"Din dhepoti": mirayiridzo kushandiswa, contraindications, nemishonga, wongororo, mapikicha

Chii chaunoziva pamusoro mishonga iyi, akadai "din dhepoti"? Mirayiridzo yokushandisa, contraindications, wongororo uye divi Migumisiro zvinodhaka ichakurukurwa mberi.

Kavha uye chimiro chinodhaka, akafanana kwayo

In ipi kugadzira mushonga se "din dhepoti"? Mirayiridzo dzokushandisa mishumo kuti zvinogona kutengwa muchimiro ane jikichira mhinduro kuti intramuscular jekiseni. The chikuru vanoshingaira wemafuta kwezvinodhaka uyu fluphenazine decanoate. Sezvazvakanyorwa anopinda kutengeswa rima magirazi ampoules, pre-mumapepa muchitokisi gandiwa nebepa packs it, ukuwo.

pharmacology

Ndezvipi semushonga yokusafa medicament "din dhepoti"? Mirayiridzo yokushandisa, wongororo vanoti kuti izvi-refu kuita mishonga ine antipsychotic. Nderake boka polyvalent neuroleptics uye Exhibits iziviswe antipsychotic ehupfumi, izvo ikashandiswa pamwe chikungiso uye antiemetic kushanda. Uyewo, mushonga uyu ane munyoro kunyaradza kushanda.

Chii chinokonzera kubudirira zvinodhaka "din dhepoti"? Mirayiridzo dzokushandisa inoti kwayo antipsychotic migumisiro chokuita blockade pamusoro dopamine D2 receptors Mesocortical uye mesolimbic nehurongwa.

Kunyaradza ehupfumi kuti medicament ichi uye zvine mwero akaratidza chete kuchengetwa apo mukuru mishonga yacho mhinduro. Zvinokonzerwa blockade pamusoro adrenergic receptors nomunhu zvikamu uropi hunde.

Panyaya Anti-emetic anokonzerwa mishonga, zvino ari chokuita blockade pakati dopamine D2 Kanotokonya rukungiso mapazi ari kurutsa centre. Zvinofanira kucherechedzwa kuti hypothermic mugumisiro zvinodhaka ichi chinoratidza blockade pakati dopamine receptors yacho hypothalamus.

Vangani mushonga anotanga kuita "din dhepoti"? Mirayiridzo dzokushandisa (Photo jekiseni mhinduro anounzwa bepa ichi) rinoshuma kuti mishonga mugumisiro zvinodhaka inowanzopiwa richiratidzwa pashure maawa 25-72 mushure jekiseni. Zvinofanira kucherechedzwa kuti zvivako zviri antipsychotic zvinodhaka pasi kukurukurwa zvinonyanya kutaurwa munguva kubva 49 kusvika 97 maawa pashure kwokubatsira mumushonga.

The kinetics zvinodhaka

Chii chakanangana pharmacokinetics zvinodhaka "din dhepoti"? Mirayiridzo Kushandisa zvinotaurwa fluphenazine muchimiro yakakwirira samolecular uremu Ester mafuta mhinduro ine mafuta asidhi anogona kuunganidza mu adipose depots, uyewo nezvishoma kubudiswa.

Pashure intramuscular jekiseni ane kunonyanyisa mumisasa yacho chinhu kunoitwa pashure maawa 25 plasma. Muchiitiko chino, fluphenazine runokusunganidzai kuti ropa rive 90%.

Viewed chinodhaka nyore chinoyambuka placental mechidziro ichipfuura ropa-pfungwa, uye havasi yabudiswa ne hemodialysis.

Fluphenazine zvachose uye nezvo metabolised ne chiropa enzayemu hurongwa chokuita cytochrome P450. Kubva muviri zviri yabudiswa pamwe bile weti uye. Active metabolites pamusoro maatomu akafanana izvi hazvina aizvinzwisisa.

Fluphenazine hafu-upenyu maawa 7-10.

umboo

Mune zvimwe zviitiko, murwere ushandiswe majekiseni "din dhepoti"? Mirayiridzo dzokushandisa zvinoreva uchapupu akadai:

• exacerbation kuti schizophrenia (nokuti muzvidzivirire);
• refu Nokuraramisa kurapwa echirwere schizophrenia.

Kurambidzwa kushandiswa

mishonga tikaritora hakubvumidzwi anotevera nyaya:

• pasi rinorema SS zvirwere, kusanganisira vane decompensated chisingaperi kweropa kukundikana uye hypotension;
• panguva yakakwirira aikanganiswa murwere kuti fluphenazine, uyewo kune dzimwe zvinhu zvinodhaka;
• vakadzvinyirirwa panguva CNS uye comatose inoti;
• panguva pamuviri;
• panguva dehenya kunotevera uye mberi systemic zvirwere uropi uye musana;
• mu richifudzwa
• pamwe vasingadzoreki chiropa nerevane ropa hurongwa;
• kusvika makore 12.

Kunyatsoverenga Kushandisa zvinodhaka

Chenjerera 'din dhepoti' zvinodhaka nachiremba:

• udhakwa, uyewo yakawedzera susceptibility kuti hepatotoxic siyana;
• Kumwe kuchinja kunotanga muropa, uyewo zvaipesana hematopoiesis;
• Kurwara phenothiazines, kusanganisira nhoroondo;
• kuvhara yemaziso;
• kenza yemazamu;
• hepatic uye / kana renal kukundikana;
• nemaronda of zvomudumbu turakiti, kusanganisira nguva rikwanise chirwere;
• prostatic hyperplasia isiri yekenza pamwe zvekuchipatara kuratidzwa;
• myxedema;
• zvirwere, achiperekedzwa thromboembolic yematambudziko;
• Parkinson nehosha;
• chirwere pamwe kufema kukundikana (kusanganisira vana);
• Reye kuti urwere;
• pfari, kurutsa, pfari;
• cachexia;
• pakukwegura.

Zvinodhaka Kugadzirisa "din dhepoti": mirayiridzo kushandiswa

The ampoules zvinodhaka izvi zvichiitirwa kuti kwenguva refu yamabwe therapy (kanenge mitatu). Ake dose kwokutanga varwere ndechokuti 12.5-25 MG. Tevera mishonga, uyewo penguva pakati majekiseni agadzirise takatsunga zvichienderana pamusoro kuchirapa mugumisiro.

Kurapa varwere hypersensitivity kune phenothiazines zvinofanira akatanga chaizvo nokungwarira.

Vakwegura zvinoda kugadzwa ezasi mishonga pane varwere muduku (vanenge 1/4 kusvika 1/3 yacho dosing). Muchiitiko ichi shure kwavo vanoda kugara achitarisirwa.

Zviitiko ne-hunhu

Zvinodhaka Kugadzirisa "din dhepoti" kungaita zvinotevera sadikanwa maitiro:

• extrapyramidal urwere, akathisia, tardive dyskinesia, dystopia, oculogyric nematambudziko, hyperreflexia, opisthotonos;

• neuroleptic akaipa urwere, izvo zvinogona kuuraya;
• orthostatic hypotension, vangadikitira, BP nokufamba, kuda kurutsa, hypotension, kurasikirwa kudya, yemaziso, kunyanya salivation, atony dundira, polyuria, bowel mhingaidzo, muromo yakaoma, tachycardia, nomusoro, madzerere, kupatira, nasal kuzara;
• ventricular arrhythmias, kufirwa, ventricular tachycardia, cardiac kusungwa;
• zvemamiriro lactation, peripheral edema, kumwedzi zvirwere, hyponatremia, kusabetsera nevanhu, kuchinja uremu muviri, kuchinja libido vakadzi;
• pruritus, exfoliative dermatitis, erythema, seborrhea, urticaria, anaphylactic siyana, photosensitivity, angioedema, Árbol spasm, laryngeal edema;
• agranulocytosis, leukopenia, cholestatic jaundice;
• nezvipusha, fivha, ECG kuchinja, kusingarapiki diskinenziyu, kurutsa, venous thromboembolism, lupus-kufanana urwere, uye vamwe.

Testimonials

Zvino, unoziva, kubva chii kuita kwepfuti "din dhepoti." Mirayiridzo yokushandisa, marwadzo, uye contraindications pakushandisa ichi mhinduro yavewo yakurukurwa pamusoro.

Maererano varwere kare kurapwa zvinodhaka antipsychotic siyana, mushonga "din dhepoti" unoshanda zvikuru zvakanyanya uye anobvisa zvose zvisina zviratidzo schizophrenia. Pakatanga kwezvinodhaka izvi akatsiga zvikuru uye kwenguva refu kanganwiro.

The chete drawback pamusoro chokushandisa ichi ndicho uwandu ne-hunhu nezviito zvikuru. Mumazuva okutanga yokurapa mune vamwe vanhu akacherekedza hyperthermia, BP uye autonomic dysfunction. Uyewo, varwere vakawanda vanoonekwa panguva giperkinezy tsandanyama mumuromo uye chiso, smacked miromo yake uye rurimi sangano. Uyezve, kushandisa zvinodhaka izvi kazhinji kunokonzerwa nokuora mwoyo kunosiyana nekuomarara.