Immunoglobulin G, nei achida munhu?

Zvinhu zvakawanda zvinopindura kurwisana nehutachiwana mumuviri womunhu. Imwe yenzvimbo dzinonyanya kukosha mune izvi ndeyekuzivikanwa kwema immunoglobulins, uye kuva yakanyatsojeka, immunoglobulin G. Pakati pemamwe marudzi e-immunoglobulins, ig Ig inokwanisa kuchengetedza muviri wechecheche kubva kune hutachiona, sezvo inokwanisa kukwanisa kupinda ropa raamai kuburikidza neparcenta, Ropa ruchiyerera rwemwana.

I Ig G mutekete inosanganisira subunit iyo inorema inenge 150 kD. Mune vanhu, pamwe chete mumakonzo, machina masukisi ane immunoglobulin G anotsanangurwa.Vakatanga kuonekwa achishandiswa nzira dzehuroloji yekuongorora. Hinge nzvimbo ye immunoglobulins inoratidzwa nenhamba yakawanda yemasara e cysteine uye proline molecules, iyo inosarudza kuchinja kwayo. Kusvibisa zvibvumirano mune chikamu ichi chema molecule zvinopesana, zvichibva pachitsigira che globulin. Saka, Gamma 1 neGamma 4 globulins dzine mabhii maviri disulfide, Gamma 2 - ina, Gamma 3 - gumi nerimwe. MuGamma 1 ketani, nzvimbo ye hinge inotangira kubva kuma216, uye inopera pa 231-m. Uye iyo hinge nzvimbo yeGamma 3 yeketani iri makumi mana nemanomwe gare gare kupfuura Gamma 1. Kuongorora kweiyi amino acid kuenzaniswa kunoita kuti zvive nyore kufunga kuti kuwedzera kwakadaro mumasara kunobatanidza kudzokorora kaviri kweGamma 1 maketani zvikamu 216-231. Hinge nzvimbo ine chinhu chinokosha: nekuda kwekubatana kwemaketani maviri akaoma, sangano rinogadzikana uye rinokonzera octapeptide rinosvika rinoshumira se-axis of rotation yezvose zvinoshandiswa hinge nzvimbo, uye naizvozvo nokuda kwezvikamu zveF Fab, izvo zvinonyanya kukosha pakubatana nemarudzi akasiyana-siyana emaanti.

Chizvarwa cheGig chinowanikwa panguva yekudzivirira kwekudzivirirwa kwemasimba ekudzivirira muviri, sezvo rudzi urwu rwechirwere chechirwere rinonyatsobudirira kupinda mukati mamasumbu, rinosunga uye, zvichizobviswa, rinobvisa maitiro anobva kune dzimwe nyika.

Nekuchengetedzwa kwema antibacterial mumuviri wemunhu inotarisirwa kunyanya immunoglobulin G. Kuwedzerwa rudzi urwu rwe globulin runogona kuva mumamiriro ezvinhu apo maitiro ezvirwere zvezvirwere zvekare anowanzotarisana nemamwe maitiro anobva kune dzimwe nyika uye akatanga kushingaira kukura ma antibodies. Nokudaro, kuonekwa kwakakodzera kwekuwedzera kwechiverengero chema immunoglobulin kunotibvumira kutanga panguva yakakodzera kuongororwa uye kurapwa kwezvirwere zvinokonzera mabhakitiriya akasiyana siyana nemavirusi.

Basa guru remhando iyi ye immunoglobulin ndekudzivirira muviri wemunhu kubva kune dzimwe nyika zvinogona kukonzera zvirwere zvinotapukira. Immunoglobulin G inorwisana zvose nemapachigoni ivo pachavo, uye nemichero yebasa ravo rinokosha ne opsonization, kuiswa kwepagocytosis systems uye rumbidzo.

Immunoglobulin G is thymus inotenderera, ndiko kuti, yakagadzirirwa mu thymus (thymus), nekubatanidzwa zvakananga kweT-lymphocytes. Iko rudzi rwe globulin ndiyo inonyanya chikamu che fraction reblobulin yeropa uye nhoroondo yeenenge 80% yemarudzi ese eununoglobulin. Nokudaro, kushandiswa kwezvinhu zvose zvinogona kuitika mumuviri, uyewo kujekesa mumamiriro ezvinhu hakusi kungopedzisira kushandiswa kweG Ig G, asiwo kubvisa zvachose.

Immunoglobulin G, iyo inowanikwa mumuviri inopesana zvichienderana nezera, inosvika pakupedzisira kwayo nemakore gumi nemashanu uye iri ma8-17 gramu neawa imwe yeropa. Muchiitiko ichi, immunoglobulins inokwanisa kuva kwete mumubhedha wemavhesi uye inopararira nemuviri pamwechete neropa, inogonawo nyore kupinda munzvimbo isina kuputika, kutanga kuita mabasa avo ose akawanda. Immunoglobulin G yakagoverwa pamwe chete mumubhedha wemavhesi uye mukati mimwe yose yomuviri maviri, kuitira kuti muviri unodzivirirwa kubva kune utachiona.