Matafura kubva kumapfudze ari pa "Roaccutane": chiso chekuongorora, mapeji mberi uye shure, murayiridzo

Mwana wega wega wega munguva yepakati penyika akawana dambudziko remakemikari kana masayendisiti nezviratidzo zvezvinyuchi. Mumwe munhu asinganzwisisiki anobatsirwa nezvipfeko zvinoshandiswa uye nzira dzekuita zvishoma nezvishoma zvakatorwa. Vanhu havanzwisisi zvose izvi zvinoitwa zveganda. Zvinyorwa zvinokonzerwa nehutachiona, chimiro nemakumbo kubva kwavari zvinopfuurira kunyange mukura. Muchiitiko ichi, munhu anongoratidzirwa kwete chete mumuviri, asiwo unhu hwakanyanya hwandinetseka. Zvinetso nechepiso remaziso zvinoita kuti zvive zvakaoma kunzwa uine chivimbo uye uchifara zvizere noupenyu. Mumamiriro ezvinhu apo dzimwe nzira dzose dzekurwisana dzinoratidza kusakosha kwavo, vanachiremba vanopa varwere mishonga Roaccutane. Kuongorora, mapepa asati apera uye pashure pekurapa nemapiritsi aya anobvumira kugumisa pamusoro pekushanda kwavo kwakabudirira. Zvisinei, zvakakosha kucherechedza kuvapo kwenhamba yakawanda yemigumisiro uye chido chekucherechedza nguva nenguva kwechirwere cheropa rehupenyu hwemagariro.

"Roakkutan" inotsvakurudza vanachiremba vakakodzera zvakanaka. Nyanzvi dzinopikisa kuti pakusabvumirana kwezvinyorwa, uye nekuchengetedza kwakakwana kwezvose zvinorumbidzwa, murwere ane unhu hwakanaka hwekurapa uye yezvigadzirwa.

Chii chinonzi mishonga iyi?

"Roaccutane" - mapiritsi, maongorori ayo anonyanya kukosha, ndeye chirwere chekunyatsorapwa kwechigamba nemakwenzi. Aya makonduru emumvuri mutsvuku ane kusimiswa, iyo inonyanya kukosha iyo isotretinoin muwandu hwe 10 mg kana 20 mg (zvichienderana nenzira yekusunungurwa). Mukuwedzera kune iri retinoid, kugadzirira kunosanganisira zvimwe zvikamu, kusanganisira mafuta e-soya, bex, glycerol, gelatin, mbatata yemashizha uye marudzi akasiyana-siyana emakisi ezvokudya. "Roaccutane" inoratidzirwa kurapwa kwemaitiro akakura emakwenzi, asingagoni kurapwa nemaitiro anowanzoitwa.

Mishonga inoshanda sei?

Chinhu chinonakidza: vanachiremba vasati vambofungisisa chaiyo nzira yekuita kwechirwere Roaccutane. Kuongorora, mapeji asati apera uye pashure pekurapa neshandiswa iyi inokurudzira vanachiremba vakawanda kuti vaukurudzire kuvarwere vavo vane mufananidzo wakaoma wezvinyama. Isotretininoin, iyo inonzi stereoisomer of trans-retinoic acid, inobata zvinotevera pamuviri womunhu:

• Kunoderedza basa rakawandisa remaronda anonyaradza.

• Inoderedza mararamiro avo.

• Ane chinopesana-kupisa simba paganda.

Nei zviputi zvichiumbwa?

Epithelium, inofukidza bhuru rebvudzi, inokura uye sluschivaetsya. Masero ayo, corneocytes, akavhara duct ye gland ne keratin uye sebum. Izvi zvinotungamirira pakuumbwa kwekomedon, inoteverwa nechisungo chekuvhiringidzika kuita. Ganda remafuta inoratidzirwa ruzivo rwekukura uye kuberekwa kwebhakitiriya we genus Propionibacterium acnes. Izvo zvinhu zvinokosha zvinotarisirwa kuti zvioneke zvakasiyana-siyana, kubwinya uye zvimwe zvinofambisa zvinhu zvisingafadzi.

Mishonga Roaccutane, zvipupuriro zvechiremba kuratidza, dermatologically yakatsigira kukwanisa kwayo kubvisa kupararira kwe sebocytes. Inodzorera muviri wepachiviriki wepamusoro wehutano hwema epithelial masero. "Roaccutane" inoderedza basa rekugadzirwa kwe sebum uye nokudaro kukura kwebhakitiriya kunomira, kuputika kubviswa, kunaka kwekunakisa kunobudirira.

Chii chinonzi pharmacokinetics chemudhaka uyu?

Isotretinoin inotorwa kubva mumugwagwa wezvokudya, uye iyo yakawanda yakanyanya kuongororwa inowanikwa muropa mukati maawa maviri nemaawa mana mushure mekudya. Kune zvimwe zviitiko zvekushandisa mishonga yeRaccutane. Mafungiro evanoongorora anotibvumira kuti tive nemhedziso inotevera: mahwendefa ari nani kunwa mushure mokudya. Izvi zvinowedzera bioavailability ye isotretinoin nechimwe chechipiri pakuenzanisa nehutungamiri hwezvinodhaka musina chinhu chiri mudumbu.

Iko inoshandiswa inoshandiswa zvakanyanya zvakakwana inosungirirwa kuropa reprotein uye inogadziriswa nekuumbwa kwezvinhu zvina zvikuru zvinowanikwa. Isotretinoin uye metabolite yayo yakanyanyiswa mumuguta nemafuta kwemaawa 19 kusvika ku29. Kudzorerwa kwehupenyu hwehutano hwe retinoids mumuviri womunhu unoitika mavhiki maviri mushure mekupedzisira kwemaitiro ekurapwa.

Ndeipi iyo inotora mushonga?

Nekuda kwekutora "Roaccutane" (mapiritsi), kuongorora kunogona kunzwika zvakasiyana. Zvinofanira kuonekwa kuti chirongwa ichi chinosimbiswa chete nechiremba anoenda, achibva mumamiriro ega ega mamiriro ezvinhu emuurwere.

Mushonga weRaccutane, kuongororwa, mapeji asati apera uye pashure pekurapa anosimbisa kushanda kwawo kwakanyanya, kazhinji inotorwa kamwe kana kaviri pazuva nemuromo.

Kuvapo kwemasimba ekurapa, pamwe nemigumisiro yakazara zvakananga kubva pakutanga kwechirwere chemurwere uye nemirairo yakatarwa. Iyi mamiriro ezvinhu anongoronga nzira yekuti munhu apiwe chirongwa cheRaccutane. Mafungiro echiremba anotibvumira kugumisa kuti nguva dzose zviri nani kutanga nehuwandu hwechirwere, izvo zvinoverengerwa kubva muchikamu che 0.5 mg ye isotretinoin pa 1 kg yehutano hwehutano hwemurwere kwemaawa makumi maviri nemana. Maererano nehuwandu, huwandu hwemuda wemishonga yakagadzirirwa ndewe 0.5-1.0 mg / kg wehureji pazuva. Kana chirwere chemuviri mumurwere chichiratidzwa sechakaoma, saka muhombe mukuru unorayirwa kwaari - kusvika ku 2.0 mg / kg pazuva. Uye mumatambudziko awa anotanga nechinguva - 10 mg / zuva uye, kana zvichidiwa, kuwedzera kusvika 1 mg / kg yehuremu mumaawa makumi maviri nemaviri.

Pane hutano hwakanaka hwekutora Roaccutane kubva kune acne. Zviratidzo zvechiremba zvinoratidza kuwanda kwemishonga yemishonga 120-150 mg / kg yehuremu, iyo inoparidzwa mukati memakore acho. Nokudaro, nguva yekurapa zvakananga inobva pane zvakatemwa zuva rega rechirwere. Kazhinji kwemavhiki makumi maviri nemasere kusvika 24 kusvika ku24 zvinogona kuitika mufananidzo wakakwana wekuregererwa kwemakwenzi. Kana murwere achitsungirira regimen yakarongeka yakaipa, ipapo chirwere chezuva nezuva chinoderedzwa, uye nguva yekurapa inowedzera.

Chaizvoizvo, imwe nzira yekurapa nemishonga inonzi Roaccutane - maongorori, mapeji asati apfuura uye mushure anosimbisa ichi chikonzero - zvakakwana kuti kuparara zvachose kwechigamba. Zvisinei, kana murwere akadzoka zvakare, chiremba anogona kupa chirwere chechipiri nguva yekurapa. Muchiitiko ichi, muyero uye nguva yehutano nemishonga inoramba ichichinjwa.

Nguva yezvipfeko, iyo inopa mapiritsi emapurisa pachiso che "Roaccutane" kudzokorora vanachiremba uye varwere vanoratidza mumavhiki masere. Nokudaro, kudiwa kwechipiri chekurapa kunowanikwa mushure mekunge nguva ino yamukati uye isina kumbobvunzwa.

Panogona kunge pane kudarika here?

Kana chirongwa chakakurudzirwa chikapfuura nemurwere paanotora Roaccutane, mirayiridzo yekushandiswa, kuongororwa kwevarwere kunoratidza kuitika kwezviratidzo zve hypervitaminosis ne vitamini A. Izvi zvinobviswa nekushambidza mudumbu, iyo inofanira kuitwa mumaawa ekutanga mushure mekushandisa zvakanyanya mishonga.

Mishonga iyi inobatanidza sei nemimwe mishonga?

Iko kushandiswa panguva imwe chete yaRoaccutane uye vitamini A kunotungamirira ku hypervitaminosis yekupedzisira, naizvozvo kuungana uku kunofanira kudziviswa.

Contraindicated joint therapy ne isotretinoin uye tetracyclines, sezvo izvi zvinoita kuti kuwedzere kusagadzikana kunetseke.

Kazhinji pane kuderera kwekubudirira kweprogesterone, inokonzera mapiritsi emucheka "Roaccutane". Zvinotaurwa nachiremba zvinoratidza kuti mukurapa kwechirwere ichi kunoshandisa nzira dzekudzivirira nekudzivirira kwehutachiona hwemhomoni uye kushandisa nzira dzokudzivirira kubata pamuviri.

Kana murwere achishandisa keratolytic agents kana kuti exfoliates munzvimbo yekurapa naRoaccutan, ganda rinogumbura rinogona kuitika.

Zvinoita here kushandisa mushonga wevakadzi vane pamuviri?

"Roaccutane" (mapiritsi, kuongororwa kunofuridzira vazhinji kuti vaedze kubudirira kwavo pachavo) kune chinhu chinokosha zvikuru: ivo vanonyatsopesana nekamuviri. Isotretinoin ine simba guru rematogogic. Kurapa kunyange pfupi uye mune zviduku zvishoma zvine mikana yakawanda kunogona kukonzera kusuruvara kwakakomba kwe fetus.

Izvi zvinobatanidza nekupikisa kwechirwere kune vakadzi vane makore ekurera vana vasingaiti zvinotevera:

• Kuvapo kwechimiro chakakomba chechigamba, chisina kubviswa nehutano hwechirwere.

• Mukadzi anonyatsonzwisisa uye anoteerera mazano ose echiremba.

• Akaudzwa nachiremba pamusoro pengozi dzakakwana dzekudzivirira neRoaccutane therapy uye mwedzi mushure maro, pamusoro pekudiwa kwekukurumidzira kubvunzurudza nemumwe nyanzvi mune imwe nguva.

• Mukadzi anoziva kuderera kana kurasikirwa kwese kwehutano hwekudzivirira.

• Anonzwisisa chinokosha uye kudiwa kwezviito zvose zvinodzivirira zvakataurwa nachiremba.

• Mukadzi anonzwisisa kukosha kwekudzivirirwa kunobva pakuberekwa panguva yose yekurapa, mwedzi musati wapfuura uye shure kwayo, uyewo kudiwa kwekushandisa kamwechete nzira mbiri dzekudzivirira kubata pamuviri (kusanganisira chidziro).

• Mukadzi ane chirwere chekuita mitezo isina kunaka, iyo inofanira kugamuchirwa mushure memazuva gumi nemana asati apera. Uyewo, kushandiswa uku kunofanira kuitwa mwedzi mumwe nomumwe panguva yekurapa uye mavhiki mashanu mushure mekupera kwayo.

• Anomanikidzwa kutanga kutora mishonga chete kwemazuva maviri ezuva rinotevera rekuenda kumwedzi.

• Mukadzi anofanira kushanyira chiremba pamwedzi.

• Zvose zviri pamusoro apa zvinobatsirawo pakudzokorora maitiro ekurapa naRoaccutane.

Zvakakosha kubatanidza kubhakwa kwechokwadi nekuna "Roaccutane" kubva kune acne. Inyanzvi dzemhinduro dzinoratidza kudikanwa kwekuteerera zvakasimba mutemo uyu nevakadzi vose, kunyange avo vasingatori mishonga yekudzivirira nekuda kwekushaya vana, vanotambura neinorrhea uye havaiti zvepabonde. Kunze kwekunogona kungoitwa chete nevarwere vakawana hysterectomy.

Chiremba anofanira kuyeuka chii?

Chiremba anofanira kuziva nezvehumwe humwe hwehutano hwemurwere asati agadzirira kurapa kuna Roaccutane. Inyanzvi dzekutsvaga dzinoratidza kuti kuitira kuti tidzivise mamiriro asingatarisirwi, chiremba anofanira kunyatsova nechokwadi mune zvinzvimbo zvinotevera:

• Murwere ane chimiro chakakomba chechigamba, chisingagoni kurapwa nedzimwe nzira dzokurapa, kureva, nodular-cystic kana conglobate phenomena iyo inotungamirira kukura.

• Mukadzi ane chirwere chepamuviri chepamuviri chisina kunaka chakaitwa mushure mekurapa, panguva yekurapa, uye vhiki shishanu mushure mokunge apedza. Zvose izvi deta zvine chiratidzo chezuva rokuongorora zvakanyatsorongedzerwa.

• Murwere anoshandisa kubata pamuviri (1, uye zviri nani 2), uye nzira yekudzivirira inomirira. Mutemo uyu unoshanda kune nguva yemwedzi usati watanga kurapwa, iyo yose yemazuva uye mazuva 30 mushure mekurapa.

• Mukadzi anonzwisisa zvakakwana kukosha kwekutevedzera matanho ose ekudzivirira kutanga kwekuita pamuviri.

• Murwere anosangana nezvose zvinorongwa pamusoro apa.

Zviratidzo zvekusatakura pamuviri

Izvo zvinofanira kuonekwa kuti kuve nekudzivirira pamuviri, kunoratidzwa nekunzwisisika kwe 25 mME / ml, kunofanira kuitwa pamazuva matatu ekutanga ekuenda kumwedzi.

Pamberi pekutangira, murwere anofanira kutanga kutora mishonga yekudzivirira mukati memwedzi. Kuedzwa kwekuita pamuviri kunoitwa pazuva rekugadzwa kwaRoaccutane, zuva rayo uye chiitiko chacho chakanyorwa nachiremba.

Penguva yekurapa murwere anofanirwa kushanyira chiremba mazuva makumi maviri nemasere nekutarisa kusungirwa kwekusabatwa kwepamuviri. Chiyero chakafanana chinoitwa mavhiki mashanu mushure mekuguma kwerapi.

"Roakkutan", kuongororwa kwevarwere pamusoro pekutaura pamusoro pekunakisa kwekunakidza kwayo, kunogadzwa kana kusarudzwa pasi pemurairo wechiremba uye kwemazuva makumi matatu chete. Kana kuenderera mberi kwechirwere kuchidiwa, zvino zvinokurudzirwa kudzokorora mimba yekuedzwa.

Ndinogona here kutora mishonga yevarume?

Kurapa kwechigamba muvarume vane chirwere Roaccutane zvakakodzera, asi murwere anofanirwa kuchenjerera kusabvisa kutora mishonga iyi nevamwe. Kubudiswa kwechirwere mumvura inonzi seminal fluid ishoma uye haikwanise kuratidza matatogenic properties.

Nzira yekugadzirira sei pamuviri?

Vakadzi vazhinji vane hanya pamusoro pekuti kutora pamuviri kuchapfuura sei Roaccutane. Zviratidzo zvechiremba zvinoratidza kuti kuronga kwepamuviri kunogona kutangiswa pasina yapfuura mwedzi umwe mushure mekupedzwa kwemaitiro ekurapwa.

Kana, nezvose zvingwarira, kutora pamuviri kwakasvika munguva inotyisa, mukadzi anofanira kunge achiziva nezvehutano hwakanyanya hwekukurira mumatusisita emuKCS akaremara, maitiro emwoyo, maziso uye endocrine. Saka, mubvunzo wekuchengetedza mwana unogadziriswa.

Mushonga we "Roaccutane" haufaniri kutorwa kuvakadzi panguva yewakabatwa, sezvo inopinda mumukaka wemvere.

Ndezvipi zvisingadiwi zvinogona kuitika?

Kune zvizhinji zvakanyanya zvemigumisiro inogona kuitika mumurwere paanoshandisa mushonga weRaccutane. Mirayiridzo, kuongororwa kwechiremba nevarwere zvinoratidza izvi zvinotevera zvisingadikanwi:

• Kuora mwoyo, kuwedzera kusagadzikana, kusuruvara, kugumburwa.

• Kuderera kwehuwandu hwemasikati uye husiku hwekuona, zvirwere zveziso, kunzwa kutadza.

• Matambudziko ekugadzirisa, kushungurudza, kubatwa kwepachivi, kuputika, kubuda ropa.

• Anemia, platelet change, ESR, hematocrit, neutropenia uye leukopenia.

• Bronchospasm.

• Kusuruvara muzvibatanidza nemisungo, hyperostosis, tendinitis, arthritis.

• Rashes, erythema, pruritus, sweat, pigmentation, thinning uye nekushaiwa bvudzi, chinyorwa allergy.

• Dzai ganda uye miromo yemukati, mashizha, mashizha uye mashizha, maziso.

• Kuchinja muzviratidzo zvebhroreta: kuwedzera kwekulesterol, triglycerides, lipoproteins, hyperglycemia.

• Zvirwere zveStptococcal zvinoshandiswa.

• Hematuria, vasculitis, hypersensitivity, lymphadenopathy.

• Stefano-Jones Syndrome, erythema multiforme, epidermal toxic necrolysis.

Ndiani anopesana nemutemo?

Chirwere ichi "Roaccutane" chinopesana nezvirwere nezvimwe zvinotevera:

• Hyperlipidemia yemhando yekutaura.

• Kuberekwa uye lactation.

• Hypervitaminosis A.

• Kurapa neTetracycline zvinodhaka.

• Chiropa kusakundikana.

• Kuwedzerwa kunzwisisika kune zvikamu zvechirwere.

• Vana kusvika makore gumi nemaviri.

Nekuchenjerera iyi mishonga inorayirwa nevarwere vane chirwere cheshuga mellitus, kudhakwa, chirwere chemagodhi, chiremera uye kuneta.

Kubudirira kwechirwere ichi hazvikonzeri kusava nechokwadi. "Roaccutane", kuongororwa, mapikicha uye maonero anoratidza uchapupu hwahwo husingaverengeki uye yezvokuzora, inoita kuti tive nechivimbo mukurapa kwemazino, kunyange mafomu akaoma zvikuru. Zvisinei, munhu anofanirwa kuyeuka zvose zvinokonzerwa nemigumisiro yemishonga, kusanzwisisana nekudzivirira uye lactation, uyewo kuvapo kwezvimwe zvinopesana. Chirevo chemishonga iyi chinoitwa chete nechiremba anoenda, uyo mumwe nomumwe anopa murwere muyero uye nguva yedzidzo yerapi.