Immunoglobulin E yaro vasiri kukosha

Immunoglobulin E yaro vasiri kukosha - nyaya zvinoda kudzidzwa. Parizvino, pane mhando inoverengeka immunoglobulins (antibodies). Kune mhando inoverengeka antibodies kuti zvisingapindirani zvakaita chiito uye mashandiro ose Anti-infective kutapata. Antibodies vanotsamwisa kunayisa uye flocculation of ichiputswa kwemabhakitiriya zvigadzirwa, agglomeration uye agglutination corpuscular maantigen (spirochetes, nemavhairasi, majemusi uye utachiona). At muchitokisi Kamudzira vibrios trypanosomes akamisa spirochetes immunoglobulins chaizvo zvivako pamwe mukwanisi, zvichikonzera platelet adsorption. Kazhinji, izvi zvinokonzera zvirwere zvabatwa mune lymphoid tishu. The immunoglobulins mumakirasi G uye M pamwe mukwanisi anogona hydrolyze spirochetes, trypanosomes, mabhakitiriya uye wanda.

Mugumisiro antibodies pamusoro utachiona hwakakura yakaturikwa kana achipinda muchitokisi, uye kwete achingoratidza antigen pamusoro sero pamusoro. Immunoglobulins kunogona kusimbisa kana kunetesa masoja kurwisa kwakaita nhengo. Antigen-antibody kunzwisisa izvo rine antigen zvakawandisa, anoita kunobatsira, uye kunzwisisa ane nekumwisa antibodies anorashisa vanetsane. Kakawanda, immunoglobulins ndiwo anokonzera autoimmune uye sema matambudziko.

IgE ari synthesized kunyanya mumasero mucous membranes ari kufema, gastro-intestinal turakiti, uyewo remunharaunda node nodes. Kokutanga, somunhu yoga boka immunoglobulin E akaziviswa muna 1966, uye muna 1968, ari NDIANI kuzivikanwa sezvo akazvimirira IgE boka immunoglobulins.

Kirasi ichi kwemapurotini zvinowanikwa muvanhu, primates uye dzimwe mhuka dzinoongororwa murabhoritari. Vakawanda E immunoglobulin mamorekuru chokuita ganda rechikepe masero uye basophils. Sezvo pasi kwomuzvarirwo ezvinhu immunoglobulin E kuwanda muropa serum ane shoma nanograms por milliliter, huru pfungwa sechivako Morekuru ichi inotengwa chete pahwaro nokudzidza myeloid mapurotini anoverengeka. Zviripachena Very yakaderera kwevari immunoglobulin E iri serum zvauya kubva chokwadi chokuti anokwanisa "kukwezvwa" kune penyika masero uye zvakasimba kusungira kuti danda rechikepe masero uye basophils.

Zvinofungidzirwa kuti Іg E ndiye kirasi guru immunoglobulins iyo pave masero rechikepe uye basophils kupinda neutachiona. Padanho mapuroteni iyi serum kuti varwere chisimbwa kunowedzera uye kazhinji kwazvo 350-800 U / MG. Total IgE wokuyera kwayo vana pasi pemakore kwemwedzi 12 kusvika 15 U / Rine mamiririta. IgE inoita basa rinokosha zvinoitwa pakarepo hypersensitivity. Immunoglobulin E wokuyera nedzevakuru siyana 0 kusvika 120 U / Rine mamiririta.

Maererano pfungwa ano, chikuru kushanda immunoglobulin E iri kudzivirira muviri mucous membranes nokuda activation vomunharaunda zvinhu zviri plasma uye effector masero. Utachiona vanokwanisa kupaza kuchengetedzwa mutsetse kuti vanoumba immunoglobulins dzekirasi A. Pashure mavhairasi kana utachiona pamusoro pemvura rechikepe masero kusungira kusaruraude immunoglobulin E kirasi, somugumisiro akadaro nekuita rechikepe masero vanogamuchira chiratidzo kusunungura pamusoro vasoactive amines uye chemotactic zvinhu, izvo zvinozoita chinokonzera inflow kuti achiparadzira IG mukirasi yacho G, mukwanisi, eosinophils uye neutrophils. Eosinophilic chemotactic chinhu, izvo asunungurwa rechikepe mumasero, kunoita kuunganidza eosinophils uye kuparadzwa honye. Zvinonzi vaidavira kuti IgE adsorbed pamusoro pemvura chisvetasimba, chinokwezva macrophages akavonga Fc-receptors.