"Celecoxib": mirayiridzo kushandiswa, wongororo. zvinodhaka analogues

Mishonga yezvirwere chokuita kuchikuvadza zvetsandanyama nemapfupa hurongwa, zvinodiwa kubva mishonga kumusika kusika zvinodhaka itsva vashoma nemishonga uye mukuru kunyatsoshanda. Masayendisiti akawana uye synthesized chizvarwa chitsva vasiri steroidal Anti-anogumbura zvinodhaka nokuda celecoxib. mishonga izvi kwakaderedza toxicity uye nani akashivirira pachitunha.

Achirondedzera "Celecoxib" chinodhaka

Fuma celecoxib ane rakachenuruka yero ruvara uye rinoreva boka coxibs izvo kuratidza chinovhiringidza zvokusarudza kuti cyclooxygenase rechipiri mhando. Medicaments inobva yeimwe aripo dzive akazivisa Anti-anogumbura uye marwadzo zvivako. Chepakutanga chinodhaka pahwaro celecoxib anoonekwa kuti kugadzirwa American kambani "Pfizer" zvinodhaka "Celebrex". zvakanga akadzidza uye havawanzoiti pharmacodynamic unhu toxicity kuti muviri womunhu.

Vamwe medicaments ine zvinoshingaira fuma celecoxib vari Generic, kusanganisira zvinodhaka "celecoxib".

chipimo chemushonga siyana

Available mushonga mu zvakaoma gelatin capsules ari chipimo chemushonga pamusoro vanoshingaira chirungiso, 100 MG uye 200 MG. Kusiyana nevamwe vasiri steroid Anti-anogumbura vamiririri, haana chipimo chemushonga chimiro sezvo okuzora, gel, injectable zvingaitwa kana suspensions. Vamwe varwere chikanganiso kunzi kusunungurwa chimiro "Celecoxib" chinodhaka - pamahwendefa, kunyange tiri kutaura pamusoro capsules.

mamiriro

The rinoita chirungiso iri celecoxib fuma iri mari 100 MG uye 200 MG. The Zvinoumba capsules zvinosanganisira ebetsero zvinoriumba kuti anopa nzvimbo zvekupfakira, kuti flowability uye kutsiga granulated nezvakasanganiswa. Izvi zvinosanganisira lactose, yavaibvisa lauryl sulfate, polyvinylpyrrolidone (K30), yavaibvisa croscarmellose, magnesium stearate.

Vasiyana mushonga "celecoxib" mirayiridzo Chinyorwa unotora murwiyo uye maitiro nezve gelatin Kamudzira deko. Maererano description, inoratidza mikukutu, vane dzinenge chena ruvara uye anozivikanwa nezviratidzo "100" kana "200", iri yebhuruu kana yeyero bhendi, ukuwo. Izvi zvinobvumira kusiyanisa capsules pamwe dosages zvakasiyana. Zvinoumba yeyero uye zvitema inks tiri kupendwa akadzama kuzozvidzorerwa madhayi hazvikuvadzi muviri.

zvinodhaka zvakafanana

Somushonga chigadzirwa "Celecoxib", analogues icho rinewo zvinoshingaira fuma celecoxib, anogona kuratidza zvakafanana kuchirapa sei chemajoini womunhu marangwanda.

The yepakutanga chinodhaka "Celebrex" uye ayo Generic "Celecoxib", "Artoksib", "Zitsel", "Revmoksib", "Ranseleks" vanoonekwa mishonga kuchinjaniswa. Zvisinei, pakutanga mutengo muchikwata achaita mari akarayira kuti unokosha anodhura pane vazvo.

Mukugadzirira "Celebrex" rine celecoxib ari chipimo chemushonga 100 uye 200 MG somunhu medicament "celecoxib". Ebetsero zvinoriumba of Kamudzira uye hamvuropu yaro zvingasiyana zvose Qualitative uye quantitative sezvamunoita usingabereki kukanganisa ehupfumi dzavo. Nezveshoko chimiro kwebhuku Generic "Celecoxib" chinodhaka analogues anobudiswa chete zvakaoma gelatin capsules kuti pezviri kushandiswa.

Kune non-steroidal Anti-anogumbura vamiririri, cyclooxygenase zvakaenzana kushandiswawo wechipiri mhando asi une kusiyana murwiyo yezviri zvinoriumba, asi pharmacokinetic uye pharmacodynamic maitiro. Izvi zvinosanganisira sulfonamide mukomboni nimesulide izvo zuva chipimo chemushonga ine 200 MG zvinobudirira anobata zviratidzo chemajoini uye dzinonzi rheumatoid arthritis. Formulations kwakavakirwa yayo Anti-anogumbura uye marwadzo chaizvoizvo kupfurikidza zvichivhiringidza ari cyclooxygenase wechipiri uye muduku zvakadini - wokutanga mhando, kukanganisa siyana nevamiririri kurwadziwa uye kuzvimba.

Sezvo nimesulide, celecoxib ndiye mumiririri sulfonamide kirasi zvinhu, uyewo zuva chipimo chemushonga pakati 200 MG anobvisa zviratidzo chemajoini. Hazvina tunodzivisa cyclooxygenase wokutanga mhando uye mabasa ari vashoma nevamiririri kurwadziwa uye kuzvimba.

An kumwe kurapa coxibs nomumukanwa Kutarisirwa vari injectable siyana NSAIDs. Mumwe mukuru zvakanakira "Celecoxib" chigadzirwa - mutengo. Majekiseni (ampoules kuti jekiseni) nevamwe vasiri steroidal Anti-anogumbura zvinodhaka mari anodhura, asi izvozvo jekiseni kunyatsoshanda nokure kuti mugumisiro nokushandisa zvinodhaka mune chikukutu siyana.

mashandiro chiito

Drug "Celecoxib" - mushonga kuti anomirira chizvarwa chitsva nonsteroidal Anti-anogumbura vamiririri, Anti-anogumbura, unonyaradza marwadzo, antipyretic basa. mashandiro ayo zvinoitwa chokuita ichivharira paumbwe anogumbura prostaglandins Akaroromesawo basa Cox-2.

Anogumbura siyana chirwise induction pamusoro cyclooxygenase yechipiri mhando, zvinozoita Inowedzera kuunganidza prostaglandin usage uye zvinhu kuti tiwedzere kuzvimba. State anovandudza kuzvimba uye kurwadziwa.

Cyclooxygenase rokutanga mhando asingadi kukanganisa kuchirapa dose "celecoxib" gadziriro. Mirayiridzo yokushandisa anorondedzera inertia zvinodhaka pakureva enzayemu ichi chokuita ayo mabasa vasiri pezvakaitwa kuitika mumasero nemudumbu uye platelet ezvirevo.

Uyewo, zviri yakapiwa umboo hunotsigira matambudziko kwezvinodhaka pamusoro neitsvo. Under Zvakaitwa celecoxib idukusa rairatidzwa weti sezvamunoita prostaglandin E2 uye F1 6-keto-prostaglandin, asi hazvichinji hurumende ichiisa B2 11-dehydro-thromboxane, izvo zvinoratidza haangotongi mugumisiro mishonga yacho.

Kushandisa zvinodhaka "Celecoxib" haitungamiriri vasanyanye ari filtration mwero iri itsvo glomeruli vakwegura uye varwere renal insufficiency.

Zvairatidza yokushandisa

Maererano pharmacodynamic zvechadenga kugadzirira "celecoxib" Chikumbiro ichava zvakabatsirawo pakurapa RA uye psoriatic chearthritis, chisingaperi kuzvimba pamwe kwokurwadziwa musana uye sacroiliac mapfundo uye osteoarthritis.

Nokuda kwayo unonyaradza marwadzo ehupfumi zvinoshandiswa anorwadza ezvinhu mune zvetsandanyama nemapfupa marwadzo mushure kuvhiya kurapwa, dysmenorrhea, icho pamwe kunorwadza kumwedzi. Anti-anogumbura mugumisiro zvinodhaka nechinangwa yokuderedza outgrowths uye polyps ari muura uye mugaranhoko iri nechirwere kuti "adenomatous polyposis".

How kutora

Tora mushonga "Celecoxib" mirayiridzo kushandiswa mukati rinokurudzira haana unobatanidza pamwe kudyiwa zvokudya. The capsules regai kuvhura uye kwete rikamunya muchindwi, uye ikamedza rose nokunwa mvura yakawanda.

The kunonyanyisa yakawanda celecoxib, izvo zvinogona kutorwa pazuva iri 0,4 d gadziriro iyi rinoshandiswa zvakanyanya chete zvisingawanzoitiki zviitiko.

Zvemwoyo yematambudziko zvinogona kukonzera dzakakwirira mishonga uye kwenguva refu kurapwa pamwe zvinodhaka "Celecoxib". Guide rine mashoko dosages diki kuti symptomatic kunorapwa nerimwe kuverenga. Rinopa kurumbidza pakushandisa pfupi.

Kubvisa zviratidzo chokuita osteoarthritis, uye ankylosing spondylitis, tora mumwe kana vaviri nguva zuva nezuva 200 MG zvinodhaka.

Kubvisa zviratidzo dzinonzi rheumatoid arthritis achishandisa zuva dose kuti 200 kana 400 MG, iyo yakatorwa sezvo kaviri.

Marwadzo uye chikuru dysmenorrhea ikarapwa rokutanga zuva mukuru dose 400 MG, pamwe zvinokwanisika kugamuchira mamwe 200 MG, pazuva uchishandisa 200 MG 2 kanomwe pazuva.

Vakwegura, uye varwere vane munyoro dhigirii kukwana chiropa kana nounyoro kuti zvive nomwero renal insufficiency, hapana recalculation kuti dose rinoitwa.

Low uremu (asingasviki 50 kg), avhareji kwokuomerwa chiropa kukundikana - date Categories varwere zvakaipa pamwe yakaderera mishonga kurapwa waakaudzwa.

Kazhinji, nokuti pakurapa anogumbura pezvakaitwa mu majoini vaishandisa kurapwa gadziriro kwakavakirwa kushandiswa kwezvinodhaka dzinoverengeka siyana chipimo chemushonga siyana. Sangana "celecoxib" Kamudzira, mafuta, kana gel-mhando nokudziya "Apizatrona" kana "finalgon. Topical kunokanganisa kwekanguva Chaizvoizvo, saka vari kushandiswa pamwe zvinodhaka nokuda indoor mabiko.

Izvi unorambidza kushandiswa

Havasi varwere vose nezvirwere ose mapfundo, unogona kutora zvinodhaka "Celecoxib". Mirayiridzo dzokushandisa ine mazita zvirwere uye mamiriro umo chishandiso zvichava zvikuru kukuvadza pane zvakanaka. Idzi dzinosanganisira:

• mikoko, asima, sema ezvinhu nokuda kuitwa asipurini nezvimwe nonsteroidal Anti-anogumbura zvinodhaka;
• kupora mashandiro chokuita coronary tsinga yokunzvenga kusonanidzwa ;
• exacerbation pamusoro peptic urikanwi;
• dumbu uye intestinal ropa;
• kuzvimba mucosa ari muura;
• mwoyo kutadza;
• ischemic zvirwere pomwoyo;
• kurasikirwa peripheral arteries uye midziyo chepfungwa pamwe havachanyatsogoni chepfungwa ropa riyerere;
• hepatic nedostatochnosttyazheloy chimiro;
• zvakakomba renal kukundikana;
• vana;
• kuyamwisa mwana;
• pasi pemakore gumi nemasere;
• hypersensitivity kune Excipients;
• yakawedzera susceptibility kuti chikamu sulfonamide.

With nokungwarira kushandiswa zvinodhaka "Celecoxib" vanofanira kuva vanhu vane zvirwere nemudumbu chokuita peptic urikanwi ropa kare, utachiona pamusoro mucous mabhakitiriya ari genus Helicobacter pylori.

mvura chengetedzo mumuviri uye akapfava munyama edema, zvirwere chiropa yechipiri pachikuva, mwoyo uye vascular zvirwere, mumuviri, sezvamakaropafadzwa kuwedzera remafuta akawandisa pamwero ari plasma vakachengeta lipid muviri, chirwere cheshuga, shuga, somatic nezvirwere zvakakomba uye vane chikonzero kunonyanyisa nokungwarira kushandiswa zvinodhaka "celecoxib" pasi pokudzora chiremba.

nemishonga

Pasinei itsva kubudirira pakasikwa chizvarwa chitsva coxibs, izvi zvinhu uye zvinodhaka kwakavakirwa pavo havana isina marwadzo.

Vachifambidzana mushonga "Celecoxib" mirayiridzo kushandiswa, murefu uchapupu uye vanachiremba - mabhuku aya ane mashoko pamusoro zvichibvira nemigumisiro kuti zvingaitika rinokosha zvomukati.

Zvingangoitwa nezvainoita zvomudumbu ezvinhu hwokuratidza NSAID-gastropathy, marwadzo mudumbu, kuda kurutsa, kurutsa, chirungurira, kuderera kudikanwa kwezvokudya yaunodya uye manyoka. Kushandiswa mukuru mishonga kwenguva refu kunogona kukonzera ulceration uye ropa iri mucous Kamudzira mudumbu uye ura, ropa matadza, kunyanya activation pamusoro transferase chiropa.

Huta Zvirwere zvinozarurwa mufaro, nomusoro, dzungu, somnolence, kushaya hope, mwoyo inoti.

Kubatsira Kwavanoita kumwoyo nokuda yakawedzera kuomesa ari arteries, uye tachycardia.

Kugadzirira "celecoxib" kunoderedza kuramba zvirwere zviri kufema ino, izvo zvinogona kuratidzwa kukura sinusitis, rhinitis, pharyngitis, marwadzo mumhino uye pahuro, chikosoro, dyspnea, bronchospasm.

Matambudziko ari zvinodhaka riri pfungwa chinokonzera zvinoderedza auditory maonero uye chitarisiko tinnitus.

On nezvezvimwe zvinetso zvedundira zvakunoita zvinodhaka "Celecoxib" kuti mugamuchire renal kukundikana pamwe kukura edema syndrome.

Maererano ropa-Anoumba nhengo, mushonga anogona kukonzera kuratidzwa agranulocytosis, kupererwa neropa, leucopenia, thrombocytopenia.

Skin rashes zvingaitika pamwe zvinenge sema pruritus, urticaria, photosensitivity, angioedema iri pachiso nharaunda, migumo, nhengo dzokubereka nadzo.

Features mutambo

Drug "Celecoxib" yokusafa chinetso chokuita mikana yakawanda nemigumisiro kumwoyo kunotungamirira thrombosis, infarction pamusoro myocardial hunoshamisa pamusoro tsandanyama uye sitiroko. Kunyanya kuwedzera ngozi panguva chisingaperi kwokubatsira mishonga nevarwere maari mune zvemwoyo.

Yekuzvidzivirira yematambudziko kwakadaro varwere kutora zvinodhaka "Celecoxib" mishonga yakadereresa dose dzakawanda pfupi kurapwa. Murwere anofanira kukurukura nachiremba wako zvingangoitika zviratidzo chirwere uye kugamuchira zano iri sei paanenge.

shandisa wemishonga acetylsalicylic asidhi mu usingashandi mishonga kuti zvinodhaka "celecoxib" Kuti kuderedza zvemwoyo zviratidzo. Reviews kuvarapi anoratidza antiplatelet mugumisiro nokuda asipurini kuti dzakaonda ropa kana achitora coxibs, izvo havana kudaro Anti-thrombotic ehupfumi. Kazhinji, zvakadai mubatanidzwa kunoratidzwa varwere vakwegura zvinetso zviri zvetsandanyama nemapfupa emuviri uye kumwoyo, gastrointestinal toxicity ichiwedzerwa apo non-zvokusarudza vasiri steroidal Anti-anogumbura zvinodhaka. Asi kushandisa pfuma celecoxib nevamwe NSAIDs haina inokurudzirwa.

For varwere vanenge cheBP, ari kuramba richiona nezvezvabuda parameter ichi apo kugamuchira "Celecoxib" chinodhaka.

Pfungwa dzinofanira kupiwa vachiongorora mamiriro nhengo akabatana anticoagulant (warfarin) uye antiplatelet zvinhu (acetylsalicylic acid, clopidogrel) kushandisa FIs zvokusarudza (citalopram, sertraline), zvichivhiringidza kweserotonin reuptake FIs pamusoro CYP2C9 isozyme, piritsi siyana glucocorticosteroids.

The mushonga "celecoxib" inosimudzira kugadzirwa prostaglandin zvinhu, izvo kutadzisa nemvura mumuviri uye inoita kuti pave edema. Zvikurukuru kungwarira pakurapa zvinodhaka izvi vanofanira kuva vanhu vanotambura pomwoyo kukundikana uye cheBP. vanofanira kurega kutora "Celecoxib" mushonga kana paine zviratidzo mumatenhere munyama.

Varwere itsvo zvirwere kurapwa coxibs zvinofanira pamwe kugara achitarisirwa dzavo dzinokosha zviratidzo.

Kana kupera mvura mumuviri kutora mushonga zvinogoneka chete pashure rehydration kosi rehydration.

Kugamuchirwa "celecoxib" antipyretic mushonga nokuda chiito kunotungamirira kuomesa ari kurwara nacho indekisi, sezvo tembiricha yakakwirira munguva kukura noutachiona ezvinhu.

Zvakaitwa zvinodhaka kungaita abnormalities mu chiropa basa, kunyanya vanhu vane pre-huripo kusagadzikana chiropa. Zvakakomba zviratidzo chokuita fulminant chiropa, chiropa nekrozomtkaney. ezvinhu akadaro kuitika pakarepo, asi mazuva chete pashure 30 pashure kushanda "celecoxib" gadziriro. Zvino unoda akuteerere kuita pakurapa chiropa chivako ichi, uye kana inorema vakakurirwa unofanira kukurumidza kukanzura kugadzwa.

Reviews nokuti pakurapa "Celecoxib"

Nonsteroidal mishonga Anti-anogumbura unotakurwa chete mushonga. Zvakabuda kushandiswa "Celecoxib" chinodhaka wongororo kwayo kuita zviri yakavhenganiswa. Imwe mishonga kunobatsira kurarama anogumbura pezvakaitwa majoini, nokuti vamwe hazvina basa uye kunokonzera dzinoverengeka nematambudziko zviitiko.

Sezvo varwere vakawanda vanoongorora mushonga "Celecoxib"? Reviews dzinoratidza nhamba matambudziko: kurwadziwa mudumbu, itsvo, kumwedzi zvirwere. chiremba varwere kwakadaro anoitisa kukanzura medicament uye ibasa kumwe kurapa.

Zvichienderana zvinofungwa varwere pamusoro zvinokonzerwa zvinodhaka pamusoro zvomoto mapfundo, zvinganzi kwakagumisa kuti abudirire pakurwisa chearthritis. Kuti vanyatsopedza marwadzo zviratidzo, kuzvimba munyama Munzvimbo imwe chirwere hunhu, varwere vari mumatsutso uye muchirimo mwero zvinodhaka mishonga "Celecoxib". Rinoshandiswa vatambi vari kunotevera uye mapfundo.

Kunyanya medicament anoita zvinobudirira akabatana achidziya nezvizoro uye gels kuti kukamura uchishandisa kushanda. Zvisinei, maererano kunenge zviri mirayiridzo kushandiswa yakapiwa NSAID vanoshandisa pfupi kosi, kuitira kuti vadzivise kuzvidya mwoyo pamusoro itsvo, chiropa, mwoyo uye dumbu. Zvikasadaro kwete kunzvenga kukundikana mubasa mitumbi izvi.