Phospholipid syndrome: zvinokonzera uye kuongororwa

Phospholipid syndrome ndiyo yakajairika yakaremara yezvokutanga. Kurwisana nemamiriro ehutachiona kazhinji pane zvipembenene zvemitsipa yeropa, itsvo, mapfu uye dzimwe nhengo. Mukushayikwa kwechirwere, chirwere chinogona kutungamirira kune zvinetso zvinotyisa kusvikira murwere afa. Uyezve, chirwere ichi chinowanzowanikwa kuvakadzi panguva yekuzvitakura, izvo zvinowedzera utano hwaamai nemwana.

Zvechokwadi, vanhu vazhinji vari kutsvaga ruzivo rwakawedzerwa, vachibvunza mibvunzo pamusoro pezvikonzero zvinokonzera chirwere chacho. Ndezvipi zviratidzo zvandinofanira kutarisa nazvo? Pane kuongororwa kwephospholipid syndrome here? Mishonga inogona kupa nzira dzinobatsira dzokurapa here?

Phospholipid syndrome: chii ichocho?

Kwenguva yokutanga chirwere ichi chakatsanangurwa kwete kare kare. Mashoko ehurumende pamusoro pake akabudiswa muma1980. Sezvo akashanda pakudzidza Chirungu chechirungu chechiGiriki Graham Hughes, chirwere ichi chinowanzonzi Hughes syndrome. Kune mamwe mazita - antiphospholipid syndrome uye syndrome ye antiphospholipid antibodies.

Phospholipid syndrome chirwere chinotapira muviri umo maitiro ezvirwere zvemasimba anotanga kubudisa zvirwere zvinorwisa phospholipid yemuviri. Sezvo izvi zvinhu zviri chikamu chemasvingo emagetsi emasero akawanda, zvipembenene mune chirwere chakadaro zvinokosha:

• Zvirwere zvinorwisa zvirwere zvinopera masero endothelial, zvichideredza kufanana kwekukura kwezvinhu uye prostacyclin, iyo inokonzera kukura kwemasvingo emidziyo. Kurwisana nemamiriro ehutachiona pane kuputsa kwe platelet aggregation.
• Phospholipid inowanikwawo mumadziro eparlatelets ivo, izvo zvinoita kuti kuwedzere kuwedzera kwavo, pamwe nekuparadzwa nokukurumidza.
• Mukuvapo kwezvirwere, kune kuwedzerwa kwekuvhara ropa uye kuderera muheparin basa.
• Nzira yekuparadza haifaniri kupfurikidza nemasero emagetsi.

Ropa rinotanga kubatana mumidziyo yeropa, kuumba ropa rinoputika, izvo zvinokanganisa kubuda kweropa, uye naizvozvo, mabasa ezvimwe nhengo dzakasiyana - iyi ndiyo nzira iyo phospholipid syndrome inokura. Zvinokonzera uye zviratidzo zvechirwere ichi zvinofadza kune vanhu vazhinji. Pashure pezvose, yekutanga chirwere chacho chinoonekwa, zvishoma zvinetso zvichaitika mumurwere.

Zvinokonzera kukonzera kwechirwere

Nei vanhu vachikura phospholipid syndrome? Zvikonzero zvinogona kunge zvakasiyana. Zvinonyatsozivikanwa kuti kazhinji muvarwere kune mararamiro anokwana. Chirwere chacho chinowedzera munyaya yekushanda kusina kunaka kwezvirwere zvemuviri, izvo chimwe chikonzero kana chimwe chinotanga kubudisa zvirwere kumasero ehupenyu hwayo. Chero zvazvingaitika, chirwere ichi chinofanira kuva chakatsamwa. Kusvika iye zvino, masayendisiti ave akakwanisa kuongorora huwandu hwezvipingamupinyi:

• Kakawanda phospholipid syndrome inorwisana nemamiriro ezvinhu e microangiopathies, kunyanya, trobocytopenia, hemolytic-uremic syndrome.
• Zvimwe zvinokonzera njodzi zvinosanganisira dzimwe zvirwere zvinodzivirira, zvakadai se lupus erythematosus, vasculitis, scleroderma.
• Chirwere ichi chinowanzotanga mukuvapo kwezviremara zvinouraya mumuviri wemurwere.
• Zvinokonzera njodzi zvinosanganisira zvirwere zvinotapukira. Inonyanya kuipa ine infectious mononucleosis uye AIDS.
• Zvirwere zvinogona kuonekwa neDIC-syndrome.
• Zvinonyatsozivikanwa kuti chirwere chinogona kukura nekusara kwekutora mamwe mishonga, kusanganisira hormonal contraceptive, psychotropic drugs, Novokainamid, nezvimwe.

Zvinonzwisisika, zvakakosha kuziva kuti sei murwere wacho akasika phospholipid syndrome. Kuongororwa uye kurapwa kunofanira kuziva uye kana zvichibvira kubvisa chinokonzera chirwere chacho.

Kushungurudzika kwemwoyo nematambudziko ne phospholipid syndrome

Ropa nemidziyo yeropa ndizvo izvi "zvinangwa" zvekutanga zvinokanganisa phospholipid syndrome. Zviratidzo zvaro zvinoenderana nesero rechirwere. Thrombi, semitemo, yakatanga kuumbwa mumidziyo miduku yemigumo. Vanovhiringidza ropa, iyo inofambidzana nematumbu ischemia. Iyo nhengo yakagadzikana inogara yakanyanya kune yakaoma kusvika kumagunha, ganda rinenge riri, uye musuru zvishoma nezvishoma atrophy. Kuvhiringidzika kwenguva refu kwezvinhu zvinotungamirira kunotungamirira ku necrosis uye nechechi inotevera.

Thrombosis yemvura yakadzika yemigumo inogonawo kuitika, iyo inofambidzana nechitarisiko chedema, kurwadziwa, uye kusununguka kwekufamba. Phospholipid syndrome inogona kuomeswa ne thrombophlebitis (kuvhuvhuta masvingo emasvingo), iyo inofambidzana nefivha, chills, kugadziriswa kweganda munzvimbo yakakanganiswa uye kurwadziwa kwakanyanya, kwakanyanya.

Kuumbwa kwe thrombi mumidziyo mikuru kunogona kutungamirira kukurudzirwa kwezviitiko zvinotevera:

• Aortic syndrome (inofambiswa nekuwedzera kwakakonzerwa nekudzvinyirirwa mumidziyo yepamusoro muviri);
• Syndrome yepamusoro vena cava (nokuti chiitiko ichi chinoratidzwa nokuzvikudza, cyanosis yeganda, kubuda kubva mumhino, trachea uye sophagus);
• Syndrome of the inferior vena cava (inopesana nokuputsana kweropa mumhepo yakadzika, kuputika kwemagumo, kurwadziwa mumakumbo, mabhu, mimba uye kugomera).

Thrombosis inobata basa remwoyo. Kazhinji chirwere chacho chinoperekedzwa nekugadzirwa kwei angina pectoris, kusingaperi kwehutano hwehutachiona, myocardial infarction.

Kuora kweiyo uye zviratidzo zvepasi

Kuumbwa kwe thrombi kunotungamirira mukuputsa kwekupararira kweropa, kwete pamagumo - nhengo dzomukati, kunyanya itsvo, dzinotamburawo. Nekukura kwenguva refu kwephospholipid syndrome, inonzi inonzi infarct yeinso inogoneka. Izvi zvinosangana nemarwadzo ari kumucheto kumashure, kuderera kwehuwandu hwemuti uye kuvepo kwekusvibiswa kweropa mairi.

I-thrombus inogona kuvhiringidza renta yemajoka, iyo inofambidzana nemarwadzo akajeka, kushungurudza uye kurutsa. Ichi chiitiko chinotyisa - kana pasina kurapwa, chirongwa chekudya chinogona kukura. Zvinokuvadza zvinokonzera phospholipid syndrome zvinosanganisira renal microangiopathy, umo madiki trombi anogadzira zvakananga mumusana we glomeuli. Izvi zvinowanzotungamirira kukurudzirwa kwekusagadzikana kwechirwere chisingaperi.

Dzimwe nguva pane kutyora kwekupararira kweropa mumadonal adlands, izvo zvinotungamirira pakaputsika kwemarimoni.

Ndezvipi dzimwe nhengo dzingakanganisa?

Phospholipid syndrome chirwere chinokanganisa nhengo dzakawanda. Sezvatotaurwa, maitiro anokonzera hutachiona anokonzera mazamu emasero emagetsi, asingagoni kuita pasina migumisiro. Varwere vazhinji vanogunun'una nezvemusoro unoramba uripo, uyo unowanzosangana nechezzinesi, kusuruvara uye kurutsa. Iko kune mikana yekuvandudza matambudziko akasiyana epfungwa.

Mune vamwe varwere, thrombi inowanikwa mumidziyo yeropa iyo inopa ropa kune inoona analyzer. Kushayikwa kwenguva refu kweokisijeni nemuviri kunokonzera kuti atrophy yeropa re optic. Kugadziriswa kunogona kuitika kwemidziyo ye retina uye inokonzerwa nehemorrhage. Zvimwe zvemaziso epanyama, zvinosuruvarisa, hazvigoneki: kushungurudzwa kunoonekwa kunogara nemurwere muupenyu.

Muchiito chetachiona, mapfupa anogonawo kubatanidzwa. Vanhu vanowanzoongororwa kuti vanodzokorora osteoporosis, iyo inofambidzana nekushanduka kwemasaga uye kazhinji kuputika. Aseptic necrosis yefupa inowedzera ngozi.

Nokuti chirwere chinoratidzirwa neganda mutsvuku. Kakawanda paganda rekumusoro nepamusoro, mapepa ansterisk anoumbwa. Dzimwe nguva unogona kuona kukanganisa kwakanyanya, kunofanana nezviduku, kuvhara ropa. Vamwe varwere vanovaka erythema pamakumbo etsoka nemichindwe. Iko kunowanzogadziriswa kwe-subcutaneous hematomas (pasina chikonzero chakajeka) uye kuora kwemvura pasi pepulisa yemakumbo. Kurwisana kwenguva refu kwehutatu hunoita kuonekwa kwevonda, iyo inoporesa kwenguva refu uye yakaoma kurapa.

Takawana kuti chii chinonzi phospholipid syndrome. Zvinokonzera uye zviratidzo zvechirwere zvinhu zvinokosha zvikuru. Mushure mezvose, ndeyezvikonzero izvi kuti chirongwa chekurapa chinosarudzwa nachiremba chichatsigira.

Phospholipid syndrome: kuongororwa

Zvechokwadi, munyaya iyi zvakakosha zvikuru kuona kuti kuvepo kwechirwere ichi munguva. Kushungurudza phospholipid syndrome chiremba anogona kugona panguva yekuunganidza yakamnesis. Kupa pfungwa iyi pfungwa yehutachiona hwetwere uye trophic ulcers, kazhinji kuora mitezo, zviratidzo zvekushaya ropa. Zvechokwadi, kumwe kuongorora kunoitwa.

Kuongororwa kwephospholipid syndrome ndekutsanangurira hutachiona hwemasikirini kune phospholipid muropa revarwere. Muchikamu chekuongorora ropa, unogona kuona kuderera kweplatelet count, kuwedzera kwe ESR, kuwedzera kwenhamba ye leukocytes. Kakawanda, chirwere chinosangana ne hemolytic anemia, iyo inogona kuonekwawo panguva yekudzidza kwema laboratori.

Mukuwedzera, chirwere chebiochemical blood test chinoitwa. Mune varwere, kuwedzera kwemazita emagamba globulins kunoonekwa. Kana chiropa ichikuvadza pamusana pehutachiona, ipapo chiyero chebilirubin uye alkaline phosphatase inowedzera muropa . Mukuvapo kwezvirwere zveputsvo, kuwedzera kwezinga re creatinine uye urea kunogona kuonekwa.

Vamwe varwere vanorayirwa zvakananga kuongororwa kwehutachiona ropa. Semuenzaniso, mabhuku e laboratori anogona kuitwa kuitira kuti aone rumumatoid factor uye lupus coagulant. Apo chirwere chephospholipid muropa chinogona kuona kuti kuvapo kwezvirwere kunokonzera erythrocytes, kuwedzerwa huwandu hwemaitiro e-lymphocytes. Kana pane kusava nechokwadi kwekukuvadza kwakanyanya kuchiropa, itsvo, mapfupa, zvinozoongorora mhando dzinoitwa, kusanganisira X-ray, ultrasound, tomography.

Ndezvipi zvinetso zvechirwere ichi?

Kana pasina mushonga, phospholipid syndrome inogona kutungamirira kune zvinetso zvakanyanya kuipa. Kurwisana nemamiriro ehutachiona, huvha hunomirira mumidziyo yeropa, iyo inotyisa mukati mawo. Ropa rinovhara midziyo yevhagi, ichivhiringidza kuratidzira kweropa rega-tishu uye nhengo hazvigamuchiri mishonga yakakwana uye oksijeni.

Kakawanda, kurwisana nemamiriro ezvinhu epachirwere muvarwere kunotanga stroke uye myocardial infarction. Kuvharwa kwemidziyo yemigumo kunogona kutungamirira pakukura kwechirwere. Sezvatotaurwa pamusoro apa, varwere vane uwandu mubasa reimpso uye adrenal glands. Dambudziko rinonyanya kukuvadza ndeyokuti thromboembolism yemapurmonary artery - ichi chirwere chinokura zvakanyanya, uye kwete mumamiriro ezvinhu ose murwere anokwanisa kutumira kuchipatara munguva.

Kubata kune varwere vane phospholipid syndrome

Sezvatotaurwa, phospholipid syndrome inowanikwa panguva yekuzvitakura. Ndeipi ngozi yekurwara uye chii chingaita mumamiriro akadaro?

Nemhaka yephospholipid syndrome, mutezo yeropa inoumba mumidziyo, iyo inovhara mishonga inotakura ropa kune placenta. Iyo embryo haigamuchiri okisijeni yakakwana nemuviri, mu 95% yemhosva inotungamirira pakuparara. Kunyangwe kana kubata kusina kukanganiswa, kune ngozi yekutanga kuputika nekunyanya kwekupedzisira gestosis, iyo inonyanya kuipa kune vose amai nemwana.

Zvakakodzera, mukadzi anofanira kuedza kuongororwa panguva yekugadzirira. Kunyange zvakadaro, phospholipid syndrome inowanzoongororwa panguva yekuzvitakura. Mumamiriro ezvinhu akadaro zvakakosha kucherechedza kuvapo kwechirwere munguva uye kutora matanho anodiwa. Nokuti kudzivirirwa kweprombosi yeamai vanouya kunogona kugadzwa kugamuchirwa kweanticoagulants mudiki madheji. Mukuwedzera, mukadzi anofanira kugara achiongororwa kuitira kuti chiremba aone kuonekwa kwekuputika kwepasitiki. Mwedzi miviri yoga yoga, vanaamai vekupedzisira vanotora chirongwa chokudzorera kurapa, kutora mishonga ine vitamini, mineral uye antioxidants. Nekutaura kwakarurama, pamuviri kanowanzoguma nekuchengeteka.

Ko kurapa kunoita sei?

Chii chingaita kana munhu ane phospholipid syndrome? Kurapa munyaya iyi kwakaoma, uye kunobva pakuvapo kwemu murwere kune mamwe matambudziko. Sezvo ropa rinoputika pamusana pechirwere ichi, kurapwa kunonyanya kunangwa pakuderedza ropa. Mutemo wokurapa, semutemo, unosanganisira kushandiswa kwemapoka akawanda emishonga:

• Pakutanga, anticoagulants yechitsauko chisina kujeka uye antiplatelet agents ("Aspirin", "Warfarin") inorayirwa.
• Kazhinji, kurapwa kunosanganisira kusarudza zvinopesana nezvinokonzera zvinodhaka zvisiri zve steroidal, kunyanya "Nimesulide" kana "Celecoxib."
• Kana chirwere chacho chichibatanidzwa ne systemic lupus erythematosus uye zvimwe zvirwere zvinotapukira, chiremba anogona kupa glucocorticoids (hormonal anti-inflammatory drugs). Pamwe chete neizvi, zvinodhaka zvemumunosuppressive zvinogona kushandiswa izvo zvinodzvinyirira basa rekudzivirirwa kwezvirwere zvemuviri uye kuderedza kushandiswa kwezvirwere zvinotyisa.
• Vakadzi vane pamuviri dzimwe nguva vanopiwa immravenous immunoglobulin.
• Varwere nguva nenguva vanotora zvinodhaka zvine B mavitamini.
• Nokuda kwehuwandu hwekuvandudza, kuchengetedzwa kwemidziyo yeropa uye masero emakamuri, antioxidant zvinodhaka zvinoshandiswa, uyewo maigadziro ane zvinyorwa zve polyunsaturated mafuta acid (Omakor, Mexicor).

Inobatsira pamamiriro evarwere ndeye nzira ye electrophoresis. Kana iri yechipiri phospholipid syndrome, zvinokosha kudzora chirwere chikuru. Somuenzaniso, varwere vane vasculitis uye lupus vanofanira kuwana mishonga yakakwana yezvirwere izvi. Zvakakoshawo kuona zvirwere zvinotapurika munguva uye kufambisa chirwere chakakodzera kusvika pakuwanazve (kana zvichibvira).

Zvirongwa zvevarwere

Kana chirwere chephospholipid chikaonekwa pane imwe nguva uye murwere akawana rubatsiro rwakakodzera, saka kufungidzira kunofadza zvikuru. Izvo zvinosuruvarisa kuti hazvigoni kubvisa chirwere zvachose, asi nekubatsirwa kwemishonga inogona kudzora kuwedzera kwayo uye kuita prophylactic kurapwa kweprombosi. Dambudziko ndiyo mamiriro ezvinhu umo chirwere chinosanganiswa ne thrombocytopenia uye kuwedzerwa kweropa.

Chero zvazvingava, pasi pekutungamirirwa kwerheumatologist, varwere vose vane chirwere che "phospholipid syndrome" vanofanira kunge varipo. Kuburikidza nehuwandu hupi vanodzokorora kuongorora, kakawanda sei zvakakosha kuongororwa pamwe nevamwe vanachiremba, ndeapi magadzirira aunoda kutora, kuti ungatarise sei mamiriro ehupenyu hwako - chiremba anotarisira achataura pamusoro peizvi zvose.