Mishonga uye kuvaka muviri. Yakakura uyerostenedione

Androstenedione inoreva mahomoni evanhukadzi. Iyi androgen inotangira testosterone. Mune varume, iyo inogadzirwa inoitika, kunyanya mumatete. Madzimai, 60% ye androstenedione inokonzerwa nekuchinja kwemhirizhonga, 40% inobudiswa mumaratani uye mavari. Mune vamiririri vevakadzi vasina simba, chiyero chekugadzirisa uye kuchengetedzwa kwei hormone yakakwirira kudarika iyo ye testosterone, uye imwezve-adrenal shanduko yayo mu testosterone inonyanya kuratidzwa.

Nhamba ye androstenedione inotsanangurwa muDHEA-C uye DHEA yakaoma. Izvi zvakakosha pakuongororwa kwezvinangwa uye nekuongorora maitiro ekurapa mumamiriro ezvinhu hyperandrogenic.

Yakakura uyerostenedione muhutano weropa ndiyo inoratidzwa nevarwere vane hyperplasia ye adrenal cortex yemuongorori. Mukuwedzera, chikwata chakareba chinowanikwa neIsenko-Cushing syndrome, testicular stromal hyperplasia kana neoplasm muovary, pamwe ne ectopic ACTH secretion.

Yakakura uyerostenedione inowanikwa kune varwere vane hirsutism uye polycystic ovary.

Mune zvekurapa, kusarudza kwema-serum hormone concentration kunowanzoshandiswa pakuongorora kubudirira kwehutano hwehutano nekushandiswa kweglucocorticoids mu congenital hyperplasia ye adrenal cortex, sezvo ichionekwa sechiratidzo chinonyatsonyanya kupfuura mamwe androgens.

Kwete yakakwirira uyerostenedione, uyewo zvinyorwa zvayo, zvinyorwa zvishoma zvishoma zvinoratidza kuvapo kwerekwe-cell anemia. Pathology inokurwisana nechekuita kweavoan uye kuwedzera kwekushaya simba.

Androstenedione. Ndeipi nguva yokutora muedzo?

Zviratidzo zvekudzidza ndezvi:

- Kurapa kurapwa uye kuongororwa kwemamiriro e hyperandrogenic;

- kutyora kwekuberekwa kunoenderana nechekuguma kwekushaya simba kwehomoni ;

- kurapwa ne glucocorticoids.

Kunyatsotarisirwa kunopiwa na androstendione nevanhu vanoita basa rekuvaka muviri. Inofungidzirwa kuti hormone nemishonga pamwe nehuwandu hwayo zvinobatsira kuti kuwedzera kwemisasa mizhinji. Zvisinei, izvi hazvisi nguva dzose.

Androstenedione ndiyo inonzi hormone huru yemadlands uye inogona kushandurwa kuva testosterone kana estrogen. Muchiitiko chekutanga, kushandurwa kwaro kunokurudzirwa neimwe enzyme. Inofanira kuonekwa kuti mune steroid chain of transformations, androstenedione iri pedyo ne testosterone kupfuura DHEA. Izvi zvinokonzera kukosha kwekushandura. Nokudaro, testosterone, yakawanikwa nechekuita kwekutendeuka kwe androstenedione, pasi pekuita kweimwe enzyme, inogona kupinda mu dehydrotestosterone. Izvi, zvakare, zvinobatsira pakuvandudzwa kwemigumisiro yakaipa yakawanda. Dehydrotestosterone inokonzera kusuruvara kwemvere kwemusoro, uye kuwedzera kweprostate gland, pamwe nekukura kukuru kwevhudzi pamuviri uye chiso. Mukuwedzera, hauna anabolic zvinhu, saka hazvina maturo pamusana wemasero. Nokudaro, kana androstenedione yakasimudzirwa, kune mukana wekuwedzerwa mukati mekutengesa dehydrotestosterone.

Mukuwedzera kumigumisiro iri pamusoro apa, pane chimwe chikonzero - gynecomastia. Kukura kwebonde kunoita kuti kutendeuka kwe testosterone ku-estradiol (aromatization).

Pasinei nekusimbiswa kwevashambadziri vakakwira uyerostenedione zvakanyanya kukanganisa kukura kwemasumbu, kana yakatorwa zvakanaka, hormonal "manipulations" kazhinji isingazivikanwi uye yakaoma nzira. Inofanirawo kuyeukwa kuti kuwedzera kwemasero e testosterone nemishonga inodhaka pasina mubvunzo kunokanganisa nzira iyo inodzora kugadzirwa kwepabonde steroid.

Nhasi, androstenedione uye nemigumisiro yayo kuvanhu haisati yakadzidza zvakakwana. Mukuwedzera, kana uchitora izvi kana zvimwe zvinodhaka zvemishonga inofanirwa kufungisisa maitiro emumwe nemuviri. Somuenzaniso, kune dzimwe, kuwedzera kukanda kwe androstenedione kunobatsira pakukura kwemasimba, asi mune vamwe inokonzera zvinetso zvakakomba.