Antidiuretic kemikari (ADH). The secretion pamusoro antidiuretic kemikari

Vasopressin - antidiuretic kemikari - zvinoberekwa hypothalamus, riri munzvimbo posterior pituitary (neurohypophysis). kemikari Izvi zvinoita homeostasis mumuviri womunhu, kuramba mvura nechiyero. Saka, Somuenzaniso, kupera mvura mumuviri kana hombe ropa pasi pokudzora vasopressin zvinosanganisira nzira kuitira kuti kumira mvura mvura kurasikirwa. Saka antidiuretic kemikari (ADH) hazviwirirani achititadzisa dziome.

Where ADH ari synthesized?

Antidiuretic kemikari anobudiswa guru muchitokisi Tutsinga tunofambisa mashoko utwu pakati supraoptic musimboti hypothalamus uye anosunga kuti neyrofizinom (akaendesa mapuroteni). Uyezve, akarayira akananga rwemberi akafukidza hypophysis uye ipapo kuunganidza pamusoro hypothalamic Tutsinga tunofambisa mashoko utwu. Sezvo zvinodiwa kubva ikoko anopinda neropa. ADH secretion iri sei:

1. BP (BP).
2. plasma osmolarity.
3. Bhuku ropa raishandiswa mumuviri.

Biological Migumisiro Anti-diuretic kemikari

Kana mukuru BP secretion pamusoro antidiuretic kemikari woutsinye uye Ukuwo, kuwa BP ne 40% kubva kwomuzvarirwo vasopressin usage zvinogona yakawedzera kubva zvatinosiita zuva chinodiwa ka100.

plasma osmolarity wakabatana zvakananga electrolyte Zvinoumba Ropa. Kana osmolarity ropa ikasawira pazasi shoma zvinogamuchirika mitemo, inotanga rakawedzera hurumende ichiisa vasopressin kupinda ropa. With kuwedzera yeplasma osmolality pamusoro bvumidzwa dzemunharaunda murume nyota. A kushandisa yakawanda emura anovanza kunayisa pamusoro kemikari. Saka, kudzivirirwa iri kuitwa kupera mvura mumuviri.

How antidiuretic kemikari unochinja kuchinja bhuku achiparadzira ropa? Kana muhombe ropa kurasikirwa chaiwo receptors iri atrium kuruboshwe akadana volyumoretseptorami kupindura vasanyanye ropa vhoriyamu uye BP inodonha. chiratidzo ichi anopinda neurohypophysis nekuona vasopressin inowedzerawo. The kemikari rine chiito pamidziyo ropa uye receptors ravo nhete ari lumen. Izvi zvinobatsira kumira ropa uye mberi kunodzivisa kuti donhwe BP.

Kutyorwa kuri kwetunhu uye secretion pakati ADH

Zvirwere izvi anogona vawadzane kukwana uwandu vasopressin kana ayo zvakawandisa. Somuenzaniso, cheshuga insipidus pane kukwana pamwero ADH, apo urwere Constantin Ion Parhon overabundance kwayo.

chirwere cheshuga insipidus

In chirwere ichi, renal reabsorption mvura shoma chaizvo. Izvi zvinogona akwanise nemamiriro ezvinhu zviviri:

1. Kukodzera secretion kuti vasopressin - kana toreva cheshuga insipidus nechepakati mavambo.
2. Akaderedza itsvo Kupindura ADH - ichi chinoitika kana neurogenic muchimiro chirwere cheshuga insipidus.

Varwere nechirwere ichi zvokurwara zuva diuresis ungasvika 20 litres. Weti apo yakaderera-yevasungwa. Varwere vanongogara nenyota uye vanonwa yakawanda Urume. Kuti tione muchimiro cheshuga insipidus murwere mhando uchitambudzika, kushandisa analogue kemikari inonzi vasopressin - mushonga "Desmopressin". The kuchirapa mugumisiro zvinodhaka kunoratidzwa chete panguva nechepakati chimiro chirwere.

urwere pakati kukodzera antidiuretic kemikari secretion

It Anonziwo urwere pakati kukodzera secretion pamusoro ADH. The chirwere kunoperekedzwa nokutaurisa secretion pamusoro vasopressin, apo pane kwakaderedza osmotic kumanikidzwa kuti plasma. Saka pane zvinotevera zviratidzo:

• Muscle twitching uye chinyamunhari chinorwadza.
• Kuda kurutsa, kushaya kudya, zvinogoneka kurutsa.
• Possible lethargy, pakoma.

Patient ezvinhu kuipa kana muviri Urume (nomutsinga kana kupinda mvura). Kana chakakomba akavarambidza kuti Urume yaunodya uye kukanzura intravenous aizomupa pavarwere kupinda kanganwiro.

Chii zviratidzo anoratidza chinhu kukwana pamwero vasopressin?

Kana antidiuretic kemikari iri synthesized havatorina, vanhu vanogona:

• Very nenyota.
• Kuita weti kakawanda.
• Kuoma ganda, iyo nguva dzose kufambira mberi.
• Kushaya kudya.
• Nezvinetso nemudumbu (gastritis, colitis, kupatira).
• Nezvinetso dzepabonde bhora. Varume - potency kuderedzwa vakadzi - kumwedzi zvirwere.
• Chisingaperi kuneta.
• Yakawedzera intracranial kumanikidzwa.
• Neb chiratidzo.

Sezvinoratidzwa vasanyanye pamusoro ADH?

Zvinoderedza ropa vasopressin kunogona kuitika mumamiriro anotevera:

• Central cheshuga insipidus.
• Nephrotic syndrome.
• Psychogenic polydipsia.

Ndezvipi zviratidzo womuratidza vawedzere secretion pamusoro ADH?

• Neb daily diuresis (weti production).
• Kufuta panguva shoma kudya.
• Lethargy uye dzungu.
• Nomusoro.
• Svoto uye kurutsa.
• Tsandanyama chinyamunhari chinorwadza.
• Various maronda ose tsinga.
• hope vachivavhiringidza.

Under chii ezvinhu ari akaona kuwedzera huwandu ADH?

Zvakawanikwa vasopressin anogona kuonekwa pathologies chemafuta akawandisa secretion kemikari inonzi, zvinosanganisira:

• Julien-Pazvibato zvechizarira syndrome.
• Intermittent chenjera porphyria.

Uyezve, zvinokwanisika pasi zvinotevera ezvinhu:

• rouropi (chikuru kana metastases).
• Zvirwere wouropi.
• Vascular zvirwere uropi.
• Tuberculous yomumuzongoza.
• Nemabayo.

Antidiuretic kemikari - apo kusarenda?

Chimwe chezvinhu nzira dzinoshanda kuti kutsunga ADH muropa riri radioimmunoassay (Ria). Parallel kuona osmolarity ropa plasma. The kuongorora zvinogona kuitwa chero momuviri pakati. private makiriniki vakawanda kuita Analyses akadaro. Ropa akabata kubva tsinga kupinda sepombi pasina preservatives.

Usati wakurukura ropa kusvikira antidiuretic kemikari inofanira kuva 10-12 awa yokumbozorora kudya. Mumuviri uye mupfungwa kunokonzerwa pamusoro avaida ropa mupiro inogona kukanganisa kuongorora. Izvi zvinoreva kuti zuva chokuendesa ari kuongorora zvinokurudzirwa kuti vasaite rinorema mumuviri basa, kwete kuita mitambo makwikwi, haisi kutora bvunzo, etc.

Zvinodhaka kuti anogona kuwedzera huwandu ADH, kunofanira kuregwa. Kana ichi zvisingaiti upi chikonzero, chikumbiro siyana zvakafanira tsanangurai chii mushonga raishandiswa, apo uye chii dose. Vasataura chaiye nenhanho ADH anogona zvinodhaka zvinotevera:

• estrogens;
• uvete mapiritsi;
• dzokutindivadza;
• mapiritsi;
• "Morphine";
• "Oxytocin";
• "Cyclophosphamide";
• "Carbamazepine";
• "Vincristine";
• "Hlorpropamid";
• "Chlorothiazide";
• "Lithium carbonate".

Kuongororwa antidiuretic kemikari zvinogona kutora yapfuura pane vhiki imwe pashure radioisotope kana radiological tsvakurudzo.

Kudzidza uku kunotipa kusiyanisa nephrogenic chirwere cheshuga insipidus uye pituitary chirwere cheshuga insipidus uye syndromes chemafuta akawandisa secretion pamusoro ADH.