The mushonga "Captopril" kubva chii? Application, nhoroondo, mutengo

Chii zvinodhaka "Captopril", umo rinoshandiswa uye chii ehupfumi? Mhinduro dzemibvunzo yose iyi inogona kuwanikwa zvinhu ino. Uyezve, isu achakuudza sei kutora zvinodhaka uye chii nemishonga uye contraindications pakushandisa yazvinofanira.

General ruzivo pamusoro somushonga chigadzirwa

Drug "Captopril" muchiLatin unorira "Captopril". mushonga uyu chakaita zvokugadzirwa inhibitor kuti angiotensin-rokutendeutsa enzayemu (ACE kana rakapfupikiswa). Ari zvinowanzoshandiswa okurapa, kuti nokukurumidza kuderedza BP.

Murwiyo uye chimiro zvinodhaka yokusunungurwa

Medicament "captopril" - umo chishandiso iri basa? Kazhinji, vanachiremba akarayira kuti vaya vanogara kutambura kubva neBP. Nechipiriso mushonga chakatengeswa chete ari muchimiro Mahwendefa spigot kuti inoiswa atorwa. The vanoshingaira wemafuta kwezvinodhaka uyu captopril. kugutsikana Its neimwe hwendefa iri 25 kana 50 MG. Mumwe pasuru kungava zvidimbu 100, 50, 40, 30, 20 kana 10.

The pharmacological zviito zvinodhaka

Sezvakakurukurwa munyaya kumusoro, "Captopril" Mahwendefa mirayiridzo riri nested mu atorwa, ndiko inhibitor kuti angiotensin-rokutendeutsa enzayemu (ACE i.e.).

Zvinofanira kucherechedzwa kuti antihypertensive ehupfumi zvinodhaka pamwe nemakwikwi chinovhiringidza pamusoro ACE basa, zvichitungamirira chinokosha kuderera yevanhu kutendeutsa angiotensin 1 kusvika angiotensin 2, chinova kumbonyanya simba zvinoriumba vasoconstrictive.

Mushure zvinokosha vasanyanye wevasungwa pamusoro angiotensin 2 ari kuwedzera kuramba ari yeplasma renin webasa Achabvisa kunaka inofambiswa kana kusunungurwa, uye zvakananga rutapudzo kuti aldosterone kugadzirwa. Mukuwedzera, medicament "Captopril", analogs zviri kukurukurwa hereinafter, anogona kudzora kallikrein-kinin hurongwa, nokudaro zvichiita kuti nokuputsika bradykinin.

Nokuda vasodilating mugumisiro zvinodhaka yekudyidzana kunoderedza zvachose vascular nemishonga (peripheral), rirambe richibvira achikanganisa kufurirwa uye pulmonary vascular nemishonga mavari. Uyezve, anogona kuwedzera miniti Vhoriyamu pomwoyo uye kushandisa shiviriro.

Kana mushonga "Captopril", wongororo zvacho zvakawanda zvakanaka, tora refu chaizvo nguva, rinovatadzisa kukura mwoyo kukundikana, akazoita kwokuomerwa myocardial hypertrophy zviri ventricle kuruboshwe, uyewo anononoka pasi kuchiita dilation.

Mukuwedzera, medicament anokwanisa kudzivirira kuchiita chirwere cheshuga nephropathy, richikwidibira inzwi efferent renal arterioles, uye glomeruli yekudyidzana kuvandudza intraglomerular hemodynamics.

Pharmacokinetics zvinodhaka

Paakatyaira mushonga mukati akakurumidza kunyura. Kuita rimwe medicament rinotanga pashure anenge 40-60 maminitsi. The kunonyanyisa wevasungwa kunokwanisika mumuviri womunhu pashure awa yokutanga.

Zvinofanira kucherechedzwa kuti mawa yaunodya zvokudya nechipo zvinodhaka kunoderedza ayo absorbability pamusoro 30-40%. Ndokusaka mahwendefa vari zano kutora pamusoro 1 awa pamberi kudya kana pashure maawa 1-1.5 pashure.

Duration chiito pashure kushandiswa medicament (kuti tikarega BP) kunoenderana multiplicity waro mabiko uye uwandu husingakuvadzi. Nokuti kukura zvizere kuchirapa nomugumisiro murwere kungada mavhiki akawanda yokurapa.

Zvinoitwa uye zvivako zvinodhaka "Captopril"

Zvino munoziva kuti ndiyo mushonga "Captopril", umo rinoshandiswa uye sei kuita pachinhu womunhu muviri. Asi kunzwisisa sei mushonga uyu yakakurumbira zvakadaro, unofanira kufunga ehupfumi ayo.

The rinoita fuma iri chikamu "Captopril" kugadzirira ane vasodilating, antihypertensive uye cardioprotective zvivako.

mushonga uyu anokwanisa kuwedzera kusunungurwa pakugadzira vanoshingaira zvinhu kuti vane natriuretic nomugumisiro. Nokuda pfuma iyi yekudyidzana kunonatsiridza ropa riyerere kuna neitsvo. Mukuwedzera, medicament "Captopril" kwokudzvinyirira uye kunoderedza zvachose post-preload pamusoro mwoyo, uye kunowedzera cardiac goho.

Zvairatidza kuti kushandiswa kwezvinodhaka

mishonga nechipiriso akaratidza kuti mishonga anotevera abnormalities:

• Chirwere cheBP uye renovascular. Rinogona ikashandiswa kana sezvo monotherapy.
• Kusagadzikana ventricle kuruboshwe. Kazhinji, mushonga unoshandiswa vanhu vakanga chemwoyo uye yava akaora yakagadzikana ezvinhu.
• Shuga nephropathy. Basa avo ane chirwere cheshuga mhando wokutanga, kureva jekiseni-nemataundi vanhu chete.
• Cardiomyopathy.

Drug "captopril" - kubva zvimwe basa mushonga uyu? Sezvo chikazozikamwa, mushonga unogona kupiwa uye kushandiswa zvizere kurapa mwoyo nokukundikana (congestive).

Contraindications kuti kushandiswa medicament

Maererano mirayiridzo, mushonga "Captopril" iri zvaisambobvumirwa kutora zvinotevera nyaya:

• Kana hypersensitivity kune basa chirungiso - captopril. Zvinofanira kucherechedzwa kuti yezviri mushonga hauna varumbidzwa vaya vane kusada pane boka pachena mishonga, izvo FIs pamusoro angiotensin-rokutendeutsa enzayemu (i.e., varwere yakatanga angionefrotichesky kuzvimba panguva kurapwa nezvimwe ACE inhibitor).
• Kana akaratidza hwevanhu chiropa oparesheni.
• In cardiogenic kuvhunduka.
• Kana zvomudumbu turakiti zvirwere.
• Kana akaratidza hwevanhu itsvo basa ezvinhu pashure transplantation ari nhengo, bilateral stenosis pamusoro arteries, azotemia, hyperkalemia, uye zvikuru hyperaldosteronism.
• Kana hypotension.
• In immunological zvirwere.
• Mitral stenosis uye kutsemuka stenosis.

Mukuwedzera, zvinodhaka "Captopril" analogues zvinodhaka ichi haina varumbidzwa kuvakadzi vane mimba, vana pasi nemakore 18, uyewo ekukurerai.

Drug "Captopril": kurayira, mutengo mishonga

Maererano zvakabatanidzwa mirayiridzo, mushonga zvinofanira kutorwa anenge 1 awa pamberi kudya. Ya yokurapa uye chipimo chemushonga zvaiitwa kurapwa akurukurwa zvinofanira yakajeka chiremba chete nomunhu, zvichienderana nemhando uye chokubuda yaivapo chirwere.

Saka sei kutora zvinodhaka "Captopril"? Dose (kutanga) zviri medicament iri nechirwere kuti BP ndiyo 12,5 MG kaviri pazuva. In chenjera kudiwa imwe nguva inogona kushandiswa achigadzirira 2 mahwendefa 25 MG. Asi iyi mabiko chinhu chinodiwa kuti kukamurwa ka3. Kufadza daily dose mumwe medicament akadaro 150 MG.

Kana chiremba wako akamuraira Nokuraramisa jekiseni kwenguva refu, mishonga "Captopril", uyo uchapupu takawongorora chete kumusoro, vanofanira kutora piritsi rokutanga (25 MG) katatu kana kaviri pazuva.

Kana renovascular neBP uye renal kutanga chipimo chemushonga pamusoro medicament ndiyo 6.25 MG katatu pazuva. Kutsigira kurapa kunofanira kusanganisira 1 piritsi Pfungwa (25 MG) katatu pazuva.

Kana chirwere chemwoyo uye pane hadzina kufambiswa zvakanaka zviri netsvo, kwokutanga chipimo chemushonga inofanira kuva 12,5 kana 6.25 MG katatu pazuva. Saka ose 2-3 vhiki anofanira kuunzwa ayo Nokuraramisa dose pamusoro 25-50 MG, pamwe chete kwenguva. Kugamuchirwa nzira postinfarction nguva medicament zvakafanana.

ACE boka zvinodhaka vakwegura vari basa chete chiremba. Panyaya iyi, marapirwo anofanira munhu mumwechete. Accepted "Captopril" vanhu ava vanofanira kuva shoma dose. Uyezve, haisi varumbidzwa kuwedzera kusvikira kurapwa. Kana zvakakodzera chaizvo, unogona Uyezve kushandisa loop diuretic.

Kana mutengo, ipapo nekuda 40 mahwendefa chigadzirwa ichi uchava kubhadhara anenge 50-60 rubles Russian. Sezvaunogona kuona, zvinoreva "Captopril" ndiwo hwakanaka chipa mushonga kuti zvinobudirira nechepazasi BP nenzira utano.

Kuendeswa nokungwarira zvakanyanyisa

mishonga nechipiriso zvinofanira kutorwa nokungwaririra zvakanyanyisa kana:

• chinovhiringidza kuti mwongo ropa kutenderera;
• zvakakomba autoimmune zvirwere;
• chirwere cheshuga;
• chepfungwa ischemia ;
• nechirwere chemwoyo.

nemishonga

Maererano mirayiridzo, mushure zvinodhaka "Captopril" zvingaitika Varwere dzinotevera divi siyana:

• bronchospasm, bronchitis, kupfupika mweya, akaoma isingabereki chikosoro;
• CNS mwoyo, nomusoro, nezvipusha, ataxia, dzungu, tingling mu okumusoro kuviri, uyewo nokunzwa chiveve, kuvhiringidzika, nenyonganiso kunhuwidza uye zvakaratidzwa, kurukutika, kuora mwoyo;
• exfoliative dermatitis, kuvaviwa, ganda mapundu, photodermatitis, pemphigus, angioedema, urticaria, anaphylactic kuvhunduka, chepfu epidermal necrolysis, alopecia;
• mwoyo mutinhimira vachivavhiringidza, angina pectoris, orthostatic hypotension, myocardial infarction, tachycardia;
• kuravira chinovanetsa, flatulence, kurasikirwa kudya, stomatitis, kuda kurutsa, kupatira, glossitis, maronda maronda ari gastric mucosa uye muromo, manyoka, kurutsa, xerostomia, abdominal kurwadziwa;
• paresthesia, arthritis, peripheral neuropathy;
• neutropenia, hyperkalemia, thrombocytopenia, agranulocytosis, eosinophilia;
• oliguria, proteinuria, vakadhakwa itsvo basa;
• cholestatic chiropa, pfungwa nomuviri zvemwana asati, cholestasis, hepatocellular necrosis.

Maererano mhinduro kuti kusiya vatengi zvinodhaka ichi, marwadzo anogona kuitika zvakawanda kana, apo kutora mushonga kuti zvinoenderana yakaderera-munyu kana munyu-akasununguka zvokudya.

Drug "Captopril": ovhadhozi

In ovhadhozi Data rinoreva varwere vanogona kuratidza marwadzo akadai myocardial infarction, uye vakanyorwa akurumidze ichidonhedzera BP, rikwanise kuvhiringidza chepfungwa kuparadzirwa uye thromboembolic matambudziko.

matanho okudzivirira

Maererano nenyanzvi, hazvina yakarumbidza kutora mushonga pamwe potassium-kuuraya diuretics, uye zvimwe zvinodhaka kuti yekudyidzana zvinowedzera wevasungwa kuti potassium muropa plasma. Kana tikasateerera Council ichi, pane mukana mukuru hyperkalemia.

Uyezve, kushandisa "Captopril" anofanira kushandiswa nokungwaririra hwakanyanya pamwe mawa kugamuchira rinoreva "Procainamide", "" allopurinol "," Azathioprine "kana zvimwe immunosuppressants, kunyanya kusagadzikana renal ushande.

In diffuse connective zvinyama zvirwere, uyewo chisingaperi mwoyo kukundikana, mushonga zvichifanira chete kutorwa pasi pedyo zvokurapa achitarisirwa.

Zvinofanira kucherechedzwa kuti, maererano varwere mishonga uye ongororo, ari hypotensive mugumisiro wacho medicament kunoderedza zvinodhaka "Indomethacin" uye estrogens.

chengetedzo mamiriro

Drug "Captopril" rinoreva zvinodhaka List B. mishonga iyi ukasunungurwa chemishonga ngetani chete chiremba mushonga. Its pasherefu upenyu makore 3 kubvira musi gadzira. nzira dzakadaro vanoumba kudiwa murima uye panzvimbo yakaoma, pane imwe tembiricha isingadariki 25 ° C.

zvinodhaka analogues

Maererano basa chirungiso ane zvinotevera STRUCTURAL analogs zvinodhaka ichi:

• "Captopril Verein";
• "Angiopril-25";
• "Captopril Acre";
• "Alkadiene";
• "Captopril Sandoz";
• "Vero Captopril";
• "Captopril UBF";
• "Blokordil";
• "Captopril Akos";
• "Captopril hexane";
• "Capoten";
• "Captopril FPO";
• "Captopril Sar";
• "Katopil";
• "Aegis Captopril";
• "Epsitron";
• "Captopril renjovhera."

Sezvaunoona, akabvuma mushonga une wandei yakasiyana. Naizvozvo, varwere kazhinji kunomutsa mubvunzo zviri nani - mushonga "Captopril" kana "Capoten". Musiyano mukuru pakati pavo. Vakasiyana mumwe chete nokuda mugadziri. Nokuda kwechikonzero ichi, zvinoreva "Capoten" kunokosha 3.5 nguva anodhura zvinodhaka "Captopril".

Reviews kugadzirira

Pasinei yakaderera mutengo, kuti medicament "Captopril" zvinobudirira lowers BP. Varwere vanenge akashandisa ashandisazve chinodhaka ichi vanoti Migumisiro yacho pachena mukati maawa 1-3 mushure ingestion.

Individual neutachiona pashure kushanda pomutumwa kuitika vanenge 5-8% yevanhu. Vakawanda vanoti mushonga uyu kunokonzera kwazvo kuzvimba. Ndokusaka asati kushandisa, iva nechokwadi kuti bvunza chiremba wako. Kana zvokurarama "Captopril" iri rinenge rimwe divi chaizvoizvo zviri zvinodiwa kuramba nayo uye kuenda mushonga cheBP neimwe boka.

Pane zvikuru zvakawanda wongororo kuti "Captopril" zvinodhaka "Capoten" uye dzimwe analogues mari izvi zvinobudirira kunobatsira kubvisa neBP vakwegura. Asi pamberi nzira yakadaro, iva nechokwadi kuti bvunza chiremba wako. Uyezve, munhu akwegura kubvisa cheBP nezvimwe zvirwere inokurudzirwa kushandisa chete yakadereresa dose kurapwa.

Zviri njodzi kushandisa zvinodhaka?

Pahwaro muchipatara romunharaunda muna Rivne (Ukraine) muna 2010, imwe ongororo chaiitirwa kakawanda nemishonga kutora zvinodhaka "Captopril". In nzira iyi, wakapindwa nevanhu nounyoro uye mwero chirwere cheBP. Somugumisiro, nyaya 500 chema divi anokonzerwa vanhu 73 chete. Izvi, 53 - regai kutora zvinodhaka, uye akasara 20 - mberi, sezvo vakaona kuti zvinounza zvizhinji zvakanaka pane zvakaipa utano.