Kuongororwa Anti-CCP mune dzinonzi rheumatoid arthritis: wokuyera decoding

Medical nenhamba inoratidza kuwedzera nhamba uye kufambira mberi nezvirwere locomotor mugadziriro. Kuwedzera, varwere vakwegura vanotsutsumwa pamusoro kurwadziwa kwavo kurwadza kwemajoini. Vechiduku chirwere chiri kurega, uye vana vanotambura nawo. Joint chirwere zvakakosha kuziva mangwanani zvikuru nzendo kudzivisa kumwe dzavo kunoita nezvimwe matambudziko. Most muvanhu pfupa romunhu hurongwa chirwere dzinonzi rheumatoid arthritis kunoratidzwa panowanikwa yakaoma uye zvishoma yakaoma kurapwa. Uye nokuti munhu wose anotambura chirwere ichi munhu anofanira kuziva pamusoro Anti-CCP munhu akaidza pavarwere vane dzinonzi rheumatoid arthritis. Richava ndozvakajairwa munyaya ino.

Ndechipi Anti-CCP bvunzo?

RA, kana dzinonzi rheumatoid arthritis - ndiko kunzwisisa zvokurwara pamusoro mapfundo inokanganisa vose vana nevakuru. The chirwere kunoratidzwa kuzvimba synovial Kamudzira, kuparadzwa vagari shwashwa, uye ayo deformation. Migumisiro kuti abnormality haana kuona mukutanga mumatanho asina chokugutsikana nokukurumidza kurapwa kunogona kuva nengozi zvikuru. Deformation nokuparadzwa vadyi kunotoreva zvachose kana kukwana nokurasikirwa gwenya basa, riri kakawanda achishandisa vakaremara.

Sei kudiwa kuongorora Anti-CCP mune dzinonzi rheumatoid arthritis? Norma waivako kwakakosha.

Chii kuti?

Danho rinokosha riri rokuongorora dzinonzi rheumatoid arthritis mune nenguva nenzira iyo vanonyorera chinobudirira uye kwakarurama mishonga murwere, ndiko kumisa kushoma uye kudzorera kwemajoini ushande. Nokuti chinangwa ichi nzira mbiri kuti kubvumira kuona wevasungwa pamusoro antibodies kuti tsitrullinovomu cyclic peptide (Anti-CCP), uye RA chinhu (RF).

Rokuongorora abnormalities vachiri Danho, vanachiremba vari zano kushandisa Anti-CCP pachisara nekuti nzira iyi zviratidzo zvikuru yakarurama uye anobvumira kuziva chirwere zvisinei kwechikuva. Kuongororwa RF rakanyatsojeka, uye rakarurama zvabuda hunoenderana ya kukura zvokurwara.

Dzinonzi rheumatoid arthritis ari kuona zvakanaka mukutanga nguva yokushandisa Anti-CCP bvunzo. Uyewo, nemhaka ropa kwake kuziva antibodies uye zvezvinangwa kuti tenderedza ikoko, panguva kuchiita chirwere. bvunzo iyi anoyera hama mari tsitrullinovogo cyclic peptide antibodies muropa. peptide ichi - chinokosha chezvinonhuwira muviri. Citrulline achiumbwa panguva maitiro achishandisa nokukanganisika anginina kusawadzana amino acid.

Ndizvo Anti-CCP mune dzinonzi rheumatoid arthritis. Norma achapiwa pazasi.

Yambiro! Ndinofanira kutaura kuti citrulline haina mumabasa mapuroteni usage uye kunoratidzwa kwenguva imwe nguva kubva mumuviri.

Kana zvinokanganisawo Hudyu yemajoini muviri kaviri zhinji kuchinja. Panguva imwe chete nemamiriro puroteni amino iine acid cheni, kukanganisa functionality ari muhudyu shwashwa, akavaka citrulline. Peptide kuti rine citrulline, iri panoonekwa zvirwere sezvo dzimwe uye inobereka antibodies kuparadza kutyisidzira ichi.

Zvakanakirei sei kuongorora Anti-CCP mune dzinonzi rheumatoid arthritis? Norma zvinofanira kuzivikanwa kuti zvose.

zvakanakira Anti-CCP

Anti-CCP bvunzo kunobatsira kuona marudzi chete zvakasiyana yemajoini, kusanganisira RA, asi hapana nzira yakakodzera diagnosing zvimwe zvirwere. nzira iyi ropa serum kunzvera chinhu chimwe chezvinhu fastidious uye chaiwo panguva imwecheteyo, nokuti anoona kwete chete chirwere achiri padanho wake, asiwo pavaipfuura chirwere uye tsika dzaro. The bvunzo inoratidzwa kuti chirwere ose rheumatic mapfundo RA pakutanga kwayo kukura. Kudzidza kunoita kuti Wekumusoro rakakwana kurapwa zano, iyo anokanda panguva ndichipfeka kubvisa marwadzo uye kuzvimba nokubviswa, vanokurumidza Kuraswa zvirwere zvakadai dzinonzi rheumatoid arthritis.

CCPA ane zvakawanda zvakwakanakira pamusoro RF: yakakwirira ndingangokuvara kuziva miedzo Anti-CCP antibodies kuti inoverengeka yakanga yapfuura kukura nonspecific articular chirwere kana dzinonzi rheumatoid arthritis ari kupfuura kunzwisisa chimiro yemajoini; kuona kutanga nzendo RA muna 70%; kuona hunhu hosha; ona RA ari mberi danho 79% nyaya; specificity uye rakarurama ongororo kubudikidza 98%.

Uye ongororo zvose izvi zvinogona kuona Anti-CCP mune dzinonzi rheumatoid arthritis. Chii, hatina akaongororwa.

CCPA nzira inogona kunzi yakakwirira-zvakarurama, maererano nako navanachiremba ake vanogona kupiwa varwere vane zvose zviratidzo chearthritis. Maererano pakuongororwa zvinogona kutsunga muchimiro arthritis, uyewo kufungidzira kutira kwayo, izvo anobvumira kuti kupa akarurama murwere kurapwa.

Zvakakurukurwa nzira

Chii nzira wokugadzirira ongororo? Pashure Kutarisirwa murwere kuongorora Anti-CCP, anofanira kuchengeta wandei mitemo. havagoni kudya pamberi bvunzo (maawa 8). Chero mvura, kusanganisira tii, muto uye kofi, haagoni kushandiswa mukati maawa 24. Utongi uhwu zvinoshanda kusvuta nokuti uchisvuta vachafanira kurega fodya nokuti 2 kwemaawa kusvikira ichaongorora Anti-CCP mune dzinonzi rheumatoid arthritis. Tsanangudzo zvichange zvakawanda yakarurama. A chepfungwa bvunzo chete anogona kumutumidza akabata usina chawadya.

The bvunzo: imwe algorithm

The bvunzo rinoitwa kutora ropa kubva tsinga. Zvadaro, zvinonzi abudisa kubva whey, iro vakabva kushandiswa dzokuongorora kuti Anti-CCP. Akapora mu serum spetstsentrifuge. Zvichienderana nokukurumidzira ongororo uye rabhoritari basa, tinoguma kuwanikwa mukati pavhiki kana kamwe pazuva yaunodya.

Kunokosha! Serum inogona chando kamwe chete, ipapo tinoguma kare kuva kururama kana kuzodzosera oma.

Ko ACCP kuongorora muna dzinonzi rheumatoid arthritis? Chii, isu kare munoziva.

About pakutsvakurudza kwacho anoti: serum anoiswa mune bvunzo chubhu uye Laser-rayed. Nzira iyi inodaidzwa tsitofluometriey. By nokuparadzira Laser danda dzaro mvura hunhu anogona kutongwa musi asipo kana kuvapo Anti-CCP mumuviri.

mari

The kuongorora yakachengeteka zvachose uye nyarara murwere, asi pricey. bvunzo mutengo zvichisiyana chiuru zviuru mazana manomwe rubles, zvichienderana yokukurumidzira rabhoritari mitengo, kuitisa muedzo. Ongororo iyi haisi akatuma kuvarwere vose, anofanira kuongorora murwere zviratidzo uye zvichemo.

Next, funga kuita decoding pakati Anti-CCP bvunzo kunoguma dzinonzi rheumatoid arthritis.

wokuyera

Maererano pakuongororwa chiremba anoziva pamusoro kuvapo kana kusavapo RA, kuti fungidzira pavaipfuura chirwere uye kukuvadza kwayo kosi. Zvinofanira kucherechedzwa kuti muedzo uyu mushonga ndechimwe mashoma ane mwero hakuiti vakasiyana nevanhu vemazera akasiyana.

Pashure pokugamuchira ropa inogona inochengeterwa asina kupfuura pavhiki panguva tembiricha anosvika 8 inegumi.

Zvadaro ongorora CCPA mune dzinonzi rheumatoid arthritis. -200 madhigirii - ndiro Zvakanyanya Kunaka Panguva Yepamuviri nechando tembiricha ropa yokuenzanisira, zvino rinogona kuchengetwa nokusingagumi kana zvakakodzera.

Norm Kuongororwa varume, vakadzi uye vana vemazera ose kunogona kurondedzerwa 3-3.1 Iu / Rine mamiririta uye chete zvimwe zvisingawanzoitiki kacho anogona zvishoma kushanduka mukutanga makore nemwana kwete zvakazara kuumbwa mapfupa hurongwa - 2,7-2,7 U / Rine mamiririta; CCPA RA vakadzi vane pamuviri - 3.8-4 U / Rine mamiririta; mune vanhu vakwegura akabvumira zvishoma nezvishoma kuwedzera kusvika 2 U / Rine mamiririta.

Sei pamire ongororo?

Kufungisisa migumisiro pachisara nyanzvi ibasa zvakaoma kurapa, kubudirira izvo zvino kuzodzosera bvunzo. Kururama marapirwo anofanira kutongwa maererano kuderedza uwandu ropa serum antibodies. Zvarinomirira kuvapo Anti-CCP sezvo dzinonzi rheumatoid arthritis: 0-20 - chakarurama akaipa; 20,0-39,9 - akanaka, zvakaneta akaratidza; 40-59,9 - akanaka; Vanopfuura 60 zviyero - akanaka, akaratidza zvakasimba.

Kunokosha! Pasinei nokuti 20 U / ML anonzi kuti ndozvakajairwa pachisara vanamazvikokota vakawanda vanofunga kuti RA inogona kunze chete kana CCPA kuongorora parameters vari zero, kureva, pasina antibodies muropa Data.

mhedziso

Zvinofanira kurangarirwa murwere ose kuti CCPA ongororo chinonzi pa 95%, uye kana bvunzo zvakaguma kunaka, asi ine zvose zviratidzo dzinonzi rheumatoid arthritis, unofanira kuitisa okuwedzera miedzo vachishandisa dzimwe nzira nechirwere, chairayirwa kupinda chiremba.

Tataura kuongorora Anti-CCP mune dzinonzi rheumatoid arthritis. Vakadzi, varume uye vana kwomuzvarirwo tsika dziri siyanei.