Zoledronic asidhi: pharmacological kushanda uye analogues

Zvinozivikanwa kuti bisphosphonates vanowanzotevedzera tunodzivisa kukura pfupa metastasis uye kudzivirira pfupa kurasikirwa. Mumwe yakanakisisa zvinodhaka enzvimbo boka iri - zoledronic acid. Uyewo, pane uchapupu hwokuti chinodhaka ichi ane angioneogenesis chinovhiringidza, bundu nechisimba, adhesion kuti bundu masero pfupa rinenge induces apoptosis, uye pane Mubatanidzwa pamwe mishonga.

Pfungwa 1 chinu

Zoledronic iine acid monohydrate - 4.26 MG Excipients - Sodium citrate, D-mannitol.

pharmacology

An inhibitor repfupa resorption. Zoledronic asidhi ndohwaJehovha boka idzva dzekirasi akakwirira bisphosphonates. It ane nomugumisiro zvokusarudza pamusoro pfupa. Kunoderedza nezvebasa osteoclasts, pasina kukonzera kunambwa nokuumbwa nohumwe unhu pfupa tishu. Igaroziva bisphosphonates pamusoro pfupa kunobva yakakwirira kufanana mineralized pfupa, asi chaiyoiyo mashandiro pamusoro mamorekuru kuti anonyaradza zvichivhiringidza nezvebasa osteoclasts, kusvikira nhasi vachiri harina kudzidza. Uyewo ine zvakananga Anti-bundu ehupfumi, kuona kushanda mune mapfupa metastasis.

Ezvokunambira kunze kwomuviri waamai akawana kuti zoledronic acid, induces apoptosis uye zvichivhiringidza kuwanda masero kuva antitumor kushanda zvakananga myeloma, uyewo kenza masero ari pazamu, apo kuderedza mukana metastasis. Uyewo, zoledronic asidhi ane pfuma kuderedza karusiyamu wevasungwa munguva serum hypercalcemia, izvo zviri kukonzerwa bundu.

zvairatidza

• Osteolytic maronda vakawanda myeloma foci.
• Osteoblastic, osteolytic vakavhengana mapfupa metastasis anomera makuru.
• Hypercalcemia, izvo zviri kukonzerwa malignancy.

Contraindications

• Pamuviri uye uchiyamwisa.
• Renal insufficiency.
• Children uye kuyaruka (chikumbiro kuchengeteka haina dzakatangwa).
• Hypersensitivity kuna bisphosphonates, uye zoledronic acid.
• Tsaona: renal dysfunction, Árbol asima, hepatic kukundikana.

nemishonga

Kupererwa, thrombocytopenia, nomusoro, dzungu, conjunctivitis, kuda kurutsa, kudya kurutsa, manyoka, mapfupa marwadzo, arthralgia, hypophosphatemia, hypocalcemia, fivha, dzihwa chirwere, kurukutika, kufuta. Mukurapa varwere zoledronic asidhi dzimwe nguva vakachengeta kukura osteonecrosis zviri rushaya (kazhinji pashure mazino kuvhiya kupindira).

Dosing

Intravenous donhwe, uye mukati maminitsi 15, asi hapana zvishoma. Metastases siyana myeloma yakarumbidza dose of 4 MG kamwe pamwedzi. Kana hypercalcemia, izvo zviri kukonzerwa chebundu bundu, mumwe dose of 4 MG kamwe zuva.

Zvokungwarira

Kana mushonga wakawanda, zvinokosha kudzora wevasungwa pamusoro magnesium, phosphorus, creatinine uye calcium yakawanda mune ropa serum. Kana zvichibvira, Zvinokurudzirwa kudzivisa mazino kuvhiyiwa.

Zoledronic acid. analogs

Zvinodhaka "Actonel", "Aneldronat", "Areda lyophilisate", "Bonviva", "Bondronat", "Bonefos", "Klobir", "ksidifon", "Lindron", "Ostalon", "Ostealen", "Osterepar" "Pamidronate", "Pomegara", "Rizendros", "Strongos", "Tevanat", "Foroza" "Fosamax", "Fosfoteh", "Rizarteva".

Zoledronic acid. mutengo

Kazhinji, Nzvimbo munyaya pakugoverwa mishonga mumutemo, anoratidza mitengo nefuma yavo. Asi, oddly zvakakwana, mutengo zoledronic asidhi inowanzopiwa akaratidza anenge. Asi paiva kukosha kwayo rinosvika vanenge 14 zviuru rubles por bhodhoro. Inotengeswa Pharmacies kubudikidza mushonga chete.

ruzivo pamusoro zvichiitirwa vanyatsoziva vashandi utano. Nyaya iyi iri pamusoro zoledronic asidhi hazvirevi kutsiva zano vakakodzera chiremba, uye haigoni kupa runovimbisa kunobatsirawo kubva kushandisa zvinodhaka.