Zvakadzama boka zvinodhaka - mishonga inorwisa mabhakitiriya tetracycline

Tetracycline mishonga - iri boka guru zvinodhaka. Medicaments vane makemikari mamiriro akafanana. Zvinofanira kucherechedzwa kuti mari idzi imwe vaikudzwa nzvimbo pakati chakarondedzera webasa zvinodhaka.

Tetracycline mishonga. tsananguro

Zvinodhaka muboka iri vane mwoyo zvainoita kubereka uye kukura giremu negative, giremu positive utachiona, tumiti (pamusoro acid), nemavhairasi guru, mamwe mabhakitiriya. Muchikwata zvinosanganisira mishonga yakadai se "chlortetracycline hydrochloride", "Oxytetracycline hydrochloride", "Tetracycline" uye vamwe. Drug kudzidza yakatangwa muna 1948. Pamusanapekushanduka nematambudziko kuwana chakaita zvokugadzirwa zvinodhaka ano vari anosikwa kushandisa biosynthesis. All mishonga tetracycline anosiyana amphoteric hunhu. chikuru unhu hwavo nokuda dimethylamino boka. Mishonga ake kuratidza acidic ehupfumi nokuda phenolic hydroxyl kuti D-mhete. Zvaaiva amphoteric remubatanidzwa soluble mune asidhi uye alkali, achiumba munyu. Ivowo hydrolyzed mu aqueous mhinduro. Dzakakwirira mumatunhu chinonditadzisa iine acid hydrolysis kwacho, uye kunayisa chawo precipitate.

All yeimwe tetracycline vane spectra yakafanana mumwe. Mune mamorekuru zviri phenolic hydroxyl kunokonzera ruvara shanduko kubudikidza maitiro pamwe ferric chloride (3). Tetracycline mishonga anoora kuumbika alkali izotetratsiklinov. Uyewo, izvi vaine pfuma iri mufananidzo. mukuru maitiro cho zvose tetracycline yeimwe. Kugadzirira kusiyanisa kubva mumwe kunobvira nekuvongwa yakasiyana staining pasi pokudzora sulfuric asidhi (pfungwa). Izvi pamwe paumbwe yeimwe, mavara rimwe tetracycline racho ruvara. Saka, Somuenzaniso, mumwe munhu mushava-tsvuku Hue, nokuti mumwe - pepuru. Mumwe zvainyanya runoonekwa kuti zvinodhaka kukwanisa fluoresce pasi pokudzora UV chiedza. It rinowanzoshandiswa sechiratidzo kwavo zvechokwadi.

Pharmacological ehupfumi tetracycline

gadziriro iyi anosiyana zvakakwana chakarondedzera basa. Its bacteriostatic nezvinozoitika nokuda chinovhiringidza mapuroteni usage causative utachiona. mushonga basa kunoratidzwa hama kuti Kurovedza giremu-zvakanaka utachiona, kusanganisira utachiona zvibereko penicillinase. The chinodhaka zvakare rinokanganisa giremu negative utachiona. Ratidza kurapika nemavhairasi diki, notumwe akawanda uye zvimwe utachiona.

Vamwe mishonga rubvumo mitemo. nenjodzi

Zvinokurudzirwa kushandisa zvinodhaka nenzira dose pamusoro 0.3 magiramu kwemazuva maviri okutanga, 0.2 magiramu mashanu kane zvinotevera mazuva. Mwandabvu (subacute uye rikwanise nyore) pamusoro kosi waakaudzwa kuti 5 g, pamwe nezvimwe - kusvika 10. Zvinokurudzirwa kuti kutora mushonga isati kana panguva zvokudya. Tikafunga kunge agumbuka mudumbu, kurutsa, kuda kurutsa.