"Naloxone": mirayiridzo kushandiswa, chaicho dzomuzana

In okurapa, pane mamiriro ezvinhu apo kushandisa zvinodhaka kunoguma overdosing kana kusafarira kubva siyana nadzo uye hurongwa. Kakawanda matambudziko akadaro chokuita opioid zvinodhaka. Kuti mhanyisa kushaya kwavo kubva pamuviri, vanachiremba vanoshandisa mishonga chaiyo. Drug "Naloxone" - Bhuku Rinobatsira kuvandudza mamiriro ane ovhadhozi pamusoro opioid analgesics. Chii uye chii mashandiro ayo chiito? Ngatiedzei kunzwisisa nyaya iyi.

Description of chinodhaka, murwiyo uye chimiro

Medicine "Naloxone" User Application chokuita opioid Kanotokonya antagonist. Its vanoshingaira fuma iri naloxone hydrochloride. Chipimo chemushonga siyana dzinogona kuwanikwa mishonga kumusika, hazvina kudaro siyana, ndiko mhinduro kuti jekiseni uye mapiritsi. Ekupedzisira vari chaizvo kashoma kushandiswa yokuora tsika. The mvura chimiro kuti intravenous kana intramuscular Kutarisirwa Kusiyana neizvi, yakakurumbira zvikuru. The Kuronga mhinduro, kuwedzera kune basa chirungiso, rinosanganisira boka neezvitendero ebetsero zvinoriumba, yavaibvisa chloride, mvura Yakanatswa, makemikari acids uye munyu ayo.

Available mushonga "Naloxone" iri negirazi rinoonekera ampoules 1 Rine mamiririta vhoriyamu imwe neimwe. Kuwanda kushingaira remubatanidzwa mune rimwe dose ndiyo 0,4 MG.

Ndokurongedza chigadzirwa ari pasuru gandiwa varnished pamwe läpinäkyvä epurasitiki chivharo kubva aruminiyamu foil kana pasina izvozvo. Mumwe rongedza akabata 5 ndiro.

1 kana 2 nematunhu Mabhokisi inoiswa munhu makadhibhokisi bhokisi, pamwe chete mirayiridzo kushandiswa kwezvinodhaka uye ampulnam Lancet. Kana ndiro takashongedzerwa aine mhete chaiyo kana pfungwa nokutyora, mapanga kuti Huro dzavo mubhokisi regai kuisa.

The mashandiro kuita zvinodhaka "Naloxone"

Sezvataurwa pamusoro apa, mushonga "Naloxone" User Application chokuita mhandu pamusoro opioid receptors. Izvi zvinoreva kuti mumiririri anokwanisa ichivharira receptors izvi, nokudaro kubvisa nechepakati uye peripheral nezviito yeimwe kubva boka opioids. Mukuwedzera, zvinodhaka kana raitongwa kunogona kukonzera ucharwadziwa vari varwere kupindwa muropa nezvinodhaka.

Kana kushandisa "Naloxone" mhinduro, izvo mashandiro chiito pamusoro apa, zvingaita kunoitika munguva pfupi. Kana nomutsinga raitongwa zvinodhaka anotora kushanda mumaminitsi 1-2, intramuscular pashure maminitsi 5. Nguva yose kuchirapa kushanda apo kuvimba nenzira chourongwa mhinduro. Kana mhinduro wakatangwa kupinda tsandanyama, mushonga unoshanda anenge ku45 uye pamusoro intravenous jekiseni - hapana asingasviki 4 maawa.

Nyanzvi dziri zvinowanzoshandiswa kurapa varwere "Naloxone" mhinduro. Mahwendefa, kusiyana, vasina simba uye pfupi.

The kushingaira wemafuta mushonga urwa iri chiropa kuti metabolites. Nguva yaro hafu-upenyu duku, maminitsi 30-80 chete. 70% of raitongwa dose "Naloxone" yabudiswa ne itsvo mukati 3 days.

The chikuru mukana zvinodhaka "Naloxone" anonzi kuti wakaratidza kusakwanisa kwevanhu inotungamirwa zvichienderana pake.

zvairatidza

Mune zvimwe zviitiko, ashandise zvinodhaka "Naloxone"? Mirayiridzo kushandiswa kwezvinodhaka ine ndandanda ezvinhu umo kushandiswa kwayo ifarirwe zvikuru. Chokutanga, zviri ushandiswe varwere pashure kuvhiyiwa. Kushandisa zvinodhaka "Naloxone" (analogues dziri rinowanzoshandiswa ari postoperative nguva) , muchiitiko ichi zvinobatsira Kurumidza kuuya murwere kubva mamiriro mishonga hope. "Naloxone" The mushonga rinoshandiswa uye kubvisa migumisiro panyaya iyi chepfu, ovhadhozi analgesics, barbiturates uye benzodiazepines.

Kazhinji kushandiswa kwayo anoruramiswa panyaya kuberekwa mwana mhoteredzo mai panguva basa vakanga vawedzera opioid analgesics. Kazhinji, vana ava pane aiomerwa vaingoerekana kufema. Drug "Naloxone" anobvisa navo uye anobatsira Activate ari kufema basa. Solution uye inowanzoshandiswa yokuongororwa mudziyo vanenge vanofungidzirwa pamberi kupindwa muropa murwere.

Zvinofanira kucherechedzwa kuti chete mamiriro ezvinhu kuti kushandiswa chokushandisa ichi - kuzviomesera zvairatidza. Ndokusaka okurapa rinoshandiswa kunoparirwa yachiremba mushonga uye pasi pokudzora yake.

Contraindications

Pakati contraindications pakushandisa "Naloxone" gadziriro mirayiridzo kushandiswa zvinoreva zvinotevera ezvinhu uye zvirwere:

• Hypersensitivity kune basa nefuma kana mumwe zvinoumba zvinodhaka;
• mwoyo chirwere (Organic);
• chakakomba chiropa uye chirwere cheitsvo;
• mumuviri kuvimba opoidnyh analgesics.

Zvokungwarira zvinofanira ushandiswe vakadzi nepamuviri zvinodhaka nedoro, sezvo ucharwadziwa, kunokonzerwa sumo chemhinduro kunogona kukanganisa fetus ezvinhu. Izvi zvinoshandawo nokushandiswa vachangoberekwa vevanaamai panguva pamuviri zvisiri zvinodhaka opoidnymi.

Chero zvazvingava, zvikomborero zvinodhaka anofanira kupfuura zvingakanganisa yematambudziko ari murwere. We kukuyeuchidza kuti chete tsika mushonga zvinodhaka "Naloxone". Yekuwana muimba rakakodzera muchimiro kubudikidza kupinda chiremba, murwere hunotora hapana zvakakomba contraindications pakushandisa zvinodhaka ichi.

Nzira Use uye chipimo chemushonga

Chipimo chemushonga uye nzira chourongwa takatsunga ne nyanzvi pahwaro mamiriro ezvinhu omurwere. Tinopa kwakajairika zvaiitwa "Naloxone" mhinduro.

Overdosing zvinodhaka unonyaradza marwadzo nedzevakuru kunoda yebhuku 0,4 kusvika 2 MG pakugadzirira (1-4 ampoules) nomutsinga kana intramuscularly. A chete dose vana vari dzaona kwakavakirwa uremu muviri, izvozvo yaiva 0.005-0.01 MG / makirogiramu.

Chokubvisa murwere kubva muhope zvinodhaka Kutemeswa (ari postoperative nguva), mushonga chinotarisirwa nomutsinga zvinotevera uwandu: mukuru mune imwe dose pamusoro 0.1 MG anoteverwa kuzodzosera sumo kuzoita vaingoerekana kufema, vana - 0.01 MG / makirogiramu muviri uremu rokudzorera kufema.

Vachangozvarwa mhinduro raitongwa nomutsinga, intramuscularly kana perkusionno mune imwe mari 0.1 MG / makirogiramu muviri uremu kamwe.

Kana zvakakodzera, kuti chirwere zvinodhaka maererano mushonga chinotarisirwa nomutsinga panguva dose pamusoro 0.08 MG.

nenjodzi

Pakati nemigumisiro yakaipa kushandiswa kwezvinodhaka, "Naloxone" muperekedzi rinotaura zvinotevera ezvinhu:

• kuda kurutsa, zvichida uchida kukurutsai;
• cheBP;
• mugari kurova kwehana;
• chakamira pakunodengenyeka zvine nokugwinha;
• vangadikitira.

In varwere opioid nedoro, kushandiswa kwezvinodhaka kunogona kukonzera manyoka, marwadzo vasingazivikanwi localization, kuzvimba nasal mucosa, kunzwa kuneta akaipisisa, chills, dumbu uye intestinal chinyamunhari chinorwadza. Izvi zvinonzi vaiona zvakafanana kuti zvinodhaka "pakumedura." Vanoedza anoverengeka makumi ezviuru maminitsi.

Drug analogues "Naloxone"

Zvinoita kutsiva Kuronga chete kugadzirira zvinodhaka "Naloxone"? Analogues kuti chivako ichi zvevakomana mashoma. Izvi zvinosanganisira "Narcan" zvinodhaka "Naltrexone", "Tsiklozotsin" uye "Narkantin". Dzavo pharmacological zvivako, zviratidzo uye contraindications yakafanana neiya iri mhinduro uye mahwendefa "Naloxone". Saka chisingadiwi kuzvishandisa pamberi ane chisimbwa pavarwere pamusoro remubatanidzwa akadai naloxone hydrochloride.

Kunyange zvakadaro, pane vane ayo zvakanakira. Somuenzaniso, mushonga "Naltrexone" unoshanda kwenguva refu (maawa anenge 24) uye rinowanika kunyanya muchimiro mahwendefa kana capsules kuti nomumukanwa Hour. It rinowanzoshandiswa Coding kubva muropa nokuita kusona capsules pasi paganda mhinduro.

Reviews kugadzirira

Pakati vanachiremba "Naloxone" chinodhaka ane mukurumbira wakanaka. Maererano navo, zvinobatsira kuti kuponesa varwere vakawanda chiitiko netsaona kana nemaune ovhadhozi zvinodhaka kubva boka analgesics uye / kana opioids. Pasinei vakawandisa contraindications uye marwadzo, mushonga anoonekwa kuti njodzi kushandisa. Uyezve, achibatsirwa kwayo, unogona kuzivisa yakavanzika kupindwa muropa nezvinodhaka.