"Disulfiram": wongororo. "Disulfiram": tsananguro, mutengo

Munyaya ino, takasarudza kukuudza kuti uyu mushonga se "Disulfiram". Mirayiridzo kushandiswa, inofambiswa uye zvinoratidza mari zvichange kurondedzerwa pazasi. Uyezve, uchadzidza kuti pane mari mishonga akati, anogadzirwa chero muchimiro Rinowanikwawo ayo akafanana, uye zvichingodaro. D.

The chimiro uye Zvinoumba kavha

The medicament "Disulfiram", mirayiridzo kushandiswa iri akanyudzwa mubhokisi chakagadzirwa makadhibhokisi, riri kutengeswa ari muchimiro jikichira mhinduro uye mahwendefa kuti kunanzvana yaitonga uye muchibereko.

Chokutanga chimiro anogadzirwa ndiro 20 Rine mamiririta, uye wechipiri nowechitatu - mu girazi zvirongo pa 10 uye 20 muzvikamu azvaitwa.

The kushingaira wemafuta ari medicament ndiyo disulfiram. Kunze kwayo, mushonga rine uyewo mamwe zvinoriumba (zvichienderana nokubudiswa siyana): yavaibvisa chloride, mannitol, starch, yavaibvisa stearate, mbambo-6000, MCC, karusiyamu diphosphate, hydroxypropyl cellulose, stearic asidhi uye polyoxyl 40.

pharmacological ehupfumi

Chii pamberi pedu mushonga? Zvavanotaura nezvake zvokurapa wongororo? "Disulfiram" ane raidudzwa Anti-doro maturo.

Kana ukapiwa chokushandisa ichi rinozivikanwa ayo chinokosha chaizvo doro muviri. Somugumisiro, njodzi metabolites vari kuumbwa, izvo zvinowedzera wevasungwa kuti zvine chepfu akadai acetaldehyde. Ndiye anosarudza kuti efficacy zvinodhaka.

With intravenous Kutarisirwa mumwe medicament, uyewo varwere yaro dzinogamuchidzanwa zvinenge pakarepo kutanga kunzwa kupisa flushes, rikwanise dyspepsia, tachycardia, asthenia simba uye kunyange richikwidibira hypotension. Mukuwedzera, chimiro kudhaka nokuda acetaldehyde kunobatsira mukupandukira doro uye kubviswa murwere wafukidzwa kuti doro.

pharmacokinetic parameters

Kufunga ane mushonga kinetic parameters? Zvakadini kwayo Absorção de Água mushumo wongororo? "Disulfiram" woga kubva dumbu nokukurumidza zvikuru uye akapotsa zvachose.

Kana kurishandisa, pane mukuru muviri yezviri zvinoriumba, panguva iyo metabolites akawanda aumba. Kunyange zvazvo kwakabva chigadzirwa rinoitwa kuburikidza mumapapu neitsvo.

zvairatidza

Drug "Disulfiram", mitengo iri pasi apa, kunoratidzwa nokuti:

• Mabatirwo chisingaperi kudhakwa;
• kudzivirira kuitazve pakurapa chirwere chidhakwa.

Mushonga uyu kungwara kwayo kunaka. Inofanira gadzai chiremba.

Contraindications

Drug "Disulfiram" nomutsinga uye nomuromo haana pachii zvinotevera zvirwere:

• neuropsychiatric zvirwere;
• pfari;
• cheshuga.

Uyewo, mushonga uyu hakuratidzwi panguva pamuviri, kuti aikanganiswa yezviri zvinoriumba uye wokuwedzera zvinoriumba, achiyamwa.

Tinofanirawo kuziva kuti nokungwarira zvakanyanyisa zvinodhaka ichi inokurudzirwa kuti kutora varwere havachanyatsogoni chiropa basa, kufema maitiro uye neitsvo.

Drug "Disulfiram": mirayiridzo kushandiswa

Kushandiswa chero mari ndiyo bvumidzwa chete yachiremba kurayira. Chiremba vanosungirwa kuitisa zvizere kuzviongorora murwere, uye ipapo kusarudza munhu kurapwa zvaiitwa uye dose naye.

Maererano mirayiridzo, avhareji zuva dose zvinodhaka kuti waiita Kutarisirwa anenge 125-500 MG.

Kana jekiseni uye muchibereko zvinodhaka, ipapo matanho aya anofanira kuitwa ane ruzivo mukoti. Panyaya iyi yakarumbidza chipimo chemushonga zvinodhaka kunoenderana zvinoitwa murwere uye kwokuomerwa aripo chirwere.

nemishonga

divi Migumisiro mushonga mu mubvunzo ndinogona kudaidza? Zvakadini ichi kutaura wongororo? "Disulfiram" Kashoma kuva chikonzero ngozi divi zvavaifunga. Kana anwa zvingava vamwe kutsaudzira muna zvomudumbu turakiti uye kuvapo esimbi kuravidza uye kukura nehepatitis.

Uyezve, kutyorwa munogona tsinga mabasa. mamiriro chisingadiwi dzakadaro dzinosanganisira polyneuritis pamusoro ezasi yayo, zvinetso zvepfungwa, kutadza kuyeuka, nekuvhiri- ngika uye kutemwa.

Uyewo, regai haabatanidzi kukura siyana neutachiona, dzakanga kukonzerwa vakadhakwa (semuenzaniso, pakaparara, sitiroko, cardiac arrhythmias, chepfungwa edema uye myocardial infarction).

Zviratidzo ovhadhozi

Kugadzirira "Disulfiram" panguva dzakakwirira mishonga inogona kukonzera migumisiro akadai dhirika, pakoma uye ngozi chetsinga siyana.

Kubvisa zviratidzo izvi vanofanira kupedza symptomatic kurapa muchipatara, izvo zvinofanira hazvo zvinosanganisira detoxification mabasa.

mushonga medicament

Nyanzvi akaratidza kuti neutralization zvinodhaka kwakakwana haagoni kunzi.

Kana zvakakodzera, kuti goho "Disulfiram" kubva mumuviri womunhu (semuenzaniso, mu kwazvo siyana kuti vachangobva vakagamuchirwa dose doro) rinoitwa kwemamwe maitirwo ezvinhu.

Sezvo mushonga uyu kushandiswa kwezvinodhaka ascorbic acid. It chinotarisirwa nomutsinga. chaikosha Izvi haabvumiri doro kuti tishandurwe kuva acetaldehyde, izvo, chokwadi, inokonzera kusagadzikana.

Vanogona kunge akashandisa ephedrine uye H1-blockers.

zvinodhaka kwavatori

Kunogamuchirika kushandisa zvimwe zvinodhaka pamberi pedu mushonga? Zvakadini zvinodhaka mukukurukurirana wongororo vanoti? "Disulfiram" akabatana anticoagulants kunowedzera zvavanoita, uye kunowedzerawo mukana ropa.

Mawa kurapwa pamwe mishonga zvinodhaka izvo rinoita ari chiropa, anogona yekudyidzana zvinoshatisa panguva kwacho.

Kusanganisa Mao FIs, tricyclic antidepressants uye phenothiazine nomukaka ne "Disulfiram" kungawedzera chidzoke kunzwisisa divi siyana.

Tikafunga izvi zvinoreva ne "buspirone" hunokonzera kugadzira zvinovadadira. mushonga akadai "Amitriptyline", kazhinji runogonesa migumisiro "Disulfiram" uye anomutsa ayo chepfu migumisiro iri tsinga.

Viewed medicament inokwanisa kuwedzera wevasungwa kuti chlordiazepoxide uye diazepam muropa, kuderedza kusimba chepfu siyana uye kukonzera dzungu.

Tiine wemishonga "Disulfiram" ne "isoniazid" anogona kuva kuora mwoyo uye dzungu, "metronidazole" - kuvhiringidzika uye rikwanise psychosis, munhu "Omeprazole" - vasingadzoreki kuziva, uye zvine caffeine - kuderedzwa excretion wayo kubva mumuviri.

"Chlorzoxazone" anowedzera wevasungwa pamusoro Anti-doro zvinodhaka muropa, uye "Chlorpromazine" anotowedzera kumukomborera hypotension.

Drug "Disulfiram": wongororo, mutengo uye analogues

Similar Migumisiro vane mishonga yakadai se "Ekzorran", "Radotera", "Aspen", "Krotenal", "Tetlong", "Refuzal", "Stoptil", "Antietil", "Kontrapot", "Tetradin", "Antietan" "Dizetil", "Alkofobin", "Aversan", "Anticoli", "Antabuse", "Esperal", "Lidevin", "Abstinil".

How kuzhinji chinodhaka "Disulfiram"? Mutengo zvinodhaka ichi pamahwandefa yemakomo 200-1000 rubles (zvichienderana mugadziri). Maererano kudyara chimiro, uyewo jikichira mhinduro, vanogona kutenga nokuda 600-2400 rubles.

Wongororo Most aripo Pfungwa akanaka. Zvinokosha kucherechedza kuti chinodhaka ichi rinowanzoshandiswa chakavanzika kurapa vanhu rokuraradza. Nyanzvi regai kuvakurudzira kupa chivako ichi pasina murwere ruzivo.

Maererano inofambiswa vaya vaishandisa mushonga nezvazvo zvinobudirira kwazvo unorwa uchida kutora mutsva dose doro. Kazhinji, mushure mekugamuchira mushonga ari murwere ichibudira mukupandukira doro. Kana doro zvakapfuudzwa pashure kushandisa zvinodhaka, kwahunokonzera rikwanise dyspepsia, Flushing, zvikuru asthenia, tachycardia, uye kunyange kutoda hypotension.