InotungamirwaSainzi

Mapuroteni denaturation

Conformation (mamiriro) pamusoro peptide cheni nomurayiro chakasiyana nomumwe puroteni. In Mamiriro ezvinhu pane mukaha yokuwanda zvisungo izvo kudzikamisa spatial nemamiriro mukomboni Morekuru. Somugumisiro, pakakoromoka zvachose yose Morekuru (kana nouchapupu mugove waro) anotora chimiro asingashumbi coils. Izvi anonzi "denaturation". kuchinja uku kungamutsawo kupisa makumi matanhatu kusvika makumi masere inegumi. Saka, mumwe nomumwe morekuru, kunoguma pakakoromoka zvingasiyana mu conformation nevamwe.

Denaturation kwemapurotini kunoitika pasi pokudzora chero vamiririri anokwanisa kuparadza dzisiri covalent zvisungo. Izvi zvinogona kuitika pasi alkaline kana acidic ezvinhu, pamusoro pemvura Pasika chikamu, pasi zvinoitwa nevamwe Organic yeimwe (phenols, alcohols nevamwe). mapuroteni denaturation anogona kuitika pasi pokudzora guanidinium chloride kana urea. Akati nevasori vanoumba simba zvisungo (hydrophobic, Ionic, rehydrogen) pamwe carbonyl kana amino mapoka peptide nomuzongoza ane vanoverengeka mapoka amino asidhi residues, dzinomiririra yavo iripo mapuroteni rehydrogen zvisungo mukati mamorekuru. Somugumisiro, kuchinja kunoitika muna yechipiri uye tertiary marongerwo.

Kupikiswa denaturing nevasori kunonyanya kubva kuvapo muna morekuru puroteni yeimwe ose disulfide kusungwa. Trypsin inhibitor ane nhatu zvisungo S - S. Under ezvinhu kuzoita mapuroteni denaturation kunoitika pasina zvimwe zvinofurira. Kana zvadaro kuisa kubatana mumamiriro ezvinhu umo oxidation rinoitwa SH-mapoka cysteine uye paumbwe disulfide zvisungo, chepakutanga conformation anomutswa. Kuvapo kunyange chimwe disulfide chisungo yekudyidzana zvinowedzera kutsiga spatial mamiriro.

mapuroteni denaturation, yemanyorero achiperekedzwa vasanyanye solubility. Pamwe chete ichi precipitate kakawanda siyana. Richiwanika muchimiro "curdled mapuroteni." At dzakakwirira kuwanda pakati yeimwe iri mhinduro, "coagulation" kaviri yose mhinduro, sezvo Somuenzaniso, izvi zvinoitika kana kufashaira mazai. Kana denaturation of puroteni anorasikirwa basa rayo yomuzvarirwo. Pfungwa iyi inobva kushandiswa carbolic asidhi (phenol aqueous mhinduro) sezvo akambozvishandisa kuuraya utachiona fuma.

Kusagadzikana of spatial mamiriro, muprista ndingangokuvara kukundikana pasi pokudzora siyana yomuchipatara zviri zvakaoma patsanura uye tsvakurudzo mapuroteni. Uyewo akasika zvimwe zvinetso kana uchishandisa yeimwe mukurapa uye indasitiri.

Kana puroteni denaturation yakanga kuitwa yokuwana yakakwirira tembiricha anononoka kutonhora kunoitika zvimwe zvinhu izvi renativatsii - kuzoita zvizvarwa (original) conformation. Izvi zvinoratidza kuti kwenheyo peptide cheni maererano zvikuru marongerwo.

Paumbwe chizvarwa conformation (panobva nzvimbo) chinhu kwatangwa muitiro. Nemamwe mashoko, urongwa uhwu anoenderana shoma uwandu vakasununguka simba iri morekuru. Mumwe anogona somugumisiro kupera kuti spatial nemamiriro mukomboni iri encoded ari amino iine acid kutevedzana ari peptide nengetani. Izvi zvinozoita zvinoreva kuti polypeptides zvose chokuita ne alternation kuti amino acids (somuenzaniso, mioglobinovye peptide ngetani), achatora ane fingapirindi conformation.

Mapuroteni vanogona Misiyano iri huru mamiriro, kunyange kana zvishoma kana zvachose zvakakura conformation.

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