa kamwechete pavhiki.

Nzira yekushandisa sei chirongwa che "Fliksotid" mishonga? Maitiro echirwere ichi anotarirwa sezvinotevera: izwi rimwe chete rechirwere rinoenderana nemashirasi maviri.

Nebhromalal asthma, vanhu vakuru vanorayirwa 100-1000 μg yezvinhu zvinoshanda kaviri pazuva. Kushandisa kwechirwere kunofanira kutanga nediki duku maitiro, shure, kana zvichidiwa, anogona kuwedzerwa. Iyo yakawandisa izwi remushonga inofanira kuva 2000 μg.

Nzira yekurapa vana sei uchishandisa aerosol "Fliksotid"? Inhalations yevana vanopfuura makore mana vane chirwere chakadai sebronchial asthma inorayirwa muwandu hwe50-100 μg kaviri pazuva. Kana zvichidiwa, muyero unogona kuwedzera zvishoma nezvishoma. Nhamba yakawanda yemishonga inodyiwa yevana vakwegura kupfuura makore mana ndiyo 400 micrograms.

Kune vanhu vakuru vane chirwere chisingaperi chisingagadziriswe chepemonic, mishonga inorayirwa 500 μg kaviri pazuva. Kana pasina kubudirira kunoonekwa pashure pemwedzi 3-6 mushure mekutanga kurapwa, chirongwa chekurapa chinofanira kuchinjwa.

Kana mwana ane makore 1 kusvika ku4 anowanikwa ane bronchial asthma, anorayirwa 100 μg yemishonga kaviri pazuva. Muchiitiko ichi, inhalation inokurudzirwa kuti iitwe nemubatsiro wepecicer mwana ane zita rinonakidza "Bebihaler".

Aerosol Fliksotid Nebula: mirayiridzo yekushandiswa

Iyi mishonga inogona kushandiswa pamuromo (pamwe nekushandiswa kwemuromo) kana musinga (ane chiso chemasikati) inhalations. Uyezve, mishonga inowanzomirirwa seyerosol ye inkjet nebulizer. Icho chisingadikanwi zvikuru kushandisa shanduro dzakagadzirwa.

Kana kushandiswa kwenguva yakareba kwemajeri kana kutungamirirwa kwemadhirwe maduku zvakakosha, saka zvisati zvaitika, chirwere chinokurudzirwa kuti chidimbure mumhinduro ye sodium chloride.

Vakuru nevechiri kuyaruka vanopfuura makore gumi nematanhatu vanokwana 0.5-2 mg kaviri zuva rimwe nerimwe. Iyo yakawanda inotapira inofanira kuteverwa mukati memavhiki mushure mekurwa kwechirwere chinopisa, uye zvishoma nezvishoma zvishoma nezvishoma.

Kana zvakaguma zvakanaka uye mamiriro acho akavandudza, tinogona kuchinja kubva kumushonga we "Fliksotid Nebula", murayiridzo wekuti unogara uchienda mutikiti, kune dzimwe mhando dzechirwere ichi.

Kumwana ari nemakore 4 kusvika kumakore gumi nematanhatu, mushonga unorayirwa muwandu we 1 mg kaviri zuva rimwe nerimwe.

Mhosva yekudarika

Kana zvikaitika kudarika, murwere anokwanisa kuora mwoyo kwenguva pfupi ye hypothalamic-pituitary-adrenal system, kuregererwa kwakanyanya kweAdrenal cortex, chirwere chakaoma cherenrenal muvana vakagamuchira chirwere che 1000 mcg pazuva kana kupfuura.

Pakati pezvimwe zvinhu, varwere vakaora mwoyo, kunetseka uye hypoglycemia inoitika. Zvinofanirawo kuonekwa kuti inonzi adrenal dambudziko inowanzotarisana nemamiriro ezvinhu akadaro sekukuvadzwa kwakanyanya, kuvhiyiwa, kuvapo kwehutachiona uye kuderera kwakakosha muyero yezvinodhaka.

Zviitiko zvakashata

Ko kugamuchirwa kwegadziriro ye "Fliksotid" kunogona kukanganisa utano hwomurwere here? Migumisiro inowanika inowanika munenge mishonga yese yezvokurapa. Uye iyo yakabudiswa inobatanidza mushonga haisi iyo.

• Immune system: ganda rekuita nekuda kwe hypersensitivity, angioedema (oropharynx uye chiso), zvisina kukodzera mumhepo yekufema (bronchospasm kana dyspnea), anaphylactic shock.
• Zvirwere zvinopararira uye zvinopararira: Candidiasis ye pharynx uye muromo, uye yakashata stomatitis. Nekukanganisa kwakadaro, zvinokurudzirwa kusunungura huro uye muromo nemvura yakawanda. Antifungal vashandi vemunzvimbo inogonawo kushandiswa. Kakawanda kamuviri kacho mushure mekushandiswa kweaerosol pneumonia, asi chete kune varwere vane COPD.
• Metabolism: hyperglycemia.
• Endocrine system: Cushing's syndrome, kudzvinyirirwa kweAdrenal cortex, kuderedza mapfupa ekuchera mineralization, kukurumidza kukura, cataract, glaucoma.
• Nervous system: kuzvidya mwoyo, maitiro uye kurara kwehope, kusagadzikana uye kusagadzikana (zvikurukuru muvana).
• Mafuta ari pasi pevhu: kuputika.
• Hemapiratori system: hoarseness yezwi (zvinokurudzirwa kusuka muromo uye muromo nemvura pakarepo mushure mekugadziriswa), zvinokonzera bronchospasm.

Mirayiridzo inokosha pakushandisa mishonga

Kugadziriswa kwezvinodhaka kunonyanyoodza mwoyo.

Kuchengetedzwa kwakakosha kunofanira kutorwa kana uchirapa varwere veGCS vasinganyatsogadziriswa vane mafomu asina kushandiswa kana kuti anoshandiswa kwepammonary tuberculosis.

Mushure mokurayira mishonga, chiremba anofanira kutarisa kana murwere angashandisa iyo inhaler. Penguva yekugadzirisa, anofanirwa kuve nechokwadi chokuti kuunza mishonga muchiito kunopfurikidza nechinyorwa nekudzivirira. Chero bedzi nenzira iyi murwere anogona kukwanisa kupa zvakanaka zvakakwana chechikamu chinoshanda kumapapu.

Zvinokurudzirwa kuti varambe vachiona kuwedzera kwekuwedzera kwevana vaduku vanogamuchira GCS yakavhara kwenguva yakareba.

Pakuendesa murwere kubva kutora GICS nenzira yekurapa, zvirwere zvinokonzerwa nehutachiona (somuenzaniso, eczema kana allergenic rhinitis), izvo zvakambopedzwa nemishonga inoshandiswa, zvinogona kuwedzera. Mumamiriro ezvinhu akadaro zvinokurudzirwa kuita zviratidzo zvinoratidzira ne antihistamines kana masheji ekugadzirira.

Sezvo nemishonga yakawanda inopinza mishonga muaerosol mapepa, chirwere chekurapa chinogona kuderera nekunotonhora kwekwanisi.

Kusvika iye zvino, pane zvinyorwa zvisinganzwisisiki kuti murwere anoshandisa mishonga yatinenge tichifunga inowedzera hutachiona hweropa. Izvi zvinofanira kurangarirwa navanachiremba pavanoronga mishonga kune varwere vane chirwere cheshuga mellitus.

Iko kushandiswa kwesimba rinoshanda pamunhu kukwanisa kudzora mishonga uye kushanda nemichina inoda kuwedzera kunyanya kutarisirwa hazvibviri.

Drug analogues

Ndeupi mushonga wokutenga kana murwere asingakwanisi kutenga kugadzirira "Fliksotid"? Analogs yei thuluzi iri anenge anengechete. Asi usati wavashandisa, zvinokurudzirwa kuti uverenge mirayiridzo yakavharwa uye bvunzurudza imwe nyanzvi.

Parizvino, pane mimwe mienzaniso inotevera yemishonga yakataurwa: kugadzirira "Kutiveyt", "Nazarel", "Fliksonase", "Fluticasone" uye "Fluticasone propionate". Inofanira kuonekwa kuti mutengo wemishonga iyi unogona kusiyana, mukuenzanisa neyakasikwa. Nenzira, unogona kutenga aerosol "Fliksotid" ye570 (50 mg, 120 doses), 840 (125 μg, 60 doses) kana 140 (250 mg, 60 doses) yeRussia rubles.

Ongororo pamusoro pekudzivirira kwekudzivirira

Ko vanachiremba nevarwere vanoti chii nezvekugadzirira "Fliksotid"? Kuongorora pamusoro peiyo tombo inowanikwa zvakanaka. Izvi zvinonyanya kubhadharwa nokuti inonzi aerosol mishonga inonyatsoshanda. Iyo inonyanya kuderedza kuitika kwekurwiswa kune varwere vane chirwere chemafi, uye kunowedzerawo maronchial patency kune avo vanotambura nezvirwere zvisingaperi zvepapupa.

Kana pane kugadzirisa kusina kunaka, kazhinji vanobva kune varwere vakashandisa mushonga nenzira isina kunaka kana kwete nokuda kwechiremba chiremba. Saka, kuti uwane chinangwa chakanakisisa usati washandisa mushonga, pamwe chete nemafananidzi ayo, zvinokurudzirwa kuti udzidze zvakadzama mazano akabatanidzwa okushandiswa. Uyezve, zvakafanira kushanyira chiremba uyo, chaizvoizvo, anofanira kukurudzira iyi mushonga, zvichienderana nemigumisiro yekurapa kwechiremba.

Nzira yekuchengetedza aerosol chigadzirwa chei?

Inhalation aerosol inokurudzirwa kuti iiswe munzvimbo ine rima, umo kutonhorera kwepanyika hakupfuuri 25 degrees. Sirifu upenyu hwemishonga ndeyemakore maviri. Mushure menguva iyi, zvinorambidzwa kushandisa.